This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008] See more...

Aliases for GPR180 Gene

Aliases for GPR180 Gene

  • G Protein-Coupled Receptor 180 2 3 5
  • Intimal Thickness-Related Receptor 3 4
  • Integral Membrane Protein GPR180 3 4
  • ITR 3 4
  • Intimal Thickness Related Receptor 2

External Ids for GPR180 Gene

Previous GeneCards Identifiers for GPR180 Gene

  • GC13P094053
  • GC13P095254
  • GC13P075851

Summaries for GPR180 Gene

Entrez Gene Summary for GPR180 Gene

  • This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR180 Gene

GPR180 (G Protein-Coupled Receptor 180) is a Protein Coding gene. Diseases associated with GPR180 include Erythema Infectiosum and Viral Exanthem. An important paralog of this gene is TMEM145.

Additional gene information for GPR180 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR180 Gene

Genomics for GPR180 Gene

GeneHancer (GH) Regulatory Elements for GPR180 Gene

Promoters and enhancers for GPR180 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J094600 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 568.1 +0.3 345 2.8 NRF1 USF1 SP1 PHF8 ZFX ZIC2 POLR2A ZNF263 FOS ZNF423 GPR180 MF281430-019
GH13J094601 Enhancer 0.6 Ensembl 500.7 -1.7 -1749 0.2 FOXA2 JUND HOMEZ RXRA KDM1A TFAP4 HNF4A NFIL3 REST NFYC GPR180 lnc-GPR180-10
GH13J094594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 65.2 -6.6 -6550 3.4 ZBTB40 SIN3A TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 POLR2A ZBTB11 lnc-DCT-12 lnc-GPR180-10 TGDS GPR180 piR-34822-083
GH13J094548 Promoter/Enhancer 1.7 EPDnew ENCODE CraniofacialAtlas 13.1 -52.4 -52395 2.5 ZBTB40 CTCF NRF1 TCF12 POLR2G NCOR1 PHF8 TEAD4 FOS ZFX DCT TRF-GAA1-5 lnc-GPR180-11 lnc-TGDS-1 piR-43773-002 GPR180 piR-55036-030
GH13J094660 Enhancer 1.7 VISTA UCNEbase Ensembl ENCODE 10.6 +59.4 59351 5.2 CTCF PHB2 ZIC2 HES1 MYC CTBP1 TAF9B ZNF341 OSR2 NCOR1 SOX21-AS1 LINC00391 SOX21 GPR180 RNA5SP36 RF00001-105 piR-57460-159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR180 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR180

Top Transcription factor binding sites by QIAGEN in the GPR180 gene promoter:
  • AML1a
  • C/EBPalpha
  • GR
  • GR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for GPR180 Gene

Genomic Locations for GPR180 Gene
chr13:94,601,850-94,634,661
(GRCh38/hg38)
Size:
32,812 bases
Orientation:
Plus strand
chr13:95,254,104-95,286,899
(GRCh37/hg19)
Size:
32,796 bases
Orientation:
Plus strand

Genomic View for GPR180 Gene

Genes around GPR180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR180 Gene

Proteins for GPR180 Gene

  • Protein details for GPR180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V85-GP180_HUMAN
    Recommended name:
    Integral membrane protein GPR180
    Protein Accession:
    Q86V85
    Secondary Accessions:
    • A8K1D5

    Protein attributes for GPR180 Gene

    Size:
    440 amino acids
    Molecular mass:
    49395 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR180 Gene

Post-translational modifications for GPR180 Gene

  • Glycosylation at Asn105 and Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR180 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR180 Gene

Domains & Families for GPR180 Gene

Gene Families for GPR180 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR180 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR180 Gene

GenScript: Design optimal peptide antigens:
  • Intimal thickness-related receptor (GP180_HUMAN)
genes like me logo Genes that share domains with GPR180: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPR180 Gene

Function for GPR180 Gene

Phenotypes From GWAS Catalog for GPR180 Gene

genes like me logo Genes that share phenotypes with GPR180: view

Animal Models for GPR180 Gene

MGI Knock Outs for GPR180:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR180

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR180 Gene

Localization for GPR180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR180 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR180 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR180: view

Pathways & Interactions for GPR180 Gene

PathCards logo

SuperPathways for GPR180 Gene

No Data Available

Interacting Proteins for GPR180 Gene

;

Gene Ontology (GO) - Biological Process for GPR180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with GPR180: view

No data available for Pathways by source and SIGNOR curated interactions for GPR180 Gene

Drugs & Compounds for GPR180 Gene

No Compound Related Data Available

Transcripts for GPR180 Gene

mRNA/cDNA for GPR180 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR180

Alternative Splicing Database (ASD) splice patterns (SP) for GPR180 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for GPR180 Gene

GeneLoc Exon Structure for
GPR180

Expression for GPR180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR180 Gene

This gene is overexpressed in Retina (18.1), Urine (12.2), Platelet (8.3), Islet of Langerhans (8.3), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR180 Gene



Protein tissue co-expression partners for GPR180 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR180

SOURCE GeneReport for Unigene cluster for GPR180 Gene:

Hs.439363

Evidence on tissue expression from TISSUES for GPR180 Gene

  • Nervous system(4.7)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with GPR180: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR180 Gene

Orthologs for GPR180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR180 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR180 31 30
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR180 31 30
  • 92.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR180 31 30
  • 91.74 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR180 31
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr180 30
  • 82.2 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR180 31
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr180 17 31 30
  • 81.97 (n)
chicken
(Gallus gallus)
Aves GPR180 31 30
  • 79.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR180 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr180 30
  • 68.49 (n)
Str.16485 30
zebrafish
(Danio rerio)
Actinopterygii LOC100329381 30
  • 57.62 (n)
GPR180 31
  • 52 (a)
OneToOne
Species where no ortholog for GPR180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR180 Gene

ENSEMBL:
Gene Tree for GPR180 (if available)
TreeFam:
Gene Tree for GPR180 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR180: view image

Paralogs for GPR180 Gene

Paralogs for GPR180 Gene

(1) SIMAP similar genes for GPR180 Gene using alignment to 1 proteins:

  • GP180_HUMAN
genes like me logo Genes that share paralogs with GPR180: view

Variants for GPR180 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR180 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
VAR_035925 A breast cancer sample p.Thr32Asn

Additional dbSNP identifiers (rs#s) for GPR180 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR180 Gene

Variant ID Type Subtype PubMed ID
esv34004 CNV loss 18971310
nsv832685 CNV gain 17160897
nsv832686 CNV gain 17160897

Variation tolerance for GPR180 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR180 Gene

Human Gene Mutation Database (HGMD)
GPR180
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR180 Gene

Disorders for GPR180 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GPR180 Gene - From: DISEASES

Disorder Aliases PubMed IDs
erythema infectiosum
  • fifth disease
viral exanthem
locked-in syndrome
  • locked in syndrome
autosomal dominant non-syndromic intellectual disability 4
  • mrd4
meningeal melanocytoma
  • leptomeningeal melanocytoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR180

genes like me logo Genes that share disorders with GPR180: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR180 Gene

Publications for GPR180 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 54
  4. Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. (PMID: 12538434) Tsukada S … Tanaka T (Circulation 2003) 2 3 54
  5. High-density SNP map of human ITR, a gene associated with vascular remodeling. (PMID: 12730718) Iida A … Nakamura Y (Journal of human genetics 2003) 3 4 54

Products for GPR180 Gene

Sources for GPR180 Gene