This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008] See more...

Aliases for GPR45 Gene

Aliases for GPR45 Gene

  • G Protein-Coupled Receptor 45 2 3 5
  • Probable G-Protein Coupled Receptor 45 3 4
  • PSP24-Alpha 3 4
  • PSP24-1 3 4
  • PSP24A 2 3
  • PSP24 2 3
  • High-Affinity Lysophosphatidic Acid Receptor 3
  • PSP24(ALPHA) 3
  • GPR45 5

External Ids for GPR45 Gene

Previous GeneCards Identifiers for GPR45 Gene

  • GC02P103722
  • GC02P104310
  • GC02P105462
  • GC02P105479
  • GC02P105316
  • GC02P105224
  • GC02P105858
  • GC02P099627

Summaries for GPR45 Gene

Entrez Gene Summary for GPR45 Gene

  • This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR45 Gene

GPR45 (G Protein-Coupled Receptor 45) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR63.

UniProtKB/Swiss-Prot Summary for GPR45 Gene

Gene Wiki entry for GPR45 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR45 Gene

Genomics for GPR45 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J105239 Enhancer 0.4 Ensembl ENCODE 250.7 -1.6 -1611 1.2 CEBPB GPR45 MRPS9-AS1 HSALNG0017566 MRPS9
GH02J104841 Promoter/Enhancer 2.7 VISTA UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.9 -387.0 -386971 25.3 ZNF654 ZNF600 ZNF223 ZNF10 POLR2A ZIC2 ZBTB10 ETS1 TRIM22 FEZF1 POU3F3 PANTR1 ENSG00000269707 GPR45 ENSG00000207249 MRPS9 LINC01114 lnc-POU3F3-4 LINC01159
GH02J105143 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -97.6 -97642 1.8 POLR2A ZNF513 KLF9 SP2 PKNOX1 MAZ CBX2 GLIS1 ZNF398 KLF1 LINC01918 GPR45 HSALNG0017562 MRPS9
GH02J105179 Enhancer 0.9 Ensembl ENCODE 11.2 -61.0 -61048 2.2 ZNF654 JUND NFIC REST CTCF ELF1 RAD21 SMC3 ZNF316 FOSL2 HSALNG0017562 GPR45 LINC01918 MRPS9
GH02J105129 Enhancer 0.9 Ensembl ENCODE 11.4 -112.9 -112942 3.6 SP1 BCL11A TRIM22 IRF4 EBF1 CBFB BHLHE40 SPI1 ELF1 STAT5A MRPS9 GPR45 TGFBRAP1 HSALNG0017559 piR-61532-145
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR45 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR45

Top Transcription factor binding sites by QIAGEN in the GPR45 gene promoter:
  • AML1a
  • AREB6
  • ARP-1
  • ATF-2
  • GATA-2
  • HTF
  • Nkx2-2
  • POU2F1a
  • USF-1
  • USF1

Genomic Locations for GPR45 Gene

Latest Assembly
chr2:105,241,743-105,243,467
(GRCh38/hg38)
Size:
1,725 bases
Orientation:
Plus strand

Previous Assembly
chr2:105,858,200-105,859,924
(GRCh37/hg19 by Entrez Gene)
Size:
1,725 bases
Orientation:
Plus strand

chr2:105,858,200-105,859,924
(GRCh37/hg19 by Ensembl)
Size:
1,725 bases
Orientation:
Plus strand

Genomic View for GPR45 Gene

Genes around GPR45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR45 Gene

Proteins for GPR45 Gene

  • Protein details for GPR45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y3-GPR45_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 45
    Protein Accession:
    Q9Y5Y3
    Secondary Accessions:
    • Q6NWS4
    • Q6NXU6

    Protein attributes for GPR45 Gene

    Size:
    372 amino acids
    Molecular mass:
    41967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR45 Gene

Post-translational modifications for GPR45 Gene

  • Glycosylation at Asn4, Asn17, and Asn20
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR45 Gene

Domains & Families for GPR45 Gene

Gene Families for GPR45 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR45 Gene

Suggested Antigen Peptide Sequences for GPR45 Gene

GenScript: Design optimal peptide antigens:
  • Orphan GPCR 45 (B5B0C1_HUMAN)
  • PSP24-alpha (GPR45_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y3

UniProtKB/Swiss-Prot:

GPR45_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR45: view

Function for GPR45 Gene

Molecular function for GPR45 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.
GENATLAS Biochemistry:
G protein coupled receptor 45,X Laevis oocyte lysophosphatidic acid receptor homolog,expressed in the brain (basal forebrain,frontal cortex,and caudate) and in the liver

Phenotypes From GWAS Catalog for GPR45 Gene

Gene Ontology (GO) - Molecular Function for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with GPR45: view
genes like me logo Genes that share phenotypes with GPR45: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR45 Gene

Localization for GPR45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR45 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR45 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR45: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR45 Gene

Pathways & Interactions for GPR45 Gene

genes like me logo Genes that share pathways with GPR45: view

Pathways by source for GPR45 Gene

Interacting Proteins for GPR45 Gene

Gene Ontology (GO) - Biological Process for GPR45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GPR45: view

No data available for SIGNOR curated interactions for GPR45 Gene

Drugs & Compounds for GPR45 Gene

No Compound Related Data Available

Transcripts for GPR45 Gene

mRNA/cDNA for GPR45 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR45

Alternative Splicing Database (ASD) splice patterns (SP) for GPR45 Gene

No ASD Table

Relevant External Links for GPR45 Gene

GeneLoc Exon Structure for
GPR45

Expression for GPR45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR45 Gene

mRNA differential expression in normal tissues according to GTEx for GPR45 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR45

SOURCE GeneReport for Unigene cluster for GPR45 Gene:

Hs.590903

mRNA Expression by UniProt/SwissProt for GPR45 Gene:

Q9Y5Y3-GPR45_HUMAN
Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
genes like me logo Genes that share expression patterns with GPR45: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR45 Gene

Orthologs for GPR45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR45 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR45 29 30
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR45 29 30
  • 88.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr45 29
  • 85.66 (n)
Mouse
(Mus musculus)
Mammalia Gpr45 29 16 30
  • 85.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR45 29 30
  • 83.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR45 30
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR45 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr45 29
  • 66.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia lpar-A-prov 29
Zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-118h3.5 29
  • 63.69 (n)
GPR45 30
  • 62 (a)
OneToOne
Species where no ortholog for GPR45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR45 Gene

ENSEMBL:
Gene Tree for GPR45 (if available)
TreeFam:
Gene Tree for GPR45 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR45: view image
Alliance of Genome Resources:
Additional Orthologs for GPR45

Paralogs for GPR45 Gene

Paralogs for GPR45 Gene

(1) SIMAP similar genes for GPR45 Gene using alignment to 2 proteins:

  • GPR45_HUMAN
  • B5B0C1_HUMAN
genes like me logo Genes that share paralogs with GPR45: view

Variants for GPR45 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR45 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_035759 A breast cancer sample p.Ser7Cys
rs35946826 -- p.Leu312Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR45 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR45 Gene

Variant ID Type Subtype PubMed ID
nsv1012462 CNV gain 25217958
nsv582577 CNV loss 21841781

Variation tolerance for GPR45 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR45 Gene

Human Gene Mutation Database (HGMD)
GPR45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR45
Leiden Open Variation Database (LOVD)
GPR45

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR45 Gene

Disorders for GPR45 Gene

Additional Disease Information for GPR45

No disorders were found for GPR45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR45 Gene

Publications for GPR45 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A … O'dowd BF (Genomics 1999) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y … Shimizu T (Biochemical and biophysical research communications 2000) 3 22
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GPR45 Gene

Sources for GPR45 Gene