Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR22 Gene

Aliases for GPR22 Gene

  • G Protein-Coupled Receptor 22 2 3 5
  • Probable G-Protein Coupled Receptor 22 3

External Ids for GPR22 Gene

Previous GeneCards Identifiers for GPR22 Gene

  • GC07P105598
  • GC07P106661
  • GC07P106675
  • GC07P106704
  • GC07P106897
  • GC07P107110
  • GC07P101471

Summaries for GPR22 Gene

Entrez Gene Summary for GPR22 Gene

  • This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR22 Gene

GPR22 (G Protein-Coupled Receptor 22) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide binding.

UniProtKB/Swiss-Prot for GPR22 Gene

  • Orphan receptor.

Gene Wiki entry for GPR22 Gene

Additional gene information for GPR22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR22 Gene

Genomics for GPR22 Gene

GeneHancer (GH) Regulatory Elements for GPR22 Gene

Promoters and enhancers for GPR22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J107470 Promoter 0.5 EPDnew 650.7 +0.0 23 0.1 GPR22 GC07M107524 COG5
GH07J107876 Enhancer 0.5 ENCODE 10.4 +407.6 407616 1.6 ZNF316 MAFF MAFG EMSY MAFK CBLL1 LOC101927974 GPR22 NRCAM LOC105375445 DLD GC07M107805
GH07J107044 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 -423.4 -423405 5.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 PRKAR2B COG5 ENSG00000272072 HBP1 LAMB1 CBLL1 ENSG00000273055 GPR22 GC07M107108
GH07J107065 Enhancer 0.4 FANTOM5 dbSUPER 2.7 -403.9 -403887 0.4 PRKAR2B GPR22 GC07M107108
GH07J107463 Enhancer 0.8 ENCODE 0.4 -6.7 -6707 0.2 HDAC1 ARNT ZNF2 RAD21 ARID2 ZNF366 ZNF207 ZNF143 RCOR1 ATF7 ENSG00000238832 GPR22 RPL37AP6 COG5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR22 gene promoter:
  • Nkx2-5
  • Tal-1beta
  • ITF-2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU3F2
  • FOXD1
  • Sox9
  • Nkx3-1 v4

Genomic Locations for GPR22 Gene

Genomic Locations for GPR22 Gene
6,195 bases
Plus strand
5,663 bases
Plus strand

Genomic View for GPR22 Gene

Genes around GPR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR22 Gene

Proteins for GPR22 Gene

  • Protein details for GPR22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 22
    Protein Accession:
    Secondary Accessions:
    • O14554

    Protein attributes for GPR22 Gene

    433 amino acids
    Molecular mass:
    49265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR22 Gene

Post-translational modifications for GPR22 Gene

  • Glycosylation at isoforms=192 and Asn16
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR22 Gene

Domains & Families for GPR22 Gene

Gene Families for GPR22 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR22 Gene


Suggested Antigen Peptide Sequences for GPR22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR22: view

Function for GPR22 Gene

Molecular function for GPR22 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
GENATLAS Biochemistry:
G protein coupled receptor 22,expressed in brain

Gene Ontology (GO) - Molecular Function for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with GPR22: view
genes like me logo Genes that share phenotypes with GPR22: view

Animal Models for GPR22 Gene

MGI Knock Outs for GPR22:
  • Gpr22 Gpr22<tm1.1Jwad>
  • Gpr22 Gpr22<tm1b(KOMP)Wtsi>

Animal Model Products

miRNA for GPR22 Gene

Clone Products

  • Addgene plasmids for GPR22

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR22 Gene

Localization for GPR22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR22 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR22 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR22 Gene

Pathways & Interactions for GPR22 Gene

genes like me logo Genes that share pathways with GPR22: view

Pathways by source for GPR22 Gene

1 BioSystems pathway for GPR22 Gene

Interacting Proteins for GPR22 Gene

Gene Ontology (GO) - Biological Process for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:1901652 response to peptide IBA --
genes like me logo Genes that share ontologies with GPR22: view

No data available for SIGNOR curated interactions for GPR22 Gene

Drugs & Compounds for GPR22 Gene

No Compound Related Data Available

Transcripts for GPR22 Gene

mRNA/cDNA for GPR22 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR22 Gene

G protein-coupled receptor 22:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR22

Alternative Splicing Database (ASD) splice patterns (SP) for GPR22 Gene

No ASD Table

Relevant External Links for GPR22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR22 Gene

mRNA differential expression in normal tissues according to GTEx for GPR22 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.5), Brain - Anterior cingulate cortex (BA24) (x7.4), Heart - Left Ventricle (x5.9), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of GPR22 Gene:


SOURCE GeneReport for Unigene cluster for GPR22 Gene:


mRNA Expression by UniProt/SwissProt for GPR22 Gene:

Tissue specificity: In the brain regions frontal cortex, caudate, putamen and thalamus; not in pons, hypothalamus and hippocampus.

Evidence on tissue expression from TISSUES for GPR22 Gene

  • Nervous system(3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with GPR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR22 Gene

Orthologs for GPR22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR22 34 33
  • 99.92 (n)
(Canis familiaris)
Mammalia GPR22 34 33
  • 96.38 (n)
(Bos Taurus)
Mammalia GPR22 34 33
  • 96.3 (n)
(Mus musculus)
Mammalia Gpr22 16 34 33
  • 90.9 (n)
(Rattus norvegicus)
Mammalia Gpr22 33
  • 90.66 (n)
(Ornithorhynchus anatinus)
Mammalia GPR22 34
  • 89 (a)
(Monodelphis domestica)
Mammalia GPR22 34
  • 38 (a)
(Gallus gallus)
Aves GPR22 34 33
  • 84.37 (n)
(Anolis carolinensis)
Reptilia GPR22 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr22 33
  • 79.69 (n)
(Danio rerio)
Actinopterygii GPR22 (2 of 2) 34
  • 72 (a)
gpr22 34 33
  • 69.19 (n)
Species where no ortholog for GPR22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR22 Gene

Gene Tree for GPR22 (if available)
Gene Tree for GPR22 (if available)
Evolutionary constrained regions (ECRs) for GPR22: view image

Paralogs for GPR22 Gene

No data available for Paralogs for GPR22 Gene

Variants for GPR22 Gene

Sequence variations from dbSNP and Humsavar for GPR22 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000598964 -- 107,469,638(+) A/G upstream_transcript_variant
rs1000928679 -- 107,469,839(+) T/A upstream_transcript_variant
rs1001663807 -- 107,470,157(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002430620 -- 107,469,215(+) T/C upstream_transcript_variant
rs1002872265 -- 107,468,951(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR22 Gene

Variant ID Type Subtype PubMed ID
nsv1024793 CNV loss 25217958

Variation tolerance for GPR22 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR22 Gene

Disorders for GPR22 Gene

Additional Disease Information for GPR22

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR22 Gene

Publications for GPR22 Gene

  1. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. (PMID: 9073069) O'Dowd BF … George SR (Gene 1997) 2 3 4 58
  2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E … Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA) (Annals of the rheumatic diseases 2011) 3 44 58
  3. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. (PMID: 20112360) Kerkhof HJ … van Meurs JB (Arthritis and rheumatism 2010) 3 44 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for GPR22 Gene

Sources for GPR22 Gene

Loading form....