This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All ... See more...

Aliases for GPR151 Gene

Aliases for GPR151 Gene

  • G Protein-Coupled Receptor 151 2 3 5
  • Galanin Receptor 4 2 3 4
  • G-Protein Coupled Receptor PGR7 3 4
  • G-Protein Coupled Receptor 151 3 4
  • Galanin-Receptor-Like Protein 3 4
  • GPCR-2037 3 4
  • GALR4 3 4
  • GALRL 3 4
  • PGR7 3 4
  • GalRL 4
  • GPCR 3

External Ids for GPR151 Gene

Previous GeneCards Identifiers for GPR151 Gene

  • GC05M145922
  • GC05M145874
  • GC05M141041

Summaries for GPR151 Gene

Entrez Gene Summary for GPR151 Gene

  • This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPR151 Gene

GPR151 (G Protein-Coupled Receptor 151) is a Protein Coding gene. Diseases associated with GPR151 include Brachial Plexus Lesion. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot Summary for GPR151 Gene

Gene Wiki entry for GPR151 Gene

Additional gene information for GPR151 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR151 Gene

Genomics for GPR151 Gene

GeneHancer (GH) Regulatory Elements for GPR151 Gene

Promoters and enhancers for GPR151 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J146515 Enhancer 0.6 Ensembl ENCODE 500.7 +0.1 90 1 POLR2G MXI1 POLR2A SMARCA4 MAX CREB1 GPR151 ENSG00000277568 RF00017-4985
GH05J146446 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11 +68.3 68303 2.6 ZBTB40 ZNF217 CTCF SIN3A MYC TCF12 USF1 POLR2G SP1 GTF2E2 TCERG1 RBM27 ENSG00000249363 LARS1 GPR151 lnc-POU4F3-2 RF00017-4985
GH05J146473 Enhancer 0.5 Ensembl 11.1 +41.1 41089 2.6 CTCF ZNF316 SPI1 FOXA1 GATA2 MAFK RBM22 POLR2A EMSY TCERG1 GPR151 lnc-POU4F3-4 NONHSAG041855.2 RF00017-4985
GH05J146466 Enhancer 0.4 Ensembl 11 +49.4 49389 0.8 CTCF SMC3 ZZZ3 RAD21 ARID3A GPR151 lnc-POU4F3-4 TCERG1 NONHSAG041855.2 RF00017-4985
GH05J146453 Enhancer 0.2 Ensembl 11 +62.3 62289 0.2 GPR151 TCERG1 lnc-POU4F3-2 RF00017-4985
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR151 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR151

Top Transcription factor binding sites by QIAGEN in the GPR151 gene promoter:
  • ATF6
  • E47
  • FOXD1
  • Hand1
  • HOXA5
  • Ik-1
  • NF-1
  • Nkx2-5
  • POU3F2
  • TBP

Genomic Locations for GPR151 Gene

Genomic Locations for GPR151 Gene
chr5:146,513,103-146,516,190
(GRCh38/hg38)
Size:
3,088 bases
Orientation:
Minus strand
chr5:145,892,666-145,895,753
(GRCh37/hg19)
Size:
3,088 bases
Orientation:
Minus strand

Genomic View for GPR151 Gene

Genes around GPR151 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR151 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR151 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR151 Gene

Proteins for GPR151 Gene

  • Protein details for GPR151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDV0-GP151_HUMAN
    Recommended name:
    G-protein coupled receptor 151
    Protein Accession:
    Q8TDV0
    Secondary Accessions:
    • Q86SN8
    • Q8NGV2

    Protein attributes for GPR151 Gene

    Size:
    419 amino acids
    Molecular mass:
    46637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR151 Gene

Post-translational modifications for GPR151 Gene

  • Glycosylation at Asn10 and Asn15
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR151 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR151 Gene

Domains & Families for GPR151 Gene

Gene Families for GPR151 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR151 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR151 Gene

GenScript: Design optimal peptide antigens:
  • GPCR-2037 (GP151_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDV0

UniProtKB/Swiss-Prot:

GP151_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR151: view

Function for GPR151 Gene

Molecular function for GPR151 Gene

UniProtKB/Swiss-Prot Function:
Proton-sensing G-protein coupled receptor.

Phenotypes From GWAS Catalog for GPR151 Gene

Gene Ontology (GO) - Molecular Function for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IMP 31119277
genes like me logo Genes that share ontologies with GPR151: view
genes like me logo Genes that share phenotypes with GPR151: view

Animal Models for GPR151 Gene

MGI Knock Outs for GPR151:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR151 Gene

Localization for GPR151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR151 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR151 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR151: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR151 Gene

Pathways & Interactions for GPR151 Gene

PathCards logo

SuperPathways for GPR151 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IMP 31119277
GO:0010447 response to acidic pH IMP 31119277
GO:0050778 positive regulation of immune response ISS --
genes like me logo Genes that share ontologies with GPR151: view

No data available for Pathways by source and SIGNOR curated interactions for GPR151 Gene

Drugs & Compounds for GPR151 Gene

(1) Drugs for GPR151 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GPR151: view

Transcripts for GPR151 Gene

mRNA/cDNA for GPR151 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR151 Gene

No ASD Table

Relevant External Links for GPR151 Gene

GeneLoc Exon Structure for
GPR151

Expression for GPR151 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR151 Gene

mRNA differential expression in normal tissues according to GTEx for GPR151 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.2), Brain - Cortex (x4.6), and Brain - Substantia nigra (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR151

SOURCE GeneReport for Unigene cluster for GPR151 Gene:

Hs.483732

mRNA Expression by UniProt/SwissProt for GPR151 Gene:

Q8TDV0-GP151_HUMAN
Tissue specificity: High expression in the spinal cord.
genes like me logo Genes that share expression patterns with GPR151: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR151 Gene

Orthologs for GPR151 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR151 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR151 31 30
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR151 31 30
  • 88.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR151 31 30
  • 86.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr151 30
  • 83.45 (n)
mouse
(Mus musculus)
Mammalia Gpr151 17 31 30
  • 82.69 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR151 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR151 31
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR151 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr151 30
  • 60.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538082 30
  • 54.44 (n)
GPR151 31
  • 28 (a)
OneToOne
Species where no ortholog for GPR151 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR151 Gene

ENSEMBL:
Gene Tree for GPR151 (if available)
TreeFam:
Gene Tree for GPR151 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR151: view image

Paralogs for GPR151 Gene

Paralogs for GPR151 Gene

genes like me logo Genes that share paralogs with GPR151: view

Variants for GPR151 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR151 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
753834 Likely Benign: not provided 146,515,868(-) C/T SYNONYMOUS_VARIANT
782100 Benign: not provided 146,515,831(-) G/A NONSENSE
rs17104742 - p.Pro40Leu
rs7709485 - p.Leu261Val
rs7713676 - p.Ala144Val

Additional dbSNP identifiers (rs#s) for GPR151 Gene

Variation tolerance for GPR151 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR151 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR151

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR151 Gene

Disorders for GPR151 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR151 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brachial plexus lesion
  • brachial plexus lesions
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR151

genes like me logo Genes that share disorders with GPR151: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR151 Gene

Publications for GPR151 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 54
  2. GPR31 and GPR151 are activated under acidic conditions. (PMID: 31119277) Mashiko M … Takeda S (Journal of biochemistry 2019) 3 4 54
  3. Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. (PMID: 15111018) Ignatov A … Schaller HC (Neuropharmacology 2004) 3 4 54
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 54
  5. Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain. (PMID: 27913310) Holmes FE … Wynick D (Molecular and cellular neurosciences 2017) 3 54

Products for GPR151 Gene

Sources for GPR151 Gene