Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3 5
  • TM7SF1L1 2 3 4
  • C11orf4 2 3 4
  • GPR137A 2 3 4
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • Integral Membrane Protein GPR137 3 4
  • GPR137 5

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. Diseases associated with GPR137 include Isolated Growth Hormone Deficiency, Type Ib. An important paralog of this gene is GPR137B.

UniProtKB/Swiss-Prot Summary for GPR137 Gene

  • Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939).
  • May activate Wnt/beta-catenin signaling to modulate epithelial cell function.

Additional gene information for GPR137 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR137 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR137 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR137

Top Transcription factor binding sites by QIAGEN in the GPR137 gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for GPR137 Gene

Genomic Locations for GPR137 Gene
chr11:64,270,062-64,289,500
(GRCh38/hg38)
Size:
19,439 bases
Orientation:
Plus strand
chr11:64,037,534-64,056,972
(GRCh37/hg19)
Size:
19,439 bases
Orientation:
Plus strand

Genomic View for GPR137 Gene

Genes around GPR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N19-G137A_HUMAN
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Q96N19
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    Size:
    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR137 Gene

Post-translational modifications for GPR137 Gene

  • Glycosylation at Asn4 and Asn257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR137 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR137 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58705, highly similar to Mus musculus G protein-coupled receptor 137 (Gpr137), mRNA (B7Z7M1_HUMAN)
  • Transmembrane 7 superfamily member 1-like 1 protein (G137A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N19

UniProtKB/Swiss-Prot:

G137A_HUMAN :
  • Belongs to the GPR137 family.
Family:
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

Molecular function for GPR137 Gene

UniProtKB/Swiss-Prot Function:
Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939).
UniProtKB/Swiss-Prot Function:
May activate Wnt/beta-catenin signaling to modulate epithelial cell function.

Phenotypes From GWAS Catalog for GPR137 Gene

genes like me logo Genes that share phenotypes with GPR137: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137

CRISPR Products

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Lysosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
lysosome 5
plasma membrane 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 31036939
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

PathCards logo

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IBA 21873635
GO:0045124 regulation of bone resorption IBA 21873635
GO:0045671 negative regulation of osteoclast differentiation IBA 21873635
GO:0045779 negative regulation of bone resorption IBA 21873635
genes like me logo Genes that share ontologies with GPR137: view

No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Drugs & Compounds for GPR137 Gene

No Compound Related Data Available

Transcripts for GPR137 Gene

mRNA/cDNA for GPR137 Gene

19 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR137

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10:
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
GPR137

Expression for GPR137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene



Protein tissue co-expression partners for GPR137 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR137

SOURCE GeneReport for Unigene cluster for GPR137 Gene:

Hs.523763

Evidence on tissue expression from TISSUES for GPR137 Gene

  • Pancreas(4.4)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GPR137: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR137 30 31
  • 99.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR137 30 31
  • 91.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR137 30 31
  • 91.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr137 30
  • 89.39 (n)
Mouse
(Mus musculus)
Mammalia Gpr137 30 17 31
  • 88.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR137 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GPR137 31
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR137 31
  • 61 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii GPR137 (1 of 2) 31
  • 51 (a)
OneToMany
gpr137 31
  • 46 (a)
OneToMany
Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

ENSEMBL:
Gene Tree for GPR137 (if available)
TreeFam:
Gene Tree for GPR137 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR137: view image

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

(4) SIMAP similar genes for GPR137 Gene using alignment to 14 proteins:

  • G137A_HUMAN
  • F5GXD9_HUMAN
  • F5GXI8_HUMAN
  • F5GXW8_HUMAN
  • F5H097_HUMAN
  • F5H0Q1_HUMAN
  • F5H1T3_HUMAN
  • F5H1V9_HUMAN
  • F5H234_HUMAN
  • F5H4R8_HUMAN
  • F5H6Y8_HUMAN
  • F5H7S0_HUMAN
  • H0YGJ1_HUMAN
  • L8EA54_HUMAN
genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Additional dbSNP identifiers (rs#s) for GPR137 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv3626658 CNV loss 21293372
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR137 Gene

Disorders for GPR137 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR137 Gene - From: DISEASES

Disorder Aliases PubMed IDs
isolated growth hormone deficiency, type ib
  • pituitary dwarfism i
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GPR137: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. (PMID: 31036939) Gan L … Meyer T (Nature cell biology 2019) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3
  5. GPR137 is a promising novel bio-marker for the prognosis of bladder cancer patients. (PMID: 31464892) Lu J … Wang C (Medicine 2019) 3

Products for GPR137 Gene

Sources for GPR137 Gene