Aliases for GPR137B Gene

Aliases for GPR137B Gene

  • G Protein-Coupled Receptor 137B 2 3 5
  • Transmembrane 7 Superfamily Member 1 (Upregulated In Kidney) 2 3
  • Transmembrane 7 Superfamily Member 1 Protein 3 4
  • Integral Membrane Protein GPR137B 3 4
  • TM7SF1 3 4

External Ids for GPR137B Gene

Previous HGNC Symbols for GPR137B Gene

  • TM7SF1

Previous GeneCards Identifiers for GPR137B Gene

  • GC01P232632
  • GC01P234372
  • GC01P236305
  • GC01P206762

Summaries for GPR137B Gene

GeneCards Summary for GPR137B Gene

GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. Diseases associated with GPR137B include Isolated Growth Hormone Deficiency, Type Ib and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. An important paralog of this gene is GPR137.

Additional gene information for GPR137B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR137B Gene

Genomics for GPR137B Gene

GeneHancer (GH) Regulatory Elements for GPR137B Gene

Promoters and enhancers for GPR137B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J236141 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 511.5 +0.7 699 4.4 ZSCAN5C SIN3A TCF12 USF1 ZFX ZNF10 ZIC2 POLR2A ZBTB10 ZBTB26 GPR137B piR-55036-010
GH01J236156 Enhancer 1.3 FANTOM5 Ensembl ENCODE 20.9 +14.7 14699 8.4 RXRA ZBTB40 SP1 EP300 TCF7 REST RELA MEF2C RCOR1 TRIM22 GPR137B LGALS8 LYST piR-55036-010
GH01J236162 Enhancer 1 Ensembl ENCODE 19.2 +22.0 21998 3.4 TOE1 TRIM22 ZNF274 FOXA2 RAD51 ZNF491 WT1 ZNF76 MEF2B NBN ARID4B HEATR1 ENSG00000273058 RPS21P1 ENSG00000230325 MTR GPR137B RPL35P1 piR-55036-010
GH01J236168 Enhancer 1 Ensembl ENCODE 16.3 +25.8 25799 3 ZNF217 CTCF ZIC2 ZNF423 AFF1 TOE1 CTBP1 MYC ATF2 ZEB1 GPR137B piR-55036-010
GH01J236151 Enhancer 0.7 ENCODE 17.8 +7.7 7674 0.2 FOXA1 ZBTB26 ZNF662 ZNF282 ZNF195 SRF ZNF207 TARDBP NBN ZNF213 ENSG00000273058 ARID4B ENSG00000230325 RPS21P1 MTR GGPS1 HEATR1 GPR137B piR-55036-010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR137B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR137B

Top Transcription factor binding sites by QIAGEN in the GPR137B gene promoter:
  • AML1a
  • Ik-3
  • LyF-1
  • Msx-1
  • p300
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • TBP

Genomic Locations for GPR137B Gene

Genomic Locations for GPR137B Gene
79,364 bases
Plus strand
79,334 bases
Plus strand

Genomic View for GPR137B Gene

Genes around GPR137B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137B Gene

Proteins for GPR137B Gene

  • Protein details for GPR137B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137B
    Protein Accession:
    Secondary Accessions:
    • Q53EK7
    • Q5TAE6
    • Q6FHI3

    Protein attributes for GPR137B Gene

    399 amino acids
    Molecular mass:
    45599 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR137B Gene

Post-translational modifications for GPR137B Gene

  • Glycosylation at Asn26, Asn263, and Asn275
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR137B Gene

No data available for DME Specific Peptides for GPR137B Gene

Domains & Families for GPR137B Gene

Gene Families for GPR137B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPR137B Gene


Suggested Antigen Peptide Sequences for GPR137B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55565, highly similar to Integral membrane protein GPR137B (B4DWI6_HUMAN)
  • Transmembrane 7 superfamily member 1 protein (G137B_HUMAN)
  • G protein-coupled receptor 137B (Q5TAF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137B: view

Function for GPR137B Gene

Phenotypes From GWAS Catalog for GPR137B Gene

genes like me logo Genes that share phenotypes with GPR137B: view

Animal Model Products

CRISPR Products

miRNA for GPR137B Gene

miRTarBase miRNAs that target GPR137B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137B Gene

Localization for GPR137B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137B Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR137B gene
Compartment Confidence
plasma membrane 4
lysosome 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPR137B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9521871
GO:0016020 membrane IEA,TAS 9521871
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR137B Gene

Pathways & Interactions for GPR137B Gene

PathCards logo

SuperPathways for GPR137B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR137B Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137B Gene

Drugs & Compounds for GPR137B Gene

No Compound Related Data Available

Transcripts for GPR137B Gene

mRNA/cDNA for GPR137B Gene

9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137B

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - -
SP3: -
SP5: -

Relevant External Links for GPR137B Gene

GeneLoc Exon Structure for

Expression for GPR137B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR137B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR137B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137B Gene

Protein tissue co-expression partners for GPR137B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR137B

SOURCE GeneReport for Unigene cluster for GPR137B Gene:


mRNA Expression by UniProt/SwissProt for GPR137B Gene:

Tissue specificity: Expressed in kidney, heart, brain and placenta.

Evidence on tissue expression from TISSUES for GPR137B Gene

  • Kidney(4.4)
  • Skin(4.4)
  • Spleen(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with GPR137B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137B Gene

Orthologs for GPR137B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR137B 31 30
  • 100 (n)
(Bos Taurus)
Mammalia GPR137B 31 30
  • 92.36 (n)
(Canis familiaris)
Mammalia GPR137B 31 30
  • 91.92 (n)
(Mus musculus)
Mammalia Gpr137b 17 31 30
  • 90.28 (n)
(Monodelphis domestica)
Mammalia GPR137B 31
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137B 31
  • 79 (a)
(Gallus gallus)
Aves GPR137B 31 30
  • 78.51 (n)
(Anolis carolinensis)
Reptilia GPR137B 31
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr137b 30
  • 72.83 (n)
Str.3726 30
(Danio rerio)
Actinopterygii GPR137B (2 of 2) 31
  • 71 (a)
LOC100001171 30
  • 70.2 (n)
GPR137B (1 of 2) 31
  • 60 (a)
wufi39g02 30
Species where no ortholog for GPR137B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137B Gene

Gene Tree for GPR137B (if available)
Gene Tree for GPR137B (if available)
Evolutionary constrained regions (ECRs) for GPR137B: view image

Paralogs for GPR137B Gene

Paralogs for GPR137B Gene

(4) SIMAP similar genes for GPR137B Gene using alignment to 4 proteins:

  • G137B_HUMAN
  • H0Y509_HUMAN
genes like me logo Genes that share paralogs with GPR137B: view

Variants for GPR137B Gene

Additional dbSNP identifiers (rs#s) for GPR137B Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR137B Gene

Variant ID Type Subtype PubMed ID
dgv156e212 CNV loss 25503493
dgv590n100 CNV gain 25217958
esv1123909 CNV insertion 17803354
esv28317 CNV loss 19812545
esv3345110 CNV duplication 20981092
esv3578490 CNV loss 25503493
esv3589211 CNV loss 21293372
nsv1005877 CNV gain 25217958
nsv1012436 CNV loss 25217958
nsv468428 CNV loss 19166990
nsv468439 CNV loss 19166990
nsv549394 CNV gain 21841781
nsv549397 CNV loss 21841781
nsv549398 CNV loss 21841781
nsv549399 CNV gain 21841781
nsv827476 CNV gain 20364138
nsv832969 CNV gain 17160897
nsv953998 CNV deletion 24416366

Variation tolerance for GPR137B Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR137B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR137B Gene

Disorders for GPR137B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR137B Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR137B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR137B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR137B Gene

Publications for GPR137B Gene

  1. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. (PMID: 9521871) Spangenberg C … Löbbert RW (Genomics 1998) 2 3 4 54
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. (PMID: 31036939) Gan L … Meyer T (Nature cell biology 2019) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for GPR137B Gene

Sources for GPR137B Gene