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Aliases for GPR171 Gene
Aliases for GPR171 Gene
External Ids for GPR171 Gene
- HGNC: 30057
- Entrez Gene: 29909
- Ensembl: ENSG00000174946
- UniProtKB: O14626
Previous GeneCards Identifiers for GPR171 Gene
- GC03M152398
- GC03M150915
- GC03M148288
Summaries for GPR171 Gene
GeneCards Summary for GPR171 Gene
GPR171 (G Protein-Coupled Receptor 171) is a Protein Coding gene. Diseases associated with GPR171 include Cataract 21, Multiple Types. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.
UniProtKB/Swiss-Prot Summary for GPR171 Gene
-
Orphan receptor.
Additional gene information for GPR171 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR171 Gene
Genomics for GPR171 Gene
GeneHancer (GH) Regulatory Elements for GPR171 Gene
Promoters and enhancers for GPR171 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR171 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR171
- Top Transcription factor binding sites by QIAGEN in the GPR171 gene promoter:
-
- Bach1
- C/EBPbeta
- Elk-1
- ER-alpha
- FOXL1
- NF-AT
- NF-AT2
- NF-AT3
- RORalpha2
Genomic Locations for GPR171 Gene
Genomic Locations for GPR171 Gene
- chr3:151,197,754-151,203,222
- (GRCh38/hg38)
- Size:
- 5,469 bases
- Orientation:
- Minus strand
- chr3:150,915,619-150,920,988
- (GRCh37/hg19)
- Size:
- 5,370 bases
- Orientation:
- Minus strand
Genomic View for GPR171 Gene
Genes around GPR171 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q25.1 by HGNC
- 3q25.1 by Entrez Gene
- 3q25.1 by Ensembl
GPR171 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR171 Gene
Proteins for GPR171 Gene
-
Protein details for GPR171 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14626-GP171_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 171
- Protein Accession:
- O14626
- D3DNJ4
- Q8IV06
Protein attributes for GPR171 Gene
- Size:
- 319 amino acids
- Molecular mass:
- 36754 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR171 Gene
Post-translational modifications for GPR171 Gene
Other Protein References for GPR171 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences GPR171 Antibody (LS-A1225) and GPR171 Antibody (LS-B8182)
- Creative Diagnostics Anti-GPR171 monoclonal antibody
- Novus Biologicals Antibodies for GPR171
- Invitrogen Antibodies for GPR171 (AFLGC-GPR171)
-
Biorbyt antibodies for GPR171
-
Boster Bio Antibodies for GPR171
Protein Products
-
OriGene Purified Proteins for GPR171
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR171
- Origene Custom Protein Services for GPR171
- antibodies-online: Show 4 available GPR171 Proteins ranked by validation data
- Compare Top GPR171 Proteins
-
Quality Products:
No data available for DME Specific Peptides for GPR171 Gene
Domains & Families for GPR171 Gene
Gene Families for GPR171 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GPR171 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR171 Gene
- GenScript: Design optimal peptide antigens:
-
- G-protein coupled receptor H963 (GP171_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14626- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR171 Gene
Molecular function for GPR171 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
Phenotypes From GWAS Catalog for GPR171 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | NAS | 9370294 |
| GO:0045028 | G protein-coupled purinergic nucleotide receptor activity | IBA | 21873635 |
Phenotypes for GPR171 Gene
- GenomeRNAi human phenotypes for GPR171:
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR171
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR171 - Select products 50% OFF >
- * GPR171 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR171
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR171
- genomics-online: gRNA clones - Search for available GPR171 gRNA products
- Overview of 96 available GPR171 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR171
miRNA for GPR171 Gene
- miRTarBase miRNAs that target GPR171
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR171
- Browse OriGene Inhibitory RNA Products For GPR171
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR171
- genomics-online: shRNA clones - Search for available GPR171 shRNA products
- Overview of 96 available GPR171 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GPR171 - Select products 50% OFF >
- * GPR171 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for GPR171
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR171
- genomics-online: cdna clones - Search for available GPR171 CDNA products
- Overview of 96 available GPR171 gene related products
- orf clones - Search for available GPR171 ORF products
- Overview of 96 available GPR171 gene related products
Cell Line Products
-
Horizon Cell Lines for GPR171
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR171 Gene
Localization for GPR171 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR171 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 9370294 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR171 Gene
Pathways & Interactions for GPR171 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
Pathways by source for GPR171 Gene
1 BioSystems pathway for GPR171 Gene
;
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | NAS | 9370294 |
| GO:0035589 | G protein-coupled purinergic nucleotide receptor signaling pathway | IEA | -- |
| GO:0045638 | negative regulation of myeloid cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for GPR171 Gene
Transcripts for GPR171 Gene
mRNA/cDNA for GPR171 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309180 1810 bps (ENST00000309180.6)
- ENST00000480322 205 bps (ENST00000480322.1)
- ENST00000617554 960 bps (ENST00000617554.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR171 - Select products 50% OFF >
- * GPR171 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR171
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR171
- genomics-online: gRNA clones - Search for available GPR171 gRNA products
- Overview of 96 available GPR171 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR171
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR171
- Browse OriGene Inhibitory RNA Products For GPR171
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR171
- genomics-online: shRNA clones - Search for available GPR171 shRNA products
- Overview of 96 available GPR171 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GPR171 - Select products 50% OFF >
- * GPR171 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for GPR171
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR171
- genomics-online: cdna clones - Search for available GPR171 CDNA products
- Overview of 96 available GPR171 gene related products
- orf clones - Search for available GPR171 ORF products
- Overview of 96 available GPR171 gene related products
Relevant External Links for GPR171 Gene
- GeneLoc Exon Structure for
- GPR171
Expression for GPR171 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
mRNA differential expression in normal tissues according to GTEx for GPR171 Gene
This gene is overexpressed in Whole Blood (x10.6), Spleen (x6.8), and Small Intestine - Terminal Ileum (x6.4).
This gene is overexpressed in CD4 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR171 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR171
SOURCE GeneReport for Unigene cluster for GPR171 Gene:
Hs.549152Evidence on tissue expression from TISSUES for GPR171 Gene
- Blood(4.2)
- Pancreas(4)
Primer Products
-
OriGene qPCR primer pairs for GPR171
-
OriGene qPCR primer pairs and template standards for GPR171
- genomics-online: primer clones - Search for available GPR171 Primer products
- Overview of 96 available GPR171 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR171 Gene
Orthologs for GPR171 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR171 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GPR171 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GPR171 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GPR171 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gpr171 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gpr171 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR171 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR171 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GPR171 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100497564 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC572354 30 |
|
||
| GPR171 31 |
|
OneToOne |
- Species where no ortholog for GPR171 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GPR171 Gene
- ENSEMBL:
- Gene Tree for GPR171 (if available)
- TreeFam:
- Gene Tree for GPR171 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR171: view image
Paralogs for GPR171 Gene
Variants for GPR171 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759188 | CNV | gain | 17122850 |
| nsv592045 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.54;
55.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR171 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR171
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR171 Gene
Disorders for GPR171 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cataract 21, multiple types |
|
|
Search GPR171 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR171
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR171 Gene
Publications for GPR171 Gene
- A genetic selection for isolating cDNAs encoding secreted proteins. (PMID: 9370294) Jacobs KA … McCoy JM (Gene 1997) 2 3 4 54
- GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. (PMID: 24043826) Gomes I … Devi LA (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 54
- Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T … Sankila EM (American journal of human genetics 2001) 3 4 54
- GPR171 expression enhances proliferation and metastasis of lung cancer cells. (PMID: 26760963) Dho SH … Kwon KS (Oncotarget 2016) 3 54
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
ExternalLinks
Products for GPR171 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GPR171
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR171
- Origene Custom Protein Services for GPR171
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR171
- Browse OriGene Inhibitory RNA Products For GPR171
- OriGene qPCR primer pairs for GPR171
- OriGene qPCR primer pairs and template standards for GPR171
- OriGene CRISPR knockouts for GPR171
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GPR171
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GPR171
- Novus Biologicals proteins and lysates for GPR171
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for GPR171
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GPR171 (AFLGC-GPR171)
- VectorBuilder Custom and pre-made DNA vectors for GPR171 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GPR171 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GPR171 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GPR171 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GPR171
- Addgene plasmids for GPR171
- antibodies-online: Show 26 available GPR171 Antibodies ranked by validation data
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- antibodies-online: Search results for available GPR171 related products ranked by validation data
- antibodies-online: Show 4 available GPR171 Proteins ranked by validation data
- Compare Top GPR171 Proteins
- Quality Products:
- Horizon Cell Lines for GPR171
- genomics-online: cdna clones - Search for available GPR171 CDNA products
- Overview of 96 available GPR171 gene related products
- orf clones - Search for available GPR171 ORF products
- Overview of 96 available GPR171 gene related products
- genomics-online: gRNA clones - Search for available GPR171 gRNA products
- Overview of 96 available GPR171 gene related products
- genomics-online: primer clones - Search for available GPR171 Primer products
- Overview of 96 available GPR171 gene related products
- genomics-online: shRNA clones - Search for available GPR171 shRNA products
- Overview of 96 available GPR171 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR171
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR171
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- Boster Bio Antibodies for GPR171
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- Biorbyt antibodies for GPR171
Sources for GPR171 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
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- (40) HGMD
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- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
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- (97) Taconic Biosciences
- (98) GTEx
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- (100) SCBT
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- (103) RVIS
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- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
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- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
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- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
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- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
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- (163) Bio Basic
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- (165) GtRNAdb
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- (168) LNCipedia
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