Aliases for GPR155 Gene

Aliases for GPR155 Gene

  • G Protein-Coupled Receptor 155 2 3 5
  • Integral Membrane Protein GPR155 3 4
  • G-Protein Coupled Receptor PGR22 3 4
  • PGR22 3 4
  • DEPDC3 3
  • DEP.7 3

External Ids for GPR155 Gene

Previous GeneCards Identifiers for GPR155 Gene

  • GC02M175500
  • GC02M175124
  • GC02M175004
  • GC02M175296
  • GC02M167176

Summaries for GPR155 Gene

GeneCards Summary for GPR155 Gene

GPR155 (G Protein-Coupled Receptor 155) is a Protein Coding gene. An important paralog of this gene is PREX1.

Gene Wiki entry for GPR155 Gene

Additional gene information for GPR155 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR155 Gene

Genomics for GPR155 Gene

GeneHancer (GH) Regulatory Elements for GPR155 Gene

Promoters and enhancers for GPR155 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR155 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR155

Top Transcription factor binding sites by QIAGEN in the GPR155 gene promoter:
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • NF-AT1
  • NF-AT2
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • RelA

Genomic Locations for GPR155 Gene

Genomic Locations for GPR155 Gene
chr2:174,431,571-174,487,094
(GRCh38/hg38)
Size:
55,524 bases
Orientation:
Minus strand
chr2:175,296,375-175,351,822
(GRCh37/hg19)
Size:
55,448 bases
Orientation:
Minus strand

Genomic View for GPR155 Gene

Genes around GPR155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR155 Gene

Proteins for GPR155 Gene

  • Protein details for GPR155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3F1-GP155_HUMAN
    Recommended name:
    Integral membrane protein GPR155
    Protein Accession:
    Q7Z3F1
    Secondary Accessions:
    • B2RCI2
    • D3DPE2
    • Q4G0Y6
    • Q53SJ3
    • Q53TA8
    • Q69YG8
    • Q86SP9
    • Q8N261
    • Q8N639
    • Q8N8K3
    • Q96MV6

    Protein attributes for GPR155 Gene

    Size:
    870 amino acids
    Molecular mass:
    96919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71170.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR155 Gene

Post-translational modifications for GPR155 Gene

  • Glycosylation at Asn9, Asn15, Asn29, Asn198, Asn309, Asn381, Asn543, and Asn612
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR155 Gene

Domains & Families for GPR155 Gene

Gene Families for GPR155 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR155 Gene

Blocks:
  • Auxin Efflux Carrier
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR155 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR22 (GP155_HUMAN)
  • GPR155 protein (Q49AJ5_HUMAN)
genes like me logo Genes that share domains with GPR155: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPR155 Gene

Function for GPR155 Gene

Phenotypes From GWAS Catalog for GPR155 Gene

Gene Ontology (GO) - Molecular Function for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GPR155: view
genes like me logo Genes that share phenotypes with GPR155: view

Animal Model Products

CRISPR Products

miRNA for GPR155 Gene

miRTarBase miRNAs that target GPR155

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR155 Gene

Localization for GPR155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR155 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR155 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GPR155: view

Pathways & Interactions for GPR155 Gene

PathCards logo

SuperPathways for GPR155 Gene

No Data Available

Interacting Proteins for GPR155 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000376335 Q7Z3F1-GP155_HUMAN for GPR155 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for GPR155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
GO:0050890 cognition IMP 17519220
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR155: view

No data available for Pathways by source and SIGNOR curated interactions for GPR155 Gene

Drugs & Compounds for GPR155 Gene

No Compound Related Data Available

Transcripts for GPR155 Gene

mRNA/cDNA for GPR155 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR155 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for GPR155 Gene

GeneLoc Exon Structure for
GPR155

Expression for GPR155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR155 Gene

This gene is overexpressed in Urine (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR155 Gene



Protein tissue co-expression partners for GPR155 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR155

SOURCE GeneReport for Unigene cluster for GPR155 Gene:

Hs.516604

Evidence on tissue expression from TISSUES for GPR155 Gene

  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with GPR155: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR155 Gene

Orthologs for GPR155 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR155 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR155 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR155 31 30
  • 93.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR155 31 30
  • 91.98 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr155 17 31 30
  • 85.68 (n)
rat
(Rattus norvegicus)
Mammalia Gpr155 30
  • 85.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR155 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR155 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR155 31 30
  • 74.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR155 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr155 30
  • 68.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19272 30
zebrafish
(Danio rerio)
Actinopterygii gpr155a 31 30
  • 60.06 (n)
OneToMany
gpr155b 31
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7510 31 30
  • 46.19 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006992 30
  • 45.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToOne
Species where no ortholog for GPR155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR155 Gene

ENSEMBL:
Gene Tree for GPR155 (if available)
TreeFam:
Gene Tree for GPR155 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR155: view image

Paralogs for GPR155 Gene

Paralogs for GPR155 Gene

genes like me logo Genes that share paralogs with GPR155: view

Variants for GPR155 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR155 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
711856 Benign: not provided 174,469,004(-) A/G SYNONYMOUS_VARIANT
727986 Likely Benign: not provided 174,436,350(-) G/A SYNONYMOUS_VARIANT
730287 Likely Benign: not provided 174,473,346(-) G/A MISSENSE_VARIANT
775787 Benign: not provided 174,460,053(-) G/A SYNONYMOUS_VARIANT
778014 Benign: not provided 174,442,157(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GPR155 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR155 Gene

Variant ID Type Subtype PubMed ID
esv3893507 CNV loss 25118596
nsv526187 CNV loss 19592680
nsv583667 CNV loss 21841781

Variation tolerance for GPR155 Gene

Residual Variation Intolerance Score: 7.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR155 Gene

Disorders for GPR155 Gene

Additional Disease Information for GPR155

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR155 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR155 Gene

Publications for GPR155 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for GPR155 Gene

Sources for GPR155 Gene