Aliases for GPR139 Gene
External Ids for GPR139 Gene
Previous GeneCards Identifiers for GPR139 Gene
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for GPR139 Gene
GPR139 (G Protein-Coupled Receptor 139) is a Protein Coding gene. Diseases associated with GPR139 include Isolated Growth Hormone Deficiency, Type Ib. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is GPR142.
UniProtKB/Swiss-Prot Summary for GPR139 Gene
Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
Orphan 7-TM receptors (orphan GPCRs) are receptors for which there are no defined ligands. Traditionally, receptors are characterized by specific ligands and stimuli; the search for ligands of orphan receptors is therefore akin to reverse-engineering this process.