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Aliases for GPR141 Gene

Aliases for GPR141 Gene

  • G Protein-Coupled Receptor 141 2 3 5
  • G-Protein Coupled Receptor PGR13 3 4
  • PGR13 3 4
  • Probable G-Protein Coupled Receptor 141 3

External Ids for GPR141 Gene

Previous GeneCards Identifiers for GPR141 Gene

  • GC07U900327
  • GC07P037520
  • GC07P037553
  • GC07P037746
  • GC07P037659

Summaries for GPR141 Gene

Entrez Gene Summary for GPR141 Gene

  • GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR141 Gene

GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR141 Gene

  • Orphan receptor.

Gene Wiki entry for GPR141 Gene

Additional gene information for GPR141 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene

Genomics for GPR141 Gene

GeneHancer (GH) Regulatory Elements for GPR141 Gene

Promoters and enhancers for GPR141 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J037682 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655 +1.6 1558 5.2 PKNOX1 RB1 BACH1 MAX BATF POLR2A NFATC1 EED ETV6 BCLAF1 GPR141 EPDR1 ENSG00000201566 ENSG00000200113 NME8 STARD3NL ELMO1 LOC100420413
GH07J037443 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.7 -236.7 -236722 6.2 HDGF SIN3A FEZF1 ZNF2 IRF4 ZNF48 YY1 GLIS2 ATF7 RUNX3 ELMO1 GPR141 RNU6-565P EPDR1 TRGV3 ENSG00000201566
GH07J037765 Enhancer 1.2 FANTOM5 Ensembl ENCODE 13.6 +82.4 82449 1.7 BATF RELA EED ATF7 NFE2 ETV6 IKZF2 RUNX3 CREM SRF GPR141 EPDR1 STARD3NL ELMO1 LOC100420413
GH07J037732 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.2 +48.8 48776 0.8 CTCF JUN MAX CEBPG ZBTB40 RAD21 RFX5 GATA3 SMC3 ZNF143 GPR141 EPDR1 NME8 LOC100420413
GH07J037728 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +45.5 45506 1.2 JUN BATF IRF4 EED ATF7 IKZF2 CREM ZNF687 CEBPB JUNB GPR141 EPDR1 NME8 LOC100420413
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR141 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR141 gene promoter:
  • AML1a
  • HNF-1A
  • HNF-1
  • Hlf
  • CUTL1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for GPR141 Gene

Genomic Locations for GPR141 Gene
150,164 bases
Plus strand
149,992 bases
Plus strand

Genomic View for GPR141 Gene

Genes around GPR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR141 Gene

Proteins for GPR141 Gene

  • Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 141
    Protein Accession:
    Secondary Accessions:
    • A4D1X7
    • Q0VAR5
    • Q86SP3

    Protein attributes for GPR141 Gene

    305 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR141 Gene

Post-translational modifications for GPR141 Gene

  • Glycosylation at Asn9 and Asn5
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR141 Gene

Domains & Families for GPR141 Gene

Gene Families for GPR141 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR141 Gene


Suggested Antigen Peptide Sequences for GPR141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR141: view

Function for GPR141 Gene

Molecular function for GPR141 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR141 Gene

Gene Ontology (GO) - Molecular Function for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR141: view
genes like me logo Genes that share phenotypes with GPR141: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR141

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene

Localization for GPR141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR141 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR141: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR141 Gene

Pathways & Interactions for GPR141 Gene

SuperPathways for GPR141 Gene

No Data Available

Interacting Proteins for GPR141 Gene

Gene Ontology (GO) - Biological Process for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR141: view

No data available for Pathways by source and SIGNOR curated interactions for GPR141 Gene

Drugs & Compounds for GPR141 Gene

No Compound Related Data Available

Transcripts for GPR141 Gene

mRNA/cDNA for GPR141 Gene

Unigene Clusters for GPR141 Gene

G protein-coupled receptor 141:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR141 Gene

No ASD Table

Relevant External Links for GPR141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR141 Gene

mRNA differential expression in normal tissues according to GTEx for GPR141 Gene

This gene is overexpressed in Whole Blood (x36.9).

NURSA nuclear receptor signaling pathways regulating expression of GPR141 Gene:


SOURCE GeneReport for Unigene cluster for GPR141 Gene:

genes like me logo Genes that share expression patterns with GPR141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR141 Gene

Orthologs for GPR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR141 34 33
  • 99.67 (n)
(Canis familiaris)
Mammalia GPR141 34 33
  • 85.94 (n)
(Bos Taurus)
Mammalia LOC538837 33
  • 83.28 (n)
GPR141 34
  • 81 (a)
(Mus musculus)
Mammalia Gpr141 16 34 33
  • 80.81 (n)
(Monodelphis domestica)
Mammalia GPR141 34
  • 58 (a)
(Gallus gallus)
Aves GPR141 34 33
  • 60.8 (n)
(Anolis carolinensis)
Reptilia GPR141 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr141 33
  • 59.31 (n)
(Danio rerio)
Actinopterygii LOC100003534 33
  • 53.88 (n)
GPR141 34
  • 37 (a)
Species where no ortholog for GPR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR141 Gene

Gene Tree for GPR141 (if available)
Gene Tree for GPR141 (if available)
Evolutionary constrained regions (ECRs) for GPR141: view image

Paralogs for GPR141 Gene

(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins:

  • GP141_HUMAN
  • C9JDP7_HUMAN Pseudogenes for GPR141 Gene

genes like me logo Genes that share paralogs with GPR141: view

No data available for Paralogs for GPR141 Gene

Variants for GPR141 Gene

Sequence variations from dbSNP and Humsavar for GPR141 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000012242 -- 37,732,472(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000058595 -- 37,685,859(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000074545 -- 37,714,067(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000084504 -- 37,725,659(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000150760 -- 37,727,512(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR141 Gene

Variant ID Type Subtype PubMed ID
dgv1281e214 CNV loss 21293372
esv2759523 CNV loss 17122850
nsv526136 CNV loss 19592680

Variation tolerance for GPR141 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR141 Gene

Disorders for GPR141 Gene

Additional Disease Information for GPR141

No disorders were found for GPR141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene

Publications for GPR141 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPR141 Gene

Sources for GPR141 Gene

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