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Aliases for GPR135 Gene

Aliases for GPR135 Gene

  • G Protein-Coupled Receptor 135 2 3 5
  • Probable G-Protein Coupled Receptor 135 3
  • G-Protein Coupled Receptor 135 3
  • HUMNPIIY20 3

External Ids for GPR135 Gene

Previous GeneCards Identifiers for GPR135 Gene

  • GC14M057920
  • GC14M059000
  • GC14M059895
  • GC14M040094

Summaries for GPR135 Gene

GeneCards Summary for GPR135 Gene

GPR135 (G Protein-Coupled Receptor 135) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR50.

UniProtKB/Swiss-Prot for GPR135 Gene

  • Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Gene Wiki entry for GPR135 Gene

Additional gene information for GPR135 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR135 Gene

Genomics for GPR135 Gene

GeneHancer (GH) Regulatory Elements for GPR135 Gene

Promoters and enhancers for GPR135 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J059463 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +0.5 491 2.1 MXI1 FOXA2 SAP130 BACH1 ARID4B SIN3A BMI1 E2F1 CTBP1 CREM GPR135 PIR32681 GC14M059465 L3HYPDH
GH14J059481 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 -18.6 -18568 5.4 HDGF PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B L3HYPDH JKAMP SCOCP1 GPR135 PCNX4 RBM8B ENSG00000258782
GH14J059771 Enhancer 1 Ensembl ENCODE 11.4 -306.3 -306340 0.3 INSM2 FEZF1 ZNF366 ZSCAN5C RCOR1 ZNF174 CEBPB ZEB2 ZNF488 TSHZ1 GPR135 GC14M059744 GC14P059777 RTN1
GH14J059175 Enhancer 0.8 ENCODE 10.5 +289.8 289758 0.1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM GPR135 PPIAP5 AKR1B1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR135 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR135 gene promoter:
  • NF-1
  • NF-1/L
  • Egr-3
  • AML1a
  • Spz1
  • POU2F1a
  • POU2F1

Genomic Locations for GPR135 Gene

Genomic Locations for GPR135 Gene
36,375 bases
Minus strand
36,321 bases
Minus strand

Genomic View for GPR135 Gene

Genes around GPR135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR135 Gene

Proteins for GPR135 Gene

  • Protein details for GPR135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 135
    Protein Accession:
    Secondary Accessions:
    • Q7Z604
    • Q86SM3
    • Q8NH39

    Protein attributes for GPR135 Gene

    494 amino acids
    Molecular mass:
    51736 Da
    Quaternary structure:
    • Interacts with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (PubMed:28827538).
    • Sequence=BAC05800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GPR135 Gene

Post-translational modifications for GPR135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPR135 Gene

Domains & Families for GPR135 Gene

Gene Families for GPR135 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR135 Gene


Suggested Antigen Peptide Sequences for GPR135 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR135: view

Function for GPR135 Gene

Molecular function for GPR135 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Gene Ontology (GO) - Molecular Function for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 28827538
GO:1990763 arrestin family protein binding IDA 28827538
genes like me logo Genes that share ontologies with GPR135: view
genes like me logo Genes that share phenotypes with GPR135: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR135

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR135 Gene

Localization for GPR135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR135 Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome. {ECO:0000269 PubMed:28827538}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR135 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 28827538
GO:0005886 plasma membrane IDA,IEA 28827538
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR135: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR135 Gene

Pathways & Interactions for GPR135 Gene

SuperPathways for GPR135 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR135: view

Pathways by source for GPR135 Gene

1 BioSystems pathway for GPR135 Gene

Gene Ontology (GO) - Biological Process for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR135: view

No data available for SIGNOR curated interactions for GPR135 Gene

Drugs & Compounds for GPR135 Gene

No Compound Related Data Available

Transcripts for GPR135 Gene

mRNA/cDNA for GPR135 Gene

Unigene Clusters for GPR135 Gene

G protein-coupled receptor 135:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR135 Gene

No ASD Table

Relevant External Links for GPR135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR135 Gene

mRNA differential expression in normal tissues according to GTEx for GPR135 Gene

This gene is overexpressed in Testis (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR135 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR135 Gene:


SOURCE GeneReport for Unigene cluster for GPR135 Gene:

genes like me logo Genes that share expression patterns with GPR135: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR135 Gene

Orthologs for GPR135 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GPR135 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR135 34 33
  • 88.91 (n)
(Canis familiaris)
Mammalia GPR135 33
  • 87.47 (n)
(Rattus norvegicus)
Mammalia Gpr135 33
  • 83.33 (n)
(Mus musculus)
Mammalia Gpr135 16 34 33
  • 83.04 (n)
(Monodelphis domestica)
Mammalia GPR135 34
  • 55 (a)
Species where no ortholog for GPR135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR135 Gene

Gene Tree for GPR135 (if available)
Gene Tree for GPR135 (if available)
Evolutionary constrained regions (ECRs) for GPR135: view image

Paralogs for GPR135 Gene

Paralogs for GPR135 Gene

genes like me logo Genes that share paralogs with GPR135: view

Variants for GPR135 Gene

Sequence variations from dbSNP and Humsavar for GPR135 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000134954 -- 59,453,806(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000189315 -- 59,452,504(-) T/C downstream_transcript_variant
rs1000234658 -- 59,456,455(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000259062 -- 59,456,239(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000463308 -- 59,454,139(-) CCCC/CCC 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR135 Gene

Variant ID Type Subtype PubMed ID
nsv832810 CNV loss 17160897

Variation tolerance for GPR135 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR135 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR135 Gene

Disorders for GPR135 Gene

Additional Disease Information for GPR135

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR135 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR135 Gene

Publications for GPR135 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 58
  2. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. (PMID: 28827538) Oishi A … Jockers R (Scientific reports 2017) 3 4 58
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for GPR135 Gene

Sources for GPR135 Gene

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