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GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. Diseases associated with GPR137B include Isolated Growth Hormone Deficiency, Type Ib and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. An important paralog of this gene is GPR137.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA,IDA | 31036939 |
GO:0005887 | integral component of plasma membrane | TAS | 9521871 |
GO:0016020 | membrane | IEA,TAS | 9521871 |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006914 | autophagy | IEA | -- |
GO:0010506 | regulation of autophagy | IMP | 31036939 |
GO:0043030 | regulation of macrophage activation | ISS | -- |
GO:0043087 | regulation of GTPase activity | IMP | 31036939 |
GO:0045671 | negative regulation of osteoclast differentiation | ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpr137b 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GPR137B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPR137B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPR137B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GPR137B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpr137b 30 |
|
||
Str.3726 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | GPR137B (2 of 2) 31 |
|
OneToMany | |
LOC100001171 30 |
|
||||
GPR137B (1 of 2) 31 |
|
OneToMany | |||
wufi39g02 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv156e212 | CNV | loss | 25503493 |
dgv590n100 | CNV | gain | 25217958 |
esv1123909 | CNV | insertion | 17803354 |
esv28317 | CNV | loss | 19812545 |
esv3345110 | CNV | duplication | 20981092 |
esv3578490 | CNV | loss | 25503493 |
esv3589211 | CNV | loss | 21293372 |
nsv1005877 | CNV | gain | 25217958 |
nsv1012436 | CNV | loss | 25217958 |
nsv468428 | CNV | loss | 19166990 |
nsv468439 | CNV | loss | 19166990 |
nsv549394 | CNV | gain | 21841781 |
nsv549397 | CNV | loss | 21841781 |
nsv549398 | CNV | loss | 21841781 |
nsv549399 | CNV | gain | 21841781 |
nsv827476 | CNV | gain | 20364138 |
nsv832969 | CNV | gain | 17160897 |
nsv953998 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
isolated growth hormone deficiency, type ib |
|
|
spinal muscular atrophy, distal, autosomal recessive, 1 |
|
|
autosomal recessive distal hereditary motor neuronopathy |
|
|