This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012] See more...

Aliases for GPR25 Gene

Aliases for GPR25 Gene

  • G Protein-Coupled Receptor 25 2 3 5
  • Probable G-Protein Coupled Receptor 25 3 4

External Ids for GPR25 Gene

Previous GeneCards Identifiers for GPR25 Gene

  • GC01P198572
  • GC01P196300
  • GC01P197308
  • GC01P198130
  • GC01P197573
  • GC01P199108
  • GC01P200842
  • GC01P172009

Summaries for GPR25 Gene

Entrez Gene Summary for GPR25 Gene

  • This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR25 Gene

GPR25 (G Protein-Coupled Receptor 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR15.

UniProtKB/Swiss-Prot Summary for GPR25 Gene

Gene Wiki entry for GPR25 Gene

Additional gene information for GPR25 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR25 Gene

Genomics for GPR25 Gene

GeneHancer (GH) Regulatory Elements for GPR25 Gene

Promoters and enhancers for GPR25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J200873 Promoter/Enhancer 0.8 Ensembl dbSUPER 500.7 +0.6 646 1.2 POLR2A EZH2 EBF1 CTCF LARP7 GPR25 DDX59-AS1 lnc-KIF21B-2
GH01J200900 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.3 +32.4 32362 7 ZNF217 NRF1 TCF12 NCOR1 EP300 TCF7 RELA SKI TRIM22 TEAD1 MROH3P ENSG00000234132 RNU6-704P GPR25 INAVA
GH01J200915 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 11 +43.9 43904 1.9 CTCF NRF1 POLR2A HDAC2 CEBPB FOS YY1 PHF8 ZBTB7A RAD21 MROH3P INAVA GPR25 ENSG00000234132 RF00026-097 RNU6-704P
GH01J200802 Enhancer 1 Ensembl ENCODE 10.8 -70.2 -70154 1.2 ZNF217 CTCF TEAD4 REST MYC RAD21 CTBP1 TRIM22 TEAD1 GATAD2B KIF14 GPR25 DDX59-AS1 piR-48759-023 CAMSAP2
GH01J201124 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.3 +253.7 253701 4.5 ZNF217 CTCF TCF12 ZIC2 ZNF423 FOXA1 ZNF623 RBM25 NR2F2 WT1 ASCL5 lnc-ASCL5-1 TMEM9 IGFN1 ENSG00000234132 GPR25 NONHSAG003915.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR25

Top Transcription factor binding sites by QIAGEN in the GPR25 gene promoter:
  • Egr-3
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • HFH-3
  • Pax-5

Genomic Locations for GPR25 Gene

Genomic Locations for GPR25 Gene
chr1:200,872,955-200,874,178
(GRCh38/hg38)
Size:
1,224 bases
Orientation:
Plus strand
chr1:200,842,083-200,843,306
(GRCh37/hg19)
Size:
1,224 bases
Orientation:
Plus strand

Genomic View for GPR25 Gene

Genes around GPR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR25 Gene

Proteins for GPR25 Gene

  • Protein details for GPR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00155-GPR25_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 25
    Protein Accession:
    O00155
    Secondary Accessions:
    • A0AVJ5

    Protein attributes for GPR25 Gene

    Size:
    361 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR25 Gene

Post-translational modifications for GPR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR25 Gene

Domains & Families for GPR25 Gene

Gene Families for GPR25 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR25 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 25 (GPR25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00155

UniProtKB/Swiss-Prot:

GPR25_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR25: view

Function for GPR25 Gene

Molecular function for GPR25 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
GENATLAS Biochemistry:
G protein coupled receptor 25

Phenotypes From GWAS Catalog for GPR25 Gene

Gene Ontology (GO) - Molecular Function for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPR25: view
genes like me logo Genes that share phenotypes with GPR25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR25

Clone Products

  • Addgene plasmids for GPR25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR25 Gene

Localization for GPR25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR25 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0005887 integral component of plasma membrane TAS 9020062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR25 Gene

Pathways & Interactions for GPR25 Gene

genes like me logo Genes that share pathways with GPR25: view

Pathways by source for GPR25 Gene

Gene Ontology (GO) - Biological Process for GPR25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GPR25: view

No data available for SIGNOR curated interactions for GPR25 Gene

Drugs & Compounds for GPR25 Gene

No Compound Related Data Available

Transcripts for GPR25 Gene

mRNA/cDNA for GPR25 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR25

Alternative Splicing Database (ASD) splice patterns (SP) for GPR25 Gene

No ASD Table

Relevant External Links for GPR25 Gene

GeneLoc Exon Structure for
GPR25

Expression for GPR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR25 Gene

mRNA differential expression in normal tissues according to GTEx for GPR25 Gene

This gene is overexpressed in Whole Blood (x11.1), Testis (x4.5), and Stomach (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR25 Gene



Protein tissue co-expression partners for GPR25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR25

SOURCE GeneReport for Unigene cluster for GPR25 Gene:

Hs.534316

Evidence on tissue expression from TISSUES for GPR25 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with GPR25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR25 Gene

Orthologs for GPR25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR25 31 30
  • 99.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr25 17 31 30
  • 81.47 (n)
dog
(Canis familiaris)
Mammalia GPR25 31 30
  • 78.31 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR25 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GPR25 31
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486541 30
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC795188 30
  • 52.11 (n)
GPR25 31
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for GPR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR25 Gene

ENSEMBL:
Gene Tree for GPR25 (if available)
TreeFam:
Gene Tree for GPR25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR25: view image

Paralogs for GPR25 Gene

Paralogs for GPR25 Gene

(5) SIMAP similar genes for GPR25 Gene using alignment to 1 proteins:

  • GPR25_HUMAN
genes like me logo Genes that share paralogs with GPR25: view

Variants for GPR25 Gene

Additional dbSNP identifiers (rs#s) for GPR25 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR25 Gene

Variant ID Type Subtype PubMed ID
esv33174 CNV loss 17666407
esv3588563 CNV gain 21293372
nsv1000619 CNV gain 25217958
nsv1012562 CNV gain 25217958
nsv506973 OTHER sequence alteration 20534489
nsv548991 CNV gain 21841781

Variation tolerance for GPR25 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR25 Gene

Disorders for GPR25 Gene

Additional Disease Information for GPR25

No disorders were found for GPR25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR25 Gene

Publications for GPR25 Gene

  1. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. (PMID: 9020062) Jung BP … O'Dowd BF (Biochemical and biophysical research communications 1997) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 54
  5. A catalogue of putative HIV-1 protease host cell substrates. (PMID: 22944692) Impens F … Gevaert K (Biological chemistry 2012) 3 54

Products for GPR25 Gene

Sources for GPR25 Gene