Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR151 Gene

Aliases for GPR151 Gene

  • G Protein-Coupled Receptor 151 2 3 5
  • G-Protein Coupled Receptor PGR7 3 4
  • Galanin Receptor 4 2 3
  • GPCR-2037 3 4
  • PGR7 3 4
  • Probable G-Protein Coupled Receptor 151 3
  • GALR4 3
  • GALRL 3
  • GPCR 3

External Ids for GPR151 Gene

Previous GeneCards Identifiers for GPR151 Gene

  • GC05M145922
  • GC05M145874
  • GC05M141041

Summaries for GPR151 Gene

Entrez Gene Summary for GPR151 Gene

  • This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPR151 Gene

GPR151 (G Protein-Coupled Receptor 151) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR151 Gene

  • Orphan receptor.

Gene Wiki entry for GPR151 Gene

Additional gene information for GPR151 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR151 Gene

Genomics for GPR151 Gene

GeneHancer (GH) Regulatory Elements for GPR151 Gene

Promoters and enhancers for GPR151 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J146515 Enhancer 0.4 ENCODE 650.7 +0.2 157 0.2 MXI1 CREB1 GPR151 ENSG00000277568
GH05J146446 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11 +68.4 68364 2.5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 TCERG1 RBM27 LARS GPR151 ENSG00000277568
GH05J146451 Enhancer 0.4 Ensembl 11 +64.5 64489 0.6 CTCF ZEB2 ZNF18 GPR151 TCERG1 ENSG00000277568
GH05J146450 Enhancer 0.4 Ensembl 11 +65.9 65889 0.2 ZNF664 ZNF189 GPR151 TCERG1 ENSG00000277568
GH05J146344 Enhancer 0.7 FANTOM5 ENCODE 2.5 +171.3 171265 0.3 POLR2A SUZ12 SIN3A EZH2 GC05P146343 ENSG00000250025 GRXCR2 GPR151 GC05P146357
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR151 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR151 gene promoter:
  • Nkx2-5
  • Hand1
  • E47
  • NF-1
  • HOXA5
  • Ik-1
  • POU3F2
  • TBP
  • FOXD1
  • ATF6

Genomic Locations for GPR151 Gene

Genomic Locations for GPR151 Gene
3,088 bases
Minus strand
3,088 bases
Minus strand

Genomic View for GPR151 Gene

Genes around GPR151 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR151 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR151 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR151 Gene

Proteins for GPR151 Gene

  • Protein details for GPR151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 151
    Protein Accession:
    Secondary Accessions:
    • Q86SN8
    • Q8NGV2

    Protein attributes for GPR151 Gene

    419 amino acids
    Molecular mass:
    46637 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR151 Gene

Post-translational modifications for GPR151 Gene

  • Glycosylation at isoforms=15 and Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR151 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR151 Gene

Domains & Families for GPR151 Gene

Gene Families for GPR151 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR151 Gene


Suggested Antigen Peptide Sequences for GPR151 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR151: view

Function for GPR151 Gene

Molecular function for GPR151 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR151: view
genes like me logo Genes that share phenotypes with GPR151: view

Animal Models for GPR151 Gene

MGI Knock Outs for GPR151:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR151 Gene

Localization for GPR151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR151 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR151 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR151: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR151 Gene

Pathways & Interactions for GPR151 Gene

SuperPathways for GPR151 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR151: view

No data available for Pathways by source and SIGNOR curated interactions for GPR151 Gene

Drugs & Compounds for GPR151 Gene

(1) Drugs for GPR151 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GPR151: view

Transcripts for GPR151 Gene

mRNA/cDNA for GPR151 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR151 Gene

G protein-coupled receptor 151:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR151 Gene

No ASD Table

Relevant External Links for GPR151 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR151 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR151 Gene

mRNA differential expression in normal tissues according to GTEx for GPR151 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.2), Brain - Cortex (x4.6), and Brain - Substantia nigra (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of GPR151 Gene:


SOURCE GeneReport for Unigene cluster for GPR151 Gene:

genes like me logo Genes that share expression patterns with GPR151: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR151 Gene

Orthologs for GPR151 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR151 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR151 34 33
  • 99.52 (n)
(Bos Taurus)
Mammalia GPR151 34 33
  • 88.59 (n)
(Canis familiaris)
Mammalia GPR151 34 33
  • 86.99 (n)
(Rattus norvegicus)
Mammalia Gpr151 33
  • 83.45 (n)
(Mus musculus)
Mammalia Gpr151 16 34 33
  • 82.69 (n)
(Monodelphis domestica)
Mammalia GPR151 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia GPR151 34
  • 63 (a)
(Anolis carolinensis)
Reptilia GPR151 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr151 33
  • 60.54 (n)
(Danio rerio)
Actinopterygii LOC100538082 33
  • 54.44 (n)
GPR151 34
  • 28 (a)
Species where no ortholog for GPR151 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR151 Gene

Gene Tree for GPR151 (if available)
Gene Tree for GPR151 (if available)
Evolutionary constrained regions (ECRs) for GPR151: view image

Paralogs for GPR151 Gene

No data available for Paralogs for GPR151 Gene

Variants for GPR151 Gene

Sequence variations from dbSNP and Humsavar for GPR151 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000003124 -- 146,517,171(-) T/C upstream_transcript_variant
rs1002021721 -- 146,514,556(-) C/T downstream_transcript_variant
rs1003610712 -- 146,517,577(-) T/A upstream_transcript_variant
rs1004452677 -- 146,517,997(-) T/C upstream_transcript_variant
rs1004827206 -- 146,517,797(-) C/T upstream_transcript_variant

Variation tolerance for GPR151 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR151 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR151 Gene

Disorders for GPR151 Gene

Additional Disease Information for GPR151

No disorders were found for GPR151 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR151 Gene

Publications for GPR151 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  3. Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain. (PMID: 27913310) Holmes FE … Wynick D (Molecular and cellular neurosciences 2017) 3 58
  4. Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates. (PMID: 25116430) Broms J … Ibañez-Tallon I (The Journal of comparative neurology 2015) 3 58
  5. Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors. (PMID: 24503482) Kakarala KK … Jamil K (Molecular phylogenetics and evolution 2014) 3 58

Products for GPR151 Gene

Sources for GPR151 Gene

Loading form....