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Aliases for GPR174 Gene

Aliases for GPR174 Gene

  • G Protein-Coupled Receptor 174 2 3 5
  • Probable G-Protein Coupled Receptor 174 3
  • FKSG79 3
  • GPCR17 3
  • LYPSR3 3

External Ids for GPR174 Gene

Previous GeneCards Identifiers for GPR174 Gene

  • GC0XP078232
  • GC0XP078313
  • GC0XP078426
  • GC0XP072005

Summaries for GPR174 Gene

Entrez Gene Summary for GPR174 Gene

  • This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR174 Gene

GPR174 (G Protein-Coupled Receptor 174) is a Protein Coding gene. Diseases associated with GPR174 include Autoimmune Polyendocrine Syndrome, Type Ii and Autoimmune Disease Of Endocrine System. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY10.

UniProtKB/Swiss-Prot for GPR174 Gene

  • Putative receptor for purines coupled to G-proteins.

Gene Wiki entry for GPR174 Gene

Additional gene information for GPR174 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR174 Gene

Genomics for GPR174 Gene

GeneHancer (GH) Regulatory Elements for GPR174 Gene

Promoters and enhancers for GPR174 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI079169 Enhancer 0.4 ENCODE dbSUPER 550.8 -0.3 -325 2.1 GPR174 ITM2A GC0XM079072
GH0XI079257 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +88.4 88411 4.7 PKNOX1 SMAD1 RB1 BMI1 YBX1 BATF IRF4 ZNF207 ATF7 ETV6 GPR174 ITM2A RTL3 P2RY10 GC0XM079197 GC0XM079265
GH0XI079106 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -62.6 -62557 3.8 SMARCA5 ZNF687 NR2F1 JUNB ELF1 ATF2 FOXA1 RELA ZNF217 BCL11A ITM2A GPR174 P2RY10 LPAR4 GC0XM079072
GH0XI079142 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -20.3 -20256 15.5 YBX1 BATF RELA ZNF366 POLR2A SCRT2 ATF7 ETV6 BCLAF1 IKZF2 ITM2A P2RY10 GPR174 RTL3 LPAR4 GC0XM079072
GH0XI079336 Enhancer 0.5 Ensembl ENCODE 12.5 +166.4 166436 0.9 ATF4 ITM2A GPR174 KIF4CP PIR45005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR174 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR174 gene promoter:

Genomic Locations for GPR174 Gene

Genomic Locations for GPR174 Gene
1,258 bases
Plus strand

Genomic View for GPR174 Gene

Genes around GPR174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR174 Gene

Proteins for GPR174 Gene

  • Protein details for GPR174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 174
    Protein Accession:
    Secondary Accessions:
    • Q2M3F7

    Protein attributes for GPR174 Gene

    333 amino acids
    Molecular mass:
    38503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR174 Gene

Post-translational modifications for GPR174 Gene

  • Ubiquitination at isoforms=317
  • Glycosylation at posLast=44 and posLast=164164
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR174 Gene

Domains & Families for GPR174 Gene

Gene Families for GPR174 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR174 Gene

Suggested Antigen Peptide Sequences for GPR174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR174: view

Function for GPR174 Gene

Molecular function for GPR174 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045125 bioactive lipid receptor activity IEA --
genes like me logo Genes that share ontologies with GPR174: view
genes like me logo Genes that share phenotypes with GPR174: view

Animal Models for GPR174 Gene

MGI Knock Outs for GPR174:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR174

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR174 Gene

Localization for GPR174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR174 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR174 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR174: view

Pathways & Interactions for GPR174 Gene

genes like me logo Genes that share pathways with GPR174: view

Pathways by source for GPR174 Gene

1 BioSystems pathway for GPR174 Gene

Interacting Proteins for GPR174 Gene

Selected Interacting proteins: Q9BXC1-GP174_HUMAN for GPR174 Gene via IID

Gene Ontology (GO) - Biological Process for GPR174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0043029 T cell homeostasis IEA --
genes like me logo Genes that share ontologies with GPR174: view

No data available for SIGNOR curated interactions for GPR174 Gene

Drugs & Compounds for GPR174 Gene

(1) Drugs for GPR174 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysophosphatidylserine Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR174: view

Transcripts for GPR174 Gene

mRNA/cDNA for GPR174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR174 Gene

G protein-coupled receptor 174:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR174 Gene

No ASD Table

Relevant External Links for GPR174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR174 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.5), Whole Blood (x5.8), and Spleen (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of GPR174 Gene:


SOURCE GeneReport for Unigene cluster for GPR174 Gene:


Evidence on tissue expression from TISSUES for GPR174 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPR174: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR174 Gene

Orthologs for GPR174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR174 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia GPR174 34
  • 94 (a)
LOC100683878 33
  • 91.18 (n)
(Bos Taurus)
Mammalia GPR174 33 34
  • 89.09 (n)
(Mus musculus)
Mammalia Gpr174 33 16 34
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Gpr174 33
  • 86.79 (n)
(Monodelphis domestica)
Mammalia GPR174 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia GPR174 34
  • 63 (a)
(Gallus gallus)
Aves GPR174 33 34
  • 67.53 (n)
(Anolis carolinensis)
Reptilia GPR174 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr174 33
  • 66.99 (n)
(Danio rerio)
Actinopterygii LOC100151331 33
  • 59.19 (n)
CR931764.1 34
  • 54 (a)
Species where no ortholog for GPR174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR174 Gene

Gene Tree for GPR174 (if available)
Gene Tree for GPR174 (if available)

Paralogs for GPR174 Gene

(15) SIMAP similar genes for GPR174 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR174: view

Variants for GPR174 Gene

Sequence variations from dbSNP and Humsavar for GPR174 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001595903 -- 79,170,243(+) T/G upstream_transcript_variant
rs1002023202 -- 79,169,923(+) T/C upstream_transcript_variant
rs1003304257 -- 79,170,753(+) G/A upstream_transcript_variant
rs1005779538 -- 79,169,619(+) A/G upstream_transcript_variant
rs1006218561 -- 79,170,075(+) A/G upstream_transcript_variant

Variation tolerance for GPR174 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR174 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR174 Gene

Disorders for GPR174 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR174 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR174

genes like me logo Genes that share disorders with GPR174: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR174 Gene

Publications for GPR174 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  4. Role of the X-linked gene GPR174 in autoimmune Addison's disease. (PMID: 25295623) Napier C … Pearce SH (The Journal of clinical endocrinology and metabolism 2015) 3 58
  5. Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope. (PMID: 25367286) Huang YJ … Bao L (Pediatric cardiology 2015) 3 58

Products for GPR174 Gene

Sources for GPR174 Gene

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