Aliases for GPR4 Gene

Aliases for GPR4 Gene

  • G Protein-Coupled Receptor 4 2 3 5
  • G-Protein Coupled Receptor 6C.L 3 4
  • G-Protein Coupled Receptor 4 3 4
  • GPR6C.L 3 4
  • G-Protein Coupled Receptor 19 3
  • GPR4 5

External Ids for GPR4 Gene

Previous GeneCards Identifiers for GPR4 Gene

  • GC19M046736
  • GC19M046483
  • GC19M050769
  • GC19M050784
  • GC19M046093
  • GC19M042522

Summaries for GPR4 Gene

GeneCards Summary for GPR4 Gene

GPR4 (G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with GPR4 include Prolactin Producing Pituitary Tumor and Central Hypoventilation Syndrome, Congenital. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR65.

UniProtKB/Swiss-Prot Summary for GPR4 Gene

  • Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).

Gene Wiki entry for GPR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR4 Gene

Genomics for GPR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR4

Top Transcription factor binding sites by QIAGEN in the GPR4 gene promoter:
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-5
  • Olf-1
  • Sp1
  • USF-1
  • USF1

Genomic Locations for GPR4 Gene

Latest Assembly
chr19:45,589,764-45,602,212
(GRCh38/hg38)
Size:
12,449 bases
Orientation:
Minus strand

Previous Assembly
chr19:46,093,022-46,105,470
(GRCh37/hg19 by Entrez Gene)
Size:
12,449 bases
Orientation:
Minus strand

chr19:46,093,022-46,105,466
(GRCh37/hg19 by Ensembl)
Size:
12,445 bases
Orientation:
Minus strand

Genomic View for GPR4 Gene

Genes around GPR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR4 Gene

Proteins for GPR4 Gene

  • Protein details for GPR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46093-GPR4_HUMAN
    Recommended name:
    G-protein coupled receptor 4
    Protein Accession:
    P46093
    Secondary Accessions:
    • A8K3T3
    • B0M0K1
    • Q6NWM4

    Protein attributes for GPR4 Gene

    Size:
    362 amino acids
    Molecular mass:
    40982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA63180.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for GPR4 Gene

Post-translational modifications for GPR4 Gene

  • Glycosylation at Asn3 and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR4 Gene

No data available for DME Specific Peptides for GPR4 Gene

Domains & Families for GPR4 Gene

Gene Families for GPR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR4 Gene

InterPro:
Blocks:
  • Probable GPCR GPR4 signature

Suggested Antigen Peptide Sequences for GPR4 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 19 (GPR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46093

UniProtKB/Swiss-Prot:

GPR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR4: view

Function for GPR4 Gene

Molecular function for GPR4 Gene

UniProtKB/Swiss-Prot Function:
Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).
GENATLAS Biochemistry:
G protein coupled receptor 4,with homology to the platelet-activating factor receptor (PTAFR),expressed in kidney,heart and lung

Phenotypes From GWAS Catalog for GPR4 Gene

Gene Ontology (GO) - Molecular Function for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS,IMP 20211729
genes like me logo Genes that share ontologies with GPR4: view
genes like me logo Genes that share phenotypes with GPR4: view

Animal Models for GPR4 Gene

MGI Knock Outs for GPR4:

Animal Models for research

  • Taconic Biosciences Mouse Models for GPR4

miRNA for GPR4 Gene

miRTarBase miRNAs that target GPR4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR4 Gene

Localization for GPR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR4 Gene

Pathways & Interactions for GPR4 Gene

genes like me logo Genes that share pathways with GPR4: view

Gene Ontology (GO) - Biological Process for GPR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP 12955148
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IMP 20211729
GO:0010447 response to acidic pH IEA,IMP 12955148
genes like me logo Genes that share ontologies with GPR4: view

No data available for SIGNOR curated interactions for GPR4 Gene

Drugs & Compounds for GPR4 Gene

(2) Drugs for GPR4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR4: view

Transcripts for GPR4 Gene

mRNA/cDNA for GPR4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR4

Alternative Splicing Database (ASD) splice patterns (SP) for GPR4 Gene

No ASD Table

Relevant External Links for GPR4 Gene

GeneLoc Exon Structure for
GPR4

Expression for GPR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.7).

Protein differential expression in normal tissues from HIPED for GPR4 Gene

This gene is overexpressed in Esophagus (27.8), Liver (16.0), Ovary (9.4), Urinary Bladder (6.2), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR4

SOURCE GeneReport for Unigene cluster for GPR4 Gene:

Hs.17170

Evidence on tissue expression from TISSUES for GPR4 Gene

  • Nervous system(4.5)
  • Lung(4.4)
  • Heart(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with GPR4: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR4 Gene

Orthologs for GPR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia GPR4 29 30
  • 92.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR4 29 30
  • 91.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr4 29
  • 87.8 (n)
Mouse
(Mus musculus)
Mammalia Gpr4 29 16 30
  • 87.06 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 31 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 26 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC563762 29
  • 69.14 (n)
gpr4 30
  • 66 (a)
OneToOne
Species where no ortholog for GPR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR4 Gene

ENSEMBL:
Gene Tree for GPR4 (if available)
TreeFam:
Gene Tree for GPR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR4: view image
Alliance of Genome Resources:
Additional Orthologs for GPR4

Paralogs for GPR4 Gene

(11) SIMAP similar genes for GPR4 Gene using alignment to 1 proteins:

  • GPR4_HUMAN
genes like me logo Genes that share paralogs with GPR4: view

Variants for GPR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs36012326 -- p.Ser295Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR4 Gene

Variant ID Type Subtype PubMed ID
esv1941589 CNV deletion 18987734
esv2718633 CNV deletion 23290073
esv2718634 CNV deletion 23290073
nsv833848 CNV loss 17160897

Variation tolerance for GPR4 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR4
Leiden Open Variation Database (LOVD)
GPR4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR4 Gene

Disorders for GPR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR4 Gene - From: COP

Disorder Aliases PubMed IDs
prolactin producing pituitary tumor
  • malignant prolactin producing neoplasm of pituitary gland
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search GPR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR4

genes like me logo Genes that share disorders with GPR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR4 Gene

Publications for GPR4 Gene

  1. Proton-sensing G-protein-coupled receptors. (PMID: 12955148) Ludwig MG … Seuwen K (Nature 2003) 3 4 22
  2. Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. (PMID: 8595909) Mahadevan MS … Korneluk RG (Genomics 1995) 2 3 4
  3. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. (PMID: 22110680) Chen A … Yang LV (PloS one 2011) 3 4
  4. Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways. (PMID: 20211729) Liu JP … Okajima F (Pharmacological research 2010) 3 4
  5. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. (PMID: 17462861) Tobo M … Okajima F (Cellular signalling 2007) 3 4

Products for GPR4 Gene

Sources for GPR4 Gene