This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012] See more...

Aliases for GPR15 Gene

Aliases for GPR15 Gene

  • G Protein-Coupled Receptor 15 2 3 5
  • G-Protein Coupled Receptor 15 3 4
  • Brother Of Bonzo 3 4
  • BOB 3
  • BoB 4

External Ids for GPR15 Gene

Previous GeneCards Identifiers for GPR15 Gene

  • GC03P094873
  • GC03P097554
  • GC03P099532
  • GC03P099571
  • GC03P099733
  • GC03P098250
  • GC03P095623

Summaries for GPR15 Gene

Entrez Gene Summary for GPR15 Gene

  • This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR15 Gene

GPR15 (G Protein-Coupled Receptor 15) is a Protein Coding gene. Diseases associated with GPR15 include Mediastinal Malignant Lymphoma and Human Immunodeficiency Virus Type 1. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is GPR25.

UniProtKB/Swiss-Prot Summary for GPR15 Gene

  • Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Wiki entry for GPR15 Gene

Additional gene information for GPR15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR15 Gene

Genomics for GPR15 Gene

GeneHancer (GH) Regulatory Elements for GPR15 Gene

Promoters and enhancers for GPR15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098529 Enhancer 0.8 Ensembl dbSUPER 500.7 -1.8 -1798 0.2 CTBP1 POLR2A SRF ARNT CHD1 ELF1 IKZF1 TBP NR2F1 HDGF GPR15 RPL38P4 ENSG00000285635
GH03J098531 Enhancer 0.7 dbSUPER 500.7 +1.0 965 1.7 SIN3A RELA POLR2A CBFB SRF ARNT CHD1 PBX2 SPI1 WRNIP1 GPR15 RIOX2 DCBLD2 L13714-326 ENSG00000285635
GH03J098535 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +6.8 6753 5.3 ZBTB40 SP1 FOS EP300 JUND RELA MEF2C RCOR1 TRIM22 POLR2A CLDND1 GPR15 ST3GAL6-AS1 OR5K2 CPOX OR5K4 ST3GAL6 L13714-326 ENSG00000285635
GH03J098550 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE dbSUPER 9.1 +23.2 23163 8.2 RXRA SP1 EP300 JUND RELA MEF2C HES1 MYC RCOR1 REST CLDND1 CPOX GPR15 DCBLD2 ST3GAL6-AS1 OR5H6 OR5H2 L13714-326 ENSG00000285635
GH03J098560 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +33.1 33050 8.4 SP1 EP300 JUND RELA MEF2C TRIM22 POLR2A OSR2 BCL11A TCF12 CPOX OR5K2 ST3GAL6-AS1 ST3GAL6 GPR15 CLDND1 L13714-326 ENSG00000285635
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR15

Top Transcription factor binding sites by QIAGEN in the GPR15 gene promoter:
  • AhR
  • AML1a
  • Bach2
  • FOXD1
  • GATA-3
  • Gfi-1
  • IRF-1
  • MRF-2

Genomic Locations for GPR15 Gene

Genomic Locations for GPR15 Gene
chr3:98,531,899-98,534,681
(GRCh38/hg38)
Size:
2,783 bases
Orientation:
Plus strand
chr3:98,250,743-98,251,960
(GRCh37/hg19)
Size:
1,218 bases
Orientation:
Plus strand

Genomic View for GPR15 Gene

Genes around GPR15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR15 Gene

Proteins for GPR15 Gene

  • Protein details for GPR15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49685-GPR15_HUMAN
    Recommended name:
    G-protein coupled receptor 15
    Protein Accession:
    P49685
    Secondary Accessions:
    • Q3MIL4
    • Q6ISN6

    Protein attributes for GPR15 Gene

    Size:
    360 amino acids
    Molecular mass:
    40787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR15 Gene

Post-translational modifications for GPR15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR15 Gene

Domains & Families for GPR15 Gene

Gene Families for GPR15 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR15 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 15 (B6V9G9_HUMAN)
  • Brother of Bonzo (GPR15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49685

UniProtKB/Swiss-Prot:

GPR15_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR15: view

Function for GPR15 Gene

Molecular function for GPR15 Gene

UniProtKB/Swiss-Prot Function:
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
GENATLAS Biochemistry:
G protein coupled receptor 15

Gene Ontology (GO) - Molecular Function for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 15650194
GO:0004930 G protein-coupled receptor activity IBA,IDA 28900043
GO:0005515 protein binding IPI 28936214
GO:0015026 coreceptor activity IDA 15650194
genes like me logo Genes that share ontologies with GPR15: view
genes like me logo Genes that share phenotypes with GPR15: view

Animal Models for GPR15 Gene

MGI Knock Outs for GPR15:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR15

CRISPR Products

Clone Products

  • Addgene plasmids for GPR15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR15 Gene

Localization for GPR15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR15 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 28615320
GO:0005886 plasma membrane IBA,TAS --
GO:0005887 integral component of plasma membrane TAS 8838812
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR15 Gene

Pathways & Interactions for GPR15 Gene

genes like me logo Genes that share pathways with GPR15: view

Pathways by source for GPR15 Gene

Gene Ontology (GO) - Biological Process for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0046718 viral entry into host cell IDA 15650194
GO:0072678 T cell migration IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for SIGNOR curated interactions for GPR15 Gene

Drugs & Compounds for GPR15 Gene

No Compound Related Data Available

Transcripts for GPR15 Gene

mRNA/cDNA for GPR15 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR15

Alternative Splicing Database (ASD) splice patterns (SP) for GPR15 Gene

No ASD Table

Relevant External Links for GPR15 Gene

GeneLoc Exon Structure for
GPR15

Expression for GPR15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR15 Gene

Protein differential expression in normal tissues from HIPED for GPR15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR15 Gene



Protein tissue co-expression partners for GPR15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR15

SOURCE GeneReport for Unigene cluster for GPR15 Gene:

Hs.563128

Evidence on tissue expression from TISSUES for GPR15 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with GPR15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR15 Gene

Orthologs for GPR15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR15 31 30
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR15 31 30
  • 86.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR15 31 30
  • 82.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr15 30
  • 80 (n)
mouse
(Mus musculus)
Mammalia Gpr15 17 31 30
  • 79.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GPR15 31 30
  • 64.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR15 31
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX957297.1 31
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for GPR15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR15 Gene

ENSEMBL:
Gene Tree for GPR15 (if available)
TreeFam:
Gene Tree for GPR15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR15: view image

Paralogs for GPR15 Gene

Paralogs for GPR15 Gene

(15) SIMAP similar genes for GPR15 Gene using alignment to 2 proteins:

  • GPR15_HUMAN
  • B6V9G9_HUMAN
genes like me logo Genes that share paralogs with GPR15: view

Variants for GPR15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR15 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
767919 Benign: not provided 98,532,367(+) A/G MISSENSE_VARIANT
791939 Benign: not provided 98,532,771(+) C/T SYNONYMOUS_VARIANT
rs149131823 Uncertain Significance: not provided 98,532,227(+) G/A MISSENSE_VARIANT
rs2230344 - p.Pro37Ser
rs35320046 - p.Met112Val

Additional dbSNP identifiers (rs#s) for GPR15 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR15 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
nsv236502 CNV deletion 16902084
nsv591065 CNV gain 21841781
nsv834774 CNV loss 17160897
nsv834775 CNV gain 17160897

Variation tolerance for GPR15 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR15 Gene

Disorders for GPR15 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GPR15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mediastinal malignant lymphoma
  • lymphoma of mediastinum
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
gray zone lymphoma
  • b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
thymus basaloid carcinoma
  • basaloid carcinoma of the thymus
- elite association - COSMIC cancer census association via MalaCards
Search GPR15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR15

genes like me logo Genes that share disorders with GPR15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR15 Gene

Publications for GPR15 Gene

  1. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. (PMID: 8838812) Heiber M … O'Dowd BF (Genomics 1996) 2 3 4 54
  2. Use of alternate coreceptors on primary cells by two HIV-1 isolates. (PMID: 15992849) Cilliers T … Morris L (Virology 2005) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Specific induction of the unique GPR15 expression in heterogeneous blood lymphocytes by tobacco smoking. (PMID: 30387691) Bauer M … Herberth G (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2019) 3 54
  5. A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. (PMID: 28936214) Ocón B … Butcher EC (Frontiers in immunology 2017) 3 54

Products for GPR15 Gene

  • Biorbyt antibodies for GPR15

Sources for GPR15 Gene