Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR33 Gene

Aliases for GPR33 Gene

  • G Protein-Coupled Receptor 33 (Gene/Pseudogene) 2 3 5
  • G Protein-Coupled Receptor 33 Pseudogene 2 3
  • G Protein-Coupled Receptor 33, Pseudogene 2
  • Probable G-Protein Coupled Receptor 33 3
  • G Protein-Coupled Receptor 33 2

External Ids for GPR33 Gene

Previous GeneCards Identifiers for GPR33 Gene

  • GC14U990024
  • GC14M029943
  • GC14M029945
  • GC14M029946
  • GC14M031021
  • GC14M031953
  • GC14M012069

Summaries for GPR33 Gene

Entrez Gene Summary for GPR33 Gene

  • This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]

GeneCards Summary for GPR33 Gene

GPR33 (G Protein-Coupled Receptor 33 (Gene/Pseudogene)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is CMKLR1.

UniProtKB/Swiss-Prot for GPR33 Gene

  • Orphan receptor; could be a chemoattractant receptor.

Gene Wiki entry for GPR33 Gene

Additional gene information for GPR33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR33 Gene

Genomics for GPR33 Gene

GeneHancer (GH) Regulatory Elements for GPR33 Gene

Promoters and enhancers for GPR33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J031489 Enhancer 0.5 ENCODE 650.7 -1.7 -1708 0.1 IKZF1 DPF2 IKZF2 RUNX3 SPI1 LOC105370438 GPR33 NUBPL HEATR5A LOC101927124
GH14J031089 Enhancer 1.4 FANTOM5 Ensembl ENCODE 1.6 +396.9 396908 3.3 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ATF7 FOS RXRA RNU6-541P GPR33 STRN3 SCFD1 RPL21P5 AP4S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR33 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR33 Gene

Genomic Locations for GPR33 Gene
5,268 bases
Minus strand
5,002 bases
Minus strand

Genomic View for GPR33 Gene

Genes around GPR33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR33 Gene

Proteins for GPR33 Gene

  • Protein details for GPR33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 33
    Protein Accession:

    Protein attributes for GPR33 Gene

    333 amino acids
    Molecular mass:
    38232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR33 Gene

Post-translational modifications for GPR33 Gene

  • Glycosylation at isoforms=272, Asn19, Asn12, and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR33 Gene

Domains & Families for GPR33 Gene

Gene Families for GPR33 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR33 Gene

Suggested Antigen Peptide Sequences for GPR33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR33: view

Function for GPR33 Gene

Molecular function for GPR33 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor; could be a chemoattractant receptor.
GENATLAS Biochemistry:
G protein coupled receptor 33,chemoattractant related receptor,pseudogene

Gene Ontology (GO) - Molecular Function for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004875 complement receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR33: view

Phenotypes for GPR33 Gene

genes like me logo Genes that share phenotypes with GPR33: view

Animal Models for GPR33 Gene

MGI Knock Outs for GPR33:
  • Gpr33 Gpr33<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR33

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR33

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR33 Gene

Localization for GPR33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR33 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR33: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GPR33 Gene

Pathways & Interactions for GPR33 Gene

SuperPathways for GPR33 Gene

No Data Available

Interacting Proteins for GPR33 Gene

Gene Ontology (GO) - Biological Process for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA --
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR33: view

No data available for Pathways by source and SIGNOR curated interactions for GPR33 Gene

Drugs & Compounds for GPR33 Gene

No Compound Related Data Available

Transcripts for GPR33 Gene

mRNA/cDNA for GPR33 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR33 Gene

G protein-coupled receptor 33 (gene/pseudogene):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR33

Alternative Splicing Database (ASD) splice patterns (SP) for GPR33 Gene

No ASD Table

Relevant External Links for GPR33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR33 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR33 Gene:


SOURCE GeneReport for Unigene cluster for GPR33 Gene:


mRNA Expression by UniProt/SwissProt for GPR33 Gene:

Tissue specificity: Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.
genes like me logo Genes that share expression patterns with GPR33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR33 Gene

Orthologs for GPR33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR33 34 33
  • 99.3 (n)
(Canis familiaris)
Mammalia GPR33 34 33
  • 85.7 (n)
(Bos Taurus)
Mammalia GPR33 34 33
  • 83.63 (n)
(Mus musculus)
Mammalia Gpr33 16 34 33
  • 79.82 (n)
(Rattus norvegicus)
Mammalia Gpr33 33
  • 76.6 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
-- 34
  • 36 (a)
-- 34
  • 36 (a)
-- 34
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731186 33
  • 52.09 (n)
(Danio rerio)
Actinopterygii si:ch211-137j23.7 34
  • 27 (a)
CABZ01029333.1 34
  • 25 (a)
CABZ01029334.1 34
  • 24 (a)
si:ch211-171h4.6 34
  • 24 (a)
CABZ01029332.1 34
  • 23 (a)
si:dkey-211g8.1 34
  • 23 (a)
Species where no ortholog for GPR33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR33 Gene

Gene Tree for GPR33 (if available)
Gene Tree for GPR33 (if available)
Evolutionary constrained regions (ECRs) for GPR33: view image

Paralogs for GPR33 Gene

Paralogs for GPR33 Gene

(16) SIMAP similar genes for GPR33 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR33: view

Variants for GPR33 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GPR33 Gene

In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

Sequence variations from dbSNP and Humsavar for GPR33 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000037707 -- 31,486,817(-) T/C intron_variant
rs1000410262 -- 31,486,541(-) G/A intron_variant
rs1001187417 -- 31,486,025(-) G/A intron_variant
rs1001456781 -- 31,485,361(-) C/T intron_variant
rs1001849816 -- 31,489,332(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR33 Gene

Variant ID Type Subtype PubMed ID
nsv1145707 CNV deletion 24896259
nsv456198 CNV loss 19166990
nsv564179 CNV loss 21841781

Additional Variant Information for GPR33 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Variation tolerance for GPR33 Gene

Disorders for GPR33 Gene

Additional Disease Information for GPR33

No disorders were found for GPR33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR33 Gene

Publications for GPR33 Gene

  1. The rise and fall of the chemoattractant receptor GPR33. (PMID: 15987686) Römpler H … Schöneberg T (The Journal of biological chemistry 2005) 3 4 58
  2. Cloning genes encoding receptors related to chemoattractant receptors. (PMID: 9653656) Marchese A … O'Dowd BF (Genomics 1998) 2 3 58
  3. Involvement of the chemokine-like receptor GPR33 in innate immunity. (PMID: 20399748) Bohnekamp J … Schöneberg T (Biochemical and biophysical research communications 2010) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GPR33 Gene

Sources for GPR33 Gene

Loading form....