Aliases for GPR171 Gene

Aliases for GPR171 Gene

  • G Protein-Coupled Receptor 171 2 3 5
  • Probable G-Protein Coupled Receptor 171 3 4
  • Platelet Activating Receptor Homolog 2 3
  • G-Protein Coupled Receptor H963 3 4
  • H963 3 4
  • F730001G15Rik 3

External Ids for GPR171 Gene

Previous GeneCards Identifiers for GPR171 Gene

  • GC03M152398
  • GC03M150915
  • GC03M148288

Summaries for GPR171 Gene

GeneCards Summary for GPR171 Gene

GPR171 (G Protein-Coupled Receptor 171) is a Protein Coding gene. Diseases associated with GPR171 include Cataract 21, Multiple Types. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot Summary for GPR171 Gene

Gene Wiki entry for GPR171 Gene

Additional gene information for GPR171 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR171 Gene

Genomics for GPR171 Gene

GeneHancer (GH) Regulatory Elements for GPR171 Gene

Promoters and enhancers for GPR171 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151199 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.6 1629 4.3 EP300 BCL11A NFIC ZNF384 NFATC3 NFIB TBX21 NFATC1 PAX5 NFIA GPR171 P2RY14 AADAC AADACL2 MF281437-038 RNA5SP145 RF00001-229 MED12L
GH03J151203 Enhancer 0.3 ENCODE dbSUPER 500.7 -1.4 -1400 1.4 GPR171 RF00017-4142 MED12L
GH03J151182 Enhancer 0.9 FANTOM5 Ensembl ENCODE 6.8 +19.9 19921 2.2 USF1 GATA3 ZSCAN16 HMG20A HLF GATA2 SREBF1 P2RY14 MED12L GPR87 GPR171 AADAC MF281437-038 RF00001-229 RNA5SP145 hsa-miR-1273e-049
GH03J150759 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.5 +440.2 440215 8 EP300 FOXK2 HNRNPK ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G USF1 SIAH2-AS1 SIAH2 lnc-SELENOT-45 lnc-SIAH2-2 EIF2A ERICH6 ERICH6-AS1 TSC22D2 SERP1 GPR171
GH03J151198 Enhancer 1.1 Ensembl dbSUPER 0.7 +4.4 4422 0.8 EP300 POLR2G NCOR1 KDM6A TCF7 ZBTB25 SMARCC2 SKI TEAD1 TBX3 GPR171 MF281437-038 RNA5SP145 RF00001-229 MED12L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR171 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR171

Top Transcription factor binding sites by QIAGEN in the GPR171 gene promoter:
  • Bach1
  • C/EBPbeta
  • Elk-1
  • ER-alpha
  • FOXL1
  • NF-AT
  • NF-AT2
  • NF-AT3
  • RORalpha2

Genomic Locations for GPR171 Gene

Genomic Locations for GPR171 Gene
5,469 bases
Minus strand
5,370 bases
Minus strand

Genomic View for GPR171 Gene

Genes around GPR171 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR171 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR171 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR171 Gene

Proteins for GPR171 Gene

  • Protein details for GPR171 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 171
    Protein Accession:
    Secondary Accessions:
    • D3DNJ4
    • Q8IV06

    Protein attributes for GPR171 Gene

    319 amino acids
    Molecular mass:
    36754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR171 Gene

Post-translational modifications for GPR171 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR171 Gene

No data available for DME Specific Peptides for GPR171 Gene

Domains & Families for GPR171 Gene

Gene Families for GPR171 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR171 Gene


Suggested Antigen Peptide Sequences for GPR171 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor H963 (GP171_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR171: view

Function for GPR171 Gene

Molecular function for GPR171 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR171 Gene

Gene Ontology (GO) - Molecular Function for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity NAS 9370294
GO:0045028 G protein-coupled purinergic nucleotide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR171: view
genes like me logo Genes that share phenotypes with GPR171: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR171

CRISPR Products

miRNA for GPR171 Gene

miRTarBase miRNAs that target GPR171

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR171 Gene

Localization for GPR171 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR171 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR171 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9370294
genes like me logo Genes that share ontologies with GPR171: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR171 Gene

Pathways & Interactions for GPR171 Gene

PathCards logo

SuperPathways for GPR171 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR171: view

Pathways by source for GPR171 Gene

1 BioSystems pathway for GPR171 Gene

Interacting Proteins for GPR171 Gene


Gene Ontology (GO) - Biological Process for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway NAS 9370294
GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0045638 negative regulation of myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with GPR171: view

No data available for SIGNOR curated interactions for GPR171 Gene

Drugs & Compounds for GPR171 Gene

No Compound Related Data Available

Transcripts for GPR171 Gene

mRNA/cDNA for GPR171 Gene

3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR171 Gene

No ASD Table

Relevant External Links for GPR171 Gene

GeneLoc Exon Structure for

Expression for GPR171 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR171 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR171 Gene

This gene is overexpressed in Whole Blood (x10.6), Spleen (x6.8), and Small Intestine - Terminal Ileum (x6.4).

Protein differential expression in normal tissues from HIPED for GPR171 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR171 Gene

Protein tissue co-expression partners for GPR171 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR171

SOURCE GeneReport for Unigene cluster for GPR171 Gene:


Evidence on tissue expression from TISSUES for GPR171 Gene

  • Blood(4.2)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with GPR171: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR171 Gene

Orthologs for GPR171 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR171 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR171 31 30
  • 100 (n)
(Bos Taurus)
Mammalia GPR171 31 30
  • 88.92 (n)
(Canis familiaris)
Mammalia GPR171 31 30
  • 87.88 (n)
(Monodelphis domestica)
Mammalia GPR171 31
  • 86 (a)
(Mus musculus)
Mammalia Gpr171 17 31 30
  • 85.85 (n)
(Rattus norvegicus)
Mammalia Gpr171 30
  • 85.12 (n)
(Ornithorhynchus anatinus)
Mammalia GPR171 31
  • 83 (a)
(Gallus gallus)
Aves GPR171 31 30
  • 68.91 (n)
(Anolis carolinensis)
Reptilia GPR171 31
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497564 30
  • 65.58 (n)
(Danio rerio)
Actinopterygii LOC572354 30
  • 56.97 (n)
GPR171 31
  • 47 (a)
Species where no ortholog for GPR171 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR171 Gene

Gene Tree for GPR171 (if available)
Gene Tree for GPR171 (if available)
Evolutionary constrained regions (ECRs) for GPR171: view image

Paralogs for GPR171 Gene

Paralogs for GPR171 Gene

(10) SIMAP similar genes for GPR171 Gene using alignment to 2 proteins:

  • GP171_HUMAN
  • C9JR91_HUMAN
genes like me logo Genes that share paralogs with GPR171: view

Variants for GPR171 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR171 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
709196 Benign: not provided 151,199,372(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs3732756 - p.Ile283Val

Additional dbSNP identifiers (rs#s) for GPR171 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR171 Gene

Variant ID Type Subtype PubMed ID
esv2759188 CNV gain 17122850
nsv592045 CNV gain 21841781

Variation tolerance for GPR171 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR171 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR171 Gene

Disorders for GPR171 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR171 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 21, multiple types
  • ctrct21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR171

genes like me logo Genes that share disorders with GPR171: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR171 Gene

Publications for GPR171 Gene

  1. A genetic selection for isolating cDNAs encoding secreted proteins. (PMID: 9370294) Jacobs KA … McCoy JM (Gene 1997) 2 3 4 54
  2. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. (PMID: 24043826) Gomes I … Devi LA (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 54
  3. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T … Sankila EM (American journal of human genetics 2001) 3 4 54
  4. GPR171 expression enhances proliferation and metastasis of lung cancer cells. (PMID: 26760963) Dho SH … Kwon KS (Oncotarget 2016) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for GPR171 Gene

Sources for GPR171 Gene