Aliases for GPR161 Gene
External Ids for GPR161 Gene
Previous GeneCards Identifiers for GPR161 Gene
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
GeneCards Summary for GPR161 Gene
GPR161 (G Protein-Coupled Receptor 161) is a Protein Coding gene. Diseases associated with GPR161 include Pituitary Stalk Interruption Syndrome and Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled amine receptor activity. An important paralog of this gene is HTR4.
UniProtKB/Swiss-Prot Summary for GPR161 Gene
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).