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Aliases for GPR52 Gene

Aliases for GPR52 Gene

  • G Protein-Coupled Receptor 52 2 3 5

External Ids for GPR52 Gene

Previous GeneCards Identifiers for GPR52 Gene

  • GC01P171956
  • GC01P169845
  • GC01P170998
  • GC01P171656
  • GC01P171148
  • GC01P172683
  • GC01P174417
  • GC01P145642

Summaries for GPR52 Gene

Entrez Gene Summary for GPR52 Gene

  • Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]

GeneCards Summary for GPR52 Gene

GPR52 (G Protein-Coupled Receptor 52) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is GPR21.

UniProtKB/Swiss-Prot for GPR52 Gene

  • Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).

Gene Wiki entry for GPR52 Gene

Additional gene information for GPR52 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR52 Gene

Genomics for GPR52 Gene

GeneHancer (GH) Regulatory Elements for GPR52 Gene

Promoters and enhancers for GPR52 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I174448 Promoter 0.5 EPDnew 550.8 +0.0 1 0.1 GC01M174448 GPR52 TNN RABGAP1L
GH01I174015 Enhancer 0.2 FANTOM5 1.4 -432.9 -432914 0.2 RC3H1-IT1 ZBTB37 SERPINC1 GAS5 SNORD81 RC3H1 GPR52 GC01M174037 RNA5SP68
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR52 gene promoter:

Genomic Locations for GPR52 Gene

Genomic Locations for GPR52 Gene
chr1:174,448,074-174,449,545
(GRCh38/hg38)
Size:
1,472 bases
Orientation:
Plus strand
chr1:174,417,212-174,418,683
(GRCh37/hg19)

Genomic View for GPR52 Gene

Genes around GPR52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR52 Gene

Proteins for GPR52 Gene

  • Protein details for GPR52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T5-GPR52_HUMAN
    Recommended name:
    G-protein coupled receptor 52
    Protein Accession:
    Q9Y2T5
    Secondary Accessions:
    • O75654
    • Q4VBL6
    • Q6ISM0

    Protein attributes for GPR52 Gene

    Size:
    361 amino acids
    Molecular mass:
    41354 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR52 Gene

Post-translational modifications for GPR52 Gene

  • Glycosylation at posLast=22, isoforms=13, and isoforms=20

Other Protein References for GPR52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR52 Gene

Domains & Families for GPR52 Gene

Gene Families for GPR52 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR52 Gene

Suggested Antigen Peptide Sequences for GPR52 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2T5

UniProtKB/Swiss-Prot:

GPR52_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR52: view

Function for GPR52 Gene

Molecular function for GPR52 Gene

GENATLAS Biochemistry:
G protein coupled receptor 52,with high homology to GRP21,HRH2,HTR4
UniProtKB/Swiss-Prot Function:
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).

Gene Ontology (GO) - Molecular Function for GPR52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IDA,TAS 24587241
genes like me logo Genes that share ontologies with GPR52: view
genes like me logo Genes that share phenotypes with GPR52: view

Animal Models for GPR52 Gene

MGI Knock Outs for GPR52:

Clone Products

  • Addgene plasmids for GPR52

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR52 Gene

Localization for GPR52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR52 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR52 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9931487
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR52: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR52 Gene

Pathways & Interactions for GPR52 Gene

genes like me logo Genes that share pathways with GPR52: view

Pathways by source for GPR52 Gene

1 BioSystems pathway for GPR52 Gene

Gene Ontology (GO) - Biological Process for GPR52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9931487
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0007626 locomotory behavior ISS --
GO:0042493 response to drug IDA 24587241
genes like me logo Genes that share ontologies with GPR52: view

No data available for SIGNOR curated interactions for GPR52 Gene

Drugs & Compounds for GPR52 Gene

No Compound Related Data Available

Transcripts for GPR52 Gene

mRNA/cDNA for GPR52 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR52 Gene

G protein-coupled receptor 52:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR52

Alternative Splicing Database (ASD) splice patterns (SP) for GPR52 Gene

No ASD Table

Relevant External Links for GPR52 Gene

GeneLoc Exon Structure for
GPR52
ECgene alternative splicing isoforms for
GPR52

Expression for GPR52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR52 Gene

mRNA differential expression in normal tissues according to GTEx for GPR52 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x15.7), Brain - Putamen (basal ganglia) (x12.2), and Brain - Caudate (basal ganglia) (x9.1).

Protein differential expression in normal tissues from HIPED for GPR52 Gene

This gene is overexpressed in Serum (52.9) and Heart (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR52 Gene



Protein tissue co-expression partners for GPR52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR52 Gene:

GPR52

SOURCE GeneReport for Unigene cluster for GPR52 Gene:

Hs.673850

mRNA Expression by UniProt/SwissProt for GPR52 Gene:

Q9Y2T5-GPR52_HUMAN
Tissue specificity: Expressed in brain, especially in striatum.
genes like me logo Genes that share expression patterns with GPR52: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR52 Gene

Orthologs for GPR52 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR52 33
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia GPR52 33 34
  • 92.71 (n)
dog
(Canis familiaris)
Mammalia GPR52 33
  • 92.15 (n)
mouse
(Mus musculus)
Mammalia Gpr52 33 16
  • 91.51 (n)
chicken
(Gallus gallus)
Aves GPR52 33
  • 80.98 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr52 33
  • 74.42 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR52 34
  • 77 (a)
OneToOne
LOC101884270 33
  • 71.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA21 33
  • 42.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta DopEcR 33 34
  • 41.64 (n)
worm
(Caenorhabditis elegans)
Secernentea F59D12.1 34
  • 21 (a)
OneToMany
Species where no ortholog for GPR52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR52 Gene

ENSEMBL:
Gene Tree for GPR52 (if available)
TreeFam:
Gene Tree for GPR52 (if available)

Paralogs for GPR52 Gene

Paralogs for GPR52 Gene

(1) SIMAP similar genes for GPR52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR52: view

Variants for GPR52 Gene

Sequence variations from dbSNP and Humsavar for GPR52 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000118000 -- 174,446,299(+) G/A upstream_transcript_variant
rs1000905014 -- 174,449,922(+) A/C/G downstream_transcript_variant
rs1003125843 -- 174,446,585(+) T/G upstream_transcript_variant
rs1003635851 -- 174,449,259(+) A/G 3_prime_UTR_variant
rs1003925962 -- 174,449,577(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR52 Gene

Variant ID Type Subtype PubMed ID
nsv548194 CNV loss 21841781
nsv470746 CNV loss 18288195
nsv465672 CNV loss 19166990

Variation tolerance for GPR52 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR52 Gene

Disorders for GPR52 Gene

Additional Disease Information for GPR52

No disorders were found for GPR52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR52 Gene

Publications for GPR52 Gene

  1. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PMID: 9931487) Sawzdargo M … O'Dowd BF (Brain research. Molecular brain research 1999) 2 3 4 58
  2. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. (PMID: 25738228) Yao Y … Lu B (eLife 2015) 3 4 58
  3. Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. (PMID: 24587241) Komatsu H … Mori M (PloS one 2014) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPR52 Gene

  • Addgene plasmids for GPR52

Sources for GPR52 Gene

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