GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, Ma... See more...

Aliases for GPR27 Gene

Aliases for GPR27 Gene

  • G Protein-Coupled Receptor 27 2 3 5
  • Super Conserved Receptor Expressed In Brain 1 3 4
  • Probable G-Protein Coupled Receptor 27 3 4
  • SREB1 3 4

External Ids for GPR27 Gene

Previous GeneCards Identifiers for GPR27 Gene

  • GC03M070539
  • GC03P071416
  • GC03P071607
  • GC03P071723
  • GC03P071885
  • GC03P071803

Summaries for GPR27 Gene

Entrez Gene Summary for GPR27 Gene

  • GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]

GeneCards Summary for GPR27 Gene

GPR27 (G Protein-Coupled Receptor 27) is a Protein Coding gene. Diseases associated with GPR27 include Eyelid Disease. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot Summary for GPR27 Gene

  • Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Gene Wiki entry for GPR27 Gene

Additional gene information for GPR27 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR27 Gene

Genomics for GPR27 Gene

GeneHancer (GH) Regulatory Elements for GPR27 Gene

Promoters and enhancers for GPR27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J071753 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 507.7 +0.4 446 3.8 ZFX GABPA ZBTB26 EZH2 POLR2A MYC SMC3 REST MXI1 CTCF GPR27 EIF4E3 ENSG00000285708
GH03J071720 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 33.9 -30.0 -29983 5.9 ZNF217 USF1 TEAD4 ZFX ZIC2 ZBTB26 CTBP1 EZH2 HDAC2 MXI1 EIF4E3 GPR27 PROK2 FOXP1 lnc-GPR27-5 lnc-PROK2-2 ENSG00000285708 lnc-EIF4E3-2
GH03J071781 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl 46.1 +29.8 29846 3.8 USF1 ZBTB26 ZNF341 EZH2 MXI1 ZNF76 KLF8 ZFHX2 ZNF777 GLI4 PROK2 ENSG00000287131 HSALNG0026781 LOC105377156 GPR27 EIF4E3 FOXP1 lnc-PROK2-1
GH03J071779 Enhancer 0.9 FANTOM5 ENCODE 45.7 +26.2 26204 0.9 TEAD4 ZBTB11 ZNF316 GABPA CTCF NFE2 ZNF395 FOXM1 PRDM6 ETV1 PROK2 GPR27 EIF4E3 FOXP1 HSALNG0026781
GH03J071850 Enhancer 1.1 FANTOM5 Ensembl ENCODE 32.7 +99.4 99446 13 CTCF REST RAD21 MXI1 ESRRA NFIC SMC3 GABPA CEBPG FOS PROK2 GPR27 EIF4E3 FOXP1 lnc-GPR27-8 RF00017-4047 lnc-GPR27-7 RN7SL271P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR27

Top Transcription factor binding sites by QIAGEN in the GPR27 gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1
  • HNF-3beta
  • Spz1

Genomic Locations for GPR27 Gene

Genomic Locations for GPR27 Gene
chr3:71,753,855-71,756,496
(GRCh38/hg38)
Size:
2,642 bases
Orientation:
Plus strand
chr3:71,803,201-71,805,647
(GRCh37/hg19)
Size:
2,447 bases
Orientation:
Plus strand

Genomic View for GPR27 Gene

Genes around GPR27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR27 Gene

Proteins for GPR27 Gene

  • Protein details for GPR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS67-GPR27_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 27
    Protein Accession:
    Q9NS67

    Protein attributes for GPR27 Gene

    Size:
    375 amino acids
    Molecular mass:
    39818 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR27 Gene

Post-translational modifications for GPR27 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR27 Gene

Domains & Families for GPR27 Gene

Gene Families for GPR27 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR27 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 27 (F1DAM3_HUMAN)
  • Super conserved receptor expressed in brain 1 (GPR27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS67

UniProtKB/Swiss-Prot:

GPR27_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR27: view

Function for GPR27 Gene

Molecular function for GPR27 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Phenotypes From GWAS Catalog for GPR27 Gene

Gene Ontology (GO) - Molecular Function for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR27: view
genes like me logo Genes that share phenotypes with GPR27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR27

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR27

Clone Products

  • Addgene plasmids for GPR27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR27 Gene

Localization for GPR27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR27 gene
Compartment Confidence
plasma membrane 4
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR27: view

Pathways & Interactions for GPR27 Gene

genes like me logo Genes that share pathways with GPR27: view

Pathways by source for GPR27 Gene

Interacting Proteins for GPR27 Gene

;

Gene Ontology (GO) - Biological Process for GPR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR27: view

No data available for SIGNOR curated interactions for GPR27 Gene

Drugs & Compounds for GPR27 Gene

No Compound Related Data Available

Transcripts for GPR27 Gene

mRNA/cDNA for GPR27 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR27

Clone Products

  • Addgene plasmids for GPR27

Alternative Splicing Database (ASD) splice patterns (SP) for GPR27 Gene

No ASD Table

Relevant External Links for GPR27 Gene

GeneLoc Exon Structure for
GPR27

Expression for GPR27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR27 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR27

SOURCE GeneReport for Unigene cluster for GPR27 Gene:

Hs.591653

mRNA Expression by UniProt/SwissProt for GPR27 Gene:

Q9NS67-GPR27_HUMAN
Tissue specificity: Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Evidence on tissue expression from TISSUES for GPR27 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPR27: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR27 Gene

Orthologs for GPR27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR27 30
  • 96.53 (n)
mouse
(Mus musculus)
Mammalia Gpr27 17 31 30
  • 94.12 (n)
rat
(Rattus norvegicus)
Mammalia Gpr27 30
  • 93.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR27 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR27 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR27 31
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gpr27 31
  • 55 (a)
OneToOne
Species where no ortholog for GPR27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR27 Gene

ENSEMBL:
Gene Tree for GPR27 (if available)
TreeFam:
Gene Tree for GPR27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR27: view image

Paralogs for GPR27 Gene

Paralogs for GPR27 Gene

(2) SIMAP similar genes for GPR27 Gene using alignment to 2 proteins:

  • GPR27_HUMAN
  • F1DAM3_HUMAN
genes like me logo Genes that share paralogs with GPR27: view

Variants for GPR27 Gene

Additional dbSNP identifiers (rs#s) for GPR27 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR27 Gene

Variant ID Type Subtype PubMed ID
dgv8373n54 CNV gain 21841781
dgv8374n54 CNV gain 21841781
esv28633 CNV loss 19812545
nsv1144994 CNV deletion 24896259
nsv524847 CNV loss 19592680
nsv590600 CNV loss 21841781
nsv590606 CNV loss 21841781
nsv590610 CNV gain+loss 21841781
nsv590611 CNV loss 21841781

Variation tolerance for GPR27 Gene

Gene Damage Index Score: 0.46; 9.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR27 Gene

Disorders for GPR27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR27 Gene - From: DISEASES

Disorder Aliases PubMed IDs
eyelid disease
  • abnormality of the eyelid
- elite association - COSMIC cancer census association via MalaCards
Search GPR27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR27

genes like me logo Genes that share disorders with GPR27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR27 Gene

Publications for GPR27 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M … Furuichi K (Biochemical and biophysical research communications 2000) 2 3 4 54
  2. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. (PMID: 25113059) Kotov IN … Marti TM (Molecular oncology 2014) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M … Kleinman JE (Brain research. Molecular brain research 2005) 23 54

Products for GPR27 Gene

Sources for GPR27 Gene