Aliases for GPR17 Gene

Aliases for GPR17 Gene

  • G Protein-Coupled Receptor 17 2 3 5
  • Uracil Nucleotide/Cysteinyl Leukotriene Receptor 3 4
  • UDP/CysLT Receptor 3 4
  • P2Y-Like Receptor 3 4
  • R12 3 4
  • G-Protein Coupled Receptor 17 4
  • GPR17 5

External Ids for GPR17 Gene

Previous GeneCards Identifiers for GPR17 Gene

  • GC02P125701
  • GC02P126328
  • GC02P128308
  • GC02P128497
  • GC02P128119
  • GC02P128403
  • GC02P120709

Summaries for GPR17 Gene

GeneCards Summary for GPR17 Gene

GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Diseases associated with GPR17 include Muscular Dystrophy, Autosomal Recessive, With Cardiomyopathy And Triangular Tongue and Suppression Amblyopia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CYSLTR2.

UniProtKB/Swiss-Prot Summary for GPR17 Gene

  • Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Wiki entry for GPR17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR17 Gene

Genomics for GPR17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR17

Top Transcription factor binding sites by QIAGEN in the GPR17 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • HEN1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-5

Genomic Locations for GPR17 Gene

Latest Assembly
chr2:127,645,864-127,652,639
(GRCh38/hg38)
Size:
6,776 bases
Orientation:
Plus strand

Previous Assembly
chr2:128,403,728-128,410,213
(GRCh37/hg19 by Entrez Gene)
Size:
6,486 bases
Orientation:
Plus strand

chr2:128,403,439-128,410,213
(GRCh37/hg19 by Ensembl)
Size:
6,775 bases
Orientation:
Plus strand

Genomic View for GPR17 Gene

Genes around GPR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR17 Gene

Proteins for GPR17 Gene

  • Protein details for GPR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13304-GPR17_HUMAN
    Recommended name:
    Uracil nucleotide/cysteinyl leukotriene receptor
    Protein Accession:
    Q13304
    Secondary Accessions:
    • A8K9L0
    • B2R9X0
    • Q8N5S7
    • Q9UDZ6
    • Q9UE21

    Protein attributes for GPR17 Gene

    Size:
    367 amino acids
    Molecular mass:
    40989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR17 Gene

Post-translational modifications for GPR17 Gene

  • Glycosylation at Asn42, Asn204, and Asn282
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR17 Gene

Domains & Families for GPR17 Gene

Gene Families for GPR17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR17 Gene

InterPro:
Blocks:
  • P2 purinoceptor signature

Suggested Antigen Peptide Sequences for GPR17 Gene

GenScript: Design optimal peptide antigens:
  • R12 (GPR17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13304

UniProtKB/Swiss-Prot:

GPR17_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR17: view

Function for GPR17 Gene

Molecular function for GPR17 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Phenotypes From GWAS Catalog for GPR17 Gene

Gene Ontology (GO) - Molecular Function for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004950 chemokine receptor activity TAS 8558062
GO:0033612 receptor serine/threonine kinase binding IEA --
genes like me logo Genes that share ontologies with GPR17: view
genes like me logo Genes that share phenotypes with GPR17: view

Animal Models for GPR17 Gene

MGI Knock Outs for GPR17:

Animal Models for research

  • Taconic Biosciences Mouse Models for GPR17

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR17

Clone products for research

  • Addgene plasmids for GPR17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR17 Gene

Localization for GPR17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR17 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR17 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR17: view

Pathways & Interactions for GPR17 Gene

genes like me logo Genes that share pathways with GPR17: view

SIGNOR curated interactions for GPR17 Gene

Activates:

Gene Ontology (GO) - Biological Process for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA 21873635
GO:0048709 oligodendrocyte differentiation IEA --
genes like me logo Genes that share ontologies with GPR17: view

Drugs & Compounds for GPR17 Gene

(12) Drugs for GPR17 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uracil Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist 0
ASN02563583 Pharma Agonist 0
ASN04421891 Pharma Agonist 0
ASN04450772 Pharma Agonist 0

(1) Additional Compounds for GPR17 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
UDP
Agonist
genes like me logo Genes that share compounds with GPR17: view

Transcripts for GPR17 Gene

mRNA/cDNA for GPR17 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR17

Clone products for research

  • Addgene plasmids for GPR17

Alternative Splicing Database (ASD) splice patterns (SP) for GPR17 Gene

No ASD Table

Relevant External Links for GPR17 Gene

GeneLoc Exon Structure for
GPR17

Expression for GPR17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR17 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for GPR17 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR17 Gene



Protein tissue co-expression partners for GPR17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR17

SOURCE GeneReport for Unigene cluster for GPR17 Gene:

Hs.46453

mRNA Expression by UniProt/SwissProt for GPR17 Gene:

Q13304-GPR17_HUMAN
Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.

Evidence on tissue expression from TISSUES for GPR17 Gene

  • Nervous system(4.9)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with GPR17: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR17 Gene

Orthologs for GPR17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR17 29 30
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR17 29 30
  • 90.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR17 29 30
  • 87.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpr17 29 16 30
  • 84.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr17 29
  • 83.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia GPR17 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GPR17 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR17 29 30
  • 74.01 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR17 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr17 29
  • 57.72 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-194h10.4 29
  • 59.25 (n)
GPR17 30
  • 55 (a)
OneToOne
Species where no ortholog for GPR17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR17 Gene

ENSEMBL:
Gene Tree for GPR17 (if available)
TreeFam:
Gene Tree for GPR17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR17: view image
Alliance of Genome Resources:
Additional Orthologs for GPR17

Paralogs for GPR17 Gene

genes like me logo Genes that share paralogs with GPR17: view

Variants for GPR17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR17 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
1029142 Uncertain Significance: Muscular dystrophy, limb-girdle, type 2W 127,651,723(+) G/A
NM_001161403.3(LIMS2):c.359+2701C>T
MISSENSE_VARIANT,INTRON
1029143 Pathogenic: Muscular dystrophy, limb-girdle, type 2W 127,650,907(+) C/T
NM_001161403.3(LIMS2):c.359+3517G>A
NONSENSE,INTRON
rs201325616 Likely Benign: not provided 127,651,176(+) C/T
NM_001161415.1(GPR17):c.525C>T (p.Tyr175=)
SYNONYMOUS_VARIANT,INTRON
rs61738377 Benign: not provided 127,650,815(+) C/T
NM_001161415.1(GPR17):c.164C>T (p.Thr55Met)
MISSENSE_VARIANT,INTRON
rs6708099 Benign: not provided 127,651,269(+) G/A
NM_001161415.1(GPR17):c.618G>A (p.Thr206=)
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR17 Gene

Variant ID Type Subtype PubMed ID
dgv4068n100 CNV gain 25217958
dgv4069n100 CNV gain 25217958
nsv470482 CNV loss 18288195
nsv508864 CNV insertion 20534489
nsv517532 CNV loss 19592680
nsv518085 CNV loss 19592680
nsv583038 CNV loss 21841781
nsv953155 CNV deletion 24416366

Variation tolerance for GPR17 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR17
Leiden Open Variation Database (LOVD)
GPR17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR17 Gene

Disorders for GPR17 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPR17 Gene - From: CVR and COP

- elite association - COSMIC cancer census association via MalaCards
Search GPR17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR17

genes like me logo Genes that share disorders with GPR17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR17 Gene

Publications for GPR17 Gene

  1. New members of the chemokine receptor gene family. (PMID: 8558062) Raport CJ … Gray PW (Journal of leukocyte biology 1996) 2 3 4
  2. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (PMID: 16990797) Ciana P … Abbracchio MP (The EMBO journal 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. (PMID: 9523551) Bläsius R … Ogilvie A (Journal of neurochemistry 1998) 3 4
  5. FLIM-FRET-Based Structural Characterization of a Class-A GPCR Dimer in the Cell Membrane. (PMID: 32553728) Yang J … Zhang WP (Journal of molecular biology 2020) 3

Products for GPR17 Gene

Sources for GPR17 Gene