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Aliases for GPR156 Gene

Aliases for GPR156 Gene

  • G Protein-Coupled Receptor 156 2 3 5
  • GABAB-Related G-Protein Coupled Receptor 3 4
  • GABABL 3 4
  • PGR28 3 4
  • Probable G-Protein Coupled Receptor 156 3
  • G Protein-Coupled Receptor PGR28 3
  • G-Protein Coupled Receptor PGR28 4

External Ids for GPR156 Gene

Previous GeneCards Identifiers for GPR156 Gene

  • GC03M121206
  • GC03M121368
  • GC03M119883
  • GC03M117260

Summaries for GPR156 Gene

Entrez Gene Summary for GPR156 Gene

  • G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR156 Gene

GPR156 (G Protein-Coupled Receptor 156) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled GABA receptor activity. An important paralog of this gene is GABBR2.

UniProtKB/Swiss-Prot for GPR156 Gene

  • Orphan receptor.

Gene Wiki entry for GPR156 Gene

Additional gene information for GPR156 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR156 Gene

Genomics for GPR156 Gene

GeneHancer (GH) Regulatory Elements for GPR156 Gene

Promoters and enhancers for GPR156 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J120284 Promoter 0.8 Ensembl 655.9 -0.1 -77 0.8 POLR2A L3MBTL2 ZFX MAFK GPR156 PIR32890
GH03J120330 Promoter 0.5 EPDnew 650.2 -45.5 -45544 0.1 GPR156 GC03M120325 LRRC58
GH03J120347 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19 -64.3 -64303 3.4 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC100130701 LRRC58 TMEM39A GPR156 POGLUT1 MAATS1 LOC442087
GH03J120416 Enhancer 1.4 Ensembl ENCODE dbSUPER 24 -134.3 -134252 6.7 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF143 FOS ATF7 GPR156 FSTL1 RPL10P7 LOC100130701 LRRC58 MIR198
GH03J120202 Enhancer 0.9 Ensembl ENCODE 15.2 +81.8 81837 1.4 MAX FEZF1 RAD21 YY1 POLR2A EGR1 HNF4G RXRA CEBPB REST GPR156 GSK3B GC03P120211 PIR46565
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR156 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR156 gene promoter:
  • AP-4
  • AREB6
  • MyoD
  • ZID
  • E47
  • HNF-1
  • HNF-1A
  • Lmo2

Genomic Locations for GPR156 Gene

Genomic Locations for GPR156 Gene
120,480 bases
Minus strand
120,450 bases
Minus strand

Genomic View for GPR156 Gene

Genes around GPR156 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR156 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR156 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR156 Gene

Proteins for GPR156 Gene

  • Protein details for GPR156 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 156
    Protein Accession:
    Secondary Accessions:
    • B7ZL66
    • E9PFZ4
    • Q14CM1
    • Q86SN6

    Protein attributes for GPR156 Gene

    814 amino acids
    Molecular mass:
    89097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR156 Gene


neXtProt entry for GPR156 Gene

Post-translational modifications for GPR156 Gene

  • Glycosylation at isoforms=26
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR156 Gene

Domains & Families for GPR156 Gene

Gene Families for GPR156 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR156 Gene


Suggested Antigen Peptide Sequences for GPR156 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
genes like me logo Genes that share domains with GPR156: view

Function for GPR156 Gene

Molecular function for GPR156 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR156 Gene

Gene Ontology (GO) - Molecular Function for GPR156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004965 G-protein coupled GABA receptor activity IEA --
genes like me logo Genes that share ontologies with GPR156: view
genes like me logo Genes that share phenotypes with GPR156: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR156

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR156 Gene

Localization for GPR156 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR156 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR156 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR156: view

Pathways & Interactions for GPR156 Gene

genes like me logo Genes that share pathways with GPR156: view

Pathways by source for GPR156 Gene

1 KEGG pathway for GPR156 Gene

Interacting Proteins for GPR156 Gene

Gene Ontology (GO) - Biological Process for GPR156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR156: view

No data available for SIGNOR curated interactions for GPR156 Gene

Drugs & Compounds for GPR156 Gene

No Compound Related Data Available

Transcripts for GPR156 Gene

mRNA/cDNA for GPR156 Gene

(9) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR156 Gene

G protein-coupled receptor 156:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR156 Gene

No ASD Table

Relevant External Links for GPR156 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR156 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR156 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR156 Gene

This gene is overexpressed in Testis (x10.9).

Protein differential expression in normal tissues from HIPED for GPR156 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR156 Gene

Protein tissue co-expression partners for GPR156 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR156 Gene:


SOURCE GeneReport for Unigene cluster for GPR156 Gene:


mRNA Expression by UniProt/SwissProt for GPR156 Gene:

Tissue specificity: Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.

Evidence on tissue expression from TISSUES for GPR156 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR156: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR156 Gene

Orthologs for GPR156 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR156 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR156 34 33
  • 99.51 (n)
(Bos Taurus)
Mammalia GPR156 34 33
  • 84.76 (n)
(Canis familiaris)
Mammalia GPR156 34 33
  • 82.15 (n)
(Rattus norvegicus)
Mammalia Gpr156 33
  • 78.62 (n)
(Mus musculus)
Mammalia Gpr156 16 34 33
  • 78.25 (n)
(Ornithorhynchus anatinus)
Mammalia GPR156 34
  • 62 (a)
(Monodelphis domestica)
Mammalia GPR156 34
  • 56 (a)
(Gallus gallus)
Aves GPR156 34 33
  • 60.41 (n)
(Anolis carolinensis)
Reptilia GPR156 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr156 33
  • 52.35 (n)
(Danio rerio)
Actinopterygii LOC101885196 33
  • 50.77 (n)
GPR156 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta GABA-B-R3 34
  • 10 (a)
Species where no ortholog for GPR156 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR156 Gene

Gene Tree for GPR156 (if available)
Gene Tree for GPR156 (if available)
Evolutionary constrained regions (ECRs) for GPR156: view image

Paralogs for GPR156 Gene

Paralogs for GPR156 Gene

genes like me logo Genes that share paralogs with GPR156: view

Variants for GPR156 Gene

Sequence variations from dbSNP and Humsavar for GPR156 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004877 -- 120,228,054(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000173064 -- 120,280,330(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000238094 -- 120,251,259(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000240026 -- 120,169,856(-) C/T genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000297867 -- 120,243,898(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR156 Gene

Variant ID Type Subtype PubMed ID
dgv125n6 CNV deletion 16902084
dgv2584n106 CNV deletion 24896259
esv1006353 CNV deletion 20482838
esv1045898 CNV deletion 17803354
esv1439832 CNV insertion 17803354
esv1543050 CNV insertion 17803354
esv2257745 CNV deletion 18987734
esv2596469 CNV deletion 19546169
esv2725828 CNV deletion 23290073
esv2834458 CNV deletion 24192839
esv3302551 CNV tandem duplication 20981092
esv3302848 CNV tandem duplication 20981092
esv3440107 CNV duplication 20981092
esv3562453 CNV deletion 23714750
esv3597570 CNV loss 21293372
esv4361 CNV loss 18987735
esv6870 CNV gain 19470904
esv7231 CNV loss 19470904
esv998169 CNV deletion 20482838
nsv1008362 CNV loss 25217958
nsv1013788 CNV gain 25217958
nsv1071507 CNV deletion 25765185
nsv1078809 CNV insertion 25765185
nsv1125781 CNV tandem duplication 24896259
nsv1129237 CNV insertion 24896259
nsv1147119 CNV deletion 26484159
nsv1153396 CNV insertion 26484159
nsv3967 CNV deletion 18451855
nsv513068 CNV loss 21212237
nsv518052 CNV loss 19592680
nsv829697 CNV loss 17160897
nsv829698 CNV gain 17160897
nsv956808 CNV deletion 24416366

Variation tolerance for GPR156 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR156 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR156 Gene

Disorders for GPR156 Gene

Additional Disease Information for GPR156

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR156 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR156 Gene

Publications for GPR156 Gene

  1. Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. (PMID: 12591167) Calver AR … Pangalos MN (Brain research. Molecular brain research 2003) 2 3 4 22 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPR156 Gene

Sources for GPR156 Gene

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