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Aliases for GPR182 Gene

Aliases for GPR182 Gene

  • G Protein-Coupled Receptor 182 2 3 5
  • Adrenomedullin Receptor 2 3
  • ADMR 3 4
  • G-Protein Coupled Receptor 182 3
  • HrhAMR 3
  • Gamrh 3
  • 7TMR 3
  • AM-R 3
  • G10D 3
  • L1-R 3
  • AMR 3

External Ids for GPR182 Gene

Previous HGNC Symbols for GPR182 Gene

  • ADMR

Previous GeneCards Identifiers for GPR182 Gene

  • GC12P055675
  • GC12P057388
  • GC12P054428

Summaries for GPR182 Gene

Entrez Gene Summary for GPR182 Gene

  • Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR182 Gene

GPR182 (G Protein-Coupled Receptor 182) is a Protein Coding gene. Among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for GPR182 Gene

  • Orphan receptor.

Gene Wiki entry for GPR182 Gene

Additional gene information for GPR182 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR182 Gene

Genomics for GPR182 Gene

GeneHancer (GH) Regulatory Elements for GPR182 Gene

Promoters and enhancers for GPR182 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056994 Promoter 0.6 EPDnew 650.7 +0.1 118 0.1 IKZF1 PIR47701 GPR182
GH12J056764 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11 -231.0 -230955 0.4 CTCF TAF1 RXRA ZSCAN4 TRIM22 REST RAD21 YY1 TEAD3 SP1 PIR51277 HSD17B6 GPR182 NACA MYO1A SDR9C7 GC12P056811
GH12J057069 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 +75.7 75731 2.1 HDAC1 HDGF PKNOX1 ARNT ARID4B ZNF2 IRF4 DNMT3B RAD21 YY1 ZBTB39 GPR182 LRP1 STAT6 MYO1A DTX3 GC12P057053 NEMP1
GH12J056838 Enhancer 0.9 Ensembl ENCODE 11.9 -154.2 -154235 3 HDAC1 CTCF RB1 NFATC3 RAD21 YY1 TEAD3 CC2D1A GATA3 ZNF157 ENSG00000273536 GPR182 ENSG00000258199 MYO1A RDH16 STAT6 BAZ2A HSD17B6 YWHAQP3
GH12J056835 Enhancer 0.9 Ensembl ENCODE 11.1 -157.7 -157663 1.4 NFIB FOSL1 ZNF776 ZNF350 CBFA2T2 FOS SRF L3MBTL2 NFIA USF2 IKZF4 PAN2 ANKRD52 HSPD1P4 NEMP1 TSPAN31 ENSG00000212383 BAZ2A ENSG00000257740 GPR182
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR182 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR182 gene promoter:
  • CUTL1
  • C/EBPalpha
  • Nkx3-1 v1
  • Evi-1
  • AREB6
  • Nkx3-1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • IRF-1

Genomic Locations for GPR182 Gene

Genomic Locations for GPR182 Gene
5,653 bases
Plus strand
2,240 bases
Plus strand

Genomic View for GPR182 Gene

Genes around GPR182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR182 Gene

Proteins for GPR182 Gene

  • Protein details for GPR182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 182
    Protein Accession:

    Protein attributes for GPR182 Gene

    404 amino acids
    Molecular mass:
    45323 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR182 Gene

Post-translational modifications for GPR182 Gene

  • Glycosylation at Asn37 and isoforms=28
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR182 Gene

No data available for DME Specific Peptides for GPR182 Gene

Domains & Families for GPR182 Gene

Gene Families for GPR182 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR182 Gene

Suggested Antigen Peptide Sequences for GPR182 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR182: view

Function for GPR182 Gene

Molecular function for GPR182 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR182 Gene

Gene Ontology (GO) - Molecular Function for GPR182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9367907
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR182: view
genes like me logo Genes that share phenotypes with GPR182: view

Animal Models for GPR182 Gene

MGI Knock Outs for GPR182:
  • Gpr182 Gpr182<tm2b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR182

Clone Products

  • R&D Systems cDNA Clones for GPR182 (Adrenomedullin R/ADMR)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR182 Gene

Localization for GPR182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR182 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR182 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,TAS --
genes like me logo Genes that share ontologies with GPR182: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR182 Gene

Pathways & Interactions for GPR182 Gene

genes like me logo Genes that share pathways with GPR182: view

Pathways by source for GPR182 Gene

1 BioSystems pathway for GPR182 Gene
1 PharmGKB pathway for GPR182 Gene

Interacting Proteins for GPR182 Gene

Gene Ontology (GO) - Biological Process for GPR182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9367907
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with GPR182: view

No data available for SIGNOR curated interactions for GPR182 Gene

Drugs & Compounds for GPR182 Gene

(1) Drugs for GPR182 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for GPR182 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR182: view

Transcripts for GPR182 Gene

mRNA/cDNA for GPR182 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR182 Gene

G protein-coupled receptor 182:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for GPR182 (Adrenomedullin R/ADMR)

Alternative Splicing Database (ASD) splice patterns (SP) for GPR182 Gene

No ASD Table

Relevant External Links for GPR182 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR182 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR182 Gene

This gene is overexpressed in Spleen (x23.2), Liver (x4.5), and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for GPR182 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR182 Gene

Protein tissue co-expression partners for GPR182 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR182 Gene:


SOURCE GeneReport for Unigene cluster for GPR182 Gene:


mRNA Expression by UniProt/SwissProt for GPR182 Gene:

Tissue specificity: Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver.

Evidence on tissue expression from TISSUES for GPR182 Gene

  • Intestine(4)
  • Muscle(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with GPR182: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR182 Gene

Orthologs for GPR182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR182 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR182 34 33
  • 97.02 (n)
(Bos Taurus)
Mammalia GPR182 34 33
  • 85.28 (n)
(Rattus norvegicus)
Mammalia Gpr182 33
  • 81.03 (n)
(Mus musculus)
Mammalia Gpr182 16 34 33
  • 80.74 (n)
(Canis familiaris)
Mammalia GPR182 34 33
  • 77.98 (n)
(Monodelphis domestica)
Mammalia GPR182 34
  • 71 (a)
(Gallus gallus)
Aves GPR182 34 33
  • 69.1 (n)
(Anolis carolinensis)
Reptilia GPR182 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498373 33
  • 60.56 (n)
Str.12498 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69068 33
(Danio rerio)
Actinopterygii gpr182 34 33
  • 54.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for GPR182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR182 Gene

Gene Tree for GPR182 (if available)
Gene Tree for GPR182 (if available)
Evolutionary constrained regions (ECRs) for GPR182: view image

Paralogs for GPR182 Gene

Paralogs for GPR182 Gene

(8) SIMAP similar genes for GPR182 Gene using alignment to 1 proteins:

  • GP182_HUMAN
genes like me logo Genes that share paralogs with GPR182: view

Variants for GPR182 Gene

Sequence variations from dbSNP and Humsavar for GPR182 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015762 -- 56,991,924(+) C/A/T upstream_transcript_variant
rs1000901224 -- 56,997,414(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001271160 -- 56,997,754(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001362700 -- 56,997,326(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1001393785 -- 56,997,091(+) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR182 Gene

Variant ID Type Subtype PubMed ID
esv3580285 CNV loss 25503493
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for GPR182 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR182 Gene

Disorders for GPR182 Gene

Additional Disease Information for GPR182

No disorders were found for GPR182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR182 Gene

Publications for GPR182 Gene

  1. Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. (PMID: 9535752) Kennedy SP … Hill RJ (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  2. Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. (PMID: 9367907) Hänze J … Rascher W (Biochemical and biophysical research communications 1997) 2 3 4 22 58
  3. Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age. (PMID: 17939601) Marinoni E … Di Iorio R (The Journal of reproductive medicine 2007) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]. (PMID: 14720432) Xu P … Song WD (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 2003) 3 22 58

Products for GPR182 Gene

Sources for GPR182 Gene

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