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Aliases for GPR37L1 Gene

Aliases for GPR37L1 Gene

  • G Protein-Coupled Receptor 37 Like 1 2 3 5
  • Endothelin B Receptor-Like Protein 2 3 4
  • ETBR-LP-2 3 4
  • ETBRLP2 3 4
  • Endothelin Type B Receptor-Like Protein 2 3
  • G-Protein Coupled Receptor 37-Like 1 4
  • Prosaposin Receptor GPR37L1 3
  • ET(B)R-LP-2 3

External Ids for GPR37L1 Gene

Previous GeneCards Identifiers for GPR37L1 Gene

  • GC01U990381
  • GC01P199381
  • GC01P198823
  • GC01P200358
  • GC01P202091
  • GC01P173257

Summaries for GPR37L1 Gene

GeneCards Summary for GPR37L1 Gene

GPR37L1 (G Protein-Coupled Receptor 37 Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is GPR37.

UniProtKB/Swiss-Prot for GPR37L1 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37L1 Gene

Additional gene information for GPR37L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37L1 Gene

Genomics for GPR37L1 Gene

GeneHancer (GH) Regulatory Elements for GPR37L1 Gene

Promoters and enhancers for GPR37L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202117 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 658.9 -0.1 -87 2.1 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZBTB7B ZNF766 ZNF207 ZNF143 DEK GPR37L1 LOC105371684 RNPEP ENSG00000273478 HNRNPA1P59 ELF3-AS1 KDM5B LOC100506672 IPO9 RPS27P8
GH01J202122 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 655 +4.1 4115 0.2 GTF2F1 CTCF CLOCK MAX ZBTB7B RAD21 ZNF507 TEAD3 CTBP1 VEZF1 GPR37L1 LOC105371683 LOC105371684
GH01J202067 Promoter/Enhancer 1.3 EPDnew dbSUPER 650.2 -51.2 -51185 0.1 HDAC1 PKNOX1 ATF1 ARNT TCF12 GATA2 CREM NCOA1 ZEB2 SMARCB1 GPR37L1 ENSG00000212512 ENSG00000235811
GH01J201954 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -163.2 -163184 2.5 MLX DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC TIMM17A RNPEP ENSG00000273478 KDM5B HNRNPA1P59 RPS27P8 IPO9 ELF3-AS1 IPO9-AS1 LMOD1
GH01J202142 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.9 +25.5 25451 3.2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A YY1 SP3 SP5 REST ZNF592 ARL8A ENSG00000236390 LOC100506747 PTPRVP KDM5B ELF3-AS1 HNRNPA1P59 GPR37L1 GC01P202132
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR37L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR37L1 gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • ER-alpha
  • Elk-1
  • NF-1
  • NF-AT1
  • NF-AT4
  • NF-AT3

Genomic Locations for GPR37L1 Gene

Genomic Locations for GPR37L1 Gene
14,888 bases
Plus strand
10,735 bases
Plus strand

Genomic View for GPR37L1 Gene

Genes around GPR37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37L1 Gene

Proteins for GPR37L1 Gene

  • Protein details for GPR37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prosaposin receptor GPR37L1
    Protein Accession:
    Secondary Accessions:
    • B2R7M9
    • Q5SXP7
    • Q86VP7

    Protein attributes for GPR37L1 Gene

    481 amino acids
    Molecular mass:
    52771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR37L1 Gene

Post-translational modifications for GPR37L1 Gene

  • O-glycosylated.
  • Glycosylation at Thr107, isoforms=105, Thr95, isoforms=86, isoforms=85, and isoforms=79
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ETBR2_HUMAN (661)

Other Protein References for GPR37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37L1 Gene

Domains & Families for GPR37L1 Gene

Gene Families for GPR37L1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR37L1 Gene

Suggested Antigen Peptide Sequences for GPR37L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37L1: view

Function for GPR37L1 Gene

Molecular function for GPR37L1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Ontology (GO) - Molecular Function for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 20517885
GO:0008528 G-protein coupled peptide receptor activity IDA 23690594
GO:0036505 prosaposin receptor activity IDA 23690594
GO:0042277 peptide binding IPI 23690594
genes like me logo Genes that share ontologies with GPR37L1: view
genes like me logo Genes that share phenotypes with GPR37L1: view

Animal Models for GPR37L1 Gene

MGI Knock Outs for GPR37L1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR37L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR37L1 Gene

Localization for GPR37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR37L1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9539149
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR37L1 Gene

Pathways & Interactions for GPR37L1 Gene

genes like me logo Genes that share pathways with GPR37L1: view

Pathways by source for GPR37L1 Gene

1 Cell Signaling Technology pathway for GPR37L1 Gene

Gene Ontology (GO) - Biological Process for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 23690594
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA --
GO:0043410 positive regulation of MAPK cascade IDA,IEA 23690594
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for SIGNOR curated interactions for GPR37L1 Gene

Drugs & Compounds for GPR37L1 Gene

(1) Drugs for GPR37L1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
prosaptide Pharma Agonist 0
genes like me logo Genes that share compounds with GPR37L1: view

Transcripts for GPR37L1 Gene

mRNA/cDNA for GPR37L1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37L1 Gene

G protein-coupled receptor 37 like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37L1 Gene

No ASD Table

Relevant External Links for GPR37L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR37L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR37L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37L1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Putamen (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Amygdala (x5.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GPR37L1 Gene

This gene is overexpressed in Spinal cord (46.8) and Frontal cortex (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR37L1 Gene

Protein tissue co-expression partners for GPR37L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR37L1 Gene:


SOURCE GeneReport for Unigene cluster for GPR37L1 Gene:


mRNA Expression by UniProt/SwissProt for GPR37L1 Gene:

Tissue specificity: Expressed in the central nervous system.

Evidence on tissue expression from TISSUES for GPR37L1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GPR37L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR37L1 Gene

Orthologs for GPR37L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR37L1 34 33
  • 99.1 (n)
(Rattus norvegicus)
Mammalia Gpr37l1 33
  • 86.97 (n)
(Canis familiaris)
Mammalia GPR37L1 34 33
  • 86.93 (n)
(Mus musculus)
Mammalia Gpr37l1 16 34 33
  • 86.07 (n)
(Monodelphis domestica)
Mammalia GPR37L1 34
  • 82 (a)
(Bos Taurus)
Mammalia GPR37L1 34 33
  • 78.93 (n)
(Ornithorhynchus anatinus)
Mammalia GPR37L1 34
  • 77 (a)
(Gallus gallus)
Aves GPR37L1 34 33
  • 76.09 (n)
(Anolis carolinensis)
Reptilia GPR37L1 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr37l1 33
  • 57.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18103 33
(Danio rerio)
Actinopterygii gpr37l1b 34 33
  • 59.46 (n)
gpr37l1a 34
  • 48 (a)
Species where no ortholog for GPR37L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37L1 Gene

Gene Tree for GPR37L1 (if available)
Gene Tree for GPR37L1 (if available)
Evolutionary constrained regions (ECRs) for GPR37L1: view image

Paralogs for GPR37L1 Gene

Paralogs for GPR37L1 Gene

(1) SIMAP similar genes for GPR37L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37L1: view

Variants for GPR37L1 Gene

Sequence variations from dbSNP and Humsavar for GPR37L1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000921 -- 202,122,461(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000115168 -- 202,122,135(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000115749 -- 202,125,881(+) C/T intron_variant
rs1000299850 -- 202,133,299(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000415742 -- 202,133,576(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Variation tolerance for GPR37L1 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR37L1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR37L1 Gene

Disorders for GPR37L1 Gene

Additional Disease Information for GPR37L1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR37L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR37L1 Gene

Publications for GPR37L1 Gene

  1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PMID: 9539149) Valdenaire O … Richards JG (FEBS letters 1998) 2 3 4 22 58
  2. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID: 23690594) Meyer RC … Hall RA (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  3. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PMID: 20360844) Arking DE … Chugh SS (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. (PMID: 28688853) Giddens MM … Hall RA (Neurobiology of disease 2017) 3 58

Products for GPR37L1 Gene

Sources for GPR37L1 Gene

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