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Aliases for GPR158 Gene

Aliases for GPR158 Gene

  • G Protein-Coupled Receptor 158 2 3 5
  • Probable G-Protein Coupled Receptor 158 3
  • KIAA1136 4

External Ids for GPR158 Gene

Previous GeneCards Identifiers for GPR158 Gene

  • GC10P025467
  • GC10P025504

Summaries for GPR158 Gene

GeneCards Summary for GPR158 Gene

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene. Diseases associated with GPR158 include Smallpox and Steroid-Induced Glaucoma. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR179.

UniProtKB/Swiss-Prot for GPR158 Gene

  • Orphan receptor.

Gene Wiki entry for GPR158 Gene

Additional gene information for GPR158 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR158 Gene

Genomics for GPR158 Gene

GeneHancer (GH) Regulatory Elements for GPR158 Gene

Promoters and enhancers for GPR158 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J025174 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -70 1.1 PKNOX1 ATF1 SIN3A FEZF1 ZNF2 YY1 ETS1 SLC30A9 ZNF766 GLIS2 GC10M025172 GPR158 GPR158-AS1 LINC01516
GH10J024236 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.3 -935.8 -935792 4.5 PKNOX1 FOXA2 ZSCAN4 RFX5 RARA ZSCAN5C SCRT2 HMG20B GATAD2B SP1 GPR158 ENSG00000277563 GC10P024187 KIAA1217
GH10J024951 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 -222.0 -221951 3.4 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A ZNF2 POLR2B ZNF766 ZNF143 PRTFDC1 ENSG00000273107 THNSL1 GPR158 ARHGAP21 RN7SKP241 GC10M024909
GH10J024956 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -216.5 -216510 3.1 HDAC1 ATF1 NFRKB ZBTB40 CHAMP1 TCF12 ZNF766 FOS ZBTB11 NCOA1 PRTFDC1 THNSL1 ARHGAP21 GPR158
GH10J024811 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 1.4 -362.7 -362654 0.3 SOX5 SOX13 FOXA2 TCF7 ARHGAP21 GPR158 LOC105376456 ENSG00000228667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR158 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR158 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • Max
  • c-Myc
  • Arnt
  • AhR
  • FOXF2
  • Evi-1
  • Egr-1
  • Nkx3-1 v4

Genomic Locations for GPR158 Gene

Genomic Locations for GPR158 Gene
427,497 bases
Plus strand
427,168 bases
Plus strand

Genomic View for GPR158 Gene

Genes around GPR158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR158 Gene

Proteins for GPR158 Gene

  • Protein details for GPR158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 158
    Protein Accession:
    Secondary Accessions:
    • Q6QR81
    • Q9ULT3

    Protein attributes for GPR158 Gene

    1215 amino acids
    Molecular mass:
    135489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS18315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR158 Gene

Post-translational modifications for GPR158 Gene

  • Glycosylation at isoforms=333, isoforms=274, Asn215, Asn143, and isoforms=98
  • Ubiquitination at Lys774
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR158 Gene

Domains & Families for GPR158 Gene

Gene Families for GPR158 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR158 Gene


Suggested Antigen Peptide Sequences for GPR158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPR158: view

Function for GPR158 Gene

Molecular function for GPR158 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR158 Gene

Gene Ontology (GO) - Molecular Function for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR158: view
genes like me logo Genes that share phenotypes with GPR158: view

Animal Models for GPR158 Gene

MGI Knock Outs for GPR158:
  • Gpr158 Gpr158<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR158

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR158 Gene

Localization for GPR158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR158 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR158 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

Pathways & Interactions for GPR158 Gene

SuperPathways for GPR158 Gene

No Data Available

Interacting Proteins for GPR158 Gene

Gene Ontology (GO) - Biological Process for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

No data available for Pathways by source and SIGNOR curated interactions for GPR158 Gene

Drugs & Compounds for GPR158 Gene

No Compound Related Data Available

Transcripts for GPR158 Gene

mRNA/cDNA for GPR158 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR158 Gene

G protein-coupled receptor 158:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR158 Gene

No ASD Table

Relevant External Links for GPR158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR158 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.3), Brain - Cerebellum (x6.3), Brain - Putamen (basal ganglia) (x5.5), Brain - Caudate (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GPR158 Gene

This gene is overexpressed in Retina (32.4), Frontal cortex (25.0), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR158 Gene

Protein tissue co-expression partners for GPR158 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR158 Gene:


SOURCE GeneReport for Unigene cluster for GPR158 Gene:


Evidence on tissue expression from TISSUES for GPR158 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with GPR158: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR158 Gene

Orthologs for GPR158 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR158 34 33
  • 99.62 (n)
(Canis familiaris)
Mammalia GPR158 34 33
  • 90.13 (n)
(Bos Taurus)
Mammalia GPR158 34 33
  • 87.29 (n)
(Rattus norvegicus)
Mammalia Gpr158 33
  • 86.29 (n)
(Mus musculus)
Mammalia Gpr158 16 34 33
  • 86.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
-- 34
  • 49 (a)
(Monodelphis domestica)
Mammalia GPR158 34
  • 79 (a)
(Gallus gallus)
Aves GPR158 34 33
  • 75.25 (n)
(Anolis carolinensis)
Reptilia GPR158 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr158 33
  • 64 (n)
(Danio rerio)
Actinopterygii LOC570001 33
  • 60.62 (n)
GPR158 (2 of 2) 34
  • 46 (a)
gpr158a 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta pog 34
  • 16 (a)
CG31760 34
  • 15 (a)
CG43795 34
  • 14 (a)
CG31195 34
  • 10 (a)
(Caenorhabditis elegans)
Secernentea F39B2.8 34
  • 20 (a)
Species where no ortholog for GPR158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR158 Gene

Gene Tree for GPR158 (if available)
Gene Tree for GPR158 (if available)
Evolutionary constrained regions (ECRs) for GPR158: view image

Paralogs for GPR158 Gene

Paralogs for GPR158 Gene

genes like me logo Genes that share paralogs with GPR158: view

Variants for GPR158 Gene

Sequence variations from dbSNP and Humsavar for GPR158 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000000991 -- 25,442,104(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000014352 -- 25,275,767(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000017283 -- 25,413,074(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000028847 -- 25,204,648(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000037831 -- 25,374,112(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR158 Gene

Variant ID Type Subtype PubMed ID
esv1180990 CNV insertion 17803354
esv1997102 CNV deletion 18987734
esv2492571 CNV deletion 19546169
esv2656793 CNV deletion 23128226
esv2659443 CNV deletion 23128226
esv2662962 CNV deletion 23128226
esv2664122 CNV deletion 23128226
esv2668854 CNV deletion 23128226
esv2673507 CNV deletion 23128226
esv2675139 CNV deletion 23128226
esv26962 CNV loss 19812545
esv2734184 CNV deletion 23290073
esv2734195 CNV deletion 23290073
esv2760120 CNV loss 21179565
esv2760160 CNV loss 21179565
esv2761583 CNV gain 21179565
esv2761584 CNV loss 21179565
esv3307161 CNV mobile element insertion 20981092
esv3351033 CNV insertion 20981092
esv3361013 CNV insertion 20981092
esv3394342 CNV insertion 20981092
esv3546035 CNV deletion 23714750
esv3546036 CNV deletion 23714750
esv3546038 CNV deletion 23714750
esv3622660 CNV loss 21293372
esv3622662 CNV gain 21293372
esv3622663 CNV loss 21293372
esv3622665 CNV loss 21293372
esv3622666 CNV loss 21293372
esv3622668 CNV gain 21293372
esv3622669 CNV loss 21293372
esv3622670 CNV loss 21293372
nsv1044482 CNV gain 25217958
nsv1124613 CNV duplication 24896259
nsv1139518 CNV duplication 24896259
nsv25401 CNV deletion 16902084
nsv476033 CNV novel sequence insertion 20440878
nsv509345 CNV insertion 20534489
nsv51 CNV insertion 15895083
nsv550225 CNV loss 21841781
nsv550226 CNV loss 21841781
nsv550227 CNV loss 21841781
nsv6110 CNV insertion 18451855
nsv947771 CNV duplication 23825009
nsv947772 CNV duplication 23825009

Variation tolerance for GPR158 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.98; 96.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR158 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR158 Gene

Disorders for GPR158 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR158 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
steroid-induced glaucoma
  • corticosteroid-induced glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR158

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR158 Gene

Publications for GPR158 Gene

  1. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. (PMID: 25792749) Orlandi C … Martemyanov KA (The Journal of biological chemistry 2015) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D … Taylor PR (International journal of cancer 2008) 3 44 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for GPR158 Gene

Sources for GPR158 Gene

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