This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 20... See more...

Aliases for GPR26 Gene

Aliases for GPR26 Gene

  • G Protein-Coupled Receptor 26 2 3 5
  • G-Protein Coupled Receptor 26 3 4

External Ids for GPR26 Gene

Previous GeneCards Identifiers for GPR26 Gene

  • GC10U990029
  • GC10P124675
  • GC10P125432
  • GC10P124966
  • GC10P125415
  • GC10P119041

Summaries for GPR26 Gene

Entrez Gene Summary for GPR26 Gene

  • This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]

GeneCards Summary for GPR26 Gene

GPR26 (G Protein-Coupled Receptor 26) is a Protein Coding gene. Diseases associated with GPR26 include Deafness, Autosomal Recessive 102. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR78.

UniProtKB/Swiss-Prot Summary for GPR26 Gene

  • Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Wiki entry for GPR26 Gene

Additional gene information for GPR26 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR26 Gene

Genomics for GPR26 Gene

GeneHancer (GH) Regulatory Elements for GPR26 Gene

Promoters and enhancers for GPR26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J123666 Promoter 1 EPDnew Ensembl 500.7 -0.1 -54 0.2 HDAC2 EZH2 REST YY1 SIN3A SUZ12 ZNF143 RBBP5 MAX GPR26 piR-49628 piR-41306-039
GH10J124339 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 6.2 +674.0 674046 5.2 EP300 TBX3 NR2F2 TCF12 CREB1 POLR2A ARNT MEF2B PBX2 NFE2 lnc-LHPP-7 CHST15 GPR26 FAM53B lnc-OAT-1
GH10J123758 Enhancer 0.7 Ensembl ENCODE CraniofacialAtlas 10.2 +93.2 93203 1.5 CREB1 ZNF652 GPR26 ENSG00000231138 HSALNG0081314 CPXM2
GH10J123639 Enhancer 0.6 Ensembl ENCODE 12.3 -26.4 -26354 2 HDAC2 JUND TAF1 GPR26 lnc-GPR26-5 piR-41306-039
GH10J123797 Enhancer 0.6 Ensembl ENCODE 10.2 +132.3 132298 1.5 GATA3 POU5F1 NANOG ZNF316 ZNF157 GPR26 piR-39416-010 LOC105378533 CPXM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR26 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR26

Genomic Locations for GPR26 Gene

Genomic Locations for GPR26 Gene
chr10:123,666,355-123,697,399
(GRCh38/hg38)
Size:
31,045 bases
Orientation:
Plus strand
chr10:125,425,871-125,456,915
(GRCh37/hg19)
Size:
31,045 bases
Orientation:
Plus strand

Genomic View for GPR26 Gene

Genes around GPR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR26 Gene

Proteins for GPR26 Gene

  • Protein details for GPR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV2-GPR26_HUMAN
    Recommended name:
    G-protein coupled receptor 26
    Protein Accession:
    Q8NDV2
    Secondary Accessions:
    • Q2M2E2

    Protein attributes for GPR26 Gene

    Size:
    337 amino acids
    Molecular mass:
    37604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR26 Gene

Post-translational modifications for GPR26 Gene

No Post-translational modifications

Other Protein References for GPR26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR26 Gene

Domains & Families for GPR26 Gene

Gene Families for GPR26 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR26 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 26 (GPR26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NDV2

UniProtKB/Swiss-Prot:

GPR26_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR26: view

Function for GPR26 Gene

Molecular function for GPR26 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Phenotypes From GWAS Catalog for GPR26 Gene

Gene Ontology (GO) - Molecular Function for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IDA 17363172
genes like me logo Genes that share ontologies with GPR26: view
genes like me logo Genes that share phenotypes with GPR26: view

Animal Models for GPR26 Gene

MGI Knock Outs for GPR26:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR26

CRISPR Products

miRNA for GPR26 Gene

miRTarBase miRNAs that target GPR26

Clone Products

  • Addgene plasmids for GPR26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR26 Gene

Localization for GPR26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR26 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR26 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR26 Gene

Pathways & Interactions for GPR26 Gene

PathCards logo

SuperPathways for GPR26 Gene

No Data Available

Interacting Proteins for GPR26 Gene

;

Gene Ontology (GO) - Biological Process for GPR26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA 17363172
genes like me logo Genes that share ontologies with GPR26: view

No data available for Pathways by source and SIGNOR curated interactions for GPR26 Gene

Drugs & Compounds for GPR26 Gene

No Compound Related Data Available

Transcripts for GPR26 Gene

mRNA/cDNA for GPR26 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR26

Alternative Splicing Database (ASD) splice patterns (SP) for GPR26 Gene

No ASD Table

Relevant External Links for GPR26 Gene

GeneLoc Exon Structure for
GPR26

Expression for GPR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR26 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.2), Brain - Frontal Cortex (BA9) (x8.1), Brain - Cortex (x7.6), Brain - Substantia nigra (x5.5), and Brain - Hippocampus (x4.8).

Protein differential expression in normal tissues from HIPED for GPR26 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR26 Gene



Protein tissue co-expression partners for GPR26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR26

SOURCE GeneReport for Unigene cluster for GPR26 Gene:

Hs.12751

mRNA Expression by UniProt/SwissProt for GPR26 Gene:

Q8NDV2-GPR26_HUMAN
Tissue specificity: Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.

Evidence on tissue expression from TISSUES for GPR26 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GPR26: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR26 Gene

Orthologs for GPR26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR26 31 30
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR26 31 30
  • 94.76 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr26 17 31 30
  • 91.2 (n)
rat
(Rattus norvegicus)
Mammalia Gpr26 30
  • 91 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR26 31
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR26 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR26 31 30
  • 69.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR26 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr26 30
  • 67.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564928 30
  • 66.77 (n)
GPR26 31
  • 61 (a)
OneToOne
Species where no ortholog for GPR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR26 Gene

ENSEMBL:
Gene Tree for GPR26 (if available)
TreeFam:
Gene Tree for GPR26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR26: view image

Paralogs for GPR26 Gene

Paralogs for GPR26 Gene

(1) SIMAP similar genes for GPR26 Gene using alignment to 1 proteins:

  • GPR26_HUMAN
genes like me logo Genes that share paralogs with GPR26: view

Variants for GPR26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR26 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
711539 Benign: not provided 123,667,031(+) G/C SYNONYMOUS_VARIANT
776548 Benign: not provided 123,687,995(+) G/A SYNONYMOUS_VARIANT
788827 Benign: not provided 123,666,737(+) C/T SYNONYMOUS_VARIANT
rs193920957 Uncertain Significance: Malignant tumor of prostate 123,666,478(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GPR26 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR26 Gene

Variant ID Type Subtype PubMed ID
esv1548382 CNV deletion 17803354
esv1711299 CNV insertion 17803354
esv3144012 CNV deletion 24192839
esv3546982 CNV deletion 23714750
esv991778 CNV deletion 20482838
nsv1113342 CNV deletion 24896259
nsv467469 CNV loss 19166990
nsv527554 CNV loss 19592680
nsv552276 CNV loss 21841781
nsv832011 CNV gain+loss 17160897

Variation tolerance for GPR26 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR26 Gene

Disorders for GPR26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 102
  • dfnb102
- elite association - COSMIC cancer census association via MalaCards
Search GPR26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR26 Gene

Publications for GPR26 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. GPR26: a marker for primary glioblastoma? (PMID: 18037267) Carter AN … Shervington AA (Molecular and cellular probes 2008) 3 4 54
  3. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. (PMID: 17363172) Jones PG … Pausch MH (Biochimica et biophysica acta 2007) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases. (PMID: 26303144) Mori F … Wakabayashi K (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3 54

Products for GPR26 Gene

Sources for GPR26 Gene