Aliases for GPR31 Gene

Aliases for GPR31 Gene

  • G Protein-Coupled Receptor 31 2 3 5
  • 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Receptor 3 4
  • Hydroxyeicosatetraenoic (HETE) Acid Receptor 1 2 3
  • 12-(S)-HETE Acid Receptor 2 3
  • 12-(S)-HETE Receptor 3 4
  • 12-HETER 3 4
  • 12-(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid (HETE) Receptor 3
  • BA517H2.2 (G Protein-Coupled Receptor 31) 3
  • Probable G-Protein Coupled Receptor 31 3
  • G-Protein Coupled Receptor 31 4
  • HETER1 3
  • HETER 3

External Ids for GPR31 Gene

Previous GeneCards Identifiers for GPR31 Gene

  • GC06M166923
  • GC06M167443
  • GC06M167479
  • GC06M167540
  • GC06M165042

Summaries for GPR31 Gene

GeneCards Summary for GPR31 Gene

GPR31 (G Protein-Coupled Receptor 31) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Free fatty acid receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is HCAR3.

UniProtKB/Swiss-Prot Summary for GPR31 Gene

  • High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Gene Wiki entry for GPR31 Gene

Additional gene information for GPR31 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR31 Gene

Genomics for GPR31 Gene

GeneHancer (GH) Regulatory Elements for GPR31 Gene

Promoters and enhancers for GPR31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR31 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR31

Top Transcription factor binding sites by QIAGEN in the GPR31 gene promoter:
  • AML1a
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)

Genomic Locations for GPR31 Gene

Genomic Locations for GPR31 Gene
chr6:167,156,271-167,158,329
(GRCh38/hg38)
Size:
2,059 bases
Orientation:
Minus strand
chr6:167,569,759-167,571,817
(GRCh37/hg19)
Size:
2,059 bases
Orientation:
Minus strand

Genomic View for GPR31 Gene

Genes around GPR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR31 Gene

Proteins for GPR31 Gene

  • Protein details for GPR31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00270-GPR31_HUMAN
    Recommended name:
    12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
    Protein Accession:
    O00270
    Secondary Accessions:
    • B0M0K2
    • Q4VBL3
    • Q9NQ20

    Protein attributes for GPR31 Gene

    Size:
    319 amino acids
    Molecular mass:
    35075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR31 Gene

Post-translational modifications for GPR31 Gene

  • Glycosylation at Asn5

Other Protein References for GPR31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR31 Gene

Domains & Families for GPR31 Gene

Gene Families for GPR31 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR31 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR31 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 31 (GPR31_HUMAN)
  • GPR31 protein (Q4VBL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00270

UniProtKB/Swiss-Prot:

GPR31_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR31: view

Function for GPR31 Gene

Molecular function for GPR31 Gene

UniProtKB/Swiss-Prot Function:
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.
GENATLAS Biochemistry:
G protein coupled receptor 31,with homology with the orphan receptor HM74

Phenotypes From GWAS Catalog for GPR31 Gene

Gene Ontology (GO) - Molecular Function for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS --
GO:0005515 protein binding IPI 28619714
genes like me logo Genes that share ontologies with GPR31: view
genes like me logo Genes that share phenotypes with GPR31: view

Animal Models for GPR31 Gene

MGI Knock Outs for GPR31:

Clone Products

  • Addgene plasmids for GPR31

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR31 Gene

Localization for GPR31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR31 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR31 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9205127
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR31: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR31 Gene

Pathways & Interactions for GPR31 Gene

genes like me logo Genes that share pathways with GPR31: view

Pathways by source for GPR31 Gene

Gene Ontology (GO) - Biological Process for GPR31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002237 response to molecule of bacterial origin ISS --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0050778 positive regulation of immune response IEA --
genes like me logo Genes that share ontologies with GPR31: view

No data available for SIGNOR curated interactions for GPR31 Gene

Drugs & Compounds for GPR31 Gene

No Compound Related Data Available

Transcripts for GPR31 Gene

mRNA/cDNA for GPR31 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR31

Alternative Splicing Database (ASD) splice patterns (SP) for GPR31 Gene

No ASD Table

Relevant External Links for GPR31 Gene

GeneLoc Exon Structure for
GPR31

Expression for GPR31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR31 Gene

mRNA differential expression in normal tissues according to GTEx for GPR31 Gene

This gene is overexpressed in Testis (x12.4), Small Intestine - Terminal Ileum (x8.7), and Spleen (x5.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR31

SOURCE GeneReport for Unigene cluster for GPR31 Gene:

Hs.248124
genes like me logo Genes that share expression patterns with GPR31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR31 Gene

Orthologs for GPR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR31 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR31 31 30
  • 74.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR31 31 30
  • 72.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr31 30
  • 71.26 (n)
mouse
(Mus musculus)
Mammalia Gpr31b 17 31 30
  • 71.06 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR31 31
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR31 31
  • 26 (a)
OneToOne
Species where no ortholog for GPR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR31 Gene

ENSEMBL:
Gene Tree for GPR31 (if available)
TreeFam:
Gene Tree for GPR31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR31: view image

Paralogs for GPR31 Gene

(7) SIMAP similar genes for GPR31 Gene using alignment to 1 proteins:

  • GPR31_HUMAN
genes like me logo Genes that share paralogs with GPR31: view

Variants for GPR31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR31 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs6902566 - p.His91Arg

Additional dbSNP identifiers (rs#s) for GPR31 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR31 Gene

Variant ID Type Subtype PubMed ID
dgv1240e214 CNV gain 21293372
dgv6194n100 CNV gain 25217958
esv2752099 CNV gain 17911159
esv2759492 CNV gain 17122850
esv3611649 CNV gain 21293372
nsv469673 CNV loss 16826518

Variation tolerance for GPR31 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR31

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR31 Gene

Disorders for GPR31 Gene

Additional Disease Information for GPR31

No disorders were found for GPR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR31 Gene

Publications for GPR31 Gene

  1. Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. (PMID: 21712392) Guo Y … Honn KV (The Journal of biological chemistry 2011) 2 3 4 54
  2. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PMID: 9205127) Zingoni A … Napolitano M (Genomics 1997) 2 3 4 54
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  4. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. (PMID: 29227475) Zhang XJ … Li H (Nature medicine 2018) 3 54
  5. Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer. (PMID: 30416315) Rong YM … Lan P (World journal of gastroenterology 2018) 3 54

Products for GPR31 Gene

Sources for GPR31 Gene