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Aliases for GPR148 Gene
Aliases for GPR148 Gene
External Ids for GPR148 Gene
- HGNC: 23623
- Entrez Gene: 344561
- Ensembl: ENSG00000173302
- UniProtKB: Q8TDV2
Previous GeneCards Identifiers for GPR148 Gene
- GC02P131697
- GC02P131320
- GC02P131203
- GC02P131486
- GC02P123559
- GC02P130730
- GC02P130998
- GC02P131023
- GC02P131026
- GC02P132454
- GC02P130820
- GC02P130850
- GC02P130866
- GC02P130881
- GC02P130906
- GC02P130925
- GC02P130951
- GC02P130970
Summaries for GPR148 Gene
GeneCards Summary for GPR148 Gene
GPR148 (G Protein-Coupled Receptor 148) is a Protein Coding gene. Diseases associated with GPR148 include Cicatricial Entropion and Median Neuropathy. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is NMUR1.
UniProtKB/Swiss-Prot Summary for GPR148 Gene
-
Orphan receptor.
Additional gene information for GPR148 Gene
- HGNC(23623)
- Entrez Gene(344561)
- Ensembl(ENSG00000173302)
- UniProtKB(Q8TDV2)
- Open Targets Platform(ENSG00000173302)
- Search for GPR148 at DataMed
- Search for GPR148 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR148 Gene
Genomics for GPR148 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPR148 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J130726 | Promoter/Enhancer | 1.2 | ENCODE CraniofacialAtlas | 600.7 | -1.4 | -1359 | 2.5 | SP1 CREB1 ZIC2 PKNOX1 REST POLR2A ZNF600 ZNF341 ZFX NRF1 | GPR148 RF00994-516 ENSG00000229797 POTEJ | |
| GH02J130823 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 10.9 | +97.7 | 97651 | 6.2 | TEAD4 ZNF629 KDM1A BACH1 LARP7 ZNF143 RELA TCF12 IKZF2 TRIM22 | GPR148 ARHGEF4 ENSG00000233221 MZT2B CCDC74A lnc-ARHGEF4-3 AMER3 | |
| GH02J130819 | Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 10.9 | +91.1 | 91130 | 2 | CTCF KDM1A ZIC2 ZNF652 NR3C1 | GPR148 ARHGEF4 ENSG00000233221 lnc-ARHGEF4-3 AMER3 | |
| GH02J130824 | Enhancer | 0.7 | FANTOM5 Ensembl dbSUPER | 10.9 | +94.2 | 94216 | 0.3 | SMARCA4 | GPR148 ARHGEF4 lnc-ARHGEF4-3 AMER3 | |
| GH02J130814 | Enhancer | 0.3 | Ensembl | 10.3 | +85.2 | 85231 | 0.2 | KLF4 KLF9 | GPR148 lnc-ARHGEF4-3 ARHGEF4 AMER3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR148 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR148
Genomic Locations for GPR148 Gene
Genomic Locations for GPR148 Gene
- chr2:130,729,070-130,730,336
- (GRCh38/hg38)
- Size:
- 1,267 bases
- Orientation:
- Plus strand
- chr2:131,486,643-131,487,909
- (GRCh37/hg19)
- Size:
- 1,267 bases
- Orientation:
- Plus strand
Genomic View for GPR148 Gene
Genes around GPR148 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q21.1 by HGNC
- 2q21.1 by Entrez Gene
- 2q21.1 by Ensembl
GPR148 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR148 Gene
Proteins for GPR148 Gene
-
Protein details for GPR148 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDV2-GP148_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 148
- Protein Accession:
- Q8TDV2
- Q2M369
- Q86SP7
- Q86U87
Protein attributes for GPR148 Gene
- Size:
- 347 amino acids
- Molecular mass:
- 38288 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR148 Gene
Post-translational modifications for GPR148 Gene
Other Protein References for GPR148 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GPR148 Antibody and Immunotag™ GP148 Polyclonal Antibody
- Novus Biologicals Antibodies for GPR148
- Invitrogen Antibodies for GPR148 (AFLGC-GPR148)
-
Boster Bio Antibodies for GPR148
Protein Products
-
OriGene Purified Proteins for GPR148
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR148
- Origene Custom Protein Services for GPR148
No data available for DME Specific Peptides for GPR148 Gene
Domains & Families for GPR148 Gene
Gene Families for GPR148 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR148 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR148 Gene
- GenScript: Design optimal peptide antigens:
-
- G-protein coupled receptor PGR6 (GP148_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TDV2- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR148 Gene
Molecular function for GPR148 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
| GO:0004930 | G protein-coupled receptor activity | IEA | -- |
Phenotypes for GPR148 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR148 - Select products 50% OFF >
- * GPR148 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR148
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR148
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR148
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR148
- Browse OriGene Inhibitory RNA Products For GPR148
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Clone Products
- Applied Biological Materials (abm): Clones for GPR148 - Select products 50% OFF >
- * GPR148 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GPR148
- Addgene plasmids for GPR148
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR148
Cell Line Products
-
Horizon Cell Lines for GPR148
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR148 Gene
Localization for GPR148 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR148 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR148 Gene
Pathways & Interactions for GPR148 Gene
Interacting Proteins for GPR148 Gene
Selected Interacting proteins:
Q8TDV2-GP148_HUMAN
ENSP00000308908
for GPR148 Gene via
UniProtKB
STRING
GPS-Prot Interaction Network for GPR148
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR148 Gene
Transcripts for GPR148 Gene
mRNA/cDNA for GPR148 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309926 1267 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR148 - Select products 50% OFF >
- * GPR148 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR148
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR148
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR148
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR148
- Browse OriGene Inhibitory RNA Products For GPR148
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR148
Clone Products
- Applied Biological Materials (abm): Clones for GPR148 - Select products 50% OFF >
- * GPR148 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GPR148
- Addgene plasmids for GPR148
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR148
Relevant External Links for GPR148 Gene
- GeneLoc Exon Structure for
- GPR148
Expression for GPR148 Gene
mRNA differential expression in normal tissues according to GTEx for GPR148 Gene
This gene is overexpressed in Pituitary (x11.0), Brain - Cerebellar Hemisphere (x8.0), and Brain - Cerebellum (x7.8).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR148 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR148
SOURCE GeneReport for Unigene cluster for GPR148 Gene:
Hs.452574mRNA Expression by UniProt/SwissProt for GPR148 Gene:
Q8TDV2-GP148_HUMAN
Tissue specificity:
Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.
Evidence on tissue expression from TISSUES for GPR148 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for GPR148
-
OriGene qPCR primer pairs and template standards for GPR148
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR148 Gene
Orthologs for GPR148 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR148 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPR148 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GPR148 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GPR148 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101885431 30 |
|
||
| BX323035.1 31 |
|
OneToOne |
- Species where no ortholog for GPR148 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPR148 Gene
- ENSEMBL:
- Gene Tree for GPR148 (if available)
- TreeFam:
- Gene Tree for GPR148 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR148: view image
Paralogs for GPR148 Gene
Variants for GPR148 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR148 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs272128 | - | p.Thr317Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2032n106 | OTHER | inversion | 24896259 |
| dgv4074n100 | CNV | gain | 25217958 |
| dgv4075n100 | CNV | gain | 25217958 |
| dgv616e201 | CNV | deletion | 23290073 |
| dgv731e199 | CNV | deletion | 23128226 |
| esv2670824 | CNV | deletion | 23128226 |
| esv2759092 | CNV | gain+loss | 17122850 |
| esv2760576 | CNV | gain+loss | 21179565 |
| esv3575299 | CNV | gain | 25503493 |
| esv3893337 | CNV | loss | 25118596 |
| nsv1014723 | CNV | loss | 25217958 |
| nsv1147463 | OTHER | inversion | 26484159 |
| nsv428403 | CNV | loss | 18775914 |
| nsv524021 | CNV | loss | 19592680 |
| nsv583135 | CNV | loss | 21841781 |
| nsv583136 | CNV | loss | 21841781 |
| nsv7327 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.37;
63.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR148 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR148
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR148 Gene
Disorders for GPR148 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cicatricial entropion |
|
|
| median neuropathy |
|
|
| hypotrichosis-lymphedema-telangiectasia-renal defect syndrome |
|
|
| branchiootic syndrome |
|
|
Search GPR148 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR148
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR148 Gene
Publications for GPR148 Gene
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A novel human G protein-coupled receptor is over-expressed in prostate cancer. (PMID: 15688318) Parmigiani RB … Malnic B (Genetics and molecular research : GMR 2004) 3 4
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for GPR148 Gene
- Custom Antibody Services
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- Custom Assay Services
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- OriGene qPCR primer pairs for GPR148
- OriGene qPCR primer pairs and template standards for GPR148
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- OriGene ORF clones in human for GPR148
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- Novus Biologicals proteins and lysates for GPR148
- Browse Antibodies
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- Invitrogen Antibodies for GPR148 (AFLGC-GPR148)
- VectorBuilder Custom and pre-made DNA vectors for GPR148 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GPR148 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 22 available GPR148 Antibodies ranked by validation data
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- Boster Bio Antibodies for GPR148
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Sources for GPR148 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
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- (49) Leiden
- (50) miRBase
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
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- (132) dbSUPER
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- (135) abm
- (136) Human Protein Atlas
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- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
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- (148) RNACentral
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- (152) DiseaseEnhancer
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- (154) Biorbyt
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- (159) GeneImprint
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- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (171) SRPDB
- (172) GENCODE
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- (177) snoDB
- (178) MirGeneDB