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This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]
GPR33 (G Protein-Coupled Receptor 33) is a Protein Coding gene. Diseases associated with GPR33 include Epidermolysis Bullosa Simplex With Nail Dystrophy and Epiphyseal Dysplasia, Multiple, 2. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is CMKLR1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004875 | complement receptor activity | IBA | 21873635 |
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002430 | complement receptor mediated signaling pathway | IBA | 21873635 |
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR33 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPR33 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPR33 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpr33 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gpr33 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731186 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-137j23.7 31 |
|
ManyToMany | |
CABZ01029333.1 31 |
|
ManyToMany | |||
CABZ01029334.1 31 |
|
ManyToMany | |||
si:ch211-171h4.6 31 |
|
ManyToMany | |||
CABZ01029332.1 31 |
|
ManyToMany | |||
si:dkey-211g8.1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
870147 | Uncertain Significance: Epidermolysis bullosa simplex with nail dystrophy | 31,483,121(-) | A/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
epidermolysis bullosa simplex with nail dystrophy |
|
|
epiphyseal dysplasia, multiple, 2 |
|
|
multiple epiphyseal dysplasia due to collagen 9 anomaly |
|
|
epiphyseal dysplasia, multiple, 1 |
|
|
hypoascorbemia |
|
|