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Aliases for GPR20 Gene

Aliases for GPR20 Gene

  • G Protein-Coupled Receptor 20 2 3 5
  • G-Protein Coupled Receptor 20 3
  • CTD-3064M3.3 3

External Ids for GPR20 Gene

Previous GeneCards Identifiers for GPR20 Gene

  • GC08U990036
  • GC08P142612
  • GC08M142051
  • GC08M142338
  • GC08M142436
  • GC08M142437
  • GC08M142366
  • GC08M137677

Summaries for GPR20 Gene

GeneCards Summary for GPR20 Gene

GPR20 (G Protein-Coupled Receptor 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR20 Gene

  • Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.

Gene Wiki entry for GPR20 Gene

Additional gene information for GPR20 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR20 Gene

Genomics for GPR20 Gene

GeneHancer (GH) Regulatory Elements for GPR20 Gene

Promoters and enhancers for GPR20 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J141365 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 +0.5 537 1.8 ATF1 NFIB MAX ZIC2 ZFHX2 GLIS2 POLR2A PRDM10 CHD2 EGR2 GPR20 ENSG00000254291 ENSG00000261655
GH08J141368 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 -1.8 -1779 1.2 MAX BCL11B ZFHX2 EGR1 PATZ1 FOSL2 FOS NFE2 CHD2 EGR2 GPR20 LOC101928037
GH08J141225 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +139.8 139780 3.4 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 SLC45A4 ENSG00000280035 DENND3 ENSG00000253307 LOC105375787 LINC01300 GPR20 PTP4A3
GH08J141391 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 7.9 -25.1 -25076 1.9 HDGF CLOCK ARNT SIN3A ZNF766 E2F8 FOS ATF7 SP5 NCOA1 ENSG00000244998 PTP4A3 LOC105375790 GPR20 LINC01300
GH08J141374 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 7.4 -8.4 -8385 2.4 ELF3 FOXA2 MLX ZSCAN9 RARA GLIS2 RXRA ELF1 PPARG NR2F2 LOC101928037 GPR20 SLC45A4 LOC105375790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR20 gene promoter:
  • Arnt
  • LCR-F1
  • c-Ets-1
  • NF-1
  • Bach2
  • MZF-1
  • CREB
  • FOXL1
  • STAT1beta
  • STAT1alpha

Genomic Locations for GPR20 Gene

Genomic Locations for GPR20 Gene
13,865 bases
Minus strand
10,783 bases
Minus strand

Genomic View for GPR20 Gene

Genes around GPR20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR20 Gene

Proteins for GPR20 Gene

  • Protein details for GPR20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 20
    Protein Accession:
    Secondary Accessions:
    • Q17R96

    Protein attributes for GPR20 Gene

    358 amino acids
    Molecular mass:
    38650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR20 Gene

Post-translational modifications for GPR20 Gene

  • Glycosylation at Asn26 and Asn16
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR20 Gene

Domains & Families for GPR20 Gene

Gene Families for GPR20 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR20 Gene


Suggested Antigen Peptide Sequences for GPR20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR20: view

Function for GPR20 Gene

Molecular function for GPR20 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
GENATLAS Biochemistry:
G protein coupled receptor 20,expressed in brain,liver

Phenotypes From GWAS Catalog for GPR20 Gene

Gene Ontology (GO) - Molecular Function for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 18347022
genes like me logo Genes that share ontologies with GPR20: view
genes like me logo Genes that share phenotypes with GPR20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR20

Clone Products

  • Addgene plasmids for GPR20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR20 Gene

Localization for GPR20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR20 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR20 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18347022
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR20 Gene

Pathways & Interactions for GPR20 Gene

genes like me logo Genes that share pathways with GPR20: view

Pathways by source for GPR20 Gene

Gene Ontology (GO) - Biological Process for GPR20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR20: view

No data available for SIGNOR curated interactions for GPR20 Gene

Drugs & Compounds for GPR20 Gene

No Compound Related Data Available

Transcripts for GPR20 Gene

mRNA/cDNA for GPR20 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR20 Gene

G protein-coupled receptor 20:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR20

Alternative Splicing Database (ASD) splice patterns (SP) for GPR20 Gene

No ASD Table

Relevant External Links for GPR20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR20 Gene

mRNA differential expression in normal tissues according to GTEx for GPR20 Gene

This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Coronary (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of GPR20 Gene:


SOURCE GeneReport for Unigene cluster for GPR20 Gene:


mRNA Expression by UniProt/SwissProt for GPR20 Gene:

Tissue specificity: Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.

Evidence on tissue expression from TISSUES for GPR20 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with GPR20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR20 Gene

Orthologs for GPR20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR20 34 33
  • 98.23 (n)
(Canis familiaris)
Mammalia GPR20 34 33
  • 88.01 (n)
(Bos Taurus)
Mammalia GPR20 34 33
  • 87.62 (n)
(Mus musculus)
Mammalia Gpr20 16 34 33
  • 82.63 (n)
(Rattus norvegicus)
Mammalia Gpr20 33
  • 82.24 (n)
(Monodelphis domestica)
Mammalia GPR20 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia GPR20 34
  • 59 (a)
(Gallus gallus)
Aves GPR20 34 33
  • 61.37 (n)
(Anolis carolinensis)
Reptilia GPR20 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr20 33
  • 63.72 (n)
(Danio rerio)
Actinopterygii LOC794428 33
  • 61.64 (n)
GPR20 (2 of 2) 34
  • 54 (a)
GPR20 (1 of 2) 34
  • 44 (a)
Species where no ortholog for GPR20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR20 Gene

Gene Tree for GPR20 (if available)
Gene Tree for GPR20 (if available)
Evolutionary constrained regions (ECRs) for GPR20: view image

Paralogs for GPR20 Gene

Paralogs for GPR20 Gene

(1) SIMAP similar genes for GPR20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR20: view

Variants for GPR20 Gene

Sequence variations from dbSNP and Humsavar for GPR20 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000272094 -- 141,363,580(-) T/G intron_variant
rs1000472621 -- 141,364,050(-) G/A intron_variant
rs1000591995 -- 141,362,990(-) T/C intron_variant
rs1000880390 -- 141,368,479(-) C/G/T upstream_transcript_variant
rs1001492976 -- 141,360,989(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR20 Gene

Variant ID Type Subtype PubMed ID
dgv7330n100 CNV gain 25217958
dgv7331n100 CNV gain 25217958
esv2737756 CNV deletion 23290073
nsv1023036 CNV loss 25217958
nsv1126125 CNV deletion 24896259
nsv465956 CNV gain 19166990
nsv465957 CNV loss 19166990
nsv465958 CNV loss 19166990
nsv465959 CNV loss 19166990
nsv470240 CNV loss 18288195
nsv509285 CNV insertion 20534489
nsv612575 CNV gain 21841781
nsv612576 CNV loss 21841781
nsv612577 CNV loss 21841781
nsv612578 CNV loss 21841781
nsv831484 CNV loss 17160897
nsv949996 CNV deletion 24416366

Variation tolerance for GPR20 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR20 Gene

Disorders for GPR20 Gene

Additional Disease Information for GPR20

No disorders were found for GPR20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR20 Gene

Publications for GPR20 Gene

  1. Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (PMID: 18347022) Hase M … Nakamura M (The Journal of biological chemistry 2008) 2 3 4 58
  2. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. (PMID: 9073069) O'Dowd BF … George SR (Gene 1997) 3 4 58
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R … Collins BM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 58
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for GPR20 Gene

Sources for GPR20 Gene

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