Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008] See more...

Aliases for GPR176 Gene

Aliases for GPR176 Gene

  • G Protein-Coupled Receptor 176 2 3 5
  • G-Protein Coupled Receptor 176 3 4
  • HB-954 3 4
  • Probable G-Protein Coupled Receptor 176 3
  • GPR176 5
  • Gm1012 2

External Ids for GPR176 Gene

Previous GeneCards Identifiers for GPR176 Gene

  • GC15M037881
  • GC15M040091
  • GC15M016936

Summaries for GPR176 Gene

Entrez Gene Summary for GPR176 Gene

  • Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

GeneCards Summary for GPR176 Gene

GPR176 (G Protein-Coupled Receptor 176) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR135.

UniProtKB/Swiss-Prot Summary for GPR176 Gene

  • Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.

Gene Wiki entry for GPR176 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR176 Gene

Genomics for GPR176 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR176 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J039918 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 252.2 +1.7 1715 4.8 ZNF600 MYC ZNF592 POLR2A NFIC ZIC2 ZBTB10 YY1 MXD4 NONO GPR176 GPR176-DT EIF2AK4 SRP14-AS1 piR-46168 piR-36393-166 FSIP1
GH15J039922 Promoter 0.5 Ensembl 250.7 -1.4 -1362 0.2 ZBTB48 ZBTB17 ENSG00000200305 GPR176 GPR176-DT piR-46168 EIF2AK4
GH15J039884 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +33.4 33438 7.4 ZNF654 POLR2A CEBPB CTCF EP300 THAP11 FOXA2 RXRA RAD21 SMC3 GPR176 EIF2AK4 GPR176-DT ENSG00000200305 FSIP1 piR-54764-193 piR-32214-201
GH15J039895 Enhancer 1 Ensembl ENCODE 19.7 +23.5 23538 3.6 IKZF1 NCOR1 NFIC ARNT TAL1 NFE2 NCOA2 ATF1 STAT5A MCM7 GPR176 GPR176-DT ENSG00000200305 EIF2AK4 DNAJC17 FSIP1 PAK6 PAK6-AS1 piR-36393-166
GH15J039882 Enhancer 0.9 Ensembl dbSUPER 15.5 +37.9 37938 0.4 MYC NCOR1 IKZF1 REST HES1 ARNT TAL1 ETV1 TCF12 MTA2 GPR176 EIF2AK4 ENSG00000200305 GPR176-DT FSIP1 piR-32214-201 piR-54764-193
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR176 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR176

Top Transcription factor binding sites by QIAGEN in the GPR176 gene promoter:
  • CREB
  • deltaCREB
  • NF-kappaB1
  • p53

Genomic Locations for GPR176 Gene

Latest Assembly
chr15:39,795,049-39,920,939
(GRCh38/hg38)
Size:
125,891 bases
Orientation:
Minus strand

Previous Assembly
chr15:40,091,209-40,212,467
(GRCh37/hg19 by Entrez Gene)
Size:
121,259 bases
Orientation:
Minus strand

chr15:40,091,233-40,213,093
(GRCh37/hg19 by Ensembl)
Size:
121,861 bases
Orientation:
Minus strand

Genomic View for GPR176 Gene

Genes around GPR176 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR176 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR176 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR176 Gene

Proteins for GPR176 Gene

  • Protein details for GPR176 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14439-GP176_HUMAN
    Recommended name:
    G-protein coupled receptor 176
    Protein Accession:
    Q14439
    Secondary Accessions:
    • B4DZ23
    • H9NIL9
    • J3KNC6
    • Q6NXF6

    Protein attributes for GPR176 Gene

    Size:
    515 amino acids
    Molecular mass:
    56998 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR176 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR176 Gene

Post-translational modifications for GPR176 Gene

  • Glycosylation at Asn4, Asn11, Asn17, and Asn27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR176 Gene

Domains & Families for GPR176 Gene

Gene Families for GPR176 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR176 Gene

Suggested Antigen Peptide Sequences for GPR176 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50302, highly similar to Probable G-protein coupled receptor 176 (B4DZ23_HUMAN)
  • HB-954 (GP176_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14439

UniProtKB/Swiss-Prot:

GP176_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR176: view

Function for GPR176 Gene

Molecular function for GPR176 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.

Phenotypes From GWAS Catalog for GPR176 Gene

Gene Ontology (GO) - Molecular Function for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS,ISS --
genes like me logo Genes that share ontologies with GPR176: view
genes like me logo Genes that share phenotypes with GPR176: view

Animal Models for GPR176 Gene

MGI Knock Outs for GPR176:

Animal Models for research

  • Taconic Biosciences Mouse Models for GPR176

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR176

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR176 Gene

Localization for GPR176 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR176 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR176 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7893747
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with GPR176: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR176 Gene

Pathways & Interactions for GPR176 Gene

genes like me logo Genes that share pathways with GPR176: view

Pathways by source for GPR176 Gene

1 BioSystems pathway for GPR176 Gene

Interacting Proteins for GPR176 Gene

Gene Ontology (GO) - Biological Process for GPR176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA --
GO:0007268 chemical synaptic transmission TAS 7893747
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with GPR176: view

No data available for SIGNOR curated interactions for GPR176 Gene

Drugs & Compounds for GPR176 Gene

No Compound Related Data Available

Transcripts for GPR176 Gene

mRNA/cDNA for GPR176 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR176

Alternative Splicing Database (ASD) splice patterns (SP) for GPR176 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -

Relevant External Links for GPR176 Gene

GeneLoc Exon Structure for
GPR176

Expression for GPR176 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR176 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR176 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR176

SOURCE GeneReport for Unigene cluster for GPR176 Gene:

Hs.37196

Evidence on tissue expression from TISSUES for GPR176 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR176: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR176 Gene

Orthologs for GPR176 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR176 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR176 29 30
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR176 29 30
  • 91.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR176 29 30
  • 90.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr176 29
  • 87.59 (n)
Mouse
(Mus musculus)
Mammalia Gpr176 29 16 30
  • 87.16 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GPR176 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR176 30
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR176 29 30
  • 73.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR176 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr176 29
  • 70.1 (n)
Zebrafish
(Danio rerio)
Actinopterygii gpr176 29 30
  • 65.03 (n)
OneToOne
Species where no ortholog for GPR176 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR176 Gene

ENSEMBL:
Gene Tree for GPR176 (if available)
TreeFam:
Gene Tree for GPR176 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR176: view image
Alliance of Genome Resources:
Additional Orthologs for GPR176

Paralogs for GPR176 Gene

Paralogs for GPR176 Gene

(2) SIMAP similar genes for GPR176 Gene using alignment to 4 proteins:

  • GP176_HUMAN
  • B4DZ23_HUMAN
  • H9NIL9_HUMAN
  • J3KNC6_HUMAN
genes like me logo Genes that share paralogs with GPR176: view

Variants for GPR176 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR176 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR176 Gene

Variant ID Type Subtype PubMed ID
esv1572077 CNV insertion 17803354
esv3333387 CNV insertion 20981092
esv3569465 CNV gain 25503493
esv3581639 CNV loss 25503493
nsv471961 CNV novel sequence insertion 20440878
nsv832978 CNV gain 17160897
nsv832979 CNV gain+loss 17160897
nsv832983 CNV gain 17160897

Variation tolerance for GPR176 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR176 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR176
Leiden Open Variation Database (LOVD)
GPR176

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR176 Gene

Disorders for GPR176 Gene

Additional Disease Information for GPR176

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GPR176 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR176 Gene

Publications for GPR176 Gene

  1. cDNA cloning of a putative G protein-coupled receptor from brain. (PMID: 7893747) Hata S … Osumi T (Biochimica et biophysica acta 1995) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]. (PMID: 28502923) Goto K … Okamura H (Endocrine journal 2017) 3

Products for GPR176 Gene

Sources for GPR176 Gene