This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. [provided by RefSeq, Nov 2012] See more...

Aliases for GPR32 Gene

Aliases for GPR32 Gene

  • G Protein-Coupled Receptor 32 2 3 5
  • Probable G-Protein Coupled Receptor 32 3 4
  • Resolvin D1 Receptor 2 3
  • RVDR1 3

External Ids for GPR32 Gene

Previous GeneCards Identifiers for GPR32 Gene

  • GC19P051902
  • GC19P051635
  • GC19P055949
  • GC19P055965
  • GC19P051276
  • GC19P047608

Summaries for GPR32 Gene

Entrez Gene Summary for GPR32 Gene

  • This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR32 Gene

GPR32 (G Protein-Coupled Receptor 32) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot Summary for GPR32 Gene

Gene Wiki entry for GPR32 Gene

Additional gene information for GPR32 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR32 Gene

Genomics for GPR32 Gene

GeneHancer (GH) Regulatory Elements for GPR32 Gene

Promoters and enhancers for GPR32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050720 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.2 -47.1 -47108 5.7 ZNF217 EP300 CTCF ZSCAN5C TCF12 NRF1 GTF2E2 PHF8 ZFX ZBTB5 CLEC11A C19orf48 GPR32 AKT1S1 SNORD88A SNORD88B SNORD88C LINC01869 NUP62 KLK1
GH19J050727 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 12.2 -42.0 -42025 1.4 NRF1 USF1 SIX5 ZBTB26 MYC CTBP1 POLR2A DEAF1 NCOR1 KDM5B GPR32 SNORD88A SNORD88B SNORD88C C19orf48 LINC01869 KLK1 KLK15 FUZ KLK8
GH19J050537 Enhancer 1.1 ENCODE dbSUPER 11.6 -232.6 -232585 0.1 ZNF217 CTCF TEAD4 ZBTB10 GABPA REST MYC RAD21 CTBP1 TRIM22 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
GH19J050538 Enhancer 0.9 dbSUPER 11.6 -233.0 -233026 0.7 ZNF217 CTCF ZBTB10 GABPA REST MYC RAD21 CTBP1 TEAD1 ZEB1 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
GH19J050548 Promoter/Enhancer 0.6 EPDnew dbSUPER 11.7 -221.6 -221580 0.1 KDM1A JOSD2 GPR32 CLEC11A ENSG00000268231 LRRC4B piR-34822-165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR32 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR32

Top Transcription factor binding sites by QIAGEN in the GPR32 gene promoter:
  • ARP-1
  • Gfi-1
  • NF-1
  • NF-1/L
  • Pax-6
  • SRF
  • SRF (504 AA)
  • TGIF

Genomic Locations for GPR32 Gene

Genomic Locations for GPR32 Gene
chr19:50,770,464-50,771,732
(GRCh38/hg38)
Size:
1,269 bases
Orientation:
Plus strand
chr19:51,273,721-51,274,989
(GRCh37/hg19)
Size:
1,269 bases
Orientation:
Plus strand

Genomic View for GPR32 Gene

Genes around GPR32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR32 Gene

Proteins for GPR32 Gene

  • Protein details for GPR32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75388-GPR32_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 32
    Protein Accession:
    O75388
    Secondary Accessions:
    • Q502U7
    • Q6NWS5

    Protein attributes for GPR32 Gene

    Size:
    356 amino acids
    Molecular mass:
    40087 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR32 Gene

Post-translational modifications for GPR32 Gene

  • Glycosylation at Asn30 and Asn199
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR32 Gene

Domains & Families for GPR32 Gene

Gene Families for GPR32 Gene

Protein Domains for GPR32 Gene

Blocks:
  • Formyl-methionyl peptide receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR32 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 32 (GPR32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75388

UniProtKB/Swiss-Prot:

GPR32_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR32: view

Function for GPR32 Gene

Molecular function for GPR32 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
GENATLAS Biochemistry:
G protein coupled receptor 32,chemoattractant related receptor

Phenotypes From GWAS Catalog for GPR32 Gene

Gene Ontology (GO) - Molecular Function for GPR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS,IBA 21873635
GO:0004982 N-formyl peptide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR32: view
genes like me logo Genes that share phenotypes with GPR32: view

Clone Products

  • Addgene plasmids for GPR32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR32 Gene

Localization for GPR32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR32 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR32 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9653656
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR32 Gene

Pathways & Interactions for GPR32 Gene

genes like me logo Genes that share pathways with GPR32: view

Pathways by source for GPR32 Gene

Interacting Proteins for GPR32 Gene

;

Gene Ontology (GO) - Biological Process for GPR32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GPR32: view

No data available for SIGNOR curated interactions for GPR32 Gene

Drugs & Compounds for GPR32 Gene

(4) Drugs for GPR32 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]resolvin D1 Pharma Agonist 0
LXA<sub>4</sub> Pharma Partial agonist, Agonist, Full agonist 0
resolvin D1 Pharma Full agonist, Agonist 0
RVD1-ME Pharma 0
genes like me logo Genes that share compounds with GPR32: view

Transcripts for GPR32 Gene

mRNA/cDNA for GPR32 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR32

Alternative Splicing Database (ASD) splice patterns (SP) for GPR32 Gene

No ASD Table

Relevant External Links for GPR32 Gene

GeneLoc Exon Structure for
GPR32

Expression for GPR32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR32 Gene

mRNA differential expression in normal tissues according to GTEx for GPR32 Gene

This gene is overexpressed in Testis (x16.8), Brain - Cerebellum (x7.0), and Brain - Cerebellar Hemisphere (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR32

SOURCE GeneReport for Unigene cluster for GPR32 Gene:

Hs.515555
genes like me logo Genes that share expression patterns with GPR32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR32 Gene

Orthologs for GPR32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR32 31 30
  • 99.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR32 30
  • 70.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
OneToMany
-- 31
  • 34 (a)
OneToMany
-- 31
  • 33 (a)
OneToMany
-- 31
  • 29 (a)
OneToMany
-- 31
  • 26 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GPR32 31
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR847899.1 31
  • 22 (a)
ManyToMany
Species where no ortholog for GPR32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR32 Gene

ENSEMBL:
Gene Tree for GPR32 (if available)
TreeFam:
Gene Tree for GPR32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR32: view image

Paralogs for GPR32 Gene

Paralogs for GPR32 Gene

(8) SIMAP similar genes for GPR32 Gene using alignment to 2 proteins:

  • GPR32_HUMAN
  • H9NIL6_HUMAN

Pseudogenes.org Pseudogenes for GPR32 Gene

genes like me logo Genes that share paralogs with GPR32: view

Variants for GPR32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR32 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1864011 - p.Phe327Leu

Additional dbSNP identifiers (rs#s) for GPR32 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR32 Gene

Variant ID Type Subtype PubMed ID
esv26629 CNV gain+loss 19812545
esv2718749 CNV deletion 23290073
esv3644653 CNV loss 21293372
esv3644654 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv1146125 CNV deletion 26484159
nsv517376 CNV loss 19592680

Variation tolerance for GPR32 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR32

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR32 Gene

Disorders for GPR32 Gene

Additional Disease Information for GPR32

No disorders were found for GPR32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR32 Gene

Publications for GPR32 Gene

  1. Cloning genes encoding receptors related to chemoattractant receptors. (PMID: 9653656) Marchese A … O'Dowd BF (Genomics 1998) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production. (PMID: 29083412) Zheng S … Thickett DR (Laboratory investigation; a journal of technical methods and pathology 2018) 3 54
  4. S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. (PMID: 26339162) Taylan A … Sari I (Journal of Korean medical science 2015) 3 54
  5. Effect of diclofenac on the levels of lipoxin A4 and Resolvin D1 and E1 in the post-ERCP pancreatitis. (PMID: 25030943) Zhao XW … Xu JM (Digestive diseases and sciences 2014) 3 54

Products for GPR32 Gene

Sources for GPR32 Gene