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GPR171 Gene(Protein Coding)

G Protein-Coupled Receptor 171

GCID:
GC03M151197
GIFtS:
43
Genes Participants
UDN Logo

Aliases for GPR171 Gene

Aliases for GPR171 Gene

  • G Protein-Coupled Receptor 171 2 3 5
  • Platelet Activating Receptor Homolog 2 3
  • G-Protein Coupled Receptor H963 3 4
  • H963 3 4
  • Probable G-Protein Coupled Receptor 171 3
  • F730001G15Rik 3

External Ids for GPR171 Gene

Previous GeneCards Identifiers for GPR171 Gene

  • GC03M152398
  • GC03M150915
  • GC03M148288

Summaries for GPR171 Gene

GeneCards Summary for GPR171 Gene

GPR171 (G Protein-Coupled Receptor 171) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR171 Gene

  • Orphan receptor.

Gene Wiki entry for GPR171 Gene

Additional gene information for GPR171 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR171 Gene

Genomics for GPR171 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for GPR171 Gene

Promoters and enhancers for GPR171 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I151199 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1629 4.3 SMAD1 NFIA NFIB NFIC LCORL POLR2A BCL11A NFATC1 ATF7 RUNX3 GPR171 P2RY14 AADAC AADACL2 RNA5SP145 MED12L
GH03I151203 Enhancer 0.4 ENCODE dbSUPER 550.8 -1.4 -1400 1.4 GPR171 GC03M151222 MED12L
GH03I151182 Enhancer 0.7 FANTOM5 ENCODE 6.8 +19.8 19760 1.3 SREBF1 USF1 ZSCAN16 HLF P2RY14 MED12L GPR87 GPR171 AADAC GC03P151189 GC03M151148
GH03I150759 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 +440.5 440473 7.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 SIAH2 SIAH2-AS1 TSC22D2 SERP1 GPR171 SELENOT LOC105374155
GH03I151209 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -7.3 -7318 2.4 ELF3 SOX13 CTCF TFAP4 FOXA2 TAF1 SAP130 ZNF644 RAD21 ZNF48 P2RY14 GPR87 MED12L GPR171 GC03M151222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR171 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR171 gene promoter:

Genomic Locations for GPR171 Gene

Genomic Locations for GPR171 Gene
chr3:151,197,754-151,203,222
(GRCh38/hg38)
Size:
5,469 bases
Orientation:
Minus strand
chr3:150,915,619-150,920,988
(GRCh37/hg19)

Genomic View for GPR171 Gene

Genes around GPR171 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR171 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR171 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR171 Gene

Proteins for GPR171 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPR171 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14626-GP171_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 171
    Protein Accession:
    O14626
    Secondary Accessions:
    • D3DNJ4
    • Q8IV06

    Protein attributes for GPR171 Gene

    Size:
    319 amino acids
    Molecular mass:
    36754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR171 Gene

Protein Expression for GPR171 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPR171 Gene

  • Glycosylation at posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR171 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR171 Gene

Domains & Families for GPR171 Gene

Gene Families for GPR171 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR171 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR171 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14626

UniProtKB/Swiss-Prot:

GP171_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR171: view

Function for GPR171 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GPR171 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 9370294
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR171: view
genes like me logo Genes that share phenotypes with GPR171: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR171

miRNA for GPR171 Gene

miRTarBase miRNAs that target GPR171

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR171 Gene

Localization for GPR171 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR171 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR171 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9370294
genes like me logo Genes that share ontologies with GPR171: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR171 Gene

Pathways & Interactions for GPR171 Gene

genes like me logo Genes that share pathways with GPR171: view

Pathways by source for GPR171 Gene

1 BioSystems pathway for GPR171 Gene

Interacting Proteins for GPR171 Gene

Selected Interacting proteins: O14626-GP171_HUMAN for GPR171 Gene via IID

Gene Ontology (GO) - Biological Process for GPR171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 9370294
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0045638 negative regulation of myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with GPR171: view

No data available for SIGNOR curated interactions for GPR171 Gene

Drugs & Compounds for GPR171 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GPR171 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GPR171 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR171 Gene

G protein-coupled receptor 171:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR171 Gene

No ASD Table

Relevant External Links for GPR171 Gene

GeneLoc Exon Structure for
GPR171
ECgene alternative splicing isoforms for
GPR171

Expression for GPR171 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR171 Gene

mRNA expression in normal human tissues for GPR171 Gene
mRNA expression by BioGPS for GPR171 GenemRNA expression by GTEx for GPR171 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR171 Gene

This gene is overexpressed in Whole Blood (x10.6), Spleen (x6.8), and Small Intestine - Terminal Ileum (x6.4).

Protein differential expression in normal tissues from HIPED for GPR171 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR171 Gene



Protein tissue co-expression partners for GPR171 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR171 Gene:

GPR171

SOURCE GeneReport for Unigene cluster for GPR171 Gene:

Hs.549152

Evidence on tissue expression from TISSUES for GPR171 Gene

  • Blood(4.2)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with GPR171: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR171 Gene

Orthologs for GPR171 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR171 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR171 33 34
  • 100 (n)
cow
(Bos Taurus)
 Mammalia GPR171 33 34
  • 88.92 (n)
dog
(Canis familiaris)
 Mammalia GPR171 33 34
  • 87.88 (n)
oppossum
(Monodelphis domestica)
 Mammalia GPR171 34
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpr171 33 16 34
  • 85.85 (n)
rat
(Rattus norvegicus)
 Mammalia Gpr171 33
  • 85.12 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia GPR171 34
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GPR171 33 34
  • 68.91 (n)
lizard
(Anolis carolinensis)
 Reptilia GPR171 34
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100497564 33
  • 65.58 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC572354 33
  • 56.97 (n)
GPR171 34
  • 47 (a)
 OneToOne
Species where no ortholog for GPR171 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR171 Gene

ENSEMBL:
Gene Tree for GPR171 (if available)
TreeFam:
Gene Tree for GPR171 (if available)

Paralogs for GPR171 Gene

Paralogs for GPR171 Gene

(10) SIMAP similar genes for GPR171 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR171: view

Variants for GPR171 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for GPR171 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000808796 -- 151,202,692(-) A/T genic_upstream_transcript_variant, intron_variant
rs1001050057 -- 151,200,233(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001870958 -- 151,199,923(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002492520 -- 151,199,557(-) C/G intron_variant
rs1002671193 -- 151,204,838(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR171 Gene

Variant ID Type Subtype PubMed ID
esv2759188 CNV gain 17122850
nsv592045 CNV gain 21841781

Variation tolerance for GPR171 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR171 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR171

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR171 Gene

Disorders for GPR171 Gene

Additional Disease Information for GPR171

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR171 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR171 Gene

Publications for GPR171 Gene

  1. A genetic selection for isolating cDNAs encoding secreted proteins. (PMID: 9370294) Jacobs KA … McCoy JM (Gene 1997) 2 3 4 58
  2. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. (PMID: 24043826) Gomes I … Devi LA (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 58
  3. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T … Sankila EM (American journal of human genetics 2001) 3 4 58
  4. GPR171 expression enhances proliferation and metastasis of lung cancer cells. (PMID: 26760963) Dho SH … Kwon KS (Oncotarget 2016) 3 58
  5. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay IC … Ouwehand WH (Blood 2007) 3 58

Products for GPR171 Gene

Sources for GPR171 Gene

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