Aliases for GPR148 Gene
Aliases for GPR148 Gene
External Ids for GPR148 Gene
- HGNC: 23623
- Entrez Gene: 344561
- Ensembl: ENSG00000173302
- UniProtKB: Q8TDV2
Previous GeneCards Identifiers for GPR148 Gene
- GC02P131697
- GC02P131320
- GC02P131203
- GC02P131486
- GC02P123559
- GC02P130729
- GC02P130730
- GC02P130820
- GC02P130850
- GC02P130866
- GC02P130881
- GC02P130906
- GC02P130925
Summaries for GPR148 Gene
GeneCards Summary for GPR148 Gene
GPR148 (G Protein-Coupled Receptor 148) is a Protein Coding gene. Diseases associated with GPR148 include Cicatricial Entropion and Median Neuropathy. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.
UniProtKB/Swiss-Prot for GPR148 Gene
-
Orphan receptor.
Additional gene information for GPR148 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR148 Gene
Genomics for GPR148 Gene
GeneHancer (GH) Regulatory Elements for GPR148 Gene
Promoters and enhancers for GPR148 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J130726 | Enhancer | 1.1 | Ensembl ENCODE | 650.7 | -0.4 | -445 | 2.5 | PKNOX1 ATF1 SIN3A KLF14 ZBTB40 ZNF335 POLR2B ATF7 CREM KLF13 | GC02M130719 GPR148 GC02P130573 | |
| GH02J130823 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 10.9 | +96.4 | 96431 | 1.9 | HDGF BMI1 BATF IRF4 ZSCAN5C ZNF207 ZNF143 ATF7 FOS ETV6 | GPR148 ARHGEF4 MZT2B CCDC74A CYCSP8 GC02P130573 | |
| GH02J130819 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 10.9 | +92.3 | 92295 | 1.1 | CTCF REST ZIC2 | GPR148 ARHGEF4 CYCSP8 GC02P130573 | |
| GH02J130824 | Enhancer | 0.5 | FANTOM5 dbSUPER | 10.9 | +95.1 | 95130 | 0.3 | GPR148 ARHGEF4 CYCSP8 GC02P130573 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR148 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GPR148 Gene
Genomic Locations for GPR148 Gene
- chr2:130,728,156-130,730,544
- (GRCh38/hg38)
- Size:
- 2,389 bases
- Orientation:
- Plus strand
- chr2:131,486,643-131,487,909
- (GRCh37/hg19)
- Size:
- 1,267 bases
- Orientation:
- Plus strand
Genomic View for GPR148 Gene
Genes around GPR148 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q21.1 by Entrez Gene
- 2q21.1 by HGNC
- 2q21.1 by Ensembl
GPR148 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR148 Gene
Proteins for GPR148 Gene
-
Protein details for GPR148 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDV2-GP148_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 148
- Protein Accession:
- Q8TDV2
- Q2M369
- Q86SP7
- Q86U87
Protein attributes for GPR148 Gene
- Size:
- 347 amino acids
- Molecular mass:
- 38288 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR148 Gene
Post-translational modifications for GPR148 Gene
Other Protein References for GPR148 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR148
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Protein Products
-
OriGene Purified Proteins for GPR148
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Assay Products
No data available for DME Specific Peptides for GPR148 Gene
Domains & Families for GPR148 Gene
Gene Families for GPR148 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR148 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR148 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDV2- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR148 Gene
Molecular function for GPR148 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
Phenotypes for GPR148 Gene
Animal Model Products
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-
CRISPR Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR148
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- genomics-online: cdna clones - Search results for available GPR148 gene related products
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-
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Cell Line Products
-
Horizon Cell Lines for GPR148
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR148 Gene
Localization for GPR148 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR148 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR148 Gene
Pathways & Interactions for GPR148 Gene
No Data Available
Interacting Proteins for GPR148 Gene
GPS-Prot Interaction Network for GPR148
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR148 Gene
Transcripts for GPR148 Gene
mRNA/cDNA for GPR148 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000309926 1267 bps (uc002trv.2)
Unigene Clusters for GPR148 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR148
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- Applied Biological Materials CRISPR for GPR148
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR148
- GenScript: Design CRISPR guide RNA sequences for GPR148
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR148
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR148
- genomics-online: shRNA clones - Search results for available GPR148 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GPR148
- VectorBuilder custom plasmid, inducible vectors for GPR148
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR148
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR148
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR148
- genomics-online: cdna clones - Search results for available GPR148 gene related products
- orf clones - Search results for available GPR148 gene related products
- Applied Biological Materials Clones for GPR148
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR148
Expression for GPR148 Gene
mRNA differential expression in normal tissues according to GTEx for GPR148 Gene
This gene is overexpressed in Pituitary (x11.0), Brain - Cerebellar Hemisphere (x8.0), and Brain - Cerebellum (x7.8).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR148 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GPR148 Gene:
GPR148SOURCE GeneReport for Unigene cluster for GPR148 Gene:
Hs.452574mRNA Expression by UniProt/SwissProt for GPR148 Gene:
Q8TDV2-GP148_HUMAN
Tissue specificity:
Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.
Evidence on tissue expression from TISSUES for GPR148 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR148
-
OriGene qPCR primer pairs for GPR148
- genomics-online: primer clones - Search results for available GPR148 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR148 Gene
Orthologs for GPR148 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR148 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GPR148 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR148 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GPR148 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | LOC101885431 33 |
|
||
| BX323035.1 34 |
|
OneToOne |
- Species where no ortholog for GPR148 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GPR148 Gene
- ENSEMBL:
- Gene Tree for GPR148 (if available)
- TreeFam:
- Gene Tree for GPR148 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR148: view image
Paralogs for GPR148 Gene
No data available for Paralogs for GPR148 Gene
Variants for GPR148 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001359097 | -- | 130,729,688(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1002397711 | -- | 130,730,328(+) | G/A | 3_prime_UTR_variant | |
| rs1003036273 | -- | 130,728,303(+) | A/C | upstream_transcript_variant | |
| rs1003836663 | -- | 130,727,310(+) | G/C | upstream_transcript_variant | |
| rs1004281422 | -- | 130,727,328(+) | G/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2032n106 | OTHER | inversion | 24896259 |
| dgv4074n100 | CNV | gain | 25217958 |
| dgv4075n100 | CNV | gain | 25217958 |
| dgv616e201 | CNV | deletion | 23290073 |
| dgv731e199 | CNV | deletion | 23128226 |
| esv2670824 | CNV | deletion | 23128226 |
| esv2759092 | CNV | gain+loss | 17122850 |
| esv2760576 | CNV | gain+loss | 21179565 |
| esv3575299 | CNV | gain | 25503493 |
| esv3893337 | CNV | loss | 25118596 |
| nsv1014723 | CNV | loss | 25217958 |
| nsv1147463 | OTHER | inversion | 26484159 |
| nsv428403 | CNV | loss | 18775914 |
| nsv524021 | CNV | loss | 19592680 |
| nsv583135 | CNV | loss | 21841781 |
| nsv583136 | CNV | loss | 21841781 |
| nsv7327 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.37;
63.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR148 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR148
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR148 Gene
Disorders for GPR148 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cicatricial entropion |
|
|
| median neuropathy |
|
|
Search GPR148 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR148
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR148 Gene
Publications for GPR148 Gene
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A novel human G protein-coupled receptor is over-expressed in prostate cancer. (PMID: 15688318) Parmigiani RB … Malnic B (Genetics and molecular research : GMR 2004) 3 4 58
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
- Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148. (PMID: 22543972) Dharmadhikari AV … Stankiewicz P (Human molecular genetics 2012) 3 58
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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Sources for GPR148 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
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- (169) Biorbyt