G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006] See more...

Aliases for GPR34 Gene

Aliases for GPR34 Gene

  • G Protein-Coupled Receptor 34 2 3 5
  • Probable G-Protein Coupled Receptor 34 3 4
  • LYPSR1 3

External Ids for GPR34 Gene

Previous GeneCards Identifiers for GPR34 Gene

  • GC0XP039574
  • GC0XP039796
  • GC0XP040392
  • GC0XP040579
  • GC0XP041304
  • GC0XP041433
  • GC0XP041548
  • GC0XP039279

Summaries for GPR34 Gene

Entrez Gene Summary for GPR34 Gene

  • G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

GeneCards Summary for GPR34 Gene

GPR34 (G Protein-Coupled Receptor 34) is a Protein Coding gene. Diseases associated with GPR34 include Alzheimer Disease 14 and Congenital Stationary Night Blindness. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot Summary for GPR34 Gene

Gene Wiki entry for GPR34 Gene

Additional gene information for GPR34 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR34 Gene

Genomics for GPR34 Gene

GeneHancer (GH) Regulatory Elements for GPR34 Gene

Promoters and enhancers for GPR34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ041690 Promoter 1 EPDnew Ensembl 506.3 +0.6 642 2.4 JUND FOXM1 RXRA MAX HNF4A EGR1 SP1 FOXA2 GPR34 GPR82 RF00017-8335 CASK
GH0XJ041687 Promoter 0.5 Ensembl 512.2 -1.4 -1358 0.8 NFIC IKZF1 GPR34 lnc-MED14-8 RF00017-8335 CASK
GH0XJ041867 Enhancer 0.8 Ensembl ENCODE 21.6 +181.6 181553 5.8 ZSCAN5C TCF7 FOXA2 CEBPB ZNF316 CREM PRDM6 KDM1A MAFF NFIL3 GPR34 CASK RNU6-202P piR-38051-316 RF00017-8338 lnc-PPP1R2C-9
GH0XJ041889 Enhancer 0.6 Ensembl 21.8 +200.6 200642 1.6 FOS FOXA2 FOSL2 CEBPB JUN JUND FOXA1 EP300 DPF2 STAT3 piR-31937-264 GPR34 RNU6-202P CASK piR-48325-156 lnc-PPP1R2C-9
GH0XJ041920 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5 +233.7 233700 4.9 ZBTB40 EP300 NRF1 POLR2G ZFX ZIC2 POLR2A ZBTB26 CTBP1 SKI CASK lnc-PPP1R2C-9 GPR34 RNU6-202P RF00026-1159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR34 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR34

Top Transcription factor binding sites by QIAGEN in the GPR34 gene promoter:
  • aMEF-2
  • Brachyury
  • C/EBPbeta
  • MEF-2
  • MEF-2A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v4

Genomic Locations for GPR34 Gene

Genomic Locations for GPR34 Gene
chrX:41,688,959-41,697,277
(GRCh38/hg38)
Size:
8,319 bases
Orientation:
Plus strand
chrX:41,548,226-41,556,530
(GRCh37/hg19)
Size:
8,305 bases
Orientation:
Plus strand

Genomic View for GPR34 Gene

Genes around GPR34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR34 Gene

Proteins for GPR34 Gene

  • Protein details for GPR34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPC5-GPR34_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 34
    Protein Accession:
    Q9UPC5
    Secondary Accessions:
    • O95853

    Protein attributes for GPR34 Gene

    Size:
    381 amino acids
    Molecular mass:
    43860 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR34 Gene

Post-translational modifications for GPR34 Gene

  • Glycosylation at Asn28, Asn36, Asn42, Asn200, and Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR34 Gene

No data available for DME Specific Peptides for GPR34 Gene

Domains & Families for GPR34 Gene

Gene Families for GPR34 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR34 Gene

Blocks:
  • P2 purinoceptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR34 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 34 (GPR34_HUMAN)
  • G-protein-coupled receptor 34 splice variant (Q3SAH2_HUMAN)
  • G-protein-coupled receptor 34 (Q5VT14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UPC5

UniProtKB/Swiss-Prot:

GPR34_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR34: view

Function for GPR34 Gene

Molecular function for GPR34 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
GENATLAS Biochemistry:
G protein coupled receptor 34,similar to the P2Y receptor subfamily,expressed in the brain (caudate,frontal cortex,putamen,thalamus) and in peripheral tissues with adipose tissue,placenta,fetal liver,spleen)

Gene Ontology (GO) - Molecular Function for GPR34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 10036181
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR34: view
genes like me logo Genes that share phenotypes with GPR34: view

Animal Models for GPR34 Gene

MGI Knock Outs for GPR34:
  • Gpr34 Gpr34<tm1.1Shbg>
  • Gpr34 Gpr34<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR34

CRISPR Products

miRNA for GPR34 Gene

miRTarBase miRNAs that target GPR34

Clone Products

  • Addgene plasmids for GPR34

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR34 Gene

Localization for GPR34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR34 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR34 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10036181
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR34: view

Pathways & Interactions for GPR34 Gene

PathCards logo

SuperPathways for GPR34 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR34: view

Pathways by source for GPR34 Gene

1 BioSystems pathway for GPR34 Gene

Interacting Proteins for GPR34 Gene

Selected Interacting proteins: Q9UPC5-GPR34_HUMAN for GPR34 Gene via IID

Symbol External ID(s) Details
C3AR1
;

SIGNOR curated interactions for GPR34 Gene

Activates:

Gene Ontology (GO) - Biological Process for GPR34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA,IEA 21873635
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR34: view

Drugs & Compounds for GPR34 Gene

(1) Drugs for GPR34 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylserine Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR34: view

Transcripts for GPR34 Gene

mRNA/cDNA for GPR34 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR34

Alternative Splicing Database (ASD) splice patterns (SP) for GPR34 Gene

No ASD Table

Relevant External Links for GPR34 Gene

GeneLoc Exon Structure for
GPR34

Expression for GPR34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR34

SOURCE GeneReport for Unigene cluster for GPR34 Gene:

Hs.495989

mRNA Expression by UniProt/SwissProt for GPR34 Gene:

Q9UPC5-GPR34_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for GPR34 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GPR34: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR34 Gene

Orthologs for GPR34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR34 31 30
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR34 31 30
  • 88.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr34 17 31 30
  • 87.49 (n)
dog
(Canis familiaris)
Mammalia GPR34 31 30
  • 87.05 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr34 30
  • 86.34 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR34 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR34 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR34 31 30
  • 67.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR34 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170488 30
  • 61.66 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr34b 31
  • 39 (a)
OneToOne
Species where no ortholog for GPR34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR34 Gene

ENSEMBL:
Gene Tree for GPR34 (if available)
TreeFam:
Gene Tree for GPR34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR34: view image

Paralogs for GPR34 Gene

Paralogs for GPR34 Gene

(20) SIMAP similar genes for GPR34 Gene using alignment to 4 proteins:

  • GPR34_HUMAN
  • Q3SAH0_HUMAN
  • Q3SAH2_HUMAN
  • Q5VT14_HUMAN
genes like me logo Genes that share paralogs with GPR34: view

Variants for GPR34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR34 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
713839 Benign: not provided 41,696,521(+) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT
rs61746390 Benign/Likely Benign: not provided 41,696,517(+) A/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GPR34 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR34 Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV loss 17666407
nsv523134 CNV gain 19592680

Variation tolerance for GPR34 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR34 Gene

Disorders for GPR34 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR34 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease 14
  • ad14
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search GPR34 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR34

genes like me logo Genes that share disorders with GPR34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR34 Gene

Publications for GPR34 Gene

  1. Discovery of three novel orphan G-protein-coupled receptors. (PMID: 10036181) Marchese A … O'dowd BF (Genomics 1999) 2 3 4 54
  2. A novel subgroup of class I G-protein-coupled receptors. (PMID: 10395919) Schöneberg T … Gudermann T (Biochimica et biophysica acta 1999) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1. (PMID: 10982042) Jacobi FK … Pusch CM (Human genetics 2000) 3 4 54

Products for GPR34 Gene

Sources for GPR34 Gene