Aliases for GPR171 Gene
Aliases for GPR171 Gene
External Ids for GPR171 Gene
- HGNC: 30057
- Entrez Gene: 29909
- Ensembl: ENSG00000174946
- UniProtKB: O14626
Previous GeneCards Identifiers for GPR171 Gene
- GC03M152398
- GC03M150915
- GC03M148288
Summaries for GPR171 Gene
GeneCards Summary for GPR171 Gene
GPR171 (G Protein-Coupled Receptor 171) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY12.
UniProtKB/Swiss-Prot for GPR171 Gene
-
Orphan receptor.
Additional gene information for GPR171 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR171 Gene
Genomics for GPR171 Gene
GeneHancer (GH) Regulatory Elements for GPR171 Gene
Promoters and enhancers for GPR171 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J151199 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +1.6 | 1629 | 4.3 | SMAD1 NFIA NFIB NFIC LCORL POLR2A BCL11A NFATC1 ATF7 IKZF2 | GPR171 P2RY14 AADAC AADACL2 RNA5SP145 MED12L | |
| GH03J151203 | Enhancer | 0.4 | ENCODE dbSUPER | 650.7 | -1.4 | -1400 | 1.4 | GPR171 GC03M151222 MED12L | ||
| GH03J151182 | Enhancer | 0.7 | FANTOM5 ENCODE | 6.8 | +19.8 | 19760 | 1.3 | SREBF1 USF1 ZSCAN16 HLF | P2RY14 MED12L GPR87 GPR171 AADAC GC03P151189 GC03M151148 | |
| GH03J150759 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 1.5 | +440.5 | 440473 | 7.5 | HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 | SIAH2 SIAH2-AS1 TSC22D2 SERP1 GPR171 SELENOT LOC105374155 | |
| GH03J151209 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.4 | -7.3 | -7318 | 2.4 | ELF3 SOX13 CTCF TFAP4 FOXA2 TAF1 SAP130 ERF ZNF644 KDM3A | P2RY14 GPR87 MED12L GPR171 GC03M151222 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR171 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GPR171 gene promoter:
-
- ER-alpha
- Elk-1
- FOXL1
- Bach1
- C/EBPbeta
- RORalpha2
- NF-AT
- NF-AT2
- NF-AT3
Regulatory Element Products
Genomic Locations for GPR171 Gene
Genomic Locations for GPR171 Gene
- chr3:151,197,754-151,203,222
- (GRCh38/hg38)
- Size:
- 5,469 bases
- Orientation:
- Minus strand
- chr3:150,915,619-150,920,988
- (GRCh37/hg19)
- Size:
- 5,370 bases
- Orientation:
- Minus strand
Genomic View for GPR171 Gene
Genes around GPR171 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q25.1 by Entrez Gene
- 3q25.1 by HGNC
- 3q25.1 by Ensembl
GPR171 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR171 Gene
Proteins for GPR171 Gene
-
Protein details for GPR171 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14626-GP171_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 171
- Protein Accession:
- O14626
- D3DNJ4
- Q8IV06
Protein attributes for GPR171 Gene
- Size:
- 319 amino acids
- Molecular mass:
- 36754 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR171 Gene
Post-translational modifications for GPR171 Gene
Other Protein References for GPR171 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR171
- Invitrogen Antibodies for GPR171 (AFLGC-GPR171)
- GeneTex GPR171 Antibody for GPR171
Protein Products
-
OriGene Purified Proteins for GPR171
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- antibodies-online: Search results for 4 available GPR171 Proteins ranked by validation data
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-
Quality Products:
- Search GeneTex for Proteins for GPR171
Assay Products
No data available for DME Specific Peptides for GPR171 Gene
Domains & Families for GPR171 Gene
Gene Families for GPR171 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GPR171 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR171 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14626- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR171 Gene
Molecular function for GPR171 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | NAS | 9370294 |
| GO:0045028 | G-protein coupled purinergic nucleotide receptor activity | IBA | -- |
Phenotypes for GPR171 Gene
- GenomeRNAi human phenotypes for GPR171:
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR171
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR171
-
CRISPR Products
-
OriGene CRISPR knockouts for GPR171
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- Overview of 84 available GPR171 gene related products
- Applied Biological Materials CRISPR for GPR171
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR171
- GenScript: Design CRISPR guide RNA sequences for GPR171
miRNA for GPR171 Gene
- miRTarBase miRNAs that target GPR171
miRNA Products
Inhibitory RNA Products
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- Overview of 84 available GPR171 gene related products
Clone Products
- Addgene plasmids for GPR171
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- Applied Biological Materials Clones for GPR171
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
-
Horizon Cell Lines for GPR171
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR171 Gene
Localization for GPR171 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR171 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 9370294 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR171 Gene
Pathways & Interactions for GPR171 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
Pathways by source for GPR171 Gene
1 BioSystems pathway for GPR171 Gene
Interacting Proteins for GPR171 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | NAS | 9370294 |
| GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway | IEA | -- |
| GO:0045638 | negative regulation of myeloid cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for GPR171 Gene
Transcripts for GPR171 Gene
mRNA/cDNA for GPR171 Gene
- (4) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000309180 1786 bps (uc003eyq.5)
- ENST00000480322 205 bps (uc062pbr.1)
- ENST00000617554 960 bps (uc062pbq.1)
Unigene Clusters for GPR171 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR171
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- Overview of 84 available GPR171 gene related products
- Applied Biological Materials CRISPR for GPR171
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR171
- GenScript: Design CRISPR guide RNA sequences for GPR171
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR171
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- Overview of 84 available GPR171 gene related products
Clone Products
- Addgene plasmids for GPR171
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- Applied Biological Materials Clones for GPR171
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR171
Expression for GPR171 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
mRNA differential expression in normal tissues according to GTEx for GPR171 Gene
This gene is overexpressed in Whole Blood (x10.6), Spleen (x6.8), and Small Intestine - Terminal Ileum (x6.4).
This gene is overexpressed in CD4 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR171 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GPR171 Gene:
GPR171SOURCE GeneReport for Unigene cluster for GPR171 Gene:
Hs.549152Evidence on tissue expression from TISSUES for GPR171 Gene
- Blood(4.2)
- Pancreas(4)
Primer Products
-
OriGene qPCR primer pairs for GPR171
-
OriGene qPCR primer pairs and template standards for GPR171
- genomics-online: primer clones - Search results for 84 available GPR171 gene related products
- Overview of 84 available GPR171 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR171 Gene
Orthologs for GPR171 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR171 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GPR171 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GPR171 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GPR171 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gpr171 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gpr171 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR171 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR171 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GPR171 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100497564 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC572354 33 |
|
||
| GPR171 34 |
|
OneToOne |
- Species where no ortholog for GPR171 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GPR171 Gene
- ENSEMBL:
- Gene Tree for GPR171 (if available)
- TreeFam:
- Gene Tree for GPR171 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR171: view image
Paralogs for GPR171 Gene
Variants for GPR171 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000808796 | -- | 151,202,692(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1001050057 | -- | 151,200,233(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001870958 | -- | 151,199,923(-) | T/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1002492520 | -- | 151,199,557(-) | C/G | intron_variant | |
| rs1002671193 | -- | 151,204,838(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759188 | CNV | gain | 17122850 |
| nsv592045 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.54;
55.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR171 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR171
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR171 Gene
Disorders for GPR171 Gene
Additional Disease Information for GPR171
No disorders were found for GPR171 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR171 Gene
Publications for GPR171 Gene
- A genetic selection for isolating cDNAs encoding secreted proteins. (PMID: 9370294) Jacobs KA … McCoy JM (Gene 1997) 2 3 4 58
- GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. (PMID: 24043826) Gomes I … Devi LA (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 58
- Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T … Sankila EM (American journal of human genetics 2001) 3 4 58
- GPR171 expression enhances proliferation and metastasis of lung cancer cells. (PMID: 26760963) Dho SH … Kwon KS (Oncotarget 2016) 3 58
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay IC … Ouwehand WH (Blood 2007) 3 58
Products for GPR171 Gene
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Sources for GPR171 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
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