Aliases for GPR4 Gene
External Ids for GPR4 Gene
Previous GeneCards Identifiers for GPR4 Gene
GeneCards Summary for GPR4 Gene
GPR4 (G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with GPR4 include Prolactin Producing Pituitary Tumor and Central Hypoventilation Syndrome, Congenital. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR65.
UniProtKB/Swiss-Prot Summary for GPR4 Gene
Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).