Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR148 Gene

Aliases for GPR148 Gene

  • G Protein-Coupled Receptor 148 2 3 5
  • Brain And Testis Restricted GPCR 3 4
  • PGR6 3 4
  • BTR 3 4
  • Probable G-Protein Coupled Receptor 148 3
  • G Protein-Coupled Receptor PGR6 3
  • G-Protein Coupled Receptor PGR6 4

External Ids for GPR148 Gene

Previous GeneCards Identifiers for GPR148 Gene

  • GC02P131697
  • GC02P131320
  • GC02P131203
  • GC02P131486
  • GC02P123559
  • GC02P130729
  • GC02P130730
  • GC02P130820
  • GC02P130850
  • GC02P130866
  • GC02P130881
  • GC02P130906
  • GC02P130925

Summaries for GPR148 Gene

GeneCards Summary for GPR148 Gene

GPR148 (G Protein-Coupled Receptor 148) is a Protein Coding gene. Diseases associated with GPR148 include Cicatricial Entropion and Median Neuropathy. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR148 Gene

  • Orphan receptor.

Gene Wiki entry for GPR148 Gene

Additional gene information for GPR148 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR148 Gene

Genomics for GPR148 Gene

GeneHancer (GH) Regulatory Elements for GPR148 Gene

Promoters and enhancers for GPR148 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J130726 Enhancer 1.1 Ensembl ENCODE 650.7 -0.4 -445 2.5 PKNOX1 ATF1 SIN3A KLF14 ZBTB40 ZNF335 POLR2B ATF7 CREM KLF13 GC02M130719 GPR148 GC02P130573
GH02J130823 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +96.4 96431 1.9 HDGF BMI1 BATF IRF4 ZSCAN5C ZNF207 ZNF143 ATF7 FOS ETV6 GPR148 ARHGEF4 MZT2B CCDC74A CYCSP8 GC02P130573
GH02J130819 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.9 +92.3 92295 1.1 CTCF REST ZIC2 GPR148 ARHGEF4 CYCSP8 GC02P130573
GH02J130824 Enhancer 0.5 FANTOM5 dbSUPER 10.9 +95.1 95130 0.3 GPR148 ARHGEF4 CYCSP8 GC02P130573
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR148 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR148 Gene

Genomic Locations for GPR148 Gene
2,389 bases
Plus strand
1,267 bases
Plus strand

Genomic View for GPR148 Gene

Genes around GPR148 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR148 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR148 Gene

Proteins for GPR148 Gene

  • Protein details for GPR148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 148
    Protein Accession:
    Secondary Accessions:
    • Q2M369
    • Q86SP7
    • Q86U87

    Protein attributes for GPR148 Gene

    347 amino acids
    Molecular mass:
    38288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR148 Gene

Post-translational modifications for GPR148 Gene

  • Glycosylation at Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR148 Gene

Domains & Families for GPR148 Gene

Gene Families for GPR148 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR148 Gene


Suggested Antigen Peptide Sequences for GPR148 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR148: view

Function for GPR148 Gene

Molecular function for GPR148 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR148: view
genes like me logo Genes that share phenotypes with GPR148: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR148

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR148 Gene

Localization for GPR148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR148 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR148 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR148: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR148 Gene

Pathways & Interactions for GPR148 Gene

SuperPathways for GPR148 Gene

No Data Available

Interacting Proteins for GPR148 Gene

Gene Ontology (GO) - Biological Process for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR148: view

No data available for Pathways by source and SIGNOR curated interactions for GPR148 Gene

Drugs & Compounds for GPR148 Gene

No Compound Related Data Available

Transcripts for GPR148 Gene

mRNA/cDNA for GPR148 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR148 Gene

G protein-coupled receptor 148:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR148

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR148 Gene

No ASD Table

Relevant External Links for GPR148 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR148 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR148 Gene

mRNA differential expression in normal tissues according to GTEx for GPR148 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Cerebellar Hemisphere (x8.0), and Brain - Cerebellum (x7.8).

Protein differential expression in normal tissues from HIPED for GPR148 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR148 Gene

Protein tissue co-expression partners for GPR148 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR148 Gene:


SOURCE GeneReport for Unigene cluster for GPR148 Gene:


mRNA Expression by UniProt/SwissProt for GPR148 Gene:

Tissue specificity: Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.

Evidence on tissue expression from TISSUES for GPR148 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR148: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR148 Gene

Orthologs for GPR148 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR148 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR148 34 33
  • 99.04 (n)
(Canis familiaris)
Mammalia GPR148 33
  • 75.6 (n)
(Ornithorhynchus anatinus)
Mammalia GPR148 34
  • 52 (a)
(Monodelphis domestica)
Mammalia GPR148 34
  • 51 (a)
(Danio rerio)
Actinopterygii LOC101885431 33
  • 46.6 (n)
BX323035.1 34
  • 28 (a)
Species where no ortholog for GPR148 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR148 Gene

Gene Tree for GPR148 (if available)
Gene Tree for GPR148 (if available)
Evolutionary constrained regions (ECRs) for GPR148: view image

Paralogs for GPR148 Gene

No data available for Paralogs for GPR148 Gene

Variants for GPR148 Gene

Sequence variations from dbSNP and Humsavar for GPR148 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001359097 -- 130,729,688(+) C/T coding_sequence_variant, synonymous_variant
rs1002397711 -- 130,730,328(+) G/A 3_prime_UTR_variant
rs1003036273 -- 130,728,303(+) A/C upstream_transcript_variant
rs1003836663 -- 130,727,310(+) G/C upstream_transcript_variant
rs1004281422 -- 130,727,328(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR148 Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2670824 CNV deletion 23128226
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv3575299 CNV gain 25503493
esv3893337 CNV loss 25118596
nsv1014723 CNV loss 25217958
nsv1147463 OTHER inversion 26484159
nsv428403 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583135 CNV loss 21841781
nsv583136 CNV loss 21841781
nsv7327 OTHER inversion 18451855

Variation tolerance for GPR148 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR148 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR148 Gene

Disorders for GPR148 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR148 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cicatricial entropion
median neuropathy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR148

genes like me logo Genes that share disorders with GPR148: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR148 Gene

Publications for GPR148 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A novel human G protein-coupled receptor is over-expressed in prostate cancer. (PMID: 15688318) Parmigiani RB … Malnic B (Genetics and molecular research : GMR 2004) 3 4 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148. (PMID: 22543972) Dharmadhikari AV … Stankiewicz P (Human molecular genetics 2012) 3 58

Products for GPR148 Gene

Sources for GPR148 Gene

Loading form....