Aliases for GPR37 Gene
External Ids for GPR37 Gene
Previous GeneCards Identifiers for GPR37 Gene
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
GeneCards Summary for GPR37 Gene
GPR37 (G Protein-Coupled Receptor 37) is a Protein Coding gene. Diseases associated with GPR37 include Parkinson Disease, Late-Onset and Autism Spectrum Disorder. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide binding. An important paralog of this gene is GPR37L1.
UniProtKB/Swiss-Prot Summary for GPR37 Gene
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.