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Aliases for GPR15 Gene

Aliases for GPR15 Gene

  • G Protein-Coupled Receptor 15 2 3 5
  • Brother Of Bonzo 3 4
  • G-Protein Coupled Receptor 15 3
  • BOB 3
  • BoB 4

External Ids for GPR15 Gene

Previous GeneCards Identifiers for GPR15 Gene

  • GC03P094873
  • GC03P097554
  • GC03P099532
  • GC03P099571
  • GC03P099733
  • GC03P098250
  • GC03P095623

Summaries for GPR15 Gene

Entrez Gene Summary for GPR15 Gene

  • This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR15 Gene

GPR15 (G Protein-Coupled Receptor 15) is a Protein Coding gene. Diseases associated with GPR15 include Human Immunodeficiency Virus Type 1 and Mediastinal Malignant Lymphoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is GPR25.

UniProtKB/Swiss-Prot for GPR15 Gene

  • Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Wiki entry for GPR15 Gene

Additional gene information for GPR15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR15 Gene

Genomics for GPR15 Gene

GeneHancer (GH) Regulatory Elements for GPR15 Gene

Promoters and enhancers for GPR15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098531 Enhancer 0.6 dbSUPER 650.7 +1.0 965 1.7 SRF PKNOX1 SMAD1 SMAD5 CBFB ZBED1 RELA POLR2A IKZF1 NFATC1 GPR15 RIOX2 DCBLD2 GC03M098547 CPOX
GH03J098535 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 13.4 +6.8 6753 5.3 PKNOX1 ATF1 SMAD1 RB1 STAT5A BMI1 BATF KLF5 IRF4 CHAMP1 CLDND1 GPR15 ST3GAL6-AS1 OR5K2 OR5K4 CPOX ST3GAL6 GC03M098547
GH03J098550 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 9.1 +23.2 23163 8.2 HDGF PKNOX1 SMAD1 IRF4 TCF12 GATA2 ATF7 RUNX3 RXRA JUNB CLDND1 CPOX GPR15 DCBLD2 ST3GAL6-AS1 OR5H6 OR5H2 GC03M098547
GH03J098560 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +33.1 33050 8.4 HDGF PKNOX1 SMAD1 RB1 STAT5A BMI1 FEZF1 BATF KLF5 IRF4 CPOX OR5K2 ST3GAL6-AS1 ST3GAL6 GPR15 CLDND1 GC03M098547
GH03J098525 Enhancer 0.9 ENCODE dbSUPER 0.4 -6.2 -6167 0.2 BACH1 STAT5A BMI1 KLF5 POLR2A NFATC1 EED ZSCAN29 ETV6 IKZF2 GC03M098527 RPL38P4 GPR15 CPOX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR15 gene promoter:
  • Gfi-1
  • FOXD1
  • GATA-3
  • IRF-1
  • Bach2
  • AhR
  • MRF-2
  • AML1a

Genomic Locations for GPR15 Gene

Genomic Locations for GPR15 Gene
1,252 bases
Plus strand
1,218 bases
Plus strand

Genomic View for GPR15 Gene

Genes around GPR15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR15 Gene

Proteins for GPR15 Gene

  • Protein details for GPR15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 15
    Protein Accession:
    Secondary Accessions:
    • Q3MIL4
    • Q6ISN6

    Protein attributes for GPR15 Gene

    360 amino acids
    Molecular mass:
    40787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR15 Gene

Post-translational modifications for GPR15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR15 Gene

Domains & Families for GPR15 Gene

Gene Families for GPR15 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR15 Gene


Suggested Antigen Peptide Sequences for GPR15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR15: view

Function for GPR15 Gene

Molecular function for GPR15 Gene

UniProtKB/Swiss-Prot Function:
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
GENATLAS Biochemistry:
G protein coupled receptor 15

Gene Ontology (GO) - Molecular Function for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 15650194
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IDA 28900043
GO:0005515 protein binding IPI 28936214
GO:0015026 coreceptor activity IDA 15650194
genes like me logo Genes that share ontologies with GPR15: view
genes like me logo Genes that share phenotypes with GPR15: view

Animal Models for GPR15 Gene

MGI Knock Outs for GPR15:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR15

Clone Products

  • Addgene plasmids for GPR15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR15 Gene

Localization for GPR15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR15 gene
Compartment Confidence
plasma membrane 5
endosome 5

Gene Ontology (GO) - Cellular Components for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 28615320
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8838812
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR15 Gene

Pathways & Interactions for GPR15 Gene

genes like me logo Genes that share pathways with GPR15: view

Pathways by source for GPR15 Gene

Gene Ontology (GO) - Biological Process for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0046718 viral entry into host cell IDA 15650194
GO:0072678 T cell migration IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for SIGNOR curated interactions for GPR15 Gene

Drugs & Compounds for GPR15 Gene

No Compound Related Data Available

Transcripts for GPR15 Gene

mRNA/cDNA for GPR15 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR15 Gene

G protein-coupled receptor 15:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR15

Alternative Splicing Database (ASD) splice patterns (SP) for GPR15 Gene

No ASD Table

Relevant External Links for GPR15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR15 Gene

Protein differential expression in normal tissues from HIPED for GPR15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR15 Gene

Protein tissue co-expression partners for GPR15 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR15 Gene:


SOURCE GeneReport for Unigene cluster for GPR15 Gene:


Evidence on tissue expression from TISSUES for GPR15 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with GPR15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR15 Gene

Orthologs for GPR15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR15 34 33
  • 99.44 (n)
(Bos Taurus)
Mammalia GPR15 34 33
  • 86.41 (n)
(Canis familiaris)
Mammalia GPR15 34 33
  • 82.78 (n)
(Rattus norvegicus)
Mammalia Gpr15 33
  • 80 (n)
(Mus musculus)
Mammalia Gpr15 16 34 33
  • 79.63 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
(Gallus gallus)
Aves GPR15 34 33
  • 64.33 (n)
(Anolis carolinensis)
Reptilia GPR15 34
  • 55 (a)
(Danio rerio)
Actinopterygii BX957297.1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for GPR15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR15 Gene

Gene Tree for GPR15 (if available)
Gene Tree for GPR15 (if available)
Evolutionary constrained regions (ECRs) for GPR15: view image

Paralogs for GPR15 Gene

Paralogs for GPR15 Gene

(15) SIMAP similar genes for GPR15 Gene using alignment to 2 proteins:

  • B6V9G9_HUMAN
genes like me logo Genes that share paralogs with GPR15: view

Variants for GPR15 Gene

Sequence variations from dbSNP and Humsavar for GPR15 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000219729 -- 98,533,436(+) G/C 3_prime_UTR_variant
rs1000335404 -- 98,533,156(+) G/A 3_prime_UTR_variant
rs1001282150 -- 98,532,857(+) T/G coding_sequence_variant, stop_gained
rs1001834914 -- 98,531,057(+) T/C upstream_transcript_variant
rs1003566456 -- 98,530,132(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR15 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
nsv236502 CNV deletion 16902084
nsv591065 CNV gain 21841781
nsv834774 CNV loss 17160897
nsv834775 CNV gain 17160897

Variation tolerance for GPR15 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR15 Gene

Disorders for GPR15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
mediastinal malignant lymphoma
  • lymphoma of mediastinum
- elite association - COSMIC cancer census association via MalaCards
Search GPR15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR15

genes like me logo Genes that share disorders with GPR15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR15 Gene

Publications for GPR15 Gene

  1. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. (PMID: 8838812) Heiber M … O'Dowd BF (Genomics 1996) 2 3 4 58
  2. Use of alternate coreceptors on primary cells by two HIV-1 isolates. (PMID: 15992849) Cilliers T … Morris L (Virology 2005) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. (PMID: 28936214) Ocón B … Butcher EC (Frontiers in immunology 2017) 3 58
  5. Differential phosphorylation signals control endocytosis of GPR15. (PMID: 28615320) Okamoto Y … Shikano S (Molecular biology of the cell 2017) 3 58

Products for GPR15 Gene

Sources for GPR15 Gene

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