GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008] See more...

Aliases for GPR142 Gene

Aliases for GPR142 Gene

  • G Protein-Coupled Receptor 142 2 3 5
  • PGR2 2 3 4
  • Probable G-Protein Coupled Receptor 142 3 4
  • G-Protein Coupled Receptor PGR2 3 4
  • G-Protein Coupled Receptor 142 Long Form 3
  • GPRg1b 3
  • GPR142 5

External Ids for GPR142 Gene

Previous GeneCards Identifiers for GPR142 Gene

  • GC17P072829
  • GC17P072919
  • GC17P069875
  • GC17P072322
  • GC17P072363

Summaries for GPR142 Gene

Entrez Gene Summary for GPR142 Gene

  • GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR142 Gene

GPR142 (G Protein-Coupled Receptor 142) is a Protein Coding gene. Diseases associated with GPR142 include Fusariosis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR139.

UniProtKB/Swiss-Prot Summary for GPR142 Gene

Gene Wiki entry for GPR142 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR142 Gene

Genomics for GPR142 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR142 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074360 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 257.8 -5.5 -5475 2.5 CTCF SIN3A REST SMC3 GABPB1 YY1 SKIL RAD21 ZNF48 ZNF664 GPR142 BTBD17 RF00017-2536 KIF19
GH17J074368 Enhancer 0.7 ENCODE 250.7 +1.0 1040 0.2 CTCF ZIC2 REST ZNF740 VEZF1 TRIM22 SMC3 RAD21 ZNF2 RBPJ GPR142 RF00017-2537 GPRC5C
GH17J074369 Enhancer 0.6 FANTOM5 250.7 +1.5 1492 0.4 ZBTB10 ZNF740 GLI4 CTCF RBPJ ZNF48 IKZF1 GLIS1 GLIS2 RELB GPR142 BTBD17 RF00017-2537 GPRC5C
GH17J074461 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 +98.4 98362 9.3 SP1 BCL11A FOXA1 MNT HES1 MBD2 POLR2A BHLHE40 NONO SIN3A CD300A NAT9 NUP85 NT5C GGA3 MGC16275 GPR142 CD300LB BTBD17 HID1-AS1
GH17J074451 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 +86.5 86524 4.1 ZBTB10 IKZF1 ZEB1 NONO ZIC2 THAP11 SIN3A VEZF1 SMAD4 SAP130 GPR142 CD300E CD300LD GPRC5C ENSG00000265800 HSALNG0118650 HSALNG0118652 CD300A RF00017-2537
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR142 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR142

Top Transcription factor binding sites by QIAGEN in the GPR142 gene promoter:
  • c-Ets-1
  • c-Myc
  • Max
  • NF-1
  • NF-1/L
  • NF-kappaB
  • NF-kappaB1
  • SREBP-1a
  • SREBP-1b
  • YY1

Genomic Locations for GPR142 Gene

Latest Assembly
5,216 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
5,095 bases
Plus strand

(GRCh37/hg19 by Ensembl)
5,216 bases
Plus strand

Genomic View for GPR142 Gene

Genes around GPR142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR142 Gene

Proteins for GPR142 Gene

  • Protein details for GPR142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 142
    Protein Accession:
    Secondary Accessions:
    • A4CYJ8
    • Q86SL3

    Protein attributes for GPR142 Gene

    462 amino acids
    Molecular mass:
    51106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR142 Gene

Post-translational modifications for GPR142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR142 Gene

No data available for DME Specific Peptides for GPR142 Gene

Domains & Families for GPR142 Gene

Gene Families for GPR142 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR142 Gene


Suggested Antigen Peptide Sequences for GPR142 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR2 (GP142_HUMAN)
  • Seven transmembrane helix receptor (Q8NGB0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR142: view

Function for GPR142 Gene

Molecular function for GPR142 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR142 Gene

Gene Ontology (GO) - Molecular Function for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR142: view
genes like me logo Genes that share phenotypes with GPR142: view

Animal Models for GPR142 Gene

MGI Knock Outs for GPR142:
  • Gpr142 Gpr142<tm1.1(KOMP)Vlcg>

Animal Models for research

  • Taconic Biosciences Mouse Models for GPR142

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR142

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR142 Gene

Localization for GPR142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR142 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR142 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GPR142: view

Pathways & Interactions for GPR142 Gene

PathCards logo

SuperPathways for GPR142 Gene

No Data Available

Interacting Proteins for GPR142 Gene

Gene Ontology (GO) - Biological Process for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR142: view

No data available for Pathways by source and SIGNOR curated interactions for GPR142 Gene

Drugs & Compounds for GPR142 Gene

No Compound Related Data Available

Transcripts for GPR142 Gene

mRNA/cDNA for GPR142 Gene

8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR142

Alternative Splicing Database (ASD) splice patterns (SP) for GPR142 Gene

No ASD Table

Relevant External Links for GPR142 Gene

GeneLoc Exon Structure for

Expression for GPR142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR142 Gene

mRNA differential expression in normal tissues according to GTEx for GPR142 Gene

This gene is overexpressed in Spleen (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR142 Gene

Protein tissue co-expression partners for GPR142 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR142

SOURCE GeneReport for Unigene cluster for GPR142 Gene:


mRNA Expression by UniProt/SwissProt for GPR142 Gene:

Tissue specificity: Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.
genes like me logo Genes that share expression patterns with GPR142: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR142 Gene

Orthologs for GPR142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR142 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR142 30 31
  • 96.64 (n)
(Canis familiaris)
Mammalia GPR142 30 31
  • 85.36 (n)
(Bos Taurus)
Mammalia GPR142 30 31
  • 84.23 (n)
(Rattus norvegicus)
Mammalia Gpr142 30
  • 81.38 (n)
(Mus musculus)
Mammalia Gpr142 30 17 31
  • 79.2 (n)
(Ornithorhynchus anatinus)
Mammalia GPR142 31
  • 66 (a)
(Gallus gallus)
Aves GPR142 30 31
  • 72.41 (n)
(Anolis carolinensis)
Reptilia GPR142 31
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr142 30
  • 60.72 (n)
(Danio rerio)
Actinopterygii LOC100000501 30
  • 60.85 (n)
gpr142 31
  • 45 (a)
Species where no ortholog for GPR142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR142 Gene

Gene Tree for GPR142 (if available)
Gene Tree for GPR142 (if available)
Evolutionary constrained regions (ECRs) for GPR142: view image

Paralogs for GPR142 Gene

Paralogs for GPR142 Gene

(1) SIMAP similar genes for GPR142 Gene using alignment to 4 proteins:

  • GP142_HUMAN
genes like me logo Genes that share paralogs with GPR142: view

Variants for GPR142 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR142 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs115408173 Benign: not provided 74,371,859(+) C/T
NM_181790.1(GPR142):c.648C>T (p.Leu216=)
rs140023314 Benign: not provided 74,372,282(+) C/A
NM_181790.1(GPR142):c.1071C>A (p.Ala357=)
rs142966948 Likely Benign: not provided 74,372,328(+) C/T
NM_181790.1(GPR142):c.1117C>T (p.Arg373Trp)
rs144235997 Benign: not provided 74,372,244(+) C/A
NM_181790.1(GPR142):c.1033C>A (p.Arg345=)
rs569465136 Likely Benign: not provided 74,370,524(+) GC/G
NM_181790.1(GPR142):c.364del (p.Gln122fs)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR142 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR142 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641237 CNV gain 21293372
nsv509673 CNV insertion 20534489
nsv517569 CNV gain+loss 19592680
nsv833538 CNV gain 17160897
nsv833539 CNV loss 17160897

Variation tolerance for GPR142 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR142 Gene

Disorders for GPR142 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR142 Gene - From: COP

Disorder Aliases PubMed IDs
  • fusarium infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR142

genes like me logo Genes that share disorders with GPR142: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR142 Gene

Publications for GPR142 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4
  2. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. (PMID: 15845401) Matsuo A … Shigeyoshi Y (Biochemical and biophysical research communications 2005) 3 4
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  4. Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. (PMID: 31010829) Kim JS … Waldman T (The Journal of biological chemistry 2019) 3
  5. Discovery and pharmacological effects of a novel GPR142 antagonist. (PMID: 27807998) Murakoshi M … Nara F (Journal of receptor and signal transduction research 2017) 3

Products for GPR142 Gene

Sources for GPR142 Gene