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This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. [provided by RefSeq, Nov 2012]
GPR32 (G Protein-Coupled Receptor 32) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is FPR2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004875 | complement receptor activity | IBA | 21873635 |
GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
GO:0004982 | N-formyl peptide receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 9653656 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | G alpha (s) signalling events | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002430 | complement receptor mediated signaling pathway | IBA | 21873635 |
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR32 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPR32 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | GPR32 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | CR847899.1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1864011 | - |
p.Phe327Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv26629 | CNV | gain+loss | 19812545 |
esv2718749 | CNV | deletion | 23290073 |
esv3644653 | CNV | loss | 21293372 |
esv3644654 | CNV | gain | 21293372 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv1146125 | CNV | deletion | 26484159 |
nsv517376 | CNV | loss | 19592680 |
No disorders were found for GPR32 Gene.