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Aliases for GPR19 Gene

Aliases for GPR19 Gene

  • G Protein-Coupled Receptor 19 2 3 5
  • GPR-NGA 3 4
  • Probable G-Protein Coupled Receptor 19 3

External Ids for GPR19 Gene

Previous GeneCards Identifiers for GPR19 Gene

  • GC12M012541
  • GC12M012958
  • GC12M012714
  • GC12M012813

Summaries for GPR19 Gene

GeneCards Summary for GPR19 Gene

GPR19 (G Protein-Coupled Receptor 19) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot for GPR19 Gene

  • Orphan receptor.

Gene Wiki entry for GPR19 Gene

Additional gene information for GPR19 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR19 Gene

Genomics for GPR19 Gene

GeneHancer (GH) Regulatory Elements for GPR19 Gene

Promoters and enhancers for GPR19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I012695 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.4 +20.3 20275 3.2 HDGF PKNOX1 ATF1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 GPR19 APOLD1 LOC105369663 ENSG00000240424 DUSP16 GC12P012702 GC12P012687
GH12I012683 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 550.3 +32.2 32204 2.2 MZF1 SIN3A ZNF766 ZNF143 RCOR1 USF2 MIER2 ZNF398 REST ZNF518A GC12P012687 GPR19 CDKN1B ENSG00000240424 DUSP16 MANSC1 APOLD1 FAM234B GSG1 ENSG00000257004
GH12I012557 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +156.2 156157 7 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 DUSP16 CREBL2 GPR19 CDKN1B ENSG00000255670 BCL2L14 GC12M012561 PIR41199
GH12I012713 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -3.0 -3029 14 ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 SSRP1 APOLD1 CDKN1B ENSG00000275560 DDX47 GPR19 RPL13AP20 MANSC1 BORCS5 DUSP16 GC12P012719
GH12I012402 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +312.5 312496 5.3 PKNOX1 ATF1 FOXA2 ARID4B FEZF1 DMAP1 YY1 SLC30A9 ATF7 RXRA CDKN1B CREBL2 DUSP16 ENSG00000240424 GPR19 BORCS5 GPRC5D-AS1 GC12M012364 GC12P012409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR19 gene promoter:

Genomic Locations for GPR19 Gene

Genomic Locations for GPR19 Gene
chr12:12,660,884-12,717,272
(GRCh38/hg38)
Size:
56,389 bases
Orientation:
Minus strand
chr12:12,813,825-12,849,141
(GRCh37/hg19)

Genomic View for GPR19 Gene

Genes around GPR19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR19 Gene

Proteins for GPR19 Gene

  • Protein details for GPR19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15760-GPR19_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 19
    Protein Accession:
    Q15760

    Protein attributes for GPR19 Gene

    Size:
    415 amino acids
    Molecular mass:
    47687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR19 Gene

Post-translational modifications for GPR19 Gene

  • Glycosylation at posLast=2525 and isoforms=52
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR19 Gene

Domains & Families for GPR19 Gene

Gene Families for GPR19 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR19 Gene

Graphical View of Domain Structure for InterPro Entry

Q15760

UniProtKB/Swiss-Prot:

GPR19_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR19: view

Function for GPR19 Gene

Molecular function for GPR19 Gene

GENATLAS Biochemistry:
G protein coupled receptor 19,with strong homology with D2 dopamine and adregenic receptors,expressed in caudate nucleus,putamen and thalamus,involved in cancer cells
UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR19 Gene

Gene Ontology (GO) - Molecular Function for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with GPR19: view
genes like me logo Genes that share phenotypes with GPR19: view

Animal Models for GPR19 Gene

MGI Knock Outs for GPR19:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR19

miRNA for GPR19 Gene

miRTarBase miRNAs that target GPR19

Clone Products

  • Addgene plasmids for GPR19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR19 Gene

Localization for GPR19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR19 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR19 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8830667
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR19 Gene

Pathways & Interactions for GPR19 Gene

genes like me logo Genes that share pathways with GPR19: view

Pathways by source for GPR19 Gene

1 BioSystems pathway for GPR19 Gene

Interacting Proteins for GPR19 Gene

Gene Ontology (GO) - Biological Process for GPR19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8830667
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007631 feeding behavior IBA --
genes like me logo Genes that share ontologies with GPR19: view

No data available for SIGNOR curated interactions for GPR19 Gene

Drugs & Compounds for GPR19 Gene

No Compound Related Data Available

Transcripts for GPR19 Gene

Unigene Clusters for GPR19 Gene

G protein-coupled receptor 19:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR19

Alternative Splicing Database (ASD) splice patterns (SP) for GPR19 Gene

No ASD Table

Relevant External Links for GPR19 Gene

GeneLoc Exon Structure for
GPR19
ECgene alternative splicing isoforms for
GPR19

Expression for GPR19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR19 Gene

This gene is overexpressed in Pituitary (x4.8), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for GPR19 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR19 Gene



Protein tissue co-expression partners for GPR19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR19 Gene:

GPR19

SOURCE GeneReport for Unigene cluster for GPR19 Gene:

Hs.657862

mRNA Expression by UniProt/SwissProt for GPR19 Gene:

Q15760-GPR19_HUMAN
Tissue specificity: Abundant expression in the brain.
genes like me logo Genes that share expression patterns with GPR19: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR19 Gene

Orthologs for GPR19 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR19 33 34
  • 98.55 (n)
dog
(Canis familiaris)
Mammalia GPR19 33 34
  • 90.2 (n)
cow
(Bos Taurus)
Mammalia GPR19 33 34
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Gpr19 33
  • 83.61 (n)
mouse
(Mus musculus)
Mammalia Gpr19 33 16 34
  • 83.05 (n)
chicken
(Gallus gallus)
Aves GPR19 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR19 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr19 33
  • 66.43 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr19 33 34
  • 62.24 (n)
zgc63912 33
fruit fly
(Drosophila melanogaster)
Insecta TrissinR 34
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-10 34
  • 20 (a)
OneToMany
npr-3 34
  • 18 (a)
OneToMany
npr-7 34
  • 18 (a)
OneToMany
npr-2 34
  • 16 (a)
OneToMany
npr-1 34
  • 15 (a)
OneToMany
npr-13 34
  • 15 (a)
OneToMany
npr-4 34
  • 15 (a)
OneToMany
npr-5 34
  • 15 (a)
OneToMany
npr-8 34
  • 12 (a)
OneToMany
Species where no ortholog for GPR19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR19 Gene

ENSEMBL:
Gene Tree for GPR19 (if available)
TreeFam:
Gene Tree for GPR19 (if available)

Paralogs for GPR19 Gene

Paralogs for GPR19 Gene

(5) SIMAP similar genes for GPR19 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR19: view

Variants for GPR19 Gene

Sequence variations from dbSNP and Humsavar for GPR19 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1060500186 pathogenic, Multiple endocrine neoplasia, type 4 12,717,887(-) GGACG/G upstream_transcript_variant
rs1060500188 uncertain-significance, Multiple endocrine neoplasia, type 4 12,718,284(-) GC/TT upstream_transcript_variant
rs1060500190 uncertain-significance, Multiple endocrine neoplasia, type 4 12,717,919(-) C/T upstream_transcript_variant
rs1060500191 uncertain-significance, Multiple endocrine neoplasia, type 4 12,718,136(-) C/T upstream_transcript_variant
rs1060500192 uncertain-significance, Multiple endocrine neoplasia, type 4 12,718,200(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR19 Gene

Variant ID Type Subtype PubMed ID
dgv89n21 CNV gain 19592680
esv2745567 CNV deletion 23290073
nsv1046355 CNV loss 25217958
nsv509456 CNV insertion 20534489
nsv983287 CNV duplication 23825009

Variation tolerance for GPR19 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR19 Gene

Disorders for GPR19 Gene

Additional Disease Information for GPR19

No disorders were found for GPR19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR19 Gene

Publications for GPR19 Gene

  1. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. (PMID: 8830667) O'Dowd BF … George SR (FEBS letters 1996) 3 4 58
  2. G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. (PMID: 28476646) Rao A … Herr DR (Biochimica et biophysica acta 2017) 3 58
  3. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W … Lau YL (American journal of human genetics 2013) 3 58
  4. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. (PMID: 22912338) Kastner S … Sommergruber W (Molecular cancer research : MCR 2012) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for GPR19 Gene

  • Addgene plasmids for GPR19

Sources for GPR19 Gene

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