This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009] See more...

Aliases for GPR173 Gene

Aliases for GPR173 Gene

  • G Protein-Coupled Receptor 173 2 3 5
  • Super Conserved Receptor Expressed In Brain 3 3 4
  • Probable G-Protein Coupled Receptor 173 3 4
  • SREB3 3 4
  • G-Protein Coupled Receptor 173 2
  • G Protein Coupled Receptor 173 2

External Ids for GPR173 Gene

Previous GeneCards Identifiers for GPR173 Gene

  • GC0XP052961
  • GC0XP053095
  • GC0XP050140

Summaries for GPR173 Gene

Entrez Gene Summary for GPR173 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]

GeneCards Summary for GPR173 Gene

GPR173 (G Protein-Coupled Receptor 173) is a Protein Coding gene. Diseases associated with GPR173 include Retinitis Pigmentosa 6 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and gonadotropin-releasing hormone receptor activity. An important paralog of this gene is GPR85.

UniProtKB/Swiss-Prot Summary for GPR173 Gene

Gene Wiki entry for GPR173 Gene

Additional gene information for GPR173 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR173 Gene

Genomics for GPR173 Gene

GeneHancer (GH) Regulatory Elements for GPR173 Gene

Promoters and enhancers for GPR173 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR173 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR173

Top Transcription factor binding sites by QIAGEN in the GPR173 gene promoter:
  • AML1a
  • AP-1
  • AREB6
  • FAC1
  • Ik-1
  • MyoD
  • p53
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for GPR173 Gene

Genomic Locations for GPR173 Gene
chrX:53,049,091-53,080,615
(GRCh38/hg38)
Size:
31,525 bases
Orientation:
Plus strand
chrX:53,078,273-53,109,797
(GRCh37/hg19)
Size:
31,525 bases
Orientation:
Plus strand

Genomic View for GPR173 Gene

Genes around GPR173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR173 Gene

Proteins for GPR173 Gene

  • Protein details for GPR173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS66-GP173_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 173
    Protein Accession:
    Q9NS66
    Secondary Accessions:
    • B1B0A5

    Protein attributes for GPR173 Gene

    Size:
    373 amino acids
    Molecular mass:
    41481 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR173 Gene

Post-translational modifications for GPR173 Gene

  • Glycosylation at Asn3 and Asn184
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR173 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR173 Gene

Domains & Families for GPR173 Gene

Gene Families for GPR173 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR173 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR173 Gene

GenScript: Design optimal peptide antigens:
  • Super conserved receptor expressed in brain 3 (GP173_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS66

UniProtKB/Swiss-Prot:

GP173_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR173: view

Function for GPR173 Gene

Molecular function for GPR173 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 10833454
GO:0004968 gonadotropin-releasing hormone receptor activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with GPR173: view
genes like me logo Genes that share phenotypes with GPR173: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR173 Gene

Localization for GPR173 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR173 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR173 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR173: view

Pathways & Interactions for GPR173 Gene

PathCards logo

SuperPathways for GPR173 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR173: view

Pathways by source for GPR173 Gene

1 BioSystems pathway for GPR173 Gene

Interacting Proteins for GPR173 Gene

;

Gene Ontology (GO) - Biological Process for GPR173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
GO:2001223 negative regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with GPR173: view

No data available for SIGNOR curated interactions for GPR173 Gene

Drugs & Compounds for GPR173 Gene

No Compound Related Data Available

Transcripts for GPR173 Gene

mRNA/cDNA for GPR173 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR173 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GPR173 Gene

GeneLoc Exon Structure for
GPR173

Expression for GPR173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR173

SOURCE GeneReport for Unigene cluster for GPR173 Gene:

Hs.193011

mRNA Expression by UniProt/SwissProt for GPR173 Gene:

Q9NS66-GP173_HUMAN
Tissue specificity: Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

Evidence on tissue expression from TISSUES for GPR173 Gene

  • Nervous system(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with GPR173: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR173 Gene

Orthologs for GPR173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR173 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR173 31 30
  • 98.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR173 31 30
  • 95.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR173 31 30
  • 94.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr173 17 31 30
  • 94.64 (n)
rat
(Rattus norvegicus)
Mammalia Gpr173 30
  • 94.64 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR173 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR27 30
  • 73.94 (n)
lizard
(Anolis carolinensis)
Reptilia GPR173 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr173 30
  • 74.12 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr173 31 30
  • 74.41 (n)
OneToOne
Species where no ortholog for GPR173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR173 Gene

ENSEMBL:
Gene Tree for GPR173 (if available)
TreeFam:
Gene Tree for GPR173 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR173: view image

Paralogs for GPR173 Gene

Paralogs for GPR173 Gene

(2) SIMAP similar genes for GPR173 Gene using alignment to 2 proteins:

  • GP173_HUMAN
  • J3KPD1_HUMAN
genes like me logo Genes that share paralogs with GPR173: view

Variants for GPR173 Gene

Additional dbSNP identifiers (rs#s) for GPR173 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR173 Gene

Variant ID Type Subtype PubMed ID
esv1009949 CNV insertion 20482838
esv24544 CNV gain 19812545
esv2740175 CNV deletion 23290073
esv3450158 CNV duplication 20981092
esv3576878 CNV gain 25503493
nsv1076709 CNV duplication 25765185
nsv1129081 CNV duplication 24896259
nsv1153074 CNV duplication 26484159
nsv435891 CNV deletion 17901297
nsv508773 CNV insertion 20534489

Variation tolerance for GPR173 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR173 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR173

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR173 Gene

Disorders for GPR173 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPR173 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 6
  • rp6
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
kallmann syndrome
  • hypogonadotropic hypogonadism and anosmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR173

genes like me logo Genes that share disorders with GPR173: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR173 Gene

Publications for GPR173 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M … Furuichi K (Biochemical and biophysical research communications 2000) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE. (PMID: 29724251) Zhang H … Yang W (Arthritis research & therapy 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. (PMID: 27184081) Yanai T … Takeda S (Genes to cells : devoted to molecular & cellular mechanisms 2016) 3 54

Products for GPR173 Gene

Sources for GPR173 Gene