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Aliases for GPR45 Gene

Aliases for GPR45 Gene

  • G Protein-Coupled Receptor 45 2 3 5
  • PSP24-Alpha 3 4
  • PSP24-1 3 4
  • High-Affinity Lysophosphatidic Acid Receptor 3
  • Probable G-Protein Coupled Receptor 45 3
  • PSP24(ALPHA) 3
  • PSP24A 3
  • PSP24 3

External Ids for GPR45 Gene

Previous GeneCards Identifiers for GPR45 Gene

  • GC02P103722
  • GC02P104310
  • GC02P105462
  • GC02P105479
  • GC02P105316
  • GC02P105224
  • GC02P105858
  • GC02P099627

Summaries for GPR45 Gene

Entrez Gene Summary for GPR45 Gene

  • This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR45 Gene

GPR45 (G Protein-Coupled Receptor 45) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR63.

UniProtKB/Swiss-Prot for GPR45 Gene

  • Orphan receptor. May play a role in brain function.

Gene Wiki entry for GPR45 Gene

Additional gene information for GPR45 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR45 Gene

Genomics for GPR45 Gene

GeneHancer (GH) Regulatory Elements for GPR45 Gene

Promoters and enhancers for GPR45 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J105239 Enhancer 0.2 ENCODE 650.7 -1.6 -1611 1.2 GPR45 UTAT33 GC02P105234
GH02J105143 Promoter/Enhancer 1.3 Ensembl ENCODE 11 -97.8 -97791 0.9 PKNOX1 NFXL1 KLF14 ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 EGR2 ZNF263 LINC01918 GPR45 LOC105373528
GH02J104847 Enhancer 0.8 FANTOM5 dbSUPER 16.9 -394.6 -394619 0.3 SP1 MXI1 PKNOX1 POLR2A SUZ12 CREB1 EZH2 GPR45 POU3F3 LINC01158 GC02M104827
GH02J104848 Enhancer 1.4 VISTA FANTOM5 dbSUPER 7.1 -391.9 -391939 2.6 CTCF MXI1 PKNOX1 FOXA2 SIN3A FEZF1 RAD21 ETS1 CTBP1 ZNF213 POU3F3 GPR45 LINC01158 GC02M104827
GH02J104873 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -368.3 -368295 0.5 CTCF MXI1 SUZ12 BACH1 ZNF48 RAD21 HIC1 ZNF335 ZFHX2 ZNF213 LINC01159 POU3F3 GPR45 ENSG00000269707 GC02P104945
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR45 gene promoter:
  • AREB6
  • HTF
  • ARP-1
  • USF1
  • USF-1
  • GATA-2
  • AML1a
  • Nkx2-2
  • ATF-2
  • POU2F1a

Genomic Locations for GPR45 Gene

Genomic Locations for GPR45 Gene
1,725 bases
Plus strand
1,725 bases
Plus strand

Genomic View for GPR45 Gene

Genes around GPR45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR45 Gene

Proteins for GPR45 Gene

  • Protein details for GPR45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 45
    Protein Accession:
    Secondary Accessions:
    • Q6NWS4
    • Q6NXU6

    Protein attributes for GPR45 Gene

    372 amino acids
    Molecular mass:
    41967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR45 Gene

Post-translational modifications for GPR45 Gene

  • Glycosylation at Asn20, isoforms=17, and Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR45 Gene

Domains & Families for GPR45 Gene

Gene Families for GPR45 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR45 Gene


Suggested Antigen Peptide Sequences for GPR45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR45: view

Function for GPR45 Gene

Molecular function for GPR45 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.
GENATLAS Biochemistry:
G protein coupled receptor 45,X Laevis oocyte lysophosphatidic acid receptor homolog,expressed in the brain (basal forebrain,frontal cortex,and caudate) and in the liver

Phenotypes From GWAS Catalog for GPR45 Gene

Gene Ontology (GO) - Molecular Function for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR45: view
genes like me logo Genes that share phenotypes with GPR45: view

Animal Model Products

Clone Products

  • Addgene plasmids for GPR45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR45 Gene

Localization for GPR45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR45 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR45 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR45: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR45 Gene

Pathways & Interactions for GPR45 Gene

genes like me logo Genes that share pathways with GPR45: view

Pathways by source for GPR45 Gene

Interacting Proteins for GPR45 Gene

Gene Ontology (GO) - Biological Process for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GPR45: view

No data available for SIGNOR curated interactions for GPR45 Gene

Drugs & Compounds for GPR45 Gene

No Compound Related Data Available

Transcripts for GPR45 Gene

mRNA/cDNA for GPR45 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR45 Gene

G protein-coupled receptor 45:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR45

Alternative Splicing Database (ASD) splice patterns (SP) for GPR45 Gene

No ASD Table

Relevant External Links for GPR45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR45 Gene

mRNA differential expression in normal tissues according to GTEx for GPR45 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of GPR45 Gene:


SOURCE GeneReport for Unigene cluster for GPR45 Gene:


mRNA Expression by UniProt/SwissProt for GPR45 Gene:

Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
genes like me logo Genes that share expression patterns with GPR45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR45 Gene

Orthologs for GPR45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR45 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia GPR45 34 33
  • 88.98 (n)
(Rattus norvegicus)
Mammalia Gpr45 33
  • 85.66 (n)
(Mus musculus)
Mammalia Gpr45 16 34 33
  • 85.22 (n)
(Bos Taurus)
Mammalia GPR45 34 33
  • 83.15 (n)
(Monodelphis domestica)
Mammalia GPR45 34
  • 74 (a)
(Anolis carolinensis)
Reptilia GPR45 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr45 33
  • 66.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia lpar-A-prov 33
(Danio rerio)
Actinopterygii si:dkeyp-118h3.5 33
  • 63.69 (n)
GPR45 34
  • 62 (a)
Species where no ortholog for GPR45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR45 Gene

Gene Tree for GPR45 (if available)
Gene Tree for GPR45 (if available)
Evolutionary constrained regions (ECRs) for GPR45: view image

Paralogs for GPR45 Gene

Paralogs for GPR45 Gene

(1) SIMAP similar genes for GPR45 Gene using alignment to 2 proteins:

  • B5B0C1_HUMAN
genes like me logo Genes that share paralogs with GPR45: view

Variants for GPR45 Gene

Sequence variations from dbSNP and Humsavar for GPR45 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_035759 A breast cancer sample p.Ser7Cys
rs1000431061 -- 105,241,815(+) G/A/C 5_prime_UTR_variant
rs1000864987 -- 105,243,547(+) C/A downstream_transcript_variant
rs1000872948 -- 105,240,616(+) C/A upstream_transcript_variant
rs1000925099 -- 105,240,999(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR45 Gene

Variant ID Type Subtype PubMed ID
nsv1012462 CNV gain 25217958
nsv582577 CNV loss 21841781

Variation tolerance for GPR45 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR45 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR45 Gene

Disorders for GPR45 Gene

Additional Disease Information for GPR45

No disorders were found for GPR45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR45 Gene

Publications for GPR45 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A … O'dowd BF (Genomics 1999) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y … Shimizu T (Biochemical and biophysical research communications 2000) 3 22 58
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 58

Products for GPR45 Gene

Sources for GPR45 Gene

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