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Aliases for GPR146 Gene

Aliases for GPR146 Gene

  • G Protein-Coupled Receptor 146 2 3 5
  • G-Protein Coupled Receptor PGR8 3 4
  • PGR8 3 4
  • Probable G-Protein Coupled Receptor 146 3

External Ids for GPR146 Gene

Previous GeneCards Identifiers for GPR146 Gene

  • GC07P000807
  • GC07P000841
  • GC07P000871
  • GC07P001050
  • GC07P001061
  • GC07P001084
  • GC07P001012

Summaries for GPR146 Gene

GeneCards Summary for GPR146 Gene

GPR146 (G Protein-Coupled Receptor 146) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPER1.

UniProtKB/Swiss-Prot for GPR146 Gene

  • Orphan receptor.

Gene Wiki entry for GPR146 Gene

Additional gene information for GPR146 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR146 Gene

Genomics for GPR146 Gene

GeneHancer (GH) Regulatory Elements for GPR146 Gene

Promoters and enhancers for GPR146 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I001051 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.4 +9.8 9824 4.8 HDAC1 ZNF335 ZNF121 GLIS2 GATA2 ATF7 CREM EGR2 ZBTB2 CEBPB GPR146 LOC105375120 LOC101927021 ZFAND2A COX19 GPER1 FAM20C ENSG00000257607 GC07P001058 GC07M001041
GH07I001043 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 +0.2 163 3 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 SP3 ZHX2 GPR146 LOC105375120 ZFAND2A MIR339 CYP2W1 COX19 LOC101927021 C7orf50 GPER1 PIR31890
GH07I000971 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.6 -68.3 -68329 8.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 COX19 CYP2W1 LOC105375120 GPR146 DNAAF5 MIR339 ADAP1 ENSG00000225146 C7orf50 SUN1
GH07I000981 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 22.2 -59.3 -59274 7.1 HDGF MLX ARID4B DMAP1 ZBTB7B ZNF48 TCF12 ZNF121 GLIS2 FOS CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
GH07I001122 Enhancer 1 Ensembl ENCODE dbSUPER 16.3 +79.7 79716 3 CTCF MAX SIN3A REST RAD21 NR2F2 TEAD3 OSR2 MITF POLR2A LOC102723758 LOC101927021 GPR146 LOC105375120 ZFAND2A CYP2W1 ENSG00000225146 MIR339 GPER1 PIR49984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR146 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR146 gene promoter:

Genomic Locations for GPR146 Gene

Genomic Locations for GPR146 Gene
chr7:1,044,573-1,059,269
(GRCh38/hg38)
Size:
14,697 bases
Orientation:
Plus strand
chr7:1,084,212-1,098,897
(GRCh37/hg19)

Genomic View for GPR146 Gene

Genes around GPR146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR146 Gene

Proteins for GPR146 Gene

  • Protein details for GPR146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CH1-GP146_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 146
    Protein Accession:
    Q96CH1
    Secondary Accessions:
    • Q86SP5

    Protein attributes for GPR146 Gene

    Size:
    333 amino acids
    Molecular mass:
    36580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR146 Gene

Post-translational modifications for GPR146 Gene

No data available for DME Specific Peptides for GPR146 Gene

Domains & Families for GPR146 Gene

Gene Families for GPR146 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR146 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CH1

UniProtKB/Swiss-Prot:

GP146_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR146: view

Function for GPR146 Gene

Molecular function for GPR146 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR146 Gene

Gene Ontology (GO) - Molecular Function for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR146: view
genes like me logo Genes that share phenotypes with GPR146: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR146 Gene

Localization for GPR146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR146 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR146 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR146: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR146 Gene

Pathways & Interactions for GPR146 Gene

SuperPathways for GPR146 Gene

No Data Available

Interacting Proteins for GPR146 Gene

Gene Ontology (GO) - Biological Process for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR146: view

No data available for Pathways by source and SIGNOR curated interactions for GPR146 Gene

Drugs & Compounds for GPR146 Gene

No Compound Related Data Available

Transcripts for GPR146 Gene

Unigene Clusters for GPR146 Gene

G protein-coupled receptor 146:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR146 Gene

No ASD Table

Relevant External Links for GPR146 Gene

GeneLoc Exon Structure for
GPR146
ECgene alternative splicing isoforms for
GPR146

Expression for GPR146 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR146 Gene:

GPR146

SOURCE GeneReport for Unigene cluster for GPR146 Gene:

Hs.718624

Evidence on tissue expression from TISSUES for GPR146 Gene

  • Kidney(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with GPR146: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR146 Gene

Orthologs for GPR146 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR146 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR146 33 34
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Gpr146 33 16 34
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Gpr146 33
  • 76.03 (n)
cow
(Bos Taurus)
Mammalia GPR146 33 34
  • 75.68 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR146 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR146 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR146 33 34
  • 66.17 (n)
lizard
(Anolis carolinensis)
Reptilia GPR146 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr146 33
  • 63.86 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr146 33 34
  • 66.77 (n)
Species where no ortholog for GPR146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR146 Gene

ENSEMBL:
Gene Tree for GPR146 (if available)
TreeFam:
Gene Tree for GPR146 (if available)

Paralogs for GPR146 Gene

Paralogs for GPR146 Gene

genes like me logo Genes that share paralogs with GPR146: view

Variants for GPR146 Gene

Sequence variations from dbSNP and Humsavar for GPR146 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000172939 -- 1,053,060(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000353609 -- 1,048,697(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000450758 -- 1,045,920(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000523743 -- 1,054,137(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000562729 -- 1,052,000(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR146 Gene

Variant ID Type Subtype PubMed ID
nsv950784 CNV deletion 24416366
nsv823960 CNV gain 20364138
nsv605720 CNV loss 21841781
nsv605705 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605699 CNV loss 21841781
nsv509183 CNV insertion 20534489
nsv464245 CNV gain 19166990
nsv1161477 CNV deletion 26073780

Variation tolerance for GPR146 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR146

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR146 Gene

Disorders for GPR146 Gene

Additional Disease Information for GPR146

No disorders were found for GPR146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR146 Gene

Publications for GPR146 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  3. Evidence for an interaction between proinsulin C-peptide and GPR146. (PMID: 23980258) Yosten GL … Samson WK (The Journal of endocrinology 2013) 3 58
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Willer CJ … Global Lipids Genetics Consortium (Nature genetics 2013) 3 58
  5. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam DE … Fredriksson R (Biochimica et biophysica acta 2005) 3 58

Products for GPR146 Gene

Sources for GPR146 Gene

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