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Aliases for GPR35 Gene
Aliases for GPR35 Gene
External Ids for GPR35 Gene
- HGNC: 4492
- NCBI Entrez Gene: 2859
- Ensembl: ENSG00000178623
- OMIM®: 602646
- UniProtKB/Swiss-Prot: Q9HC97
Previous GeneCards Identifiers for GPR35 Gene
- GC02M239906
- GC02M240750
- GC02P241588
- GC02P241889
- GC02P241286
- GC02P241215
- GC02P233327
Summaries for GPR35 Gene
GeneCards Summary for GPR35 Gene
GPR35 (G Protein-Coupled Receptor 35) is a Protein Coding gene. Diseases associated with GPR35 include Cholangitis, Primary Sclerosing and Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR55.
UniProtKB/Swiss-Prot Summary for GPR35 Gene
-
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Additional gene information for GPR35 Gene
- HGNC (4492)
- NCBI Entrez Gene (2859)
- Ensembl (ENSG00000178623)
- OMIM® (602646)
- UniProtKB/Swiss-Prot (Q9HC97)
- Open Targets Platform(ENSG00000178623)
- Monarch Initiative
- Search for GPR35 at DataMed
- Search for GPR35 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR35 Gene
Genomics for GPR35 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPR35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR35 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR35
- Top Transcription factor binding sites by QIAGEN in the GPR35 gene promoter:
-
- ATF
- c-Myc
- ER-alpha
- HOXA5
- Max
- MIF-1
- p300
- STAT5A
- USF-1
- USF1
Genomic Locations for GPR35 Gene
Latest Assembly
- chr2:240,605,430-240,631,259
- (GRCh38/hg38)
- Size:
- 25,830 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:241,544,847-241,570,670
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 25,824 bases
- Orientation:
- Plus strand
- chr2:241,544,848-241,570,676
- (GRCh37/hg19 by Ensembl)
- Size:
- 25,829 bases
- Orientation:
- Plus strand
Genomic View for GPR35 Gene
Genes around GPR35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
GPR35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR35 Gene
Proteins for GPR35 Gene
-
Protein details for GPR35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HC97-GPR35_HUMAN
- Recommended name:
- G-protein coupled receptor 35
- Protein Accession:
- Q9HC97
- J3KR30
- O43495
- Q17R58
- Q4VBN5
- Q4ZFV2
- Q6FHI8
- Q86UH4
Protein attributes for GPR35 Gene
- Size:
- 309 amino acids
- Molecular mass:
- 34072 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR35 Gene
Other Protein References for GPR35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences GPR35 Antibody (LS-A3) and GPR35 Antibody (LS-A2)
- Novus Biologicals Antibodies for GPR35
-
Abcam antibodies for GPR35
- Invitrogen Antibodies for GPR35 (AFLGC-GPR35)
-
Biorbyt antibodies for GPR35
-
Boster Bio Antibodies for GPR35
-
Custom Antibody ServicesProSci Antibodies for GPR35
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GPR35
- Origene Custom Protein Services for GPR35
- Novus Biologicals proteins for GPR35
- antibodies-online: Show 4 available GPR35 Proteins ranked by validation data
- Compare Top GPR35 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Show 6 available GPR35 Elisa Kits ranked by validation data
- Compare Top GPR35 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for GPR35 Gene
Domains & Families for GPR35 Gene
Gene Families for GPR35 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
- Transporters
Protein Domains for GPR35 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR35 Gene
- GenScript: Design optimal peptide antigens:
-
- Kynurenic acid receptor (GPR35_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HC97- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR35 Gene
Molecular function for GPR35 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
- GENATLAS Biochemistry:
- G protein coupled receptor 35,expressed in heart,spleen,liver,lung,ovary kidney
Phenotypes From GWAS Catalog for GPR35 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | TAS,IDA | 16754668 |
| GO:0016494 | C-X-C chemokine receptor activity | IMP | 25411203 |
Phenotypes for GPR35 Gene
- MGI mutant phenotypes for GPR35:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GPR35:
-
- Decreased viability
- no effect
- Decreased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Strongly decreased CFP-tsO45G cell surface transport
- Increased HPV18 LCR reporter activity
- Increased hepcidin::fluc mRNA expression
- Decreased homologous recombination repair frequency
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in glioblastoma multiforme (GBM) lineage
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GPR35 - Starting at $85 >
- * GPR35 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GPR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR35
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR35
miRNA for GPR35 Gene
- miRTarBase miRNAs that target GPR35
-
- hsa-miR-4480 (MIRT443547)
- hsa-miR-3185 (MIRT443548)
- hsa-miR-451b (MIRT443549)
- hsa-miR-6864-5p (MIRT458664)
- hsa-miR-6780b-5p (MIRT458665)
- hsa-miR-4725-3p (MIRT458666)
- hsa-miR-4271 (MIRT458667)
- hsa-miR-298 (MIRT458668)
- hsa-miR-6828-5p (MIRT458669)
- hsa-miR-3179 (MIRT458670)
- hsa-miR-7515 (MIRT458671)
- hsa-miR-6783-5p (MIRT458672)
- mmu-miR-208a-5p (MIRT595307)
- mmu-miR-669n (MIRT595308)
- mmu-miR-592-5p (MIRT595309)
- mmu-miR-3086-5p (MIRT595310)
- mmu-miR-219a-5p (MIRT595311)
- mmu-miR-712-5p (MIRT595312)
- mmu-miR-205-5p (MIRT595313)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR35
- Browse OriGene Inhibitory RNA Products For GPR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR35
Clone products for research
- Applied Biological Materials (abm): Clones for GPR35 - Starting at $45 >
- * GPR35 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204323
- MG219999
- MR204323
- MR204323L3
- MR204323L4
- MR219999
- MR219999L3
- MR219999L4
- MR229141
- RC215174
- RC215174L1
- RC215174L2
- RC215174L3
- RC215174L4
- RC231173
- RC231173L1
- RC231173L2
- RC231173L3
- RC231173L4
- RC232526
- RG215174
- RG231173
- RG232526
- RR205323
- RR205323L3
- RR205323L4
- MR204323L3V
- MR204323L4V
- MR219999L3V
- MR219999L4V
- RC215174L1V
- RC215174L2V
- RC215174L3V
- RC215174L4V
- RC231173L1V
- RC231173L2V
- RC231173L3V
- RC231173L4V
- RR205323L3V
- RR205323L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR35
- Addgene plasmids for GPR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR35
Cell Lines for research
-
Horizon Cell Lines for GPR35
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR35 Gene
Localization for GPR35 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR35 Gene
- Cell membrane. Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IDA | 16754668 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR35 Gene
Pathways & Interactions for GPR35 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
Pathways by source for GPR35 Gene
1 BioSystems pathway for GPR35 Gene
4 Reactome pathways for GPR35 Gene
1 KEGG pathway for GPR35 Gene
Interacting Proteins for GPR35 Gene
GPS-Prot Interaction Network for GPR35
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS,IDA | 16754668 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IMP | 25411203 |
| GO:0035025 | positive regulation of Rho protein signal transduction | IBA | 21873635 |
Drugs & Compounds for GPR35 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Furosemide | Approved, Vet_approved | Pharma | Agonist, Target, blocker | GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA | 285 | |
| Bumetanide | Approved | Pharma | Agonist, blocker | NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor | 29 | |
| Pyrantel | Approved, Vet_approved | Pharma | Target | 24 | ||
| Kynurenic acid | Investigational | Pharma | Agonist, Target | 4 | ||
| Zaprinast | Pharma | Agonist | phosphodiesterase inhibitor, GPR35 agonist | 0 |
(5) Tocris Compounds for GPR35 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Pamoic acid disodium salt | GPR35 agonist | 6640-22-8 |
| TC-G 1001 | GPR35 agonist; more potent than zaprinast (Cat. No. 0947) | 494191-73-0 |
| TCS 3035 | GPR35 agonist | 871085-49-3 |
| YE 120 | GPR35 agonist | 383124-82-1 |
| Zaprinast | GPR35 agonist | 37762-06-4 |
(6) ApexBio Compounds for GPR35 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CID 2745687 | GPR35 antagonist | 264233-05-8 |
| Pamoic acid disodium salt | 6640-22-8 | |
| TC-G 1001 | 494191-73-0 | |
| TCS 3035 | GPR35 agonist | 871085-49-3 |
| YE 120 | 383124-82-1 | |
| Zaprinast | phosphodiesterase inhibitor | 37762-06-4 |
Transcripts for GPR35 Gene
mRNA/cDNA for GPR35 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000319838 2250 nts (view in UCSC)
- ENST00000403859 2032 nts (view in UCSC)
- ENST00000407714 1258 nts (view in UCSC)
- ENST00000430267 1399 nts (view in UCSC)
- ENST00000438013 3821 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GPR35 - Starting at $85 >
- * GPR35 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GPR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR35
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR35
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR35
- Browse OriGene Inhibitory RNA Products For GPR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR35
Clone products for research
- Applied Biological Materials (abm): Clones for GPR35 - Starting at $45 >
- * GPR35 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204323
- MG219999
- MR204323
- MR204323L3
- MR204323L4
- MR219999
- MR219999L3
- MR219999L4
- MR229141
- RC215174
- RC215174L1
- RC215174L2
- RC215174L3
- RC215174L4
- RC231173
- RC231173L1
- RC231173L2
- RC231173L3
- RC231173L4
- RC232526
- RG215174
- RG231173
- RG232526
- RR205323
- RR205323L3
- RR205323L4
- MR204323L3V
- MR204323L4V
- MR219999L3V
- MR219999L4V
- RC215174L1V
- RC215174L2V
- RC215174L3V
- RC215174L4V
- RC231173L1V
- RC231173L2V
- RC231173L3V
- RC231173L4V
- RR205323L3V
- RR205323L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR35
- Addgene plasmids for GPR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR35
Relevant External Links for GPR35 Gene
- GeneLoc Exon Structure for
- GPR35
Expression for GPR35 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for GPR35 Gene
This gene is overexpressed in Colon - Transverse (x8.6) and Small Intestine - Terminal Ileum (x6.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR35
SOURCE GeneReport for Unigene cluster for GPR35 Gene:
Hs.112218mRNA Expression by UniProt/SwissProt for GPR35 Gene:
Q9HC97-GPR35_HUMAN
Tissue specificity:
Predominantly expressed in immune and gastrointestinal tissues.
Evidence on tissue expression from TISSUES for GPR35 Gene
- Nervous system(4.4)
- Intestine(3.9)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR35 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- urinary
Regions:
Head and neck:
- eye
- head
- mouth
Abdomen:
- abdominal wall
- biliary tract
- gallbladder
- kidney
- liver
- pancreas
Pelvis:
- ureter
- urinary bladder
General:
- skin
Primer products for research
-
OriGene qPCR primer pairs for GPR35
-
OriGene qPCR primer pairs and template standards for GPR35
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR35 Gene
Orthologs for GPR35 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR35 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC100855802 30 |
|
||
| GPR35 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | GPR35 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gpr35 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gpr35 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | GPR35 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GPR35 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | GPR35 (1 of 3) 31 |
|
OneToMany | |
| GPR35 (2 of 3) 31 |
|
OneToMany | |||
| GPR35 (3 of 3) 31 |
|
OneToMany |
- Species where no ortholog for GPR35 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPR35 Gene
- ENSEMBL:
- Gene Tree for GPR35 (if available)
- TreeFam:
- Gene Tree for GPR35 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR35: view image
Paralogs for GPR35 Gene
Paralogs for GPR35 Gene
(9) SIMAP similar genes for GPR35 Gene using alignment to 1 proteins:
- GPR35_HUMAN
Variants for GPR35 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR35 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115880579 | Benign: not provided | 240,630,118(+) |
C/T NM_001195381.2(GPR35):c.259C>T (p.Arg87Cys) |
MISSENSE | |
| rs13387859 | Benign: not provided. - | 240,630,178(+) |
G/Ap.Val76Met NM_001195381.2(GPR35):c.319G>A (p.Val107Met) |
MISSENSE | |
| rs138617727 | Benign: not provided | 240,630,690(+) |
C/T NM_001195381.2(GPR35):c.831C>T (p.Asn277=) |
SYNONYMOUS | |
| rs139197368 | Benign: not provided. - | 240,630,037(+) |
G/Ap.Val29Ile NM_001195381.2(GPR35):c.178G>A (p.Val60Ile) |
MISSENSE | |
| rs140467268 | Benign: not provided | 240,630,810(+) |
G/A NM_001195381.2(GPR35):c.951G>A (p.Ala317=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1170354 | CNV | insertion | 17803354 |
| esv1425277 | CNV | insertion | 17803354 |
| esv2721937 | CNV | deletion | 23290073 |
| esv2721938 | CNV | deletion | 23290073 |
| esv2721939 | CNV | deletion | 23290073 |
| esv2759119 | CNV | gain | 17122850 |
| esv29214 | CNV | loss | 19812545 |
| esv3389950 | CNV | duplication | 20981092 |
| esv3430269 | CNV | duplication | 20981092 |
| esv3594806 | CNV | loss | 21293372 |
| nsv1001262 | CNV | gain | 25217958 |
| nsv10227 | CNV | gain | 18304495 |
| nsv1130764 | CNV | deletion | 24896259 |
| nsv1136493 | CNV | deletion | 24896259 |
| nsv1142405 | CNV | deletion | 24896259 |
| nsv1147160 | CNV | deletion | 26484159 |
| nsv3240 | CNV | insertion | 18451855 |
| nsv460159 | CNV | loss | 19166990 |
| nsv470529 | CNV | loss | 18288195 |
| nsv584812 | CNV | gain | 21841781 |
| nsv584813 | CNV | gain | 21841781 |
| nsv584814 | CNV | gain | 21841781 |
| nsv584815 | CNV | loss | 21841781 |
| nsv820464 | CNV | duplication | 20802225 |
| nsv834586 | CNV | loss | 17160897 |
| nsv955292 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.51;
64.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR35 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR35 Gene
Disorders for GPR35 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholangitis, primary sclerosing |
|
|
| short-rib thoracic dysplasia 10 with or without polydactyly |
|
|
| pseudohypoparathyroidism, type ia |
|
|
| vacterl association |
|
|
Search GPR35 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR35
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
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- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR35 Gene
Publications for GPR35 Gene
- Discovery of three novel G-protein-coupled receptor genes. (PMID: 9479505) O'Dowd BF … George SR (Genomics 1998) 2 3 4
- GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. (PMID: 30600262) Schneditz G … Kaneider NC (Science signaling 2019) 2 3
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41
- Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design. (PMID: 18271057) Sun YV … Kardia SL (Genetic epidemiology 2008) 3 41
- Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. (PMID: 16754668) Wang J … Ling L (The Journal of biological chemistry 2006) 3 4
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Sources for GPR35 Gene
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