Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR27 Gene

Aliases for GPR27 Gene

  • G Protein-Coupled Receptor 27 2 3 5
  • Super Conserved Receptor Expressed In Brain 1 3 4
  • SREB1 3 4
  • Probable G-Protein Coupled Receptor 27 3

External Ids for GPR27 Gene

Previous GeneCards Identifiers for GPR27 Gene

  • GC03M070539
  • GC03P071416
  • GC03P071607
  • GC03P071723
  • GC03P071885
  • GC03P071803

Summaries for GPR27 Gene

Entrez Gene Summary for GPR27 Gene

  • GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]

GeneCards Summary for GPR27 Gene

GPR27 (G Protein-Coupled Receptor 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR85.

UniProtKB/Swiss-Prot for GPR27 Gene

  • Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Gene Wiki entry for GPR27 Gene

Additional gene information for GPR27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR27 Gene

Genomics for GPR27 Gene

GeneHancer (GH) Regulatory Elements for GPR27 Gene

Promoters and enhancers for GPR27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J071753 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 657.8 0.0 -49 1.2 GTF2F1 MXI1 SUZ12 SIN3A ZEB2 E2F1 ZNF335 POLR2A ZFX ZBTB26 GPR27 EIF4E3 GC03P071727
GH03J071754 Promoter 0.7 EPDnew 650.7 +0.7 743 0.1 E2F1 SIN3A GPR27 EIF4E3 PROK2
GH03J071720 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 33.9 -30.3 -30307 5.6 HDAC1 PKNOX1 INSM2 KLF17 SIN3A YY1 ZNF335 GLIS2 ZNF366 EGR2 EIF4E3 GPR27 PROK2 FOXP1 GC03P071727 GC03P071679
GH03J071779 Enhancer 1.1 FANTOM5 Ensembl ENCODE 49.2 +25.9 25851 1.8 CTCF MAX ZNF316 POLR2A SCRT2 NFE2 ZNF639 SOX6 ZBTB11 CEBPB PROK2 GPR27 EIF4E3 FOXP1
GH03J071728 Enhancer 0.9 Ensembl ENCODE 30.1 -24.4 -24393 1.5 BCOR ZNF768 CTCF ZSCAN4 MAX ZMYM3 BMI1 RAD21 ETS1 POLR2A GPR27 EIF4E3 GC03P071727
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR27 gene promoter:
  • Spz1
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HNF-3beta
  • Elk-1

Genomic Locations for GPR27 Gene

Genomic Locations for GPR27 Gene
2,447 bases
Plus strand
2,447 bases
Plus strand

Genomic View for GPR27 Gene

Genes around GPR27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR27 Gene

Proteins for GPR27 Gene

  • Protein details for GPR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 27
    Protein Accession:

    Protein attributes for GPR27 Gene

    375 amino acids
    Molecular mass:
    39818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR27 Gene

Post-translational modifications for GPR27 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR27 Gene

Domains & Families for GPR27 Gene

Gene Families for GPR27 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR27 Gene


Suggested Antigen Peptide Sequences for GPR27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR27: view

Function for GPR27 Gene

Molecular function for GPR27 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Phenotypes From GWAS Catalog for GPR27 Gene

Gene Ontology (GO) - Molecular Function for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with GPR27: view
genes like me logo Genes that share phenotypes with GPR27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR27

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR27 Gene

Localization for GPR27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR27 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR27: view

Pathways & Interactions for GPR27 Gene

genes like me logo Genes that share pathways with GPR27: view

Pathways by source for GPR27 Gene

Gene Ontology (GO) - Biological Process for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR27: view

No data available for SIGNOR curated interactions for GPR27 Gene

Drugs & Compounds for GPR27 Gene

No Compound Related Data Available

Transcripts for GPR27 Gene

mRNA/cDNA for GPR27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR27 Gene

G protein-coupled receptor 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR27

Alternative Splicing Database (ASD) splice patterns (SP) for GPR27 Gene

No ASD Table

Relevant External Links for GPR27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR27 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR27 Gene:


SOURCE GeneReport for Unigene cluster for GPR27 Gene:


mRNA Expression by UniProt/SwissProt for GPR27 Gene:

Tissue specificity: Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Evidence on tissue expression from TISSUES for GPR27 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPR27: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR27 Gene

Orthologs for GPR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR27 33
  • 96.53 (n)
(Mus musculus)
Mammalia Gpr27 16 34 33
  • 94.12 (n)
(Rattus norvegicus)
Mammalia Gpr27 33
  • 93.45 (n)
(Monodelphis domestica)
Mammalia GPR27 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia GPR27 34
  • 73 (a)
(Gallus gallus)
Aves GPR27 34
  • 67 (a)
(Danio rerio)
Actinopterygii gpr27 34
  • 55 (a)
Species where no ortholog for GPR27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR27 Gene

Gene Tree for GPR27 (if available)
Gene Tree for GPR27 (if available)
Evolutionary constrained regions (ECRs) for GPR27: view image

Paralogs for GPR27 Gene

Paralogs for GPR27 Gene

(2) SIMAP similar genes for GPR27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR27: view

Variants for GPR27 Gene

Sequence variations from dbSNP and Humsavar for GPR27 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002625859 -- 71,753,745(+) G/C upstream_transcript_variant
rs1002955887 -- 71,752,720(+) T/C upstream_transcript_variant
rs1003049084 -- 71,752,557(+) A/G upstream_transcript_variant
rs1003848179 -- 71,753,566(+) C/G upstream_transcript_variant
rs1004144191 -- 71,753,331(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR27 Gene

Variant ID Type Subtype PubMed ID
dgv8373n54 CNV gain 21841781
dgv8374n54 CNV gain 21841781
esv28633 CNV loss 19812545
nsv1144994 CNV deletion 24896259
nsv524847 CNV loss 19592680
nsv590600 CNV loss 21841781
nsv590606 CNV loss 21841781
nsv590610 CNV gain+loss 21841781
nsv590611 CNV loss 21841781

Variation tolerance for GPR27 Gene

Gene Damage Index Score: 0.46; 9.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR27 Gene

Disorders for GPR27 Gene

Additional Disease Information for GPR27

No disorders were found for GPR27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR27 Gene

Publications for GPR27 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M … Furuichi K (Biochemical and biophysical research communications 2000) 2 3 4 58
  2. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. (PMID: 25113059) Kotov IN … Marti TM (Molecular oncology 2014) 3 58
  3. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M … Kleinman JE (Brain research. Molecular brain research 2005) 22 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GPR27 Gene

Sources for GPR27 Gene

Loading form....