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Aliases for GPR162 Gene

Aliases for GPR162 Gene

  • G Protein-Coupled Receptor 162 2 3 5
  • Gene-Rich Cluster Gene A Protein 3 4
  • GRCA 3 4
  • Probable G-Protein Coupled Receptor 162 3
  • Gene Rich Cluster, A 3
  • A-2 3

External Ids for GPR162 Gene

Previous GeneCards Identifiers for GPR162 Gene

  • GC12P006941
  • GC12P006987
  • GC12P006997
  • GC12P007004
  • GC12P007013
  • GC12P007030
  • GC12P007051
  • GC12P007108
  • GC12P007135

Summaries for GPR162 Gene

Entrez Gene Summary for GPR162 Gene

  • This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR162 Gene

GPR162 (G Protein-Coupled Receptor 162) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR153.

UniProtKB/Swiss-Prot for GPR162 Gene

  • Orphan receptor.

Gene Wiki entry for GPR162 Gene

Additional gene information for GPR162 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR162 Gene

Genomics for GPR162 Gene

GeneHancer (GH) Regulatory Elements for GPR162 Gene

Promoters and enhancers for GPR162 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006820 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 87 2.7 HDGF ZSCAN4 KLF17 ZNF335 GLIS2 ZNF366 EGR2 PAF1 ZNF263 SP3 GPR162 CHD4 ZNF384 EMG1 C1RL P3H3 CD4
GH12I006788 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 -30.5 -30469 5 HDGF ELF3 FOXA2 MLX ARID4B SIN3A RAD21 THRB ZNF48 RARA CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12I006722 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -97.5 -97492 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 COPS7A ENSG00000270068 ENSG00000219410 CHD4 ZNF384 NOP2 ATN1 ENSG00000247853 NCAPD2 GNB3
GH12I006777 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.4 -42.6 -42565 2.9 HDGF PKNOX1 FOXA2 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 GPR162 P3H3 EMG1 ZNF384 ENSG00000219410 ING4 PIANP NOP2 ACRBP LPAR5
GH12I006784 Enhancer 1 Ensembl ENCODE dbSUPER 12.4 -35.6 -35630 3.3 ZNF223 MAFG ZFHX2 ZNF316 MAFF ZNF341 EMSY MAFK SPI1 CD4 RN7SL380P GPR162 P3H3 ZNF384 ENSG00000219410 ING4 ACRBP PIANP LPAR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR162 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR162 gene promoter:

Genomic Locations for GPR162 Gene

Genomic Locations for GPR162 Gene
8,428 bases
Plus strand

Genomic View for GPR162 Gene

Genes around GPR162 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR162 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR162 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR162 Gene

Proteins for GPR162 Gene

  • Protein details for GPR162 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 162
    Protein Accession:
    Secondary Accessions:
    • Q16664
    • Q59EH5
    • Q66K56

    Protein attributes for GPR162 Gene

    588 amino acids
    Molecular mass:
    63930 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR162 Gene


neXtProt entry for GPR162 Gene

Post-translational modifications for GPR162 Gene

Other Protein References for GPR162 Gene

No data available for DME Specific Peptides for GPR162 Gene

Domains & Families for GPR162 Gene

Gene Families for GPR162 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GPR162 Gene

Suggested Antigen Peptide Sequences for GPR162 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR162: view

Function for GPR162 Gene

Molecular function for GPR162 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR162 Gene

Gene Ontology (GO) - Molecular Function for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR162: view
genes like me logo Genes that share phenotypes with GPR162: view

Animal Model Products

CRISPR Products

miRNA for GPR162 Gene

miRTarBase miRNAs that target GPR162

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR162 Gene

Localization for GPR162 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR162 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR162 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR162: view

Pathways & Interactions for GPR162 Gene

SuperPathways for GPR162 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR162: view

Pathways by source for GPR162 Gene

1 BioSystems pathway for GPR162 Gene

Interacting Proteins for GPR162 Gene

Gene Ontology (GO) - Biological Process for GPR162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR162: view

No data available for SIGNOR curated interactions for GPR162 Gene

Drugs & Compounds for GPR162 Gene

No Compound Related Data Available

Transcripts for GPR162 Gene

Unigene Clusters for GPR162 Gene

G protein-coupled receptor 162:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR162 Gene

No ASD Table

Relevant External Links for GPR162 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR162 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR162 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR162 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x5.5), Brain - Cortex (x5.5), and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR162 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR162 Gene

Protein tissue co-expression partners for GPR162 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR162 Gene:


SOURCE GeneReport for Unigene cluster for GPR162 Gene:


Evidence on tissue expression from TISSUES for GPR162 Gene

  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with GPR162: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR162 Gene

Orthologs for GPR162 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR162 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR162 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia LEPREL2 34
  • 96 (a)
GPR162 33
  • 91.1 (n)
(Bos Taurus)
Mammalia GPR162 33 34
  • 91.04 (n)
(Rattus norvegicus)
Mammalia Gpr162 33
  • 89.63 (n)
(Mus musculus)
Mammalia Gpr162 33 16 34
  • 89.51 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
(Gallus gallus)
Aves GPR162 33 34
  • 72.24 (n)
(Anolis carolinensis)
Reptilia GPR162 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr162 33
  • 61.04 (n)
Species where no ortholog for GPR162 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR162 Gene

Gene Tree for GPR162 (if available)
Gene Tree for GPR162 (if available)

Paralogs for GPR162 Gene

Paralogs for GPR162 Gene

(2) SIMAP similar genes for GPR162 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR162: view

Variants for GPR162 Gene

Sequence variations from dbSNP and Humsavar for GPR162 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000128122 -- 6,821,419(+) A/C upstream_transcript_variant
rs1000506439 -- 6,825,330(+) G/A intron_variant
rs1000577100 -- 6,826,327(+) C/T coding_sequence_variant, missense_variant
rs1001516582 -- 6,821,496(+) A/G upstream_transcript_variant
rs1001850396 -- 6,820,075(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR162 Gene

Variant ID Type Subtype PubMed ID
nsv832324 CNV loss 17160897
nsv832323 CNV loss 17160897
esv3580405 CNV gain 25503493

Variation tolerance for GPR162 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR162 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR162 Gene

Disorders for GPR162 Gene

Additional Disease Information for GPR162

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR162 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR162 Gene

Publications for GPR162 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  2. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam DE … Fredriksson R (Biochimica et biophysica acta 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 3 4 58
  5. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PMID: 8723724) Ansari-Lari MA … Gibbs RA (Genome research 1996) 3 4 58

Products for GPR162 Gene

Sources for GPR162 Gene

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