Aliases for GPR35 Gene

Aliases for GPR35 Gene

  • G Protein-Coupled Receptor 35 2 3 5
  • G-Protein Coupled Receptor 35 3 4
  • Kynurenic Acid Receptor 3 4
  • KYNA Receptor 3 4

External Ids for GPR35 Gene

Previous GeneCards Identifiers for GPR35 Gene

  • GC02M239906
  • GC02M240750
  • GC02P241588
  • GC02P241889
  • GC02P241286
  • GC02P241215
  • GC02P233327

Summaries for GPR35 Gene

GeneCards Summary for GPR35 Gene

GPR35 (G Protein-Coupled Receptor 35) is a Protein Coding gene. Diseases associated with GPR35 include Cholangitis, Primary Sclerosing and Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is LPAR4.

UniProtKB/Swiss-Prot Summary for GPR35 Gene

  • Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Gene Wiki entry for GPR35 Gene

Additional gene information for GPR35 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR35 Gene

Genomics for GPR35 Gene

GeneHancer (GH) Regulatory Elements for GPR35 Gene

Promoters and enhancers for GPR35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240620 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 522.4 +18.6 18585 7.2 POLR2G SP1 NCOR1 EP300 ZIC2 KDM6A ZBTB10 GABPA TGIF2 ZBTB7A GPR35 DUSP28 CAPN10 ENSG00000219159 PASK AQP12B AQP12A MTERF4 RNPEPL1 lnc-ANKMY1-3
GH02J240603 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 506.3 0.0 -6 3.2 EP300 CTCF POLR2G NCOR1 ZIC2 REST AFF1 ZBTB25 MYC TGIF2 GPR35 ENSG00000223374 SNED1 FARP2 CAPN10 ANKMY1 NONHSAG030989.2 lnc-ANKMY1-3
GH02J240583 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.3 -19.4 -19360 5.1 ZBTB40 ZNF217 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 PHF8 SIX5 CAPN10 CAPN10-DT lnc-ANKMY1-4 piR-40197 GPR35
GH02J240596 Enhancer 0.9 Ensembl ENCODE 16 -7.7 -7744 1.5 NCOR1 KDM6A ZBTB7A SKI TEAD1 TBX3 FOXA2 SAP130 GABPB1 HDAC1 NONHSAG030989.2 GPR35 CAPN10 lnc-ANKMY1-4
GH02J240023 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 5 -580.3 -580308 3 EP300 HNRNPK ZNF217 CTCF SIN3A TCF12 POLR2G SP1 PHF8 SIX5 NDUFA10 lnc-GPC1-4 SNED1 GPR35 piR-30959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR35

Top Transcription factor binding sites by QIAGEN in the GPR35 gene promoter:
  • ATF
  • c-Myc
  • ER-alpha
  • HOXA5
  • Max
  • MIF-1
  • p300
  • STAT5A
  • USF-1
  • USF1

Genomic Locations for GPR35 Gene

Genomic Locations for GPR35 Gene
chr2:240,605,408-240,631,259
(GRCh38/hg38)
Size:
25,852 bases
Orientation:
Plus strand
chr2:241,544,825-241,570,676
(GRCh37/hg19)
Size:
25,852 bases
Orientation:
Plus strand

Genomic View for GPR35 Gene

Genes around GPR35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR35 Gene

Proteins for GPR35 Gene

  • Protein details for GPR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC97-GPR35_HUMAN
    Recommended name:
    G-protein coupled receptor 35
    Protein Accession:
    Q9HC97
    Secondary Accessions:
    • J3KR30
    • O43495
    • Q17R58
    • Q4VBN5
    • Q4ZFV2
    • Q6FHI8
    • Q86UH4

    Protein attributes for GPR35 Gene

    Size:
    309 amino acids
    Molecular mass:
    34072 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR35 Gene

Post-translational modifications for GPR35 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR35 Gene

No data available for DME Specific Peptides for GPR35 Gene

Domains & Families for GPR35 Gene

Gene Families for GPR35 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPR35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR35 Gene

GenScript: Design optimal peptide antigens:
  • Kynurenic acid receptor (GPR35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HC97

UniProtKB/Swiss-Prot:

GPR35_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR35: view

Function for GPR35 Gene

Molecular function for GPR35 Gene

UniProtKB/Swiss-Prot Function:
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
GENATLAS Biochemistry:
G protein coupled receptor 35,expressed in heart,spleen,liver,lung,ovary kidney

Phenotypes From GWAS Catalog for GPR35 Gene

Gene Ontology (GO) - Molecular Function for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IDA 16754668
GO:0016494 C-X-C chemokine receptor activity IMP 25411203
genes like me logo Genes that share ontologies with GPR35: view
genes like me logo Genes that share phenotypes with GPR35: view

Human Phenotype Ontology for GPR35 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for GPR35

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR35 Gene

Localization for GPR35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR35 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR35 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 16754668
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR35: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR35 Gene

Pathways & Interactions for GPR35 Gene

genes like me logo Genes that share pathways with GPR35: view

Pathways by source for GPR35 Gene

1 KEGG pathway for GPR35 Gene

SIGNOR curated interactions for GPR35 Gene

Gene Ontology (GO) - Biological Process for GPR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IDA,TAS 16754668
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 25411203
GO:0035025 positive regulation of Rho protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with GPR35: view

Drugs & Compounds for GPR35 Gene

(13) Drugs for GPR35 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Furosemide Approved, Vet_approved Pharma Agonist, Inhibition, Inhibitor, Target, agonist, blocker GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 250
Bumetanide Approved Pharma Agonist, Inhibition, Inhibitor, blocker NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 26
Pyrantel Approved, Vet_approved Pharma Target 22
Kynurenic acid Investigational Pharma Agonist, Target 4
Zaprinast Pharma Agonist, Inhibition, Inhibitor phosphodiesterase inhibitor, GPR35 agonist 0

(5) Tocris Compounds for GPR35 Gene

Compound Action Cas Number
Pamoic acid disodium salt GPR35 agonist 6640-22-8
TC-G 1001 GPR35 agonist; more potent than zaprinast (Cat. No. 0947) 494191-73-0
TCS 3035 GPR35 agonist 871085-49-3
YE 120 GPR35 agonist 383124-82-1
Zaprinast GPR35 agonist 37762-06-4

(7) ApexBio Compounds for GPR35 Gene

Compound Action Cas Number
CID 2745687 GPR35 antagonist 264233-05-8
ML 145 1164500-72-4
Pamoic acid disodium salt 6640-22-8
TC-G 1001 494191-73-0
TCS 3035 GPR35 agonist 871085-49-3
YE 120 383124-82-1
Zaprinast phosphodiesterase inhibitor 37762-06-4
genes like me logo Genes that share compounds with GPR35: view

Drug Products

Transcripts for GPR35 Gene

mRNA/cDNA for GPR35 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR35

Alternative Splicing Database (ASD) splice patterns (SP) for GPR35 Gene

No ASD Table

Relevant External Links for GPR35 Gene

GeneLoc Exon Structure for
GPR35

Expression for GPR35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR35 Gene

This gene is overexpressed in Colon - Transverse (x8.6) and Small Intestine - Terminal Ileum (x6.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR35

SOURCE GeneReport for Unigene cluster for GPR35 Gene:

Hs.112218

mRNA Expression by UniProt/SwissProt for GPR35 Gene:

Q9HC97-GPR35_HUMAN
Tissue specificity: Predominantly expressed in immune and gastrointestinal tissues.

Evidence on tissue expression from TISSUES for GPR35 Gene

  • Nervous system(4.3)
  • Intestine(3.8)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR35 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • urinary
Regions:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • abdominal wall
  • biliary tract
  • gallbladder
  • kidney
  • liver
  • pancreas
Pelvis:
  • ureter
  • urinary bladder
General:
  • skin
genes like me logo Genes that share expression patterns with GPR35: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPR35 Gene

Orthologs for GPR35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR35 31 30
  • 97.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855802 30
  • 79.47 (n)
GPR35 31
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR35 31 30
  • 78.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr35 17 31 30
  • 78.18 (n)
rat
(Rattus norvegicus)
Mammalia Gpr35 30
  • 77.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 45 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GPR35 31
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR35 30
  • 51.79 (n)
-- 31
  • 37 (a)
OneToMany
-- 31
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
OneToMany
-- 31
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii GPR35 (1 of 3) 31
  • 28 (a)
OneToMany
GPR35 (2 of 3) 31
  • 27 (a)
OneToMany
GPR35 (3 of 3) 31
  • 26 (a)
OneToMany
Species where no ortholog for GPR35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR35 Gene

ENSEMBL:
Gene Tree for GPR35 (if available)
TreeFam:
Gene Tree for GPR35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR35: view image

Paralogs for GPR35 Gene

(9) SIMAP similar genes for GPR35 Gene using alignment to 1 proteins:

  • GPR35_HUMAN
genes like me logo Genes that share paralogs with GPR35: view

Variants for GPR35 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR35 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
708665 Benign: not provided 240,630,630(+) C/T SYNONYMOUS_VARIANT
715950 Benign: not provided 240,630,810(+) G/A SYNONYMOUS_VARIANT
726939 Likely Benign: not provided 240,630,457(+) A/G MISSENSE_VARIANT
728209 Likely Benign: not provided 240,630,210(+) G/A SYNONYMOUS_VARIANT
750262 Likely Benign: not provided 240,630,111(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GPR35 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR35 Gene

Variant ID Type Subtype PubMed ID
esv1170354 CNV insertion 17803354
esv1425277 CNV insertion 17803354
esv2721937 CNV deletion 23290073
esv2721938 CNV deletion 23290073
esv2721939 CNV deletion 23290073
esv2759119 CNV gain 17122850
esv29214 CNV loss 19812545
esv3389950 CNV duplication 20981092
esv3430269 CNV duplication 20981092
esv3594806 CNV loss 21293372
nsv1001262 CNV gain 25217958
nsv10227 CNV gain 18304495
nsv1130764 CNV deletion 24896259
nsv1136493 CNV deletion 24896259
nsv1142405 CNV deletion 24896259
nsv1147160 CNV deletion 26484159
nsv3240 CNV insertion 18451855
nsv460159 CNV loss 19166990
nsv470529 CNV loss 18288195
nsv584812 CNV gain 21841781
nsv584813 CNV gain 21841781
nsv584814 CNV gain 21841781
nsv584815 CNV loss 21841781
nsv820464 CNV duplication 20802225
nsv834586 CNV loss 17160897
nsv955292 CNV deletion 24416366

Variation tolerance for GPR35 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR35 Gene

Human Gene Mutation Database (HGMD)
GPR35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR35

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR35 Gene

Disorders for GPR35 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPR35 Gene - From: Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GPR35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR35 Gene

Publications for GPR35 Gene

  1. Discovery of three novel G-protein-coupled receptor genes. (PMID: 9479505) O'Dowd BF … George SR (Genomics 1998) 2 3 4 54
  2. GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. (PMID: 30600262) Schneditz G … Kaneider NC (Science signaling 2019) 2 3 54
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41 54
  4. Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design. (PMID: 18271057) Sun YV … Kardia SL (Genetic epidemiology 2008) 3 41 54
  5. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. (PMID: 16754668) Wang J … Ling L (The Journal of biological chemistry 2006) 3 4 54

Products for GPR35 Gene

Sources for GPR35 Gene