Aliases for GPR137C Gene

Aliases for GPR137C Gene

  • G Protein-Coupled Receptor 137C 2 3 5
  • TM7SF1L2 2 3 4
  • Transmembrane 7 Superfamily Member 1-Like 2 Protein 3 4
  • Integral Membrane Protein GPR137C 3 4
  • G Protein-Coupled Receptor TM7SF1L2 3
  • DKFZp762F0713 2
  • GPR137C 5

External Ids for GPR137C Gene

Previous GeneCards Identifiers for GPR137C Gene

  • GC14P052090
  • GC14P053020
  • GC14P033180

Summaries for GPR137C Gene

GeneCards Summary for GPR137C Gene

GPR137C (G Protein-Coupled Receptor 137C) is a Protein Coding gene. Diseases associated with GPR137C include Short Syndrome. An important paralog of this gene is GPR137B.

UniProtKB/Swiss-Prot Summary for GPR137C Gene

  • Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes.

Additional gene information for GPR137C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR137C Gene

Genomics for GPR137C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR137C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J052551 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 606.9 +0.0 6 4.3 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 POLR2A FOS JUND TXNDC16 GPR137C NONHSAG014968.2 lnc-TXNDC16-2 RTRAF ERO1A PTGDR
GH14J051642 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -909.2 -909235 2 ZSCAN4 ZNF148 SALL2 HIC1 ZNF398 MAFK PKNOX1 TRIM9 GPR137C RNU6-301P FRMD6 ENSG00000277050 FRMD6-AS1 lnc-FRMD6-2 GNG2
GH14J052473 Enhancer 0.7 Ensembl ENCODE 10.3 -79.2 -79183 0.5 CTCF RAD21 SMC3 GATA3 ZNF654 NFIL3 HLF PTGER2 TXNDC16 GPR137C piR-56341-056 RF00876-003 lnc-TXNDC16-2
GH14J052347 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.5 -200.7 -200705 8.9 ZNF629 ZNF692 FOXA1 RELA ZSCAN4 IKZF2 PKNOX1 ZBTB44 CEBPB ARID3A piR-48759-087 PTGER2 GPR137C TXNDC16 RF00017-1551
GH14J052514 Enhancer 0.5 Ensembl 11.1 -38.2 -38235 0.4 ZIC2 TAL1 BCL6B CBFA2T3 ARID1B TXNDC16 GPR137C KR153240-003 piR-57460-183 lnc-TXNDC16-2 PTGER2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR137C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR137C

Top Transcription factor binding sites by QIAGEN in the GPR137C gene promoter:
  • FOXO4
  • MZF-1
  • NRF-2
  • NRSF form 1
  • NRSF form 2
  • Pax-3
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for GPR137C Gene

Genomic Locations for GPR137C Gene
84,878 bases
Plus strand
84,566 bases
Plus strand

Genomic View for GPR137C Gene

Genes around GPR137C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137C Gene

Proteins for GPR137C Gene

  • Protein details for GPR137C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137C
    Protein Accession:
    Secondary Accessions:
    • Q86SM2

    Protein attributes for GPR137C Gene

    429 amino acids
    Molecular mass:
    47075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR137C Gene

Post-translational modifications for GPR137C Gene

  • Glycosylation at Asn285
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR137C Gene

No data available for DME Specific Peptides for GPR137C Gene

Domains & Families for GPR137C Gene

Gene Families for GPR137C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR137C Gene


Suggested Antigen Peptide Sequences for GPR137C Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane 7 superfamily member 1-like 2 protein (G137C_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137C: view

Function for GPR137C Gene

Molecular function for GPR137C Gene

UniProtKB/Swiss-Prot Function:
Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes.

Phenotypes From GWAS Catalog for GPR137C Gene

genes like me logo Genes that share phenotypes with GPR137C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137C

CRISPR Products

miRNA for GPR137C Gene

miRTarBase miRNAs that target GPR137C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137C Gene

Localization for GPR137C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137C Gene

Lysosome membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR137C gene
Compartment Confidence
lysosome 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR137C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 31036939
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137C: view

Pathways & Interactions for GPR137C Gene

PathCards logo

SuperPathways for GPR137C Gene

No Data Available

Interacting Proteins for GPR137C Gene

Gene Ontology (GO) - Biological Process for GPR137C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904263 positive regulation of TORC1 signaling IBA 21873635
genes like me logo Genes that share ontologies with GPR137C: view

No data available for Pathways by source and SIGNOR curated interactions for GPR137C Gene

Drugs & Compounds for GPR137C Gene

No Compound Related Data Available

Transcripts for GPR137C Gene

mRNA/cDNA for GPR137C Gene

7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137C

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137C Gene

No ASD Table

Relevant External Links for GPR137C Gene

GeneLoc Exon Structure for

Expression for GPR137C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR137C Gene

mRNA differential expression in normal tissues according to GTEx for GPR137C Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.8) and Brain - Cerebellum (x8.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR137C

SOURCE GeneReport for Unigene cluster for GPR137C Gene:

genes like me logo Genes that share expression patterns with GPR137C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137C Gene

Orthologs for GPR137C Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR137C 30 31
  • 99.61 (n)
(Canis familiaris)
Mammalia GPR137C 30 31
  • 95.82 (n)
(Bos Taurus)
Mammalia GPR137C 30 31
  • 94.38 (n)
(Mus musculus)
Mammalia Gpr137c 30 17 31
  • 88.81 (n)
(Rattus norvegicus)
Mammalia Gpr137c 30
  • 87.08 (n)
(Ornithorhynchus anatinus)
Mammalia GPR137C 31
  • 74 (a)
(Monodelphis domestica)
Mammalia GPR137C 31
  • 73 (a)
(Gallus gallus)
Aves GPR137C 30 31
  • 70.26 (n)
(Anolis carolinensis)
Reptilia GPR137C 31
  • 66 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr137c 30
  • 61.37 (n)
(Danio rerio)
Actinopterygii gpr137ba 30
  • 62.16 (n)
gpr137c 31
  • 53 (a)
Species where no ortholog for GPR137C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR137C Gene

Gene Tree for GPR137C (if available)
Gene Tree for GPR137C (if available)
Evolutionary constrained regions (ECRs) for GPR137C: view image

Paralogs for GPR137C Gene

Paralogs for GPR137C Gene

(4) SIMAP similar genes for GPR137C Gene using alignment to 3 proteins:

  • G137C_HUMAN
genes like me logo Genes that share paralogs with GPR137C: view

Variants for GPR137C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR137C Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs762063 - p.Val248Ile

Additional dbSNP identifiers (rs#s) for GPR137C Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR137C Gene

Variant ID Type Subtype PubMed ID
esv2670271 CNV deletion 23128226
esv2748718 CNV deletion 23290073
esv3581208 CNV loss 25503493
esv3634524 CNV loss 21293372
nsv826955 CNV loss 20364138

Variation tolerance for GPR137C Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR137C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137C Gene

Disorders for GPR137C Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR137C Gene - From: DISEASES

Disorder Aliases PubMed IDs
short syndrome
  • short stature, hyperextensibility, hernia, ocular depression, rieger anomaly, and teething delay
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR137C

genes like me logo Genes that share disorders with GPR137C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR137C Gene

Publications for GPR137C Gene

  1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. (PMID: 31036939) Gan L … Meyer T (Nature cell biology 2019) 3 4
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GPR137C Gene

Sources for GPR137C Gene