Aliases for GPR157 Gene

Aliases for GPR157 Gene

  • G Protein-Coupled Receptor 157 2 3 5
  • G-Protein Coupled Receptor 157 3 4
  • Probable G-Protein Coupled Receptor 157 3

External Ids for GPR157 Gene

Previous GeneCards Identifiers for GPR157 Gene

  • GC01M008896
  • GC01M009121
  • GC01M008314
  • GC01M009162

Summaries for GPR157 Gene

GeneCards Summary for GPR157 Gene

GPR157 (G Protein-Coupled Receptor 157) is a Protein Coding gene. Diseases associated with GPR157 include Schnyder Corneal Dystrophy. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is TMEM116.

UniProtKB/Swiss-Prot Summary for GPR157 Gene

  • Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

Gene Wiki entry for GPR157 Gene

Additional gene information for GPR157 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR157 Gene

Genomics for GPR157 Gene

GeneHancer (GH) Regulatory Elements for GPR157 Gene

Promoters and enhancers for GPR157 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009127 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.2 +0.4 425 3.5 HNRNPK NRF1 POLR2G SP1 PHF8 ZFX ZNF10 ZIC2 ZBTB10 POLR2A GPR157 piR-44772 SLC2A5 lnc-GPR157-2
GH01J009179 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 500.2 -52.7 -52731 4.6 ZBTB40 CTCF TCF12 POLR2G PHF8 FOS ZFX ZIC2 KDM6A ZBTB10 MIR34A LNCTAM34A GPR157 SLC2A5 CTNNBIP1 MIR34AHG
GH01J008869 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 +253.4 253380 11.8 RXRA HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A MYC NRF1 POLR2G ENO1 RERE GPR157 RERE-AS1 CLSTN1 PIK3CD-AS2 MIR34AHG SLC45A1 H6PD ENO1-AS1
GH01J010031 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 -904.5 -904460 4.7 HNRNPK FOXK2 ZNF217 CTCF SIN3A NRF1 POLR2G USF1 SP1 PHB2 UBE4B LZIC GPR157 CASZ1 KIF1B RBP7 PGD piR-33124 lnc-LZIC-2
GH01J009942 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 14.4 -814.1 -814131 3 EP300 ZBTB40 ZNF217 CTCF ZSCAN5C TCF12 SIN3A POLR2G SP1 GTF2E2 LZIC NMNAT1 ENSG00000228150 RF00017-049 RF00017-050 GPR157 CASZ1 MIR34AHG RBP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR157 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR157

Top Transcription factor binding sites by QIAGEN in the GPR157 gene promoter:
  • FOXC1
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • NRSF form 1
  • NRSF form 2
  • RORalpha1
  • Sox5
  • Sp1

Genomic Locations for GPR157 Gene

Genomic Locations for GPR157 Gene
chr1:9,100,305-9,129,170
(GRCh38/hg38)
Size:
28,866 bases
Orientation:
Minus strand
chr1:9,160,364-9,189,229
(GRCh37/hg19)
Size:
28,866 bases
Orientation:
Minus strand

Genomic View for GPR157 Gene

Genes around GPR157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR157 Gene

Proteins for GPR157 Gene

  • Protein details for GPR157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5UAW9-GP157_HUMAN
    Recommended name:
    G-protein coupled receptor 157
    Protein Accession:
    Q5UAW9
    Secondary Accessions:
    • A2A334
    • Q8WWB8
    • Q9HA73

    Protein attributes for GPR157 Gene

    Size:
    335 amino acids
    Molecular mass:
    36623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13982.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for GPR157 Gene

Post-translational modifications for GPR157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR157 Gene

Antibody Products

  • Boster Bio Antibodies for GPR157
  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR157

No data available for DME Specific Peptides for GPR157 Gene

Domains & Families for GPR157 Gene

Gene Families for GPR157 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR157 Gene

Suggested Antigen Peptide Sequences for GPR157 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 157 (GP157_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5UAW9

UniProtKB/Swiss-Prot:

GP157_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GPR157: view

Function for GPR157 Gene

Molecular function for GPR157 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

Phenotypes From GWAS Catalog for GPR157 Gene

Gene Ontology (GO) - Molecular Function for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity ISS --
genes like me logo Genes that share ontologies with GPR157: view
genes like me logo Genes that share phenotypes with GPR157: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR157

CRISPR Products

miRNA for GPR157 Gene

miRTarBase miRNAs that target GPR157

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR157

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR157 Gene

Localization for GPR157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR157 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Note=Expressed in the primary cilia of radial glial progenitors (RGPs) exposed to the cerebrospinal fluid. {ECO:0000250 UniProtKB:Q8C206}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR157 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Nucleoli (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GPR157: view

Pathways & Interactions for GPR157 Gene

PathCards logo

SuperPathways for GPR157 Gene

No Data Available

Interacting Proteins for GPR157 Gene

;

Gene Ontology (GO) - Biological Process for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway ISS --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GPR157: view

No data available for Pathways by source and SIGNOR curated interactions for GPR157 Gene

Drugs & Compounds for GPR157 Gene

No Compound Related Data Available

Transcripts for GPR157 Gene

mRNA/cDNA for GPR157 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR157

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR157 Gene

No ASD Table

Relevant External Links for GPR157 Gene

GeneLoc Exon Structure for
GPR157

Expression for GPR157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR157 Gene

mRNA differential expression in normal tissues according to GTEx for GPR157 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.3), Muscle - Skeletal (x5.1), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR157 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR157 Gene



Protein tissue co-expression partners for GPR157 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR157

SOURCE GeneReport for Unigene cluster for GPR157 Gene:

Hs.632367
genes like me logo Genes that share expression patterns with GPR157: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR157 Gene

Orthologs for GPR157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR157 31 30
  • 98.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR157 31 30
  • 88.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR157 31 30
  • 85.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr157 17 31 30
  • 84.3 (n)
rat
(Rattus norvegicus)
Mammalia Gpr157 30
  • 83.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR157 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR157 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR157 31 30
  • 70.48 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr157 30
  • 64.45 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr157 31 30
  • 63.74 (n)
OneToOne
Species where no ortholog for GPR157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR157 Gene

ENSEMBL:
Gene Tree for GPR157 (if available)
TreeFam:
Gene Tree for GPR157 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR157: view image

Paralogs for GPR157 Gene

Paralogs for GPR157 Gene

Pseudogenes.org Pseudogenes for GPR157 Gene

genes like me logo Genes that share paralogs with GPR157: view

Variants for GPR157 Gene

Additional dbSNP identifiers (rs#s) for GPR157 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR157 Gene

Variant ID Type Subtype PubMed ID
esv1519481 CNV insertion 17803354
esv2422210 CNV duplication 17116639
esv2675581 CNV deletion 23128226
esv3585164 CNV loss 21293372
esv3585165 CNV loss 21293372
nsv1077038 CNV deletion 25765185
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897
nsv954649 CNV deletion 24416366

Variation tolerance for GPR157 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR157 Gene

Disorders for GPR157 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR157 Gene - From: DISEASES

Disorder Aliases PubMed IDs
schnyder corneal dystrophy
  • sccd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR157

genes like me logo Genes that share disorders with GPR157: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR157 Gene

Publications for GPR157 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 54

Products for GPR157 Gene

Sources for GPR157 Gene