This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated ... See more...

Aliases for GPR153 Gene

Aliases for GPR153 Gene

  • G Protein-Coupled Receptor 153 2 3 5
  • Probable G-Protein Coupled Receptor 153 3 4
  • G-Protein Coupled Receptor PGR1 3 4
  • PGR1 3 4

External Ids for GPR153 Gene

Previous GeneCards Identifiers for GPR153 Gene

  • GC01U900256
  • GC01M006019
  • GC01M006243
  • GC01M006307
  • GC01M005456

Summaries for GPR153 Gene

Entrez Gene Summary for GPR153 Gene

  • This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]

GeneCards Summary for GPR153 Gene

GPR153 (G Protein-Coupled Receptor 153) is a Protein Coding gene. Diseases associated with GPR153 include Childhood-Onset Schizophrenia and Schizophrenia. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR162.

UniProtKB/Swiss-Prot Summary for GPR153 Gene

Gene Wiki entry for GPR153 Gene

Additional gene information for GPR153 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR153 Gene

Genomics for GPR153 Gene

GeneHancer (GH) Regulatory Elements for GPR153 Gene

Promoters and enhancers for GPR153 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J006259 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 522.8 -0.9 -860 4.7 HNRNPK MYC ZIC2 ZBTB10 ZNF263 ZBTB26 KLF7 ZNF740 CTBP1 EZH2 GPR153 ICMT LINC00337 RPL22 LOC102724450 RNF207 CHD5 NOL9 THAP3 lnc-GPR153-1
GH01J006260 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.7 +1.6 1639 0.1 HNF4A YY1 GPR153 lnc-ACOT7-2
GH01J006246 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 15 +15.6 15597 3 HNRNPK CTCF SIN3A NRF1 ZFX ZNF10 ZIC2 REST ZBTB10 ZNF263 HES3 THAP3 GPR153 NOL9 ZBTB48 PHF13 ICMT lnc-ACOT7-2
GH01J006233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7.8 +26.0 25960 3.7 RXRA SIN3A NRF1 MYC POLR2G PHF8 ZFX ZNF639 SIX5 POLR2A ICMT LINC00337 GPR153 RNF207
GH01J006256 Enhancer 0.6 Ensembl ENCODE 21.3 +4.3 4253 0.5 CEBPB KLF17 KLF1 PKNOX1 GPR153 lnc-ACOT7-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR153 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR153

Top Transcription factor binding sites by QIAGEN in the GPR153 gene promoter:
  • AP-1
  • Bach2
  • c-Fos
  • c-Jun
  • COMP1
  • MZF-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2

Genomic Locations for GPR153 Gene

Genomic Locations for GPR153 Gene
chr1:6,247,346-6,261,098
(GRCh38/hg38)
Size:
13,753 bases
Orientation:
Minus strand
chr1:6,307,406-6,321,035
(GRCh37/hg19)
Size:
13,630 bases
Orientation:
Minus strand

Genomic View for GPR153 Gene

Genes around GPR153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR153 Gene

Proteins for GPR153 Gene

  • Protein details for GPR153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NV75-GP153_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 153
    Protein Accession:
    Q6NV75
    Secondary Accessions:
    • Q5TGR5
    • Q6AHW8
    • Q86SP8

    Protein attributes for GPR153 Gene

    Size:
    609 amino acids
    Molecular mass:
    65361 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR153 Gene

Post-translational modifications for GPR153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR153 Gene

No data available for DME Specific Peptides for GPR153 Gene

Domains & Families for GPR153 Gene

Gene Families for GPR153 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR153 Gene

Suggested Antigen Peptide Sequences for GPR153 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR1 (GP153_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NV75

UniProtKB/Swiss-Prot:

GP153_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR153: view

Function for GPR153 Gene

Molecular function for GPR153 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR153 Gene

Gene Ontology (GO) - Molecular Function for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR153: view
genes like me logo Genes that share phenotypes with GPR153: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR153

CRISPR Products

miRNA for GPR153 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR153

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR153 Gene

Localization for GPR153 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR153 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR153 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR153: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR153 Gene

Pathways & Interactions for GPR153 Gene

PathCards logo

SuperPathways for GPR153 Gene

No Data Available

Interacting Proteins for GPR153 Gene

;

Gene Ontology (GO) - Biological Process for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR153: view

No data available for Pathways by source and SIGNOR curated interactions for GPR153 Gene

Drugs & Compounds for GPR153 Gene

No Compound Related Data Available

Transcripts for GPR153 Gene

mRNA/cDNA for GPR153 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR153

Alternative Splicing Database (ASD) splice patterns (SP) for GPR153 Gene

No ASD Table

Relevant External Links for GPR153 Gene

GeneLoc Exon Structure for
GPR153

Expression for GPR153 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR153 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR153 Gene



Protein tissue co-expression partners for GPR153 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR153

SOURCE GeneReport for Unigene cluster for GPR153 Gene:

Hs.531581

Evidence on tissue expression from TISSUES for GPR153 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR153: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR153 Gene

Orthologs for GPR153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR153 31 30
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR153 31 30
  • 87.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR153 31 30
  • 87.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr153 17 31 30
  • 84.51 (n)
rat
(Rattus norvegicus)
Mammalia Gpr153 30
  • 80.86 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR153 31
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR153 31
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR153 30
  • 72.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr153 30
  • 61.15 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr153 31
  • 75 (a)
OneToMany
LOC101883998 30
  • 74.47 (n)
GPR153 (2 of 2) 31
  • 39 (a)
OneToMany
Species where no ortholog for GPR153 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR153 Gene

ENSEMBL:
Gene Tree for GPR153 (if available)
TreeFam:
Gene Tree for GPR153 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR153: view image

Paralogs for GPR153 Gene

Paralogs for GPR153 Gene

(2) SIMAP similar genes for GPR153 Gene using alignment to 1 proteins:

  • GP153_HUMAN
genes like me logo Genes that share paralogs with GPR153: view

Variants for GPR153 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR153 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
734251 Likely Benign: not provided 6,251,492(-) C/T SYNONYMOUS_VARIANT
783275 Benign: not provided 6,250,564(-) C/T MISSENSE_VARIANT
783276 Benign: not provided 6,254,688(-) C/T MISSENSE_VARIANT
783920 Benign: not provided 6,254,623(-) G/A SYNONYMOUS_VARIANT
rs776061422 Likely Pathogenic: Childhood-Onset Schizophrenia 6,254,689(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GPR153 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR153 Gene

Variant ID Type Subtype PubMed ID
dgv8n67 CNV gain 20364138
nsv1076029 CNV deletion 25765185
nsv508825 CNV insertion 20534489
nsv526371 CNV loss 19592680
nsv545236 CNV loss 21841781
nsv545237 CNV loss 21841781
nsv545238 CNV loss 21841781
nsv831425 CNV loss 17160897
nsv965 CNV deletion 18451855

Variation tolerance for GPR153 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR153 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR153 Gene

Disorders for GPR153 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GPR153 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
childhood-onset schizophrenia
  • childhood schizophrenia
schizophrenia
  • sczd
acute salpingitis
hypoplastic right heart syndrome
  • right hypoplastic heart syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR153

genes like me logo Genes that share disorders with GPR153: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR153 Gene

Publications for GPR153 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. De novo variants in sporadic cases of childhood onset schizophrenia. (PMID: 26508570) Ambalavanan A … Rouleau GA (European journal of human genetics : EJHG 2016) 3 54
  5. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. (PMID: 25696819) Krishnan A … Schiöth HB (The Journal of experimental biology 2015) 3 54

Products for GPR153 Gene

Sources for GPR153 Gene