Aliases for GPR153 Gene
External Ids for GPR153 Gene
Previous GeneCards Identifiers for GPR153 Gene
This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
GeneCards Summary for GPR153 Gene
GPR153 (G Protein-Coupled Receptor 153) is a Protein Coding gene. Diseases associated with GPR153 include Childhood-Onset Schizophrenia and Schizophrenia. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR162.
UniProtKB/Swiss-Prot Summary for GPR153 Gene