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Aliases for GPR142 Gene

Aliases for GPR142 Gene

  • G Protein-Coupled Receptor 142 2 3 5
  • G-Protein Coupled Receptor PGR2 3 4
  • PGR2 3 4
  • G-Protein Coupled Receptor 142 Long Form 3
  • Probable G-Protein Coupled Receptor 142 3
  • GPRg1b 3

External Ids for GPR142 Gene

Previous GeneCards Identifiers for GPR142 Gene

  • GC17P072829
  • GC17P072919
  • GC17P069875
  • GC17P072322
  • GC17P072363

Summaries for GPR142 Gene

Entrez Gene Summary for GPR142 Gene

  • GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR142 Gene

GPR142 (G Protein-Coupled Receptor 142) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR139.

UniProtKB/Swiss-Prot for GPR142 Gene

  • Orphan receptor.

Gene Wiki entry for GPR142 Gene

Additional gene information for GPR142 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR142 Gene

Genomics for GPR142 Gene

GeneHancer (GH) Regulatory Elements for GPR142 Gene

Promoters and enhancers for GPR142 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074360 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 657.8 -5.5 -5471 2.5 CTCF MXI1 RB1 SIN3A KMT2B ZNF48 RAD21 CC2D1A ZNF664 CTBP1 GPR142 BTBD17 KIF19
GH17J074368 Enhancer 1.2 FANTOM5 Ensembl ENCODE 650.7 +1.5 1513 1.5 CTCF RB1 EBF1 GLI4 ZIC2 ZNF2 RBPJ RAD21 FOXM1 ZFHX2 GPR142 BTBD17 GC17M074418 RNA5SP448
GH17J074461 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 +98.4 98362 9.3 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 YBX1 IRF4 ZNF766 ZNF207 ZNF143 CD300A NUP85 NAT9 NT5C GGA3 MGC16275 GPR142 CD300LB ARMC7 BTBD17
GH17J074526 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +162.9 162894 7.4 HDGF HDAC1 PKNOX1 RB1 BATF IRF4 RAD21 YY1 ZNF143 ZNF207 CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
GH17J074451 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 +86.5 86511 4.1 CLOCK ARID4B SIN3A YY1 ZNF213 ZNF143 SP3 SP5 REST KAT8 GPR142 CD300E CD300LD GPRC5C ENSG00000265800 GC17P074445 CD300A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR142 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR142 gene promoter:
  • c-Myc
  • YY1
  • c-Ets-1
  • Max
  • NF-1
  • SREBP-1a
  • NF-kappaB1
  • NF-kappaB
  • NF-1/L
  • SREBP-1b

Genomic Locations for GPR142 Gene

Genomic Locations for GPR142 Gene
5,602 bases
Plus strand
5,216 bases
Plus strand

Genomic View for GPR142 Gene

Genes around GPR142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR142 Gene

Proteins for GPR142 Gene

  • Protein details for GPR142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 142
    Protein Accession:
    Secondary Accessions:
    • A4CYJ8
    • Q86SL3

    Protein attributes for GPR142 Gene

    462 amino acids
    Molecular mass:
    51106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR142 Gene

Post-translational modifications for GPR142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR142 Gene

No data available for DME Specific Peptides for GPR142 Gene

Domains & Families for GPR142 Gene

Gene Families for GPR142 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR142 Gene


Suggested Antigen Peptide Sequences for GPR142 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR142: view

Function for GPR142 Gene

Molecular function for GPR142 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR142: view
genes like me logo Genes that share phenotypes with GPR142: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR142

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR142 Gene

Localization for GPR142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR142 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR142 gene
Compartment Confidence
plasma membrane 5
cytosol 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR142: view

Pathways & Interactions for GPR142 Gene

SuperPathways for GPR142 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR142: view

No data available for Pathways by source and SIGNOR curated interactions for GPR142 Gene

Drugs & Compounds for GPR142 Gene

No Compound Related Data Available

Transcripts for GPR142 Gene

mRNA/cDNA for GPR142 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR142 Gene

G protein-coupled receptor 142:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR142 Gene

No ASD Table

Relevant External Links for GPR142 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR142 Gene

mRNA differential expression in normal tissues according to GTEx for GPR142 Gene

This gene is overexpressed in Spleen (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR142 Gene

Protein tissue co-expression partners for GPR142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR142 Gene:


SOURCE GeneReport for Unigene cluster for GPR142 Gene:


mRNA Expression by UniProt/SwissProt for GPR142 Gene:

Tissue specificity: Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.
genes like me logo Genes that share expression patterns with GPR142: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR142 Gene

Orthologs for GPR142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR142 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR142 34 33
  • 96.64 (n)
(Canis familiaris)
Mammalia GPR142 34 33
  • 85.36 (n)
(Bos Taurus)
Mammalia GPR142 34 33
  • 84.23 (n)
(Rattus norvegicus)
Mammalia Gpr142 33
  • 81.38 (n)
(Mus musculus)
Mammalia Gpr142 16 34 33
  • 79.2 (n)
(Ornithorhynchus anatinus)
Mammalia GPR142 34
  • 66 (a)
(Gallus gallus)
Aves GPR142 34 33
  • 72.41 (n)
(Anolis carolinensis)
Reptilia GPR142 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr142 33
  • 60.72 (n)
(Danio rerio)
Actinopterygii LOC100000501 33
  • 60.85 (n)
gpr142 34
  • 45 (a)
Species where no ortholog for GPR142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR142 Gene

Gene Tree for GPR142 (if available)
Gene Tree for GPR142 (if available)
Evolutionary constrained regions (ECRs) for GPR142: view image

Paralogs for GPR142 Gene

Paralogs for GPR142 Gene

(1) SIMAP similar genes for GPR142 Gene using alignment to 4 proteins:

  • GP142_HUMAN
genes like me logo Genes that share paralogs with GPR142: view

Variants for GPR142 Gene

Sequence variations from dbSNP and Humsavar for GPR142 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000021398 -- 74,368,612(+) G/A intron_variant
rs1000536324 -- 74,366,588(+) G/A upstream_transcript_variant
rs1001198560 -- 74,368,383(+) C/T intron_variant
rs1001346651 -- 74,365,901(+) G/A upstream_transcript_variant
rs1001654456 -- 74,368,005(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR142 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641237 CNV gain 21293372
nsv509673 CNV insertion 20534489
nsv517569 CNV gain+loss 19592680
nsv833538 CNV gain 17160897
nsv833539 CNV loss 17160897

Variation tolerance for GPR142 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR142 Gene

Disorders for GPR142 Gene

Additional Disease Information for GPR142

No disorders were found for GPR142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR142 Gene

Publications for GPR142 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 58
  2. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. (PMID: 15845401) Matsuo A … Shigeyoshi Y (Biochemical and biophysical research communications 2005) 3 4 58
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  4. Discovery and pharmacological effects of a novel GPR142 antagonist. (PMID: 27807998) Murakoshi M … Nara F (Journal of receptor and signal transduction research 2017) 3 58
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z … Gao Y (Journal of proteome research 2012) 3 58

Products for GPR142 Gene

Sources for GPR142 Gene

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