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Aliases for GPR17 Gene

Aliases for GPR17 Gene

  • G Protein-Coupled Receptor 17 2 3 5
  • UDP/CysLT Receptor 3 4
  • P2Y-Like Receptor 3 4
  • R12 3 4
  • Uracil Nucleotide/Cysteinyl Leukotriene Receptor 3
  • G-Protein Coupled Receptor 17 4

External Ids for GPR17 Gene

Previous GeneCards Identifiers for GPR17 Gene

  • GC02P125701
  • GC02P126328
  • GC02P128308
  • GC02P128497
  • GC02P128119
  • GC02P128403
  • GC02P120709

Summaries for GPR17 Gene

GeneCards Summary for GPR17 Gene

GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Eicosanoid ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CYSLTR2.

UniProtKB/Swiss-Prot for GPR17 Gene

  • Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Wiki entry for GPR17 Gene

Additional gene information for GPR17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR17 Gene

Genomics for GPR17 Gene

GeneHancer (GH) Regulatory Elements for GPR17 Gene

Promoters and enhancers for GPR17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J127646 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.3 270 0.1 GPR17 GC02P127672 PIR41862 LIMS2
GH02J127647 Enhancer 0.7 Ensembl dbSUPER 650.7 +1.3 1337 1.6 RXRA ZNF184 KLF16 REST GPR17 ENSG00000272789 MYO7B GC02P127672 PIR41862 LIMS2
GH02J127644 Enhancer 0.5 Ensembl dbSUPER 650.7 -1.4 -1363 0.2 ZNF24 GPR17 LOC101927834 LIMS2
GH02J127385 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17 -257.4 -257437 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000236682 MAP3K2 ERCC3 AMMECR1L GPR17 WDR33 SAP130 ENSG00000231731 SFT2D3 GC02P127390
GH02J127635 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.1 -6.8 -6769 7.8 HDAC1 ARID4B KLF17 SIN3A DMAP1 RAD21 ZNF48 GLIS2 EGR1 ZNF207 GPR17 MYO7B ENSG00000272789 LIMS2 ENSG00000236682 MAP3K2 ERCC3 LOC101927834
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR17 gene promoter:
  • Lmo2
  • Pax-5
  • AP-1
  • c-Fos
  • c-Jun
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • HEN1

Genomic Locations for GPR17 Gene

Genomic Locations for GPR17 Gene
6,776 bases
Plus strand
6,775 bases
Plus strand

Genomic View for GPR17 Gene

Genes around GPR17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR17 Gene

Proteins for GPR17 Gene

  • Protein details for GPR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uracil nucleotide/cysteinyl leukotriene receptor
    Protein Accession:
    Secondary Accessions:
    • A8K9L0
    • B2R9X0
    • Q8N5S7
    • Q9UDZ6
    • Q9UE21

    Protein attributes for GPR17 Gene

    367 amino acids
    Molecular mass:
    40989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR17 Gene


neXtProt entry for GPR17 Gene

Post-translational modifications for GPR17 Gene

  • Glycosylation at isoforms=2282, Asn204, and Asn42
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR17 Gene

No data available for DME Specific Peptides for GPR17 Gene

Domains & Families for GPR17 Gene

Gene Families for GPR17 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR17 Gene

Suggested Antigen Peptide Sequences for GPR17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR17: view

Function for GPR17 Gene

Molecular function for GPR17 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Phenotypes From GWAS Catalog for GPR17 Gene

Gene Ontology (GO) - Molecular Function for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IBA,IEA --
GO:0004950 chemokine receptor activity TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view
genes like me logo Genes that share phenotypes with GPR17: view

Animal Models for GPR17 Gene

MGI Knock Outs for GPR17:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR17

miRNA for GPR17 Gene

miRTarBase miRNAs that target GPR17

Clone Products

  • Addgene plasmids for GPR17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR17 Gene

Localization for GPR17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR17 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR17 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8558062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR17: view

Pathways & Interactions for GPR17 Gene

genes like me logo Genes that share pathways with GPR17: view

Gene Ontology (GO) - Biological Process for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IBA --
GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with GPR17: view

No data available for SIGNOR curated interactions for GPR17 Gene

Drugs & Compounds for GPR17 Gene

(12) Drugs for GPR17 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uracil Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
ASN02563583 Pharma Agonist 0
ASN04421891 Pharma Agonist 0
ASN04450772 Pharma Agonist 0

(1) Additional Compounds for GPR17 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Agonist, Full agonist
genes like me logo Genes that share compounds with GPR17: view

Transcripts for GPR17 Gene

Unigene Clusters for GPR17 Gene

G protein-coupled receptor 17:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR17

Alternative Splicing Database (ASD) splice patterns (SP) for GPR17 Gene

No ASD Table

Relevant External Links for GPR17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR17 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for GPR17 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR17 Gene

Protein tissue co-expression partners for GPR17 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR17 Gene:


SOURCE GeneReport for Unigene cluster for GPR17 Gene:


mRNA Expression by UniProt/SwissProt for GPR17 Gene:

Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.

Evidence on tissue expression from TISSUES for GPR17 Gene

  • Nervous system(4.9)
  • Kidney(4)
genes like me logo Genes that share expression patterns with GPR17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR17 Gene

Orthologs for GPR17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR17 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia GPR17 34 33
  • 90.46 (n)
(Bos Taurus)
Mammalia GPR17 34 33
  • 87.32 (n)
(Mus musculus)
Mammalia Gpr17 16 34 33
  • 84.37 (n)
(Rattus norvegicus)
Mammalia Gpr17 33
  • 83.78 (n)
(Monodelphis domestica)
Mammalia GPR17 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GPR17 34
  • 77 (a)
(Gallus gallus)
Aves GPR17 34 33
  • 74.01 (n)
(Anolis carolinensis)
Reptilia GPR17 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr17 33
  • 57.72 (n)
(Danio rerio)
Actinopterygii si:ch73-194h10.4 33
  • 59.25 (n)
GPR17 34
  • 55 (a)
Species where no ortholog for GPR17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR17 Gene

Gene Tree for GPR17 (if available)
Gene Tree for GPR17 (if available)
Evolutionary constrained regions (ECRs) for GPR17: view image

Paralogs for GPR17 Gene

genes like me logo Genes that share paralogs with GPR17: view

Variants for GPR17 Gene

Sequence variations from dbSNP and Humsavar for GPR17 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000023950 -- 127,652,732(+) T/C downstream_transcript_variant
rs1000035540 -- 127,647,396(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000118169 -- 127,652,975(+) G/A downstream_transcript_variant
rs1000435329 -- 127,644,179(+) G/A upstream_transcript_variant
rs1000636411 -- 127,646,212(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR17 Gene

Variant ID Type Subtype PubMed ID
dgv4068n100 CNV gain 25217958
dgv4069n100 CNV gain 25217958
nsv470482 CNV loss 18288195
nsv508864 CNV insertion 20534489
nsv517532 CNV loss 19592680
nsv518085 CNV loss 19592680
nsv583038 CNV loss 21841781
nsv953155 CNV deletion 24416366

Variation tolerance for GPR17 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR17 Gene

Disorders for GPR17 Gene

Additional Disease Information for GPR17

No disorders were found for GPR17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR17 Gene

Publications for GPR17 Gene

  1. New members of the chemokine receptor gene family. (PMID: 8558062) Raport CJ … Gray PW (Journal of leukocyte biology 1996) 2 3 4 58
  2. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (PMID: 16990797) Ciana P … Abbracchio MP (The EMBO journal 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. (PMID: 9523551) Bläsius R … Ogilvie A (Journal of neurochemistry 1998) 3 4 58
  5. The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes. (PMID: 28254957) Simon K … Kostenis E (Molecular pharmacology 2017) 3 58

Products for GPR17 Gene

Sources for GPR17 Gene

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