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Aliases for GPR137 Gene
Aliases for GPR137 Gene
External Ids for GPR137 Gene
- HGNC: 24300
- Entrez Gene: 56834
- Ensembl: ENSG00000173264
- UniProtKB: Q96N19
Previous GeneCards Identifiers for GPR137 Gene
- GC11P063810
- GC11P064051
- GC11P060379
Summaries for GPR137 Gene
GeneCards Summary for GPR137 Gene
GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. Diseases associated with GPR137 include Isolated Growth Hormone Deficiency, Type Ib. An important paralog of this gene is GPR137B.
UniProtKB/Swiss-Prot Summary for GPR137 Gene
-
Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939).
-
May activate Wnt/beta-catenin signaling to modulate epithelial cell function.
Additional gene information for GPR137 Gene
- HGNC(24300)
- Entrez Gene(56834)
- Ensembl(ENSG00000173264)
- UniProtKB(Q96N19)
- Open Targets Platform(ENSG00000173264)
- Search for GPR137 at DataMed
- Search for GPR137 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR137 Gene
Genomics for GPR137 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPR137 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPR137 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR137
- Top Transcription factor binding sites by QIAGEN in the GPR137 gene promoter:
-
- ATF-2
- c-Jun
- CREB
- deltaCREB
Genomic Locations for GPR137 Gene
Genomic Locations for GPR137 Gene
- chr11:64,270,062-64,289,500
- (GRCh38/hg38)
- Size:
- 19,439 bases
- Orientation:
- Plus strand
- chr11:64,037,534-64,056,972
- (GRCh37/hg19)
- Size:
- 19,439 bases
- Orientation:
- Plus strand
Genomic View for GPR137 Gene
Genes around GPR137 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
GPR137 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR137 Gene
Proteins for GPR137 Gene
-
Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96N19-G137A_HUMAN
- Recommended name:
- Integral membrane protein GPR137
- Protein Accession:
- Q96N19
- B4DTG7
- B7Z7M1
- Q4G0Y9
- Q8N4K6
Protein attributes for GPR137 Gene
- Size:
- 417 amino acids
- Molecular mass:
- 46059 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR137 Gene
Post-translational modifications for GPR137 Gene
Other Protein References for GPR137 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005274157.1
- XP_005274159.1
- XP_005274161.1
- XP_011543470.1
- XP_011543471.1
- XP_016873505.1
- XP_024304379.1
- NP_001164351.1
- NP_001164352.1
- NP_001170829.1
- NP_001365005.1
- NP_001365006.1
- NP_001365007.1
- NP_001365008.1
- NP_001365009.1
- NP_001365010.1
- NP_001365011.1
- NP_001365012.1
- NP_001365013.1
- NP_001365014.1
- NP_001365015.1
- NP_001365016.1
- NP_001365017.1
- NP_001365018.1
- NP_064540.3
Antibody Products
- LifeSpan BioSciences GPR137 Antibody (LS-A2059) and GPR137 Antibody (LS-A2052)
- Creative Diagnostics Anti-GPR137 monoclonal antibody
- Novus Biologicals Antibodies for GPR137
- Invitrogen Antibodies for GPR137 (AFLGC-GPR137)
- antibodies-online: Show 14 available GPR137 Antibodies ranked by validation data
Protein Products
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- Novus Biologicals proteins for GPR137
No data available for DME Specific Peptides for GPR137 Gene
Domains & Families for GPR137 Gene
Gene Families for GPR137 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for GPR137 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58705, highly similar to Mus musculus G protein-coupled receptor 137 (Gpr137), mRNA (B7Z7M1_HUMAN)
- Transmembrane 7 superfamily member 1-like 1 protein (G137A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96N19- Family:
-
- Belongs to the GPR137 family.
Function for GPR137 Gene
Molecular function for GPR137 Gene
- UniProtKB/Swiss-Prot Function:
- Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939).
- UniProtKB/Swiss-Prot Function:
- May activate Wnt/beta-catenin signaling to modulate epithelial cell function.
Phenotypes From GWAS Catalog for GPR137 Gene
Phenotypes for GPR137 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR137
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR137 - Select products 50% OFF >
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-
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-
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miRNA for GPR137 Gene
- miRTarBase miRNAs that target GPR137
miRNA Products
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene
Localization for GPR137 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene
- Lysosome membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| lysosome | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
- Actin filaments (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA,IDA | 31036939 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GPR137 Gene
Interacting Proteins for GPR137 Gene
GPS-Prot Interaction Network for GPR137
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006914 | autophagy | IEA | -- |
| GO:0010506 | regulation of autophagy | IBA | 21873635 |
| GO:0045124 | regulation of bone resorption | IBA | 21873635 |
| GO:0045671 | negative regulation of osteoclast differentiation | IBA | 21873635 |
| GO:0045779 | negative regulation of bone resorption | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene
Transcripts for GPR137 Gene
mRNA/cDNA for GPR137 Gene
- 19 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313074 1485 nts (view in UCSC)
- ENST00000377702 1478 nts (view in UCSC)
- ENST00000411458 1495 nts (view in UCSC)
- ENST00000438980 1596 nts (view in UCSC)
- ENST00000535675 542 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPR137 - Select products 50% OFF >
- * GPR137 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPR137
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPR137
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR137
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPR137
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137
Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206217
- MG219521
- MG219522
- MG219524
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- MR206217L3
- MR206217L4
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- MR219521L3
- MR219521L4
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- MR219522L3
- MR219522L4
- MR219524
- MR219524L3
- MR219524L4
- RC218962
- RC218962L3
- RC218962L4
- RC229887
- RC229887L3
- RC229887L4
- RC229921
- RC229921L3
- RC229921L4
- RC229993
- RC229993L3
- RC229993L4
- RC230140
- RC230140L3
- RC230140L4
- RG218962
- RG229887
- RG229921
- RG229993
- RG230140
- RR207996
- RR207996L3
- RR207996L4
- MR206217L3V
- MR206217L4V
- MR219521L3V
- MR219521L4V
- MR219522L3V
- MR219522L4V
- MR219524L3V
- MR219524L4V
- RC218962L3V
- RC218962L4V
- RC229887L3V
- RC229887L4V
- RC229921L3V
- RC229921L4V
- RC229993L3V
- RC229993L4V
- RC230140L3V
- RC230140L4V
- RR207996L3V
- RR207996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPR137
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPR137
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - |
Relevant External Links for GPR137 Gene
- GeneLoc Exon Structure for
- GPR137
Expression for GPR137 Gene
mRNA differential expression in normal tissues according to GTEx for GPR137 Gene
This gene is overexpressed in Testis (x6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR137
SOURCE GeneReport for Unigene cluster for GPR137 Gene:
Hs.523763Evidence on tissue expression from TISSUES for GPR137 Gene
- Pancreas(4.4)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for GPR137
-
OriGene qPCR primer pairs and template standards for GPR137
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137 Gene
Orthologs for GPR137 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPR137 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPR137 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GPR137 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gpr137 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gpr137 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GPR137 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GPR137 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GPR137 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | GPR137 (1 of 2) 31 |
|
OneToMany | |
| gpr137 31 |
|
OneToMany |
- Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPR137 Gene
- ENSEMBL:
- Gene Tree for GPR137 (if available)
- TreeFam:
- Gene Tree for GPR137 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPR137: view image
Paralogs for GPR137 Gene
(4) SIMAP similar genes for GPR137 Gene using alignment to 14 proteins:
- G137A_HUMAN
- F5GXD9_HUMAN
- F5GXI8_HUMAN
- F5GXW8_HUMAN
- F5H097_HUMAN
- F5H0Q1_HUMAN
- F5H1T3_HUMAN
- F5H1V9_HUMAN
- F5H234_HUMAN
- F5H4R8_HUMAN
- F5H6Y8_HUMAN
- F5H7S0_HUMAN
- H0YGJ1_HUMAN
- L8EA54_HUMAN
Variants for GPR137 Gene
Residual Variation Intolerance Score:
21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.19;
39.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR137 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR137
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR137 Gene
Disorders for GPR137 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| isolated growth hormone deficiency, type ib |
|
|
Search GPR137 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPR137
No data available for UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene
Publications for GPR137 Gene
- The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. (PMID: 31036939) Gan L … Meyer T (Nature cell biology 2019) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3
- GPR137 is a promising novel bio-marker for the prognosis of bladder cancer patients. (PMID: 31464892) Lu J … Wang C (Medicine 2019) 3
ExternalLinks
Products for GPR137 Gene
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Genetically Engineered Models Available Immediately
- Humanized Mice
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- antibodies-online: Show 14 available GPR137 Antibodies ranked by validation data
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Sources for GPR137 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
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