Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR50 Gene

Aliases for GPR50 Gene

  • G Protein-Coupled Receptor 50 2 3 4 5
  • H9 3 4
  • Melatonin-Related Receptor 3
  • Mel1c 3

External Ids for GPR50 Gene

Previous GeneCards Identifiers for GPR50 Gene

  • GC0XP144664
  • GC0XP147028
  • GC0XP148116
  • GC0XP148985
  • GC0XP150015
  • GC0XP150095
  • GC0XP150345
  • GC0XP139205

Summaries for GPR50 Gene

Entrez Gene Summary for GPR50 Gene

  • This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

GeneCards Summary for GPR50 Gene

GPR50 (G Protein-Coupled Receptor 50) is a Protein Coding gene. Diseases associated with GPR50 include Major Depressive Disorder. Among its related pathways are Eicosanoid ligand-binding receptors and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.

UniProtKB/Swiss-Prot for GPR50 Gene

  • Does not bind melatonin.

Gene Wiki entry for GPR50 Gene

Additional gene information for GPR50 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR50 Gene

Genomics for GPR50 Gene

GeneHancer (GH) Regulatory Elements for GPR50 Gene

Promoters and enhancers for GPR50 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ151176 Promoter 0.5 EPDnew 650.7 0.0 -16 0.1 GPR50-AS1 GPR50 MIR4330
GH0XJ151177 Enhancer 0.3 ENCODE 650.7 +1.3 1280 0.2 SUZ12 GPR50 GPR50-AS1 ENSG00000269993
GH0XJ151178 Enhancer 0.2 FANTOM5 9.8 +2.4 2437 0.2 GPR50-AS1 GPR50 ENSG00000269993
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR50 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR50 gene promoter:
  • S8
  • Evi-1
  • AML1a
  • deltaCREB
  • CREB
  • AP-2gamma
  • MAZR
  • FOXO3
  • FOXO3a
  • FOXO3b

Genomic Locations for GPR50 Gene

Genomic Locations for GPR50 Gene
6,272 bases
Plus strand
4,882 bases
Plus strand

Genomic View for GPR50 Gene

Genes around GPR50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR50 Gene

Proteins for GPR50 Gene

  • Protein details for GPR50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melatonin-related receptor
    Protein Accession:
    Secondary Accessions:
    • Q0VGG3
    • Q3ZAR0

    Protein attributes for GPR50 Gene

    617 amino acids
    Molecular mass:
    67369 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MTNR1A and MTNR1B.

neXtProt entry for GPR50 Gene

Post-translational modifications for GPR50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR50 Gene

Domains & Families for GPR50 Gene

Gene Families for GPR50 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GPR50 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR50: view

Function for GPR50 Gene

Molecular function for GPR50 Gene

UniProtKB/Swiss-Prot Function:
Does not bind melatonin.
GENATLAS Biochemistry:
melatonin-related receptor,G protein coupled receptor,expressed in hypothalamus and pituitary,potentially involved in neuroendocrine function

Gene Ontology (GO) - Molecular Function for GPR50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8647286
GO:0005515 protein binding IPI 16778767
GO:0008502 melatonin receptor activity IEA --
GO:0042802 identical protein binding IPI 16778767
genes like me logo Genes that share ontologies with GPR50: view
genes like me logo Genes that share phenotypes with GPR50: view

Animal Models for GPR50 Gene

MGI Knock Outs for GPR50:
  • Gpr50 Gpr50<tm1Dgen>
  • Gpr50 Gpr50<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR50

Clone Products

  • Addgene plasmids for GPR50

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR50 Gene

Localization for GPR50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR50 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR50 gene
Compartment Confidence
plasma membrane 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA,IEA --
GO:0005887 integral component of plasma membrane TAS 8647286
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR50: view

Pathways & Interactions for GPR50 Gene

genes like me logo Genes that share pathways with GPR50: view

Pathways by source for GPR50 Gene

2 BioSystems pathways for GPR50 Gene
1 KEGG pathway for GPR50 Gene
3 Cell Signaling Technology pathways for GPR50 Gene

Gene Ontology (GO) - Biological Process for GPR50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007267 cell-cell signaling TAS 8647286
genes like me logo Genes that share ontologies with GPR50: view

No data available for SIGNOR curated interactions for GPR50 Gene

Drugs & Compounds for GPR50 Gene

(1) Drugs for GPR50 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR50 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR50: view

Transcripts for GPR50 Gene

mRNA/cDNA for GPR50 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR50 Gene

G protein-coupled receptor 50:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR50

Alternative Splicing Database (ASD) splice patterns (SP) for GPR50 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for GPR50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR50 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR50 Gene

This gene is overexpressed in Pituitary (x47.1).

Protein differential expression in normal tissues from HIPED for GPR50 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR50 Gene

Protein tissue co-expression partners for GPR50 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR50 Gene:


SOURCE GeneReport for Unigene cluster for GPR50 Gene:


mRNA Expression by UniProt/SwissProt for GPR50 Gene:

Tissue specificity: Hypothalamus and pituitary.

Evidence on tissue expression from TISSUES for GPR50 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR50: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR50 Gene

Orthologs for GPR50 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR50 34 33
  • 98.92 (n)
(Canis familiaris)
Mammalia GPR50 34 33
  • 87.1 (n)
(Bos Taurus)
Mammalia GPR50 34 33
  • 82.89 (n)
(Mus musculus)
Mammalia Gpr50 16 34 33
  • 82.14 (n)
(Rattus norvegicus)
Mammalia Gpr50 33
  • 81.3 (n)
(Monodelphis domestica)
Mammalia GPR50 34
  • 42 (a)
(Gallus gallus)
Aves -- 34
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii mtnr1al 34
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30340 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea npr-35 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
CSA.5131 34
  • 17 (a)
Species where no ortholog for GPR50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPR50 Gene

Gene Tree for GPR50 (if available)
Gene Tree for GPR50 (if available)
Evolutionary constrained regions (ECRs) for GPR50: view image

Paralogs for GPR50 Gene

Paralogs for GPR50 Gene

(9) SIMAP similar genes for GPR50 Gene using alignment to 3 proteins:

  • Q7Z581_HUMAN
  • Q7Z582_HUMAN
genes like me logo Genes that share paralogs with GPR50: view

Variants for GPR50 Gene

Sequence variations from dbSNP and Humsavar for GPR50 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000717126 -- 151,177,236(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000864690 -- 151,179,502(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001255852 -- 151,174,808(+) G/C upstream_transcript_variant
rs1001355813 -- 151,182,230(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001623658 -- 151,175,153(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR50 Gene

Variant ID Type Subtype PubMed ID
dgv1406e199 CNV deletion 23128226
nsv7152 CNV deletion 18451855

Variation tolerance for GPR50 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR50 Gene

Disorders for GPR50 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR50 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search GPR50 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR50

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR50: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR50 Gene

Publications for GPR50 Gene

  1. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. (PMID: 16436372) Bhattacharyya S … O'Rahilly S (Journal of lipid research 2006) 3 4 22 44 58
  2. Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. (PMID: 20371266) Macintyre DJ … Blackwood DH (Neuroscience letters 2010) 3 22 44 58
  3. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). (PMID: 9933574) Gubitz AK … Reppert SM (Genomics 1999) 2 3 22 58
  4. Cloning of a melatonin-related receptor from human pituitary. (PMID: 8647286) Reppert SM … Kolakowski LF (FEBS letters 1996) 3 4 22 58
  5. Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. (PMID: 20050988) Ji LD … Zhang YP (Journal of pineal research 2010) 3 44 58

Products for GPR50 Gene

  • Addgene plasmids for GPR50

Sources for GPR50 Gene

Loading form....