This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013] See more...

Aliases for GPR55 Gene

Aliases for GPR55 Gene

  • G Protein-Coupled Receptor 55 2 3 5
  • G-Protein Coupled Receptor 55 3 4
  • LPIR1 3

External Ids for GPR55 Gene

Previous GeneCards Identifiers for GPR55 Gene

  • GC02M229835
  • GC02M230503
  • GC02M231736
  • GC02M231974
  • GC02M231597
  • GC02M231480
  • GC02M223614

Summaries for GPR55 Gene

Entrez Gene Summary for GPR55 Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPR55 Gene

GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Diseases associated with GPR55 include Lysinuric Protein Intolerance and Cannabis Abuse. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is LPAR4.

UniProtKB/Swiss-Prot Summary for GPR55 Gene

  • May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Tocris Summary for GPR55 Gene

  • GPR55 is a non-CB1/CB2 receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2.

Gene Wiki entry for GPR55 Gene

Additional gene information for GPR55 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR55 Gene

Genomics for GPR55 Gene

GeneHancer (GH) Regulatory Elements for GPR55 Gene

Promoters and enhancers for GPR55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J230924 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 506.3 +35.8 35824 2.5 CTCF SIN3A SP1 EP300 ZIC2 RELA MEF2C RCOR1 RAD21 REST GPR55 ENSG00000283164 SPATA3 SPATA3-AS1 GCSIR PSMD1 lnc-SPATA3-1
GH02J230961 Enhancer 0.3 Ensembl 500.7 -0.3 -274 0.2 GLIS1 SMAD5 GPR55 piR-34696-009
GH02J230956 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 +3.9 3893 1.7 SIN3A SP1 EP300 ZBTB26 RELA MEF2C RCOR1 TRIM22 POLR2A EZH2 COX20P2 GPR55 lnc-SPATA3-1
GH02J230908 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 9.5 +52.6 52597 1.3 FOS ZBTB5 REST CTBP1 TAF9B NCOR1 NFRKB WT1 ZNF316 FOSL1 ENSG00000230385 GPR55 GCSIR
GH02J230947 Enhancer 1 FANTOM5 dbSUPER 8.8 +13.1 13054 0.4 POLR2A RELA TCF12 CBFB SMC3 NBN SPI1 BATF IRF4 EBF1 GPR55 lnc-SPATA3-1 COX20P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR55 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR55

Top Transcription factor binding sites by QIAGEN in the GPR55 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • c-Myb
  • FosB
  • Fra-1
  • JunB
  • JunD
  • MEF-2A

Genomic Locations for GPR55 Gene

Genomic Locations for GPR55 Gene
chr2:230,907,318-230,961,227
(GRCh38/hg38)
Size:
53,910 bases
Orientation:
Minus strand
chr2:231,772,033-231,825,781
(GRCh37/hg19)
Size:
53,749 bases
Orientation:
Minus strand

Genomic View for GPR55 Gene

Genes around GPR55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR55 Gene

Proteins for GPR55 Gene

  • Protein details for GPR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T6-GPR55_HUMAN
    Recommended name:
    G-protein coupled receptor 55
    Protein Accession:
    Q9Y2T6
    Secondary Accessions:
    • Q8N580

    Protein attributes for GPR55 Gene

    Size:
    319 amino acids
    Molecular mass:
    36637 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.
    SequenceCaution:
    • Sequence=AAD22410.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for GPR55 Gene

Post-translational modifications for GPR55 Gene

  • Glycosylation at Asn5 and Asn171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR55 Gene

Domains & Families for GPR55 Gene

Gene Families for GPR55 Gene

Protein Domains for GPR55 Gene

Suggested Antigen Peptide Sequences for GPR55 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA (A8K858_HUMAN)
  • G-protein coupled receptor 55 (GPR55_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2T6

UniProtKB/Swiss-Prot:

GPR55_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR55: view

Function for GPR55 Gene

Molecular function for GPR55 Gene

UniProtKB/Swiss-Prot Function:
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.
GENATLAS Biochemistry:
G protein coupled receptor 55,highly expressed in the caudate nucleus and putamen with homology to P2RY5,GPR23,GPR35,CCR4

Phenotypes From GWAS Catalog for GPR55 Gene

Gene Ontology (GO) - Molecular Function for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004949 cannabinoid receptor activity IDA,IBA 19723626
genes like me logo Genes that share ontologies with GPR55: view
genes like me logo Genes that share phenotypes with GPR55: view

Animal Models for GPR55 Gene

MGI Knock Outs for GPR55:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR55

Clone Products

  • Addgene plasmids for GPR55

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR55 Gene

Localization for GPR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR55 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR55 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA,TAS 18757503
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR55: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR55 Gene

Pathways & Interactions for GPR55 Gene

genes like me logo Genes that share pathways with GPR55: view

Pathways by source for GPR55 Gene

SIGNOR curated interactions for GPR55 Gene

Activates:

Gene Ontology (GO) - Biological Process for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity IDA 18757503
GO:0035025 positive regulation of Rho protein signal transduction IDA 18757503
GO:0038171 cannabinoid signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR55: view

Drugs & Compounds for GPR55 Gene

(35) Drugs for GPR55 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist, Antagonist, Channel blocker, Activator, Target, antagonist 0
Rimonabant Approved, Investigational Pharma Antagonist, Target, antagonist CB1 receptor antagonist 46
Palmitoylethanolamide Experimental Nutra Agonist Selective GPR55 agonist. FAAH and PAA substrate 11
Medical Cannabis Experimental, Investigational Pharma Target 0
Nabiximols Investigational Pharma Target 59

(3) Additional Compounds for GPR55 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist, Potentiation, Allosteric regulator, Full agonist, Activator, Channel blocker
oleoylethanolamide
Agonist
ML 193
713121-80-3

(5) Tocris Compounds for GPR55 Gene

Compound Action Cas Number
Abn-CBD Selective GPR55 agonist; neurobehaviorally inactive 22972-55-0
CID 16020046 Selective GPR55 antagonist 834903-43-4
ML 193 Potent, selective GPR55 antagonist 713121-80-3
O-1602 Potent GPR55 receptor agonist 317321-41-8
Palmitoylethanolamide Selective GPR55 agonist. FAAH and PAA substrate 544-31-0

(5) ApexBio Compounds for GPR55 Gene

Compound Action Cas Number
Abn-CBD 22972-55-0
CID 16020046 834903-43-4
O-1602 317321-41-8
Oleylethanolamide 111-58-0
Palmitoylethanolamide 544-31-0
genes like me logo Genes that share compounds with GPR55: view

Drug Products

Transcripts for GPR55 Gene

mRNA/cDNA for GPR55 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR55

Alternative Splicing Database (ASD) splice patterns (SP) for GPR55 Gene

No ASD Table

Relevant External Links for GPR55 Gene

GeneLoc Exon Structure for
GPR55

Expression for GPR55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR55 Gene

mRNA differential expression in normal tissues according to GTEx for GPR55 Gene

This gene is overexpressed in Testis (x5.5) and Spleen (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR55

SOURCE GeneReport for Unigene cluster for GPR55 Gene:

Hs.114545

mRNA Expression by UniProt/SwissProt for GPR55 Gene:

Q9Y2T6-GPR55_HUMAN
Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.

Evidence on tissue expression from TISSUES for GPR55 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with GPR55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR55 Gene

Orthologs for GPR55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR55 31 30
  • 98.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR55 31 30
  • 85.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR55 31 30
  • 83.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr55 17 31 30
  • 81.22 (n)
rat
(Rattus norvegicus)
Mammalia Gpr55 30
  • 79.96 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR55 31
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR55 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR55 31 30
  • 59.72 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490418 30
  • 54.22 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793909 30
  • 54.33 (n)
gpr55a 31
  • 28 (a)
OneToOne
Species where no ortholog for GPR55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR55 Gene

ENSEMBL:
Gene Tree for GPR55 (if available)
TreeFam:
Gene Tree for GPR55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR55: view image

Paralogs for GPR55 Gene

(6) SIMAP similar genes for GPR55 Gene using alignment to 3 proteins:

  • GPR55_HUMAN
  • A8K858_HUMAN
  • C9J1P7_HUMAN
genes like me logo Genes that share paralogs with GPR55: view

Variants for GPR55 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR55 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
775831 Benign: not provided 230,910,656(-) C/T MISSENSE_VARIANT
rs193920808 Uncertain Significance: Malignant tumor of prostate 230,910,022(-) G/A MISSENSE_VARIANT
rs34229723 - p.Thr215Asn
rs3749073 - p.Gly195Val

Additional dbSNP identifiers (rs#s) for GPR55 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR55 Gene

Variant ID Type Subtype PubMed ID
nsv470522 CNV loss 18288195
nsv834565 CNV gain 17160897

Variation tolerance for GPR55 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR55 Gene

Human Gene Mutation Database (HGMD)
GPR55
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR55

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR55 Gene

Disorders for GPR55 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPR55 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lysinuric protein intolerance
  • lpi
cannabis abuse
  • marijuana abuse
epileptic encephalopathy, early infantile, 6
  • ds
lennox-gastaut syndrome
  • lgs
early infantile epileptic encephalopathy
  • early infantile epileptic encephalopathy with burst-suppression
- elite association - COSMIC cancer census association via MalaCards
Search GPR55 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR55 Gene

Publications for GPR55 Gene

  1. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. (PMID: 18757503) Henstridge CM … Irving AJ (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 4 23 54
  2. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PMID: 9931487) Sawzdargo M … O'Dowd BF (Brain research. Molecular brain research 1999) 2 3 4 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (PMID: 19723626) Kapur A … Abood ME (The Journal of biological chemistry 2009) 3 4 54
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. (PMID: 19805329) Whyte LS … Rogers MJ (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 54

Products for GPR55 Gene

Sources for GPR55 Gene