Aliases for GPR155 Gene

Aliases for GPR155 Gene

  • G Protein-Coupled Receptor 155 2 3 5
  • PGR22 2 3 4
  • Integral Membrane Protein GPR155 3 4
  • G-Protein Coupled Receptor PGR22 3 4
  • DEPDC3 2 3
  • DEP.7 2 3
  • FLJ31819 2
  • GPR155 5

External Ids for GPR155 Gene

Previous GeneCards Identifiers for GPR155 Gene

  • GC02M175500
  • GC02M175124
  • GC02M175004
  • GC02M175296
  • GC02M167176

Summaries for GPR155 Gene

GeneCards Summary for GPR155 Gene

GPR155 (G Protein-Coupled Receptor 155) is a Protein Coding gene. Diseases associated with GPR155 include Isolated Growth Hormone Deficiency, Type Ib and Autism. An important paralog of this gene is PREX1.

Gene Wiki entry for GPR155 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR155 Gene

Genomics for GPR155 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR155 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR155 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR155

Top Transcription factor binding sites by QIAGEN in the GPR155 gene promoter:
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • NF-AT1
  • NF-AT2
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • RelA

Genomic Locations for GPR155 Gene

Latest Assembly
62,431 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
55,459 bases
Minus strand

(GRCh37/hg19 by Ensembl)
54,857 bases
Minus strand

Genomic View for GPR155 Gene

Genes around GPR155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR155 Gene

Proteins for GPR155 Gene

  • Protein details for GPR155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR155
    Protein Accession:
    Secondary Accessions:
    • B2RCI2
    • D3DPE2
    • Q4G0Y6
    • Q53SJ3
    • Q53TA8
    • Q69YG8
    • Q86SP9
    • Q8N261
    • Q8N639
    • Q8N8K3
    • Q96MV6

    Protein attributes for GPR155 Gene

    870 amino acids
    Molecular mass:
    96919 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71170.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR155 Gene

Post-translational modifications for GPR155 Gene

  • Glycosylation at Asn9, Asn15, Asn29, Asn198, Asn309, Asn381, Asn543, and Asn612
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR155 Gene

Domains & Families for GPR155 Gene

Gene Families for GPR155 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR155 Gene

  • Auxin Efflux Carrier

Suggested Antigen Peptide Sequences for GPR155 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR22 (GP155_HUMAN)
  • GPR155 protein (Q49AJ5_HUMAN)
genes like me logo Genes that share domains with GPR155: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPR155 Gene

Function for GPR155 Gene

Phenotypes From GWAS Catalog for GPR155 Gene

Gene Ontology (GO) - Molecular Function for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GPR155: view
genes like me logo Genes that share phenotypes with GPR155: view

miRNA for GPR155 Gene

miRTarBase miRNAs that target GPR155

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR155

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR155 Gene

Localization for GPR155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR155 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR155 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GPR155: view

Pathways & Interactions for GPR155 Gene

PathCards logo

SuperPathways for GPR155 Gene

No Data Available

Interacting Proteins for GPR155 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000376335 Q7Z3F1-GP155_HUMAN for GPR155 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
GO:0050890 cognition IMP 17519220
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR155: view

No data available for Pathways by source and SIGNOR curated interactions for GPR155 Gene

Drugs & Compounds for GPR155 Gene

No Compound Related Data Available

Transcripts for GPR155 Gene

mRNA/cDNA for GPR155 Gene

13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR155

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for GPR155 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: -
SP4: -
SP5: - -

Relevant External Links for GPR155 Gene

GeneLoc Exon Structure for

Expression for GPR155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR155 Gene

This gene is overexpressed in Urine (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR155 Gene

Protein tissue co-expression partners for GPR155 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR155

SOURCE GeneReport for Unigene cluster for GPR155 Gene:


Evidence on tissue expression from TISSUES for GPR155 Gene

  • Nervous system(4.4)
  • Eye(4.1)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with GPR155: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR155 Gene

Orthologs for GPR155 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR155 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR155 30 31
  • 99.6 (n)
(Canis familiaris)
Mammalia GPR155 30 31
  • 93.26 (n)
(Bos Taurus)
Mammalia GPR155 30 31
  • 91.98 (n)
(Mus musculus)
Mammalia Gpr155 30 17 31
  • 85.68 (n)
(Rattus norvegicus)
Mammalia Gpr155 30
  • 85.64 (n)
(Monodelphis domestica)
Mammalia GPR155 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia GPR155 31
  • 82 (a)
(Gallus gallus)
Aves GPR155 30 31
  • 74.96 (n)
(Anolis carolinensis)
Reptilia GPR155 31
  • 70 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr155 30
  • 68.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19272 30
(Danio rerio)
Actinopterygii gpr155a 30 31
  • 60.06 (n)
gpr155b 31
  • 56 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7510 30 31
  • 46.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006992 30
  • 45.63 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
Species where no ortholog for GPR155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR155 Gene

Gene Tree for GPR155 (if available)
Gene Tree for GPR155 (if available)
Evolutionary constrained regions (ECRs) for GPR155: view image

Paralogs for GPR155 Gene

Paralogs for GPR155 Gene

genes like me logo Genes that share paralogs with GPR155: view

Variants for GPR155 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR155 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs138596030 Likely Benign: not provided 174,473,346(-) G/A
NM_152529.7(GPR155):c.479C>T (p.Thr160Ile)
rs201833095 Likely Benign: not provided 174,436,350(-) G/A
NM_152529.7(GPR155):c.2379C>T (p.Val793=)
rs75119523 Benign: not provided 174,469,004(-) A/G
NM_152529.7(GPR155):c.1090T>C (p.Leu364=)
rs76781804 Benign: not provided 174,442,157(-) T/C
NM_001033045.4(GPR155):c.2136A>G (p.Gly712=)
rs78053572 Benign: not provided 174,460,053(-) G/A
NM_001033045.4(GPR155):c.1596C>T (p.Ile532=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR155 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR155 Gene

Variant ID Type Subtype PubMed ID
esv3893507 CNV loss 25118596
nsv526187 CNV loss 19592680
nsv583667 CNV loss 21841781

Variation tolerance for GPR155 Gene

Residual Variation Intolerance Score: 7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR155 Gene

Disorders for GPR155 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR155 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
isolated growth hormone deficiency, type ib
  • ighd1b
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR155

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GPR155: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR155 Gene

Publications for GPR155 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for GPR155 Gene

Sources for GPR155 Gene