Aliases for GPR37L1 Gene

Aliases for GPR37L1 Gene

  • G Protein-Coupled Receptor 37 Like 1 2 3 5
  • G-Protein Coupled Receptor 37-Like 1 3 4
  • Endothelin B Receptor-Like Protein 2 3 4
  • ETBR-LP-2 3 4
  • ETBRLP2 3 4
  • Endothelin Type B Receptor-Like Protein 2 3
  • Prosaposin Receptor GPR37L1 3
  • ET(B)R-LP-2 3

External Ids for GPR37L1 Gene

Previous GeneCards Identifiers for GPR37L1 Gene

  • GC01U990381
  • GC01P199381
  • GC01P198823
  • GC01P200358
  • GC01P202091
  • GC01P173257

Summaries for GPR37L1 Gene

GeneCards Summary for GPR37L1 Gene

GPR37L1 (G Protein-Coupled Receptor 37 Like 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Neuroscience. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled peptide receptor activity. An important paralog of this gene is GPR37.

UniProtKB/Swiss-Prot Summary for GPR37L1 Gene

  • G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).

Gene Wiki entry for GPR37L1 Gene

Additional gene information for GPR37L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR37L1 Gene

Genomics for GPR37L1 Gene

GeneHancer (GH) Regulatory Elements for GPR37L1 Gene

Promoters and enhancers for GPR37L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202117 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 758.8 -0.3 -263 2.5 GTF3C2 CTCF RBPJ SMARCE1 NR2F6 CC2D1A L3MBTL2 RAD21 DACH1 TEAD4 GPR37L1 HE855982-001 LOC105371684 RNPEP HNRNPA1P59 ELF3-AS1 ENSG00000236439 ENSG00000235449 KDM5B IPO9
GH01J202122 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 754.9 +4.1 4146 0.7 CTCF L3MBTL2 RAD21 NFIB GLIS2 REST RCOR1 GTF2F1 MAX MAZ GPR37L1 LOC105371683 LOC105371684
GH01J202067 Promoter/Enhancer 1.1 EPDnew dbSUPER 750.2 -51.2 -51185 0.1 SMARCE1 RUNX1 CC2D1A L3MBTL2 CBFA2T2 SMARCA4 TRIM24 IKZF1 ATF1 PKNOX1 lnc-ARL8A-2 GPR37L1 piR-50443-031
GH01J202116 Enhancer 0.2 Ensembl 750.6 -1.8 -1804 0.2 HE855982-001 GPR37L1 LOC105371684 lnc-GPR37L1-6
GH01J203025 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 +909.1 909092 4 PPP1R10 SP1 ZBTB40 ZBTB6 SMARCE1 POLR2A USF2 HCFC1 CC2D1A L3MBTL2 PPFIA4 ZC3H11A SNRPE KDM5B ZBED6 PRELP FMOD GPR37L1 TMEM183A HNRNPA1P59
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR37L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR37L1 gene promoter:
  • Elk-1
  • ER-alpha
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-1
  • NF-AT1
  • NF-AT3
  • NF-AT4

Genomic Locations for GPR37L1 Gene

Genomic Locations for GPR37L1 Gene
chr1:202,118,705-202,133,592
(GRCh38/hg38)
Size:
14,888 bases
Orientation:
Plus strand
chr1:202,091,986-202,102,720
(GRCh37/hg19)
Size:
10,735 bases
Orientation:
Plus strand

Genomic View for GPR37L1 Gene

Genes around GPR37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37L1 Gene

Proteins for GPR37L1 Gene

  • Protein details for GPR37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60883-G37L1_HUMAN
    Recommended name:
    G-protein coupled receptor 37-like 1
    Protein Accession:
    O60883
    Secondary Accessions:
    • B2R7M9
    • Q5SXP7
    • Q86VP7

    Protein attributes for GPR37L1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52771 Da
    Quaternary structure:
    • Interacts with the PTCH1 receptor.

neXtProt entry for GPR37L1 Gene

Post-translational modifications for GPR37L1 Gene

Other Protein References for GPR37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37L1 Gene

Domains & Families for GPR37L1 Gene

Gene Families for GPR37L1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR37L1 Gene

Suggested Antigen Peptide Sequences for GPR37L1 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 37-like 1 (ETBR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60883

UniProtKB/Swiss-Prot:

G37L1_HUMAN :
  • The N-terminal region is required for constitutive signal transduction.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The N-terminal region is required for constitutive signal transduction.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37L1: view

Function for GPR37L1 Gene

Molecular function for GPR37L1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).

Phenotypes From GWAS Catalog for GPR37L1 Gene

Gene Ontology (GO) - Molecular Function for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IDA 27072655
GO:0005515 protein binding IPI 20517885
GO:0008528 G protein-coupled peptide receptor activity IDA 23690594
GO:0036505 NOT prosaposin receptor activity IDA 27072655
GO:0042277 peptide binding IPI 23690594
genes like me logo Genes that share ontologies with GPR37L1: view
genes like me logo Genes that share phenotypes with GPR37L1: view

Animal Models for GPR37L1 Gene

MGI Knock Outs for GPR37L1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR37L1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR37L1 Gene

Localization for GPR37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37L1 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250 UniProtKB:Q99JG2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR37L1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9539149
GO:0042995 cell projection IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR37L1 Gene

Pathways & Interactions for GPR37L1 Gene

genes like me logo Genes that share pathways with GPR37L1: view

Pathways by source for GPR37L1 Gene

1 Cell Signaling Technology pathway for GPR37L1 Gene

Gene Ontology (GO) - Biological Process for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure ISS --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA 23690594
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA --
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for SIGNOR curated interactions for GPR37L1 Gene

Drugs & Compounds for GPR37L1 Gene

(1) Drugs for GPR37L1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
prosaptide Pharma Agonist 0
genes like me logo Genes that share compounds with GPR37L1: view

Transcripts for GPR37L1 Gene

mRNA/cDNA for GPR37L1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37L1 Gene

No ASD Table

Relevant External Links for GPR37L1 Gene

GeneLoc Exon Structure for
GPR37L1
ECgene alternative splicing isoforms for
GPR37L1

Expression for GPR37L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR37L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37L1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Putamen (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Amygdala (x5.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GPR37L1 Gene

This gene is overexpressed in Spinal cord (46.8) and Frontal cortex (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR37L1 Gene



Protein tissue co-expression partners for GPR37L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR37L1 Gene:

GPR37L1

SOURCE GeneReport for Unigene cluster for GPR37L1 Gene:

Hs.132049

mRNA Expression by UniProt/SwissProt for GPR37L1 Gene:

O60883-G37L1_HUMAN
Tissue specificity: Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).

Evidence on tissue expression from TISSUES for GPR37L1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GPR37L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR37L1 Gene

Orthologs for GPR37L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR37L1 33 32
  • 99.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr37l1 32
  • 86.97 (n)
dog
(Canis familiaris)
Mammalia GPR37L1 33 32
  • 86.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr37l1 17 33 32
  • 86.07 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR37L1 33
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR37L1 33 32
  • 78.93 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR37L1 33
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR37L1 33 32
  • 76.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR37L1 33
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr37l1 32
  • 57.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18103 32
zebrafish
(Danio rerio)
Actinopterygii gpr37l1b 33 32
  • 59.46 (n)
OneToMany
gpr37l1a 33
  • 48 (a)
OneToMany
Species where no ortholog for GPR37L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37L1 Gene

ENSEMBL:
Gene Tree for GPR37L1 (if available)
TreeFam:
Gene Tree for GPR37L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR37L1: view image

Paralogs for GPR37L1 Gene

Paralogs for GPR37L1 Gene

(1) SIMAP similar genes for GPR37L1 Gene using alignment to 1 proteins:

  • ETBR2_HUMAN
genes like me logo Genes that share paralogs with GPR37L1: view

Variants for GPR37L1 Gene

Sequence variations from dbSNP and Humsavar for GPR37L1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs372386575 uncertain-significance, not provided, - 202,128,157(+) G/T coding_sequence_variant, missense_variant
rs1000000921 -- 202,122,461(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000115168 -- 202,122,135(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000115749 -- 202,125,881(+) C/T intron_variant
rs1000299850 -- 202,133,299(+) C/T 3_prime_UTR_variant

Variation tolerance for GPR37L1 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR37L1 Gene

Human Gene Mutation Database (HGMD)
GPR37L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR37L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR37L1 Gene

Disorders for GPR37L1 Gene

Additional Disease Information for GPR37L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR37L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR37L1 Gene

Publications for GPR37L1 Gene

  1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PMID: 9539149) Valdenaire O … Richards JG (FEBS letters 1998) 2 3 4 23 56
  2. GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. (PMID: 28688853) Giddens MM … Hall RA (Neurobiology of disease 2017) 3 4 56
  3. Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity. (PMID: 27072655) Coleman JL … Smith NJ (Science signaling 2016) 3 4 56
  4. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID: 23690594) Meyer RC … Hall RA (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 56
  5. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PMID: 20360844) Arking DE … Chugh SS (PloS one 2010) 3 43 56

Products for GPR37L1 Gene

Sources for GPR37L1 Gene