This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008] See more...

Aliases for GPR22 Gene

Aliases for GPR22 Gene

  • G Protein-Coupled Receptor 22 2 3 5
  • G-Protein Coupled Receptor 22 3 4
  • Probable G-Protein Coupled Receptor 22 3

External Ids for GPR22 Gene

Previous GeneCards Identifiers for GPR22 Gene

  • GC07P105598
  • GC07P106661
  • GC07P106675
  • GC07P106704
  • GC07P106897
  • GC07P107110
  • GC07P101471

Summaries for GPR22 Gene

Entrez Gene Summary for GPR22 Gene

  • This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR22 Gene

GPR22 (G Protein-Coupled Receptor 22) is a Protein Coding gene. Diseases associated with GPR22 include Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide binding. An important paralog of this gene is QRFPR.

UniProtKB/Swiss-Prot Summary for GPR22 Gene

  • Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity).

Gene Wiki entry for GPR22 Gene

Additional gene information for GPR22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR22 Gene

Genomics for GPR22 Gene

GeneHancer (GH) Regulatory Elements for GPR22 Gene

Promoters and enhancers for GPR22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J107470 Promoter 0.9 EPDnew Ensembl 500.7 +0.2 183 0.4 EP300 SMARCA4 POLR2A GPR22 lnc-GPR22-1 hsa-miR-5095-470 COG5
GH07J107405 Enhancer 0.7 Ensembl ENCODE 11.3 -64.8 -64817 1.6 GATA3 CEBPB STAT5A CEBPG ATF4 MEIS2 ZMYM3 ATF3 GATA2 IKZF1 COG5 GPR22 HBP1 piR-56640-021 RF00017-6552 RF00017-6550
GH07J107876 Enhancer 0.5 ENCODE 10.4 +407.6 407616 1.6 ZNF316 MAFF USF1 MAFK MAFG CEBPB EMSY CBLL1 ENSG00000241764 GPR22 NRCAM LOC105375445 piR-43103-057
GH07J107044 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 -423.5 -423505 5.4 HNRNPK EP300 CTCF ZSCAN5C NRF1 USF1 GTF2E2 ZFX ZIC2 ZBTB10 PRKAR2B HBP1 ENSG00000272072 COG5 GPR22 RF00017-6549
GH07J107065 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 2.7 -404.3 -404262 1.1 NR3C1 ZNF830 XRCC3 ELF1 ZNF318 ZFP91 CSDE1 ZC3H8 CDC5L MLLT1 PRKAR2B ENSG00000272072 GPR22 RF00017-6549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR22

Top Transcription factor binding sites by QIAGEN in the GPR22 gene promoter:
  • FOXD1
  • ITF-2
  • Nkx2-5
  • Nkx3-1 v4
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox9
  • Tal-1beta

Genomic Locations for GPR22 Gene

Genomic Locations for GPR22 Gene
chr7:107,470,018-107,476,212
(GRCh38/hg38)
Size:
6,195 bases
Orientation:
Plus strand
chr7:107,110,463-107,116,125
(GRCh37/hg19)
Size:
5,663 bases
Orientation:
Plus strand

Genomic View for GPR22 Gene

Genes around GPR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR22 Gene

Proteins for GPR22 Gene

  • Protein details for GPR22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99680-GPR22_HUMAN
    Recommended name:
    G-protein coupled receptor 22
    Protein Accession:
    Q99680
    Secondary Accessions:
    • A4D0R8
    • O14554

    Protein attributes for GPR22 Gene

    Size:
    433 amino acids
    Molecular mass:
    49265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR22 Gene

Post-translational modifications for GPR22 Gene

  • Glycosylation at Asn16 and Asn192
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR22 Gene

Domains & Families for GPR22 Gene

Gene Families for GPR22 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR22 Gene

GenScript: Design optimal peptide antigens:
  • HCG1645679 (A4D0R8_HUMAN)
  • Probable G-protein coupled receptor 22 (GPR22_HUMAN)
  • G protein-coupled receptor 22 (Q3KNS9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99680

UniProtKB/Swiss-Prot:

GPR22_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR22: view

Function for GPR22 Gene

Molecular function for GPR22 Gene

UniProtKB/Swiss-Prot Function:
Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity).
GENATLAS Biochemistry:
G protein coupled receptor 22,expressed in brain

Phenotypes From GWAS Catalog for GPR22 Gene

Gene Ontology (GO) - Molecular Function for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IMP 18539757
genes like me logo Genes that share ontologies with GPR22: view
genes like me logo Genes that share phenotypes with GPR22: view

Animal Models for GPR22 Gene

MGI Knock Outs for GPR22:
  • Gpr22 Gpr22<tm1.1Jwad>
  • Gpr22 Gpr22<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for GPR22 Gene

Clone Products

  • Addgene plasmids for GPR22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR22 Gene

Localization for GPR22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR22 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR22 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR22 Gene

Pathways & Interactions for GPR22 Gene

PathCards logo

SuperPathways for GPR22 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR22: view

Pathways by source for GPR22 Gene

1 BioSystems pathway for GPR22 Gene

Interacting Proteins for GPR22 Gene

;

Gene Ontology (GO) - Biological Process for GPR22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with GPR22: view

No data available for SIGNOR curated interactions for GPR22 Gene

Drugs & Compounds for GPR22 Gene

No Compound Related Data Available

Transcripts for GPR22 Gene

mRNA/cDNA for GPR22 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR22

Alternative Splicing Database (ASD) splice patterns (SP) for GPR22 Gene

No ASD Table

Relevant External Links for GPR22 Gene

GeneLoc Exon Structure for
GPR22

Expression for GPR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR22 Gene

mRNA differential expression in normal tissues according to GTEx for GPR22 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.5), Brain - Anterior cingulate cortex (BA24) (x7.4), Heart - Left Ventricle (x5.9), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR22

SOURCE GeneReport for Unigene cluster for GPR22 Gene:

Hs.657277

mRNA Expression by UniProt/SwissProt for GPR22 Gene:

Q99680-GPR22_HUMAN
Tissue specificity: High expression in adult and fetal heart tissue (PubMed:18539757). Expressed in the brain, with enrichment in the accumbens, amygdala, cerebellum, cortex, and hippocampus regions (PubMed:9073069, PubMed:18539757).

Evidence on tissue expression from TISSUES for GPR22 Gene

  • Nervous system(3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with GPR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR22 Gene

Orthologs for GPR22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR22 31 30
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR22 31 30
  • 96.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR22 31 30
  • 96.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr22 17 31 30
  • 90.9 (n)
rat
(Rattus norvegicus)
Mammalia Gpr22 30
  • 90.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR22 31
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR22 31
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR22 31 30
  • 84.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR22 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr22 30
  • 79.69 (n)
zebrafish
(Danio rerio)
Actinopterygii GPR22 (2 of 2) 31
  • 72 (a)
OneToMany
gpr22 31 30
  • 69.19 (n)
OneToMany
Species where no ortholog for GPR22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR22 Gene

ENSEMBL:
Gene Tree for GPR22 (if available)
TreeFam:
Gene Tree for GPR22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR22: view image

Paralogs for GPR22 Gene

genes like me logo Genes that share paralogs with GPR22: view

Variants for GPR22 Gene

Additional dbSNP identifiers (rs#s) for GPR22 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR22 Gene

Variant ID Type Subtype PubMed ID
nsv1024793 CNV loss 25217958

Variation tolerance for GPR22 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR22 Gene

Disorders for GPR22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR22 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPR22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR22 Gene

Publications for GPR22 Gene

  1. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. (PMID: 9073069) O'Dowd BF … George SR (Gene 1997) 2 3 4 54
  2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E … Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA) (Annals of the rheumatic diseases 2011) 3 41 54
  3. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. (PMID: 20112360) Kerkhof HJ … van Meurs JB (Arthritis and rheumatism 2010) 3 41 54
  4. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. (PMID: 18539757) Adams JW … Connolly D (American journal of physiology. Heart and circulatory physiology 2008) 3 4 54
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54

Products for GPR22 Gene

Sources for GPR22 Gene