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Aliases for GPR37 Gene

Aliases for GPR37 Gene

  • G Protein-Coupled Receptor 37 2 3 5
  • G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) 2 3
  • Parkin-Associated Endothelin Receptor-Like Receptor 3 4
  • Endothelin B Receptor-Like Protein 1 3 4
  • ETBR-LP-1 3 4
  • PAELR 3 4
  • Probable G-Protein Coupled Receptor 37 3
  • Endothelin Receptor Type B-Like 2
  • G-Protein Coupled Receptor 37 4
  • Prosaposin Receptor GPR37 3
  • HET(B)R-LP 3
  • EDNRBL 3

External Ids for GPR37 Gene

Previous GeneCards Identifiers for GPR37 Gene

  • GC07M122864
  • GC07M123926
  • GC07M123940
  • GC07M123980
  • GC07M124173
  • GC07M124386
  • GC07M118751

Summaries for GPR37 Gene

Entrez Gene Summary for GPR37 Gene

  • This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

GeneCards Summary for GPR37 Gene

GPR37 (G Protein-Coupled Receptor 37) is a Protein Coding gene. Diseases associated with GPR37 include Parkinson Disease, Late-Onset. Among its related pathways are Parkinsons Disease Pathway and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide binding. An important paralog of this gene is GPR37L1.

UniProtKB/Swiss-Prot for GPR37 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37 Gene

Additional gene information for GPR37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37 Gene

Genomics for GPR37 Gene

GeneHancer (GH) Regulatory Elements for GPR37 Gene

Promoters and enhancers for GPR37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J124763 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 655.3 +0.7 725 2.8 PKNOX1 SIN3A ZNF2 GLIS2 RUNX3 SP3 REST ZNF785 SP7 CTCF GPR37 POT1-AS1 POT1 ENSG00000279419
GH07J124762 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.6 +3.0 2977 1 SOX13 TFAP4 FOXA2 MZF1 FEZF1 ZNF644 RAD21 YY1 IKZF5 ZSCAN5C GPR37 ENSG00000279419
GH07J124723 Enhancer 0.7 dbSUPER 9.2 +39.7 39732 5.3 SOX13 FOXA2 RAD21 POLR2A HNF4G CREM GATAD2A SOX5 RXRA HLF GPR37 POT1-AS1 ENSG00000279419 GC07M124660
GH07J124457 Enhancer 0.7 ENCODE 6.9 +306.7 306698 3.5 SOX13 FOXA2 CEBPG RARA GATA3 RERE NR2F6 FOS GATAD2A SOX5 GPR37 LOC102724577 SSU72P8 LOC101928211
GH07J124741 Enhancer 0.3 dbSUPER 11.5 +22.1 22138 3.9 HLF ENSG00000279419 GPR37 POT1-AS1 LOC100420864 GC07M124660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR37 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • Meis-1
  • POU2F1
  • POU2F1a
  • Meis-1a
  • Meis-1b
  • NF-AT1

Genomic Locations for GPR37 Gene

Genomic Locations for GPR37 Gene
20,425 bases
Minus strand
19,631 bases
Minus strand

Genomic View for GPR37 Gene

Genes around GPR37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37 Gene

Proteins for GPR37 Gene

  • Protein details for GPR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prosaposin receptor GPR37
    Protein Accession:
    Secondary Accessions:
    • A4D0Y6
    • O00348
    • O14768
    • Q8TD39

    Protein attributes for GPR37 Gene

    613 amino acids
    Molecular mass:
    67114 Da
    Quaternary structure:
    • Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination. Interacts with PACRG.

neXtProt entry for GPR37 Gene

Post-translational modifications for GPR37 Gene

  • Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
  • Glycosylation at Asn239, isoforms=222, and isoforms=36
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37 Gene

Domains & Families for GPR37 Gene

Gene Families for GPR37 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR37 Gene

Suggested Antigen Peptide Sequences for GPR37 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37: view

Function for GPR37 Gene

Molecular function for GPR37 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
GENATLAS Biochemistry:
putative G protein coupled receptor 37,expressed at highest levels in human brain,spinal cord and at lower levels in testis,placenta,liver,with homology to bombesin receptor

Phenotypes From GWAS Catalog for GPR37 Gene

Gene Ontology (GO) - Molecular Function for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 9144577
GO:0005515 protein binding IPI 14532270
GO:0008528 G-protein coupled peptide receptor activity IDA 23690594
GO:0030544 Hsp70 protein binding IPI 12150907
genes like me logo Genes that share ontologies with GPR37: view
genes like me logo Genes that share phenotypes with GPR37: view

Animal Models for GPR37 Gene

MGI Knock Outs for GPR37:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR37

miRNA for GPR37 Gene

Clone Products

  • Addgene plasmids for GPR37

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR37 Gene

Localization for GPR37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR37 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 12150907
GO:0005783 endoplasmic reticulum IDA 17059562
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane TAS 9144577
genes like me logo Genes that share ontologies with GPR37: view

Pathways & Interactions for GPR37 Gene

genes like me logo Genes that share pathways with GPR37: view

Pathways by source for GPR37 Gene

Gene Ontology (GO) - Biological Process for GPR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 23690594
GO:0031987 locomotion involved in locomotory behavior IEA --
GO:0042416 dopamine biosynthetic process IEA --
genes like me logo Genes that share ontologies with GPR37: view

No data available for SIGNOR curated interactions for GPR37 Gene

Drugs & Compounds for GPR37 Gene

(6) Drugs for GPR37 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bosentan Approved, Investigational Pharma 106
Macitentan Approved Pharma Endothelin (ET)(A) and ET(B) receptor antagonist 43
neuropeptide head activator Pharma Agonist 0
prosaptide Pharma Agonist 0
Bosentan Hydrate Pharma 0
genes like me logo Genes that share compounds with GPR37: view

Transcripts for GPR37 Gene

mRNA/cDNA for GPR37 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(79) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37 Gene

G protein-coupled receptor 37 (endothelin receptor type B-like):
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR37

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37 Gene

No ASD Table

Relevant External Links for GPR37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x11.3), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.4), Brain - Putamen (basal ganglia) (x4.3), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for GPR37 Gene

This gene is overexpressed in Vitreous humor (42.9) and Adrenal (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR37 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR37 Gene:


SOURCE GeneReport for Unigene cluster for GPR37 Gene:


mRNA Expression by UniProt/SwissProt for GPR37 Gene:

Tissue specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

Evidence on tissue expression from TISSUES for GPR37 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with GPR37: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR37 Gene

Orthologs for GPR37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR37 34 33
  • 99.56 (n)
(Ornithorhynchus anatinus)
Mammalia GPR37 34
  • 96 (a)
(Canis familiaris)
Mammalia GPR37 34 33
  • 87.91 (n)
(Bos Taurus)
Mammalia GPR37 34 33
  • 87.42 (n)
(Mus musculus)
Mammalia Gpr37 16 34 33
  • 81.67 (n)
(Rattus norvegicus)
Mammalia Gpr37 33
  • 81.21 (n)
(Monodelphis domestica)
Mammalia GPR37 34
  • 74 (a)
(Gallus gallus)
Aves GPR37 34 33
  • 80.32 (n)
(Anolis carolinensis)
Reptilia GPR37 34
  • 91 (a)
(Danio rerio)
Actinopterygii LOC100537916 33
  • 67.11 (n)
GPR37 (2 of 2) 34
  • 55 (a)
gpr37b 34
  • 47 (a)
Dr.17898 33
Species where no ortholog for GPR37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37 Gene

Gene Tree for GPR37 (if available)
Gene Tree for GPR37 (if available)
Evolutionary constrained regions (ECRs) for GPR37: view image

Paralogs for GPR37 Gene

Paralogs for GPR37 Gene

(1) SIMAP similar genes for GPR37 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37: view

Variants for GPR37 Gene

Sequence variations from dbSNP and Humsavar for GPR37 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000016522 -- 124,755,099(-) G/A intron_variant
rs1000068371 -- 124,767,888(-) A/C upstream_transcript_variant
rs1000095991 -- 124,756,366(-) A/G intron_variant
rs1000205915 -- 124,757,754(-) T/C intron_variant
rs1000239050 -- 124,747,578(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR37 Gene

Variant ID Type Subtype PubMed ID
nsv1027091 CNV gain 25217958
nsv1074548 CNV deletion 25765185
nsv366106 CNV deletion 16902084
nsv949935 CNV deletion 24416366

Variation tolerance for GPR37 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR37 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR37 Gene

Disorders for GPR37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR37 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search GPR37 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR37

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR37 Gene

Publications for GPR37 Gene

  1. A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. (PMID: 17059562) Omura T … Nomura Y (Journal of neurochemistry 2006) 3 4 22 58
  2. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y … Takahashi R (The Journal of biological chemistry 2003) 3 4 22 58
  3. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. (PMID: 12150907) Imai Y … Takahashi R (Molecular cell 2002) 3 4 22 58
  4. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. (PMID: 9339362) Marazziti D … Tocchini-Valentini GP (Genomics 1997) 2 3 4 58
  5. A novel endothelin receptor type-B-like gene enriched in the brain. (PMID: 9144577) Zeng Z … Li Y (Biochemical and biophysical research communications 1997) 3 4 22 58

Products for GPR37 Gene

Sources for GPR37 Gene

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