GPR33 Gene (Protein Coding)

G Protein-Coupled Receptor 33

GC14M031482
GIFtS:
25
This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010] See more...

Aliases for GPR33 Gene

Aliases for GPR33 Gene

  • G Protein-Coupled Receptor 33 2 3
  • G Protein-Coupled Receptor 33 (Gene/Pseudogene) 2 5
  • G Protein-Coupled Receptor 33 Pseudogene 2 3
  • Probable G-Protein Coupled Receptor 33 3 4
  • G Protein-Coupled Receptor 33, Pseudogene 2
  • GPR33 5

External Ids for GPR33 Gene

Previous GeneCards Identifiers for GPR33 Gene

  • GC14U990024
  • GC14M029943
  • GC14M029945
  • GC14M029946
  • GC14M031021
  • GC14M031953
  • GC14M012069

Summaries for GPR33 Gene

Entrez Gene Summary for GPR33 Gene

  • This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]

GeneCards Summary for GPR33 Gene

GPR33 (G Protein-Coupled Receptor 33) is a Protein Coding gene. Diseases associated with GPR33 include Epidermolysis Bullosa Simplex With Nail Dystrophy and Epiphyseal Dysplasia, Multiple, 2. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is CMKLR1.

UniProtKB/Swiss-Prot Summary for GPR33 Gene

Gene Wiki entry for GPR33 Gene

Additional gene information for GPR33 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR33 Gene

Genomics for GPR33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GPR33 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J031489 Enhancer 0.8 Ensembl ENCODE 600.7 +0.2 238 7.2 ATF7 ARID3A DPF2 RELB RUNX3 RAD51 YBX1 E4F1 ZNF205 NONO GPR33 ENSG00000203546 ENSG00000250365 HEATR5A COCH LOC105370438 NUBPL lnc-AP4S1-1 RPL9P4 DTD2
GH14J031089 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 +397.2 397197 4.1 GATAD2A ATF7 ZNF629 TFE3 ZNF692 FOXA1 RXRB IRF2 SP1 CEBPA RNU6-541P GPR33 STRN3 SCFD1 piR-41306-075 HSALNG0100382 AP4S1 HECTD1
GH14J031459 Promoter 1 Ensembl 0.3 +29.3 29338 0.2 FOXA1 POLR2A RXRB IRF2 SP1 CEBPA TCF12 SCRT2 KMT2B MNT ENSG00000203546 DTD2 ENSG00000250365 HEATR5A lnc-DTD2-7 GPR33
GH14J031458 Enhancer 0.9 ENCODE 0.3 +29.5 29549 0.2 GATAD2A ATF7 ZNF629 TFE3 RCOR2 FOXA1 POLR2A RXRB IRF2 SP1 ENSG00000203546 DTD2 ENSG00000250365 HEATR5A lnc-DTD2-7 GPR33
GH14J031476 Enhancer 0.5 Ensembl 0.4 +11.1 11139 1 ZNF512 PHB2 RAD51 YBX1 NONO PLRG1 ATM ZNF366 IKZF1 ENSG00000203546 ENSG00000250365 HEATR5A GPR33 RPL9P4 DTD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR33

Genomic Locations for GPR33 Gene

Genomic Locations for GPR33 Gene
chr14:31,482,875-31,488,039
(GRCh38/hg38)
Size:
5,165 bases
Orientation:
Minus strand
chr14:31,952,150-31,957,151
(GRCh37/hg19)
Size:
5,002 bases
Orientation:
Minus strand

Genomic View for GPR33 Gene

Genes around GPR33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR33 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR33 Gene

Proteins for GPR33 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPR33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49SQ1-GPR33_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 33
    Protein Accession:
    Q49SQ1

    Protein attributes for GPR33 Gene

    Size:
    333 amino acids
    Molecular mass:
    38232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR33 Gene

Post-translational modifications for GPR33 Gene

  • Glycosylation at Asn5, Asn12, Asn19, and Asn272
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR33 Gene

Domains & Families for GPR33 Gene

Gene Families for GPR33 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR33 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 33 (D8VER1_HUMAN)
  • Probable G-protein coupled receptor 33 (GPR33_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q49SQ1

UniProtKB/Swiss-Prot:

GPR33_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR33: view

Function for GPR33 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GPR33 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor; could be a chemoattractant receptor.
GENATLAS Biochemistry:
G protein coupled receptor 33,chemoattractant related receptor,pseudogene

Gene Ontology (GO) - Molecular Function for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004875 complement receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR33: view

Phenotypes for GPR33 Gene

MGI mutant phenotypes for GPR33:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPR33:
genes like me logo Genes that share phenotypes with GPR33: view

Animal Models for GPR33 Gene

MGI Knock Outs for GPR33:
  • Gpr33 Gpr33<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR33

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR33

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR33 Gene

Localization for GPR33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR33 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR33 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR33 Gene

Pathways & Interactions for GPR33 Gene

PathCards logo

SuperPathways for GPR33 Gene

No Data Available

Interacting Proteins for GPR33 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000421557 for GPR33 Gene via STRING

GPS-Prot Interaction Network for GPR33

Gene Ontology (GO) - Biological Process for GPR33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GPR33: view

No data available for Pathways by source and SIGNOR curated interactions for GPR33 Gene

Drugs & Compounds for GPR33 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GPR33 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GPR33 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR33

Alternative Splicing Database (ASD) splice patterns (SP) for GPR33 Gene

No ASD Table

Relevant External Links for GPR33 Gene

GeneLoc Exon Structure for
GPR33

Expression for GPR33 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR33 Gene

mRNA expression in normal human tissues for GPR33 Gene
mRNA expression by GTEx for GPR33 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR33

SOURCE GeneReport for Unigene cluster for GPR33 Gene:

Hs.727479

mRNA Expression by UniProt/SwissProt for GPR33 Gene:

Q49SQ1-GPR33_HUMAN
Tissue specificity: Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.
genes like me logo Genes that share expression patterns with GPR33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR33 Gene

Orthologs for GPR33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GPR33 30 31
  • 99.3 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GPR33 30 31
  • 85.7 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GPR33 30 31
  • 83.63 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gpr33 30 17 31
  • 79.82 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gpr33 30
  • 76.6 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 38 (a)
 OneToMany
-- 31
  • 36 (a)
 OneToMany
-- 31
  • 36 (a)
 OneToMany
-- 31
  • 27 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC101731186 30
  • 52.09 (n)
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-137j23.7 31
  • 27 (a)
 ManyToMany
CABZ01029333.1 31
  • 25 (a)
 ManyToMany
CABZ01029334.1 31
  • 24 (a)
 ManyToMany
si:ch211-171h4.6 31
  • 24 (a)
 ManyToMany
CABZ01029332.1 31
  • 23 (a)
 ManyToMany
si:dkey-211g8.1 31
  • 23 (a)
 ManyToMany
Species where no ortholog for GPR33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR33 Gene

ENSEMBL:
Gene Tree for GPR33 (if available)
TreeFam:
Gene Tree for GPR33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR33: view image

Paralogs for GPR33 Gene

Paralogs for GPR33 Gene

(16) SIMAP similar genes for GPR33 Gene using alignment to 2 proteins:

  • GPR33_HUMAN
  • D8VER1_HUMAN
genes like me logo Genes that share paralogs with GPR33: view

Variants for GPR33 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for GPR33 Gene

GPR33_HUMAN-Q49SQ1
In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR33 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
870147 Uncertain Significance: Epidermolysis bullosa simplex with nail dystrophy 31,483,121(-) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GPR33 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR33 Gene

Variant ID Type Subtype PubMed ID
nsv1145707 CNV deletion 24896259
nsv456198 CNV loss 19166990
nsv564179 CNV loss 21841781

Additional Variant Information for GPR33 Gene

Human Gene Mutation Database (HGMD)
GPR33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR33

SNP Genotyping and Copy Number Assay Products

No data available for Variation tolerance for GPR33 Gene

Disorders for GPR33 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GPR33 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GPR33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR33

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR33 Gene

Publications for GPR33 Gene

  1. The rise and fall of the chemoattractant receptor GPR33. (PMID: 15987686) Römpler H … Schöneberg T (The Journal of biological chemistry 2005) 2 3 4
  2. Cloning genes encoding receptors related to chemoattractant receptors. (PMID: 9653656) Marchese A … O'Dowd BF (Genomics 1998) 2 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Involvement of the chemokine-like receptor GPR33 in innate immunity. (PMID: 20399748) Bohnekamp J … Schöneberg T (Biochemical and biophysical research communications 2010) 3

ExternalLinks

View latest publications for GPR33 gene in Mastermind

Products for GPR33 Gene

Sources for GPR33 Gene