Aliases for GPR137B Gene
External Ids for GPR137B Gene
Previous HGNC Symbols for GPR137B Gene
Previous GeneCards Identifiers for GPR137B Gene
GeneCards Summary for GPR137B Gene
GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. Diseases associated with GPR137B include Isolated Growth Hormone Deficiency, Type Ib and Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1. An important paralog of this gene is GPR137.
UniProtKB/Swiss-Prot Summary for GPR137B Gene
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939).
Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).