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Aliases for GPR137B Gene
Aliases for GPR137B Gene
External Ids for GPR137B Gene
- HGNC: 11862
- Entrez Gene: 7107
- Ensembl: ENSG00000077585
- OMIM: 604658
- UniProtKB: O60478
Previous HGNC Symbols for GPR137B Gene
- TM7SF1
Previous GeneCards Identifiers for GPR137B Gene
- GC01P232632
- GC01P234372
- GC01P236305
- GC01P206762
Summaries for GPR137B Gene
GeneCards Summary for GPR137B Gene
GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. Diseases associated with GPR137B include Isolated Growth Hormone Deficiency, Type Ib and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. An important paralog of this gene is GPR137.
UniProtKB/Swiss-Prot Summary for GPR137B Gene
-
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).
-
Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Additional gene information for GPR137B Gene
- HGNC(11862)
- Entrez Gene(7107)
- Ensembl(ENSG00000077585)
- OMIM(604658)
- UniProtKB(O60478)
- Open Targets Platform(ENSG00000077585)
- Search for GPR137B at DataMed
- Search for GPR137B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR137B Gene
Genomics for GPR137B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPR137B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR137B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR137B
- Top Transcription factor binding sites by QIAGEN in the GPR137B gene promoter:
-
- AML1a
- Ik-3
- LyF-1
- Msx-1
- p300
- PPAR-gamma1
- PPAR-gamma2
- RFX1
- TBP
- TFIID
Genomic Locations for GPR137B Gene
Genomic Locations for GPR137B Gene
- chr1:236,142,505-236,221,865
- (GRCh38/hg38)
- Size:
- 79,361 bases
- Orientation:
- Plus strand
- chr1:236,305,832-236,385,165
- (GRCh37/hg19)
- Size:
- 79,334 bases
- Orientation:
- Plus strand
Genomic View for GPR137B Gene
Genes around GPR137B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.3 by HGNC
- 1q42.3 by Entrez Gene
- 1q42.3 by Ensembl
GPR137B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR137B Gene
Proteins for GPR137B Gene
-
Protein details for GPR137B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60478-G137B_HUMAN
- Recommended name:
- Integral membrane protein GPR137B
- Protein Accession:
- O60478
- Q53EK7
- Q5TAE6
- Q6FHI3
Protein attributes for GPR137B Gene
- Size:
- 399 amino acids
- Molecular mass:
- 45599 Da
- Quaternary structure:
-
- Interaction with RRAGA; increases RRAGA recruitment to lysosomes (PubMed:31036939). Interacts with MTOR; this interaction is amino acid sensitive (PubMed:31036939).
Protein Expression for GPR137B Gene
Post-translational modifications for GPR137B Gene
Other Protein References for GPR137B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GPR137B Antibody
- Novus Biologicals Antibodies for GPR137B
-
Abcam antibodies for GPR137B
- Invitrogen Antibodies for GPR137B (AFLGC-GPR137B)
- antibodies-online: Show 7 available GPR137B Antibodies ranked by validation data
-
Biorbyt antibodies for GPR137B
-
Boster Bio Antibodies for GPR137B
Protein Products
-
OriGene Purified Proteins for GPR137B
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR137B
- Origene Custom Protein Services for GPR137B
Assay Products
-
Signalway ELISA kits for GPR137B
No data available for DME Specific Peptides for GPR137B Gene
Domains & Families for GPR137B Gene
Gene Families for GPR137B Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for GPR137B Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55565, highly similar to Integral membrane protein GPR137B (B4DWI6_HUMAN)
- Transmembrane 7 superfamily member 1 protein (G137B_HUMAN)
- G protein-coupled receptor 137B (Q5TAF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60478- Family:
-
- Belongs to the GPR137 family.
Function for GPR137B Gene
Molecular function for GPR137B Gene
- UniProtKB/Swiss-Prot Function:
- Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).
- UniProtKB/Swiss-Prot Function:
- Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Phenotypes From GWAS Catalog for GPR137B Gene
Phenotypes for GPR137B Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR137B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR137B - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR137B
miRNA for GPR137B Gene
- miRTarBase miRNAs that target GPR137B
-
- hsa-miR-17-5p (MIRT000258)
- hsa-miR-181a-5p (MIRT025133)
- hsa-let-7d-5p (MIRT032128)
- hsa-miR-20a-5p (MIRT064435)
- hsa-miR-93-5p (MIRT064436)
- hsa-miR-106a-5p (MIRT064437)
- hsa-miR-106b-5p (MIRT064438)
- hsa-miR-20b-5p (MIRT064440)
- hsa-miR-526b-3p (MIRT064441)
- hsa-miR-519d-3p (MIRT064442)
- hsa-miR-548t-5p (MIRT064446)
- hsa-miR-548az-5p (MIRT064451)
- hsa-miR-183-3p (MIRT064453)
- hsa-miR-3609 (MIRT064456)
- hsa-miR-548ah-5p (MIRT064457)
- hsa-miR-19a-3p (MIRT134301)
- hsa-miR-19b-3p (MIRT134302)
- hsa-miR-7157-3p (MIRT572040)
- hsa-miR-6737-3p (MIRT572041)
- hsa-miR-5008-3p (MIRT572042)
- hsa-miR-6889-3p (MIRT572043)
- hsa-miR-586 (MIRT572044)
- hsa-miR-4796-3p (MIRT572045)
- hsa-miR-548n (MIRT572046)
- hsa-miR-7151-3p (MIRT684477)
- hsa-miR-5095 (MIRT684478)
- hsa-miR-5589-5p (MIRT684479)
- hsa-miR-4731-5p (MIRT684480)
- hsa-miR-6778-3p (MIRT684481)
- hsa-miR-6506-5p (MIRT684482)
- hsa-miR-619-5p (MIRT684483)
- hsa-miR-150-5p (MIRT684484)
- hsa-miR-7107-5p (MIRT684485)
- hsa-miR-1234-3p (MIRT684486)
- hsa-miR-186-3p (MIRT684487)
- hsa-miR-520h (MIRT684488)
- hsa-miR-520g-3p (MIRT684489)
- hsa-miR-512-3p (MIRT684490)
- hsa-miR-4438 (MIRT684491)
- hsa-miR-520e (MIRT684492)
- hsa-miR-520d-3p (MIRT684493)
- hsa-miR-520c-3p (MIRT684494)
- hsa-miR-520b (MIRT684495)
- hsa-miR-520a-3p (MIRT684496)
- hsa-miR-373-3p (MIRT684497)
- hsa-miR-372-3p (MIRT684498)
- hsa-miR-302e (MIRT684499)
- hsa-miR-302d-3p (MIRT684500)
- hsa-miR-302c-3p (MIRT684501)
- hsa-miR-302b-3p (MIRT684502)
- hsa-miR-302a-3p (MIRT684503)
- hsa-miR-6749-3p (MIRT693308)
- hsa-miR-7108-3p (MIRT693309)
- hsa-miR-4258 (MIRT693310)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR137B
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Clone Products
- Applied Biological Materials (abm): Clones for GPR137B - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for GPR137B
- Addgene plasmids for GPR137B
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Cell Line Products
-
Horizon Cell Lines for GPR137B
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137B Gene
Localization for GPR137B Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR137B Gene
- Lysosome membrane. Multi-pass membrane protein. Note=Colocalized with MTOR in lysosome after amino acid stimulation. {ECO:0000269 PubMed:31036939}.
| Compartment | Confidence |
|---|---|
| lysosome | 5 |
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA,IDA | 31036939 |
| GO:0005887 | integral component of plasma membrane | TAS | 9521871 |
| GO:0016020 | membrane | IEA,TAS | 9521871 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR137B Gene
Pathways & Interactions for GPR137B Gene
Interacting Proteins for GPR137B Gene
Selected Interacting proteins:
O60478-G137B_HUMAN
ENSP00000355551
for GPR137B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GPR137B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006914 | autophagy | IEA | -- |
| GO:0010506 | regulation of autophagy | IMP | 31036939 |
| GO:0043030 | regulation of macrophage activation | ISS | -- |
| GO:0043087 | regulation of GTPase activity | IMP | 31036939 |
| GO:0045671 | negative regulation of osteoclast differentiation | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR137B Gene
Transcripts for GPR137B Gene
mRNA/cDNA for GPR137B Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366591 803 nts (view in UCSC)
- ENST00000366592 2033 nts (view in UCSC)
- ENST00000419162 1107 nts (view in UCSC)
- ENST00000454895 1104 nts (view in UCSC)
- ENST00000477559 329 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR137B - Select products 50% OFF >
- * GPR137B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR137B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR137B
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR137B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR137B
- Browse OriGene Inhibitory RNA Products For GPR137B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137B
Clone Products
- Applied Biological Materials (abm): Clones for GPR137B - Select products 50% OFF >
- * GPR137B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for GPR137B
- Addgene plasmids for GPR137B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR137B
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for GPR137B Gene
- GeneLoc Exon Structure for
- GPR137B
Expression for GPR137B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Loop of Henle
- Proximal Tubule
- Epithelial Tubule
-
Epithelial Cells
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Eye (Sensory Organs)
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR137B
SOURCE GeneReport for Unigene cluster for GPR137B Gene:
Hs.498160mRNA Expression by UniProt/SwissProt for GPR137B Gene:
O60478-G137B_HUMAN
Tissue specificity:
Expressed in kidney, heart, brain and placenta.
Evidence on tissue expression from TISSUES for GPR137B Gene
- Skin(4.5)
- Kidney(4.4)
- Spleen(4.2)
- Nervous system(3.8)
Primer Products
-
OriGene qPCR primer pairs for GPR137B
-
OriGene qPCR primer pairs and template standards for GPR137B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137B Gene
Orthologs for GPR137B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPR137B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gpr137b 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GPR137B 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GPR137B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GPR137B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GPR137B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpr137b 30 |
|
||
| Str.3726 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | GPR137B (2 of 2) 31 |
|
OneToMany | |
| LOC100001171 30 |
|
||||
| GPR137B (1 of 2) 31 |
|
OneToMany | |||
| wufi39g02 30 |
|
- Species where no ortholog for GPR137B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPR137B Gene
- ENSEMBL:
- Gene Tree for GPR137B (if available)
- TreeFam:
- Gene Tree for GPR137B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR137B: view image
Paralogs for GPR137B Gene
Variants for GPR137B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv156e212 | CNV | loss | 25503493 |
| dgv590n100 | CNV | gain | 25217958 |
| esv1123909 | CNV | insertion | 17803354 |
| esv28317 | CNV | loss | 19812545 |
| esv3345110 | CNV | duplication | 20981092 |
| esv3578490 | CNV | loss | 25503493 |
| esv3589211 | CNV | loss | 21293372 |
| nsv1005877 | CNV | gain | 25217958 |
| nsv1012436 | CNV | loss | 25217958 |
| nsv468428 | CNV | loss | 19166990 |
| nsv468439 | CNV | loss | 19166990 |
| nsv549394 | CNV | gain | 21841781 |
| nsv549397 | CNV | loss | 21841781 |
| nsv549398 | CNV | loss | 21841781 |
| nsv549399 | CNV | gain | 21841781 |
| nsv827476 | CNV | gain | 20364138 |
| nsv832969 | CNV | gain | 17160897 |
| nsv953998 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.27;
25.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR137B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR137B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR137B Gene
Disorders for GPR137B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| isolated growth hormone deficiency, type ib |
|
|
| spinal muscular atrophy, distal, autosomal recessive, 1 |
|
|
| autosomal recessive distal hereditary motor neuronopathy |
|
|
Search GPR137B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR137B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR137B Gene
Publications for GPR137B Gene
- Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. (PMID: 9521871) Spangenberg C … Löbbert RW (Genomics 1998) 2 3 4
- The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. (PMID: 31036939) Gan L … Meyer T (Nature cell biology 2019) 3 4
- Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR137B
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for GPR137B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137B
- Boster Bio Antibodies for GPR137B
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- Biorbyt antibodies for GPR137B
- Signalway ELISA kits for GPR137B
Sources for GPR137B Gene
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