Aliases for GPR52 Gene
External Ids for GPR52 Gene
Previous GeneCards Identifiers for GPR52 Gene
Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]
GeneCards Summary for GPR52 Gene
GPR52 (G Protein-Coupled Receptor 52) is a Protein Coding gene. Diseases associated with GPR52 include Large Intestine Adenocarcinoma. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled amine receptor activity. An important paralog of this gene is GPR21.
UniProtKB/Swiss-Prot Summary for GPR52 Gene
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).