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Aliases for GPR19 Gene
Aliases for GPR19 Gene
External Ids for GPR19 Gene
- HGNC: 4473
- Entrez Gene: 2842
- Ensembl: ENSG00000183150
- OMIM: 602927
- UniProtKB: Q15760
Previous GeneCards Identifiers for GPR19 Gene
- GC12M012541
- GC12M012958
- GC12M012714
- GC12M012705
- GC12M012813
- GC12M012706
- GC12M012868
- GC12M012817
- GC12M013405
Summaries for GPR19 Gene
GeneCards Summary for GPR19 Gene
GPR19 (G Protein-Coupled Receptor 19) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is TACR2.
UniProtKB/Swiss-Prot Summary for GPR19 Gene
-
Orphan receptor.
Additional gene information for GPR19 Gene
- HGNC(4473)
- Entrez Gene(2842)
- Ensembl(ENSG00000183150)
- OMIM(602927)
- UniProtKB(Q15760)
- Open Targets Platform(ENSG00000183150)
- Monarch Initiative
- Search for GPR19 at DataMed
- Search for GPR19 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR19 Gene
Genomics for GPR19 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPR19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR19 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR19
- Top Transcription factor binding sites by QIAGEN in the GPR19 gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- FOXO1
- FOXO1a
- FOXO4
- GATA-1
- MyoD
Genomic Locations for GPR19 Gene
Genomic Locations for GPR19 Gene
- chr12:12,659,691-12,717,786
- (GRCh38/hg38)
- Size:
- 58,096 bases
- Orientation:
- Minus strand
- chr12:12,813,825-12,849,141
- (GRCh37/hg19)
- Size:
- 35,317 bases
- Orientation:
- Minus strand
Genomic View for GPR19 Gene
Genes around GPR19 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.1 by HGNC
- 12p13.1 by Entrez Gene
- 12p13.1 by Ensembl
GPR19 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR19 Gene
Proteins for GPR19 Gene
-
Protein details for GPR19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15760-GPR19_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 19
- Protein Accession:
- Q15760
Protein attributes for GPR19 Gene
- Size:
- 415 amino acids
- Molecular mass:
- 47687 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR19 Gene
Post-translational modifications for GPR19 Gene
Other Protein References for GPR19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GPR19
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-
Abcam antibodies for GPR19
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Protein Products
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-
Abcam proteins for GPR19
No data available for DME Specific Peptides for GPR19 Gene
Domains & Families for GPR19 Gene
Gene Families for GPR19 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GPR19 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR19 Gene
- GenScript: Design optimal peptide antigens:
-
- G protein-coupled receptor 19 (B9EK41_HUMAN)
- GPR-NGA (GPR19_HUMAN)
- cDNA FLJ90248 fis, clone NT2RM2001939, highly similar to Probable G-protein coupled receptor 19 (Q6IBH2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15760- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR19 Gene
Molecular function for GPR19 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
- GENATLAS Biochemistry:
- G protein coupled receptor 19,with strong homology with D2 dopamine and adregenic receptors,expressed in caudate nucleus,putamen and thalamus,involved in cancer cells
Phenotypes From GWAS Catalog for GPR19 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | TAS,IEA | -- |
Phenotypes for GPR19 Gene
- MGI mutant phenotypes for GPR19:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GPR19:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased viability ratio
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased NF-kappaB reporter expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Decreased IL-8 secretion
- Two nuclei (binuclear), polylobed nuclei, many micronuclei (grape)
Animal Models for GPR19 Gene
- MGI Knock Outs for GPR19:
-
- Gpr19 Gpr19<tm1Dgen>
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR19
CRISPR Products
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-
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miRNA for GPR19 Gene
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for GPR19
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR19 Gene
Localization for GPR19 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR19 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8830667 |
| GO:0005929 | cilium | IDA | 28154160 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR19 Gene
Pathways & Interactions for GPR19 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
Pathways by source for GPR19 Gene
1 BioSystems pathway for GPR19 Gene
Interacting Proteins for GPR19 Gene
GPS-Prot Interaction Network for GPR19
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS,IEA | -- |
No data available for SIGNOR curated interactions for GPR19 Gene
Transcripts for GPR19 Gene
mRNA/cDNA for GPR19 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332427 1743 nts (view in UCSC)
- ENST00000537507 706 nts (view in UCSC)
- ENST00000540510 1751 nts (view in UCSC)
- ENST00000540796 553 nts (view in UCSC)
- ENST00000545876 585 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR19 - Select products 50% OFF >
- * GPR19 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR19
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR19
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR19
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR19
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Clone Products
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-
- MG206429
- MG216739
- MG216755
- MG216761
- MG218196
- MG218216
- MG218232
- MR206429
- MR206429L3
- MR206429L4
- MR216739
- MR216739L3
- MR216739L4
- MR216755
- MR216755L3
- MR216755L4
- MR216761
- MR216761L3
- MR216761L4
- MR218196
- MR218196L3
- MR218196L4
- MR218216
- MR218216L3
- MR218216L4
- MR218232
- MR218232L3
- MR218232L4
- RC220379
- RC220379L1
- RC220379L2
- RC220379L3
- RC220379L4
- RG220379
- RR201195
- RR201195L3
- RR201195L4
- MR206429L3V
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- MR216739L3V
- MR216739L4V
- MR216755L3V
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- MR218196L3V
- MR218196L4V
- MR218216L3V
- MR218216L4V
- MR218232L3V
- MR218232L4V
- RC220379L1V
- RC220379L2V
- RC220379L3V
- RC220379L4V
- RR201195L3V
- RR201195L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR19
- Addgene plasmids for GPR19
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR19
Relevant External Links for GPR19 Gene
- GeneLoc Exon Structure for
- GPR19
Expression for GPR19 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for GPR19 Gene
This gene is overexpressed in Pituitary (x4.8), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Brain - Cerebellar Hemisphere (x4.1).
This gene is overexpressed in Saliva (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR19 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR19
SOURCE GeneReport for Unigene cluster for GPR19 Gene:
Hs.657862mRNA Expression by UniProt/SwissProt for GPR19 Gene:
Q15760-GPR19_HUMAN
Tissue specificity:
Abundant expression in the brain.
Primer Products
-
OriGene qPCR primer pairs for GPR19
-
OriGene qPCR primer pairs and template standards for GPR19
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR19 Gene
Orthologs for GPR19 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR19 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPR19 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GPR19 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gpr19 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gpr19 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GPR19 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GPR19 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpr19 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gpr19 30 31 |
|
OneToOne | |
| zgc63912 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | TrissinR 31 |
|
ManyToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | npr-10 31 |
|
OneToMany | |
| npr-3 31 |
|
OneToMany | |||
| npr-7 31 |
|
OneToMany | |||
| npr-2 31 |
|
OneToMany | |||
| npr-1 31 |
|
OneToMany | |||
| npr-5 31 |
|
OneToMany | |||
| npr-4 31 |
|
OneToMany | |||
| npr-13 31 |
|
OneToMany | |||
| npr-8 31 |
|
OneToMany |
- Species where no ortholog for GPR19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GPR19 Gene
- ENSEMBL:
- Gene Tree for GPR19 (if available)
- TreeFam:
- Gene Tree for GPR19 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR19: view image
Paralogs for GPR19 Gene
Paralogs for GPR19 Gene
(5) SIMAP similar genes for GPR19 Gene using alignment to 4 proteins:
- GPR19_HUMAN
- B9EK41_HUMAN
- F5GWU2_HUMAN
- Q6IBH2_HUMAN
Variants for GPR19 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR19 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 695291 | Benign: not provided | 12,717,002(-) | C/A | ||
| 713760 | Benign: not provided | 12,661,947(-) | C/T | MISSENSE_VARIANT | |
| 723538 | Benign: not provided | 12,661,285(-) | C/T | SYNONYMOUS_VARIANT | |
| 781064 | Benign: not provided | 12,662,044(-) | A/G | SYNONYMOUS_VARIANT | |
| 827022 | Uncertain Significance: Multiple endocrine neoplasia, type 4; Hereditary cancer-predisposing syndrome | 12,717,767(-) | G/A | FIVE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv89n21 | CNV | gain | 19592680 |
| esv2745567 | CNV | deletion | 23290073 |
| nsv1046355 | CNV | loss | 25217958 |
| nsv509456 | CNV | insertion | 20534489 |
| nsv983287 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.06;
21.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR19 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR19
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR19 Gene
Disorders for GPR19 Gene
Additional Disease Information for GPR19
No disorders were found for GPR19 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR19 Gene
Publications for GPR19 Gene
- A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. (PMID: 8830667) O'Dowd BF … George SR (FEBS letters 1996) 3 4
- Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. (PMID: 28154160) Badgandi HB … Mukhopadhyay S (The Journal of cell biology 2017) 3
- G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. (PMID: 28476646) Rao A … Herr DR (Biochimica et biophysica acta. Molecular cell research 2017) 3
- Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W … Lau YL (American journal of human genetics 2013) 3
- Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. (PMID: 22912338) Kastner S … Sommergruber W (Molecular cancer research : MCR 2012) 3
ExternalLinks
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- antibodies-online: Show 12 available GPR19 Antibodies ranked by validation data
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Sources for GPR19 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB