Aliases for GPR3 Gene
External Ids for GPR3 Gene
Previous GeneCards Identifiers for GPR3 Gene
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
GeneCards Summary for GPR3 Gene
GPR3 (G Protein-Coupled Receptor 3) is a Protein Coding gene. Diseases associated with GPR3 include Alzheimer Disease and Premature Ovarian Failure 1. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR6.
UniProtKB/Swiss-Prot Summary for GPR3 Gene
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).