Aliases for GPR158 Gene

Aliases for GPR158 Gene

  • G Protein-Coupled Receptor 158 2 3 5
  • Probable G-Protein Coupled Receptor 158 3 4
  • KIAA1136 4

External Ids for GPR158 Gene

Previous GeneCards Identifiers for GPR158 Gene

  • GC10P025467
  • GC10P025504
  • GC10P025124

Summaries for GPR158 Gene

GeneCards Summary for GPR158 Gene

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene. Diseases associated with GPR158 include Night Blindness, Congenital Stationary, Type 1B and Smallpox. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR179.

UniProtKB/Swiss-Prot Summary for GPR158 Gene

Gene Wiki entry for GPR158 Gene

Additional gene information for GPR158 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR158 Gene

Genomics for GPR158 Gene

GeneHancer (GH) Regulatory Elements for GPR158 Gene

Promoters and enhancers for GPR158 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J025174 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 230 1.7 ZNF217 ZSCAN5C REST ZBTB10 AFF1 ZBTB26 SAP30 ZBTB25 CHD1 TGIF2 GPR158 GPR158-AS1 lnc-ENKUR-4
GH10J025176 Promoter 0.7 Ensembl 500.7 +1.4 1363 0.2 REST ZBTB26 HDAC2 EZH2 ZBTB11 ZNF335 SIN3A CHD1 SUZ12 BACH1 GPR158 GPR158-AS1 lnc-ENKUR-4
GH10J024236 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.3 -935.8 -935792 4.5 ZSCAN5C ZIC2 RFX1 ATF2 GATAD2B CTBP1 OSR2 FOXA2 ZBTB17 GATA3 GPR158 lnc-THNSL1-3 RF00017-616 KIAA1217
GH10J024951 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2 -222.2 -222161 3.8 HNRNPK CTCF GTF2E2 ZFX ZBTB5 ZBTB10 AFF1 ZBTB26 SAP30 TOE1 PRTFDC1 ENSG00000273107 ENSG00000285859 THNSL1 GPR158 ARHGAP21
GH10J024703 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -468.6 -468647 5.4 TCF12 JUND FOS ATF2 MXI1 ZNF341 OSR2 WT1 CEBPB NFIC ARHGAP21 GPR158 piR-51671-007 lnc-PRTFDC1-1 COQ10BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR158 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR158

Top Transcription factor binding sites by QIAGEN in the GPR158 gene promoter:
  • AhR
  • Arnt
  • c-Myc
  • Egr-1
  • Evi-1
  • FOXF2
  • Max
  • Nkx3-1 v4
  • NRSF form 1
  • NRSF form 2

Genomic Locations for GPR158 Gene

Genomic Locations for GPR158 Gene
427,497 bases
Plus strand
427,168 bases
Plus strand

Genomic View for GPR158 Gene

Genes around GPR158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR158 Gene

Proteins for GPR158 Gene

  • Protein details for GPR158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 158
    Protein Accession:
    Secondary Accessions:
    • Q6QR81
    • Q9ULT3

    Protein attributes for GPR158 Gene

    1215 amino acids
    Molecular mass:
    135489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS18315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR158 Gene

Post-translational modifications for GPR158 Gene

  • Glycosylation at Asn98, Asn143, Asn215, Asn274, and Asn333
  • Ubiquitination at Lys774
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR158 Gene

Domains & Families for GPR158 Gene

Gene Families for GPR158 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR158 Gene


Suggested Antigen Peptide Sequences for GPR158 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 158 (GP158_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPR158: view

Function for GPR158 Gene

Molecular function for GPR158 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR158 Gene

Gene Ontology (GO) - Molecular Function for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR158: view
genes like me logo Genes that share phenotypes with GPR158: view

Animal Models for GPR158 Gene

MGI Knock Outs for GPR158:
  • Gpr158 Gpr158<tm1.1(KOMP)Vlcg>
  • Gpr158 Gpr158<tm1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR158

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR158 Gene

Localization for GPR158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR158 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR158 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

Pathways & Interactions for GPR158 Gene

PathCards logo

SuperPathways for GPR158 Gene

No Data Available

Interacting Proteins for GPR158 Gene


Gene Ontology (GO) - Biological Process for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

No data available for Pathways by source and SIGNOR curated interactions for GPR158 Gene

Drugs & Compounds for GPR158 Gene

No Compound Related Data Available

Transcripts for GPR158 Gene

mRNA/cDNA for GPR158 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR158 Gene

No ASD Table

Relevant External Links for GPR158 Gene

GeneLoc Exon Structure for

Expression for GPR158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR158 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.3), Brain - Cerebellum (x6.3), Brain - Putamen (basal ganglia) (x5.5), Brain - Caudate (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GPR158 Gene

This gene is overexpressed in Retina (32.4), Frontal cortex (25.0), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR158 Gene

Protein tissue co-expression partners for GPR158 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR158

SOURCE GeneReport for Unigene cluster for GPR158 Gene:


Evidence on tissue expression from TISSUES for GPR158 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with GPR158: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR158 Gene

Orthologs for GPR158 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR158 31 30
  • 99.62 (n)
(Canis familiaris)
Mammalia GPR158 31 30
  • 90.13 (n)
(Bos Taurus)
Mammalia GPR158 31 30
  • 87.29 (n)
(Rattus norvegicus)
Mammalia Gpr158 30
  • 86.29 (n)
(Mus musculus)
Mammalia Gpr158 17 31 30
  • 86.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
-- 31
  • 49 (a)
(Monodelphis domestica)
Mammalia GPR158 31
  • 79 (a)
(Gallus gallus)
Aves GPR158 31 30
  • 75.25 (n)
(Anolis carolinensis)
Reptilia GPR158 31
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr158 30
  • 64 (n)
(Danio rerio)
Actinopterygii LOC570001 30
  • 60.62 (n)
GPR158 (2 of 2) 31
  • 46 (a)
gpr158a 31
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta pog 31
  • 16 (a)
CG31760 31
  • 15 (a)
CG43795 31
  • 14 (a)
CG31195 31
  • 10 (a)
(Caenorhabditis elegans)
Secernentea F39B2.8 31
  • 20 (a)
Species where no ortholog for GPR158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR158 Gene

Gene Tree for GPR158 (if available)
Gene Tree for GPR158 (if available)
Evolutionary constrained regions (ECRs) for GPR158: view image

Paralogs for GPR158 Gene

Paralogs for GPR158 Gene

genes like me logo Genes that share paralogs with GPR158: view

Variants for GPR158 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR158 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10828833 - p.Ile1209Val
rs2480345 - p.Ala425Gly

Additional dbSNP identifiers (rs#s) for GPR158 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR158 Gene

Variant ID Type Subtype PubMed ID
esv1180990 CNV insertion 17803354
esv1997102 CNV deletion 18987734
esv2492571 CNV deletion 19546169
esv2656793 CNV deletion 23128226
esv2659443 CNV deletion 23128226
esv2662962 CNV deletion 23128226
esv2664122 CNV deletion 23128226
esv2668854 CNV deletion 23128226
esv2673507 CNV deletion 23128226
esv2675139 CNV deletion 23128226
esv26962 CNV loss 19812545
esv2734184 CNV deletion 23290073
esv2734195 CNV deletion 23290073
esv2760120 CNV loss 21179565
esv2760160 CNV loss 21179565
esv2761583 CNV gain 21179565
esv2761584 CNV loss 21179565
esv3307161 CNV mobile element insertion 20981092
esv3351033 CNV insertion 20981092
esv3361013 CNV insertion 20981092
esv3394342 CNV insertion 20981092
esv3546035 CNV deletion 23714750
esv3546036 CNV deletion 23714750
esv3546038 CNV deletion 23714750
esv3622660 CNV loss 21293372
esv3622662 CNV gain 21293372
esv3622663 CNV loss 21293372
esv3622665 CNV loss 21293372
esv3622666 CNV loss 21293372
esv3622668 CNV gain 21293372
esv3622669 CNV loss 21293372
esv3622670 CNV loss 21293372
nsv1044482 CNV gain 25217958
nsv1124613 CNV duplication 24896259
nsv1139518 CNV duplication 24896259
nsv25401 CNV deletion 16902084
nsv476033 CNV novel sequence insertion 20440878
nsv509345 CNV insertion 20534489
nsv51 CNV insertion 15895083
nsv550225 CNV loss 21841781
nsv550226 CNV loss 21841781
nsv550227 CNV loss 21841781
nsv6110 CNV insertion 18451855
nsv947771 CNV duplication 23825009
nsv947772 CNV duplication 23825009

Variation tolerance for GPR158 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.98; 96.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR158 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR158 Gene

Disorders for GPR158 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GPR158 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
night blindness, congenital stationary, type 1b
  • csnb1b
  • ordinary smallpox
corneal dystrophy, posterior polymorphous, 1
  • ppcd1
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR158

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR158 Gene

Publications for GPR158 Gene

  1. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. (PMID: 25792749) Orlandi C … Martemyanov KA (The Journal of biological chemistry 2015) 2 3 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D … Taylor PR (International journal of cancer 2008) 3 41 54
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54

Products for GPR158 Gene

Sources for GPR158 Gene