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Aliases for GPR132 Gene

Aliases for GPR132 Gene

  • G Protein-Coupled Receptor 132 2 3 5
  • Probable G-Protein Coupled Receptor 132 3 4
  • G2 Accumulation Protein 3 4
  • G2A 3 4
  • G2 Accumulation 2

External Ids for GPR132 Gene

Previous GeneCards Identifiers for GPR132 Gene

  • GC14M103489
  • GC14M103490
  • GC14M104586
  • GC14M105558
  • GC14M105560
  • GC14M085709
  • GC14M105563
  • GC14M105568
  • GC14M105573
  • GC14M105578
  • GC14M105593
  • GC14M105600
  • GC14M105608

Summaries for GPR132 Gene

Entrez Gene Summary for GPR132 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for GPR132 Gene

GPR132 (G Protein-Coupled Receptor 132) is a Protein Coding gene. Diseases associated with GPR132 include Inclusion Conjunctivitis and Lassa Fever. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot for GPR132 Gene

  • May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.

Gene Wiki entry for GPR132 Gene

Additional gene information for GPR132 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR132 Gene

Genomics for GPR132 Gene

GeneHancer (GH) Regulatory Elements for GPR132 Gene

Promoters and enhancers for GPR132 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J105058 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 621.8 +2.4 2365 10 SP1 CBFA2T2 NKRF POLR2A ZNF687 RELA CREM PRDM1 MLLT1 ZBED1 GPR132 MTA1 AHNAK2 CDCA4 JAG2 NUDT14 CLBA1 TEDC1 PLD4 BRF1
GH14J105068 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 60.1 -4.6 -4639 2.8 SP1 ZNF148 NKRF ZNF687 RELA CREM MLLT1 ZBED1 IKZF1 BACH1 GPR132 MTA1 JAG2 NUDT14 CLBA1 CRIP1 LINC02298
GH14J105074 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.4 -10.0 -9971 1.2 ZFX ZNF148 MLLT1 IKZF1 GLIS2 POLR2A BACH1 ZIC2 SCRT2 DPF2 GPR132 CLBA1 JAG2 NUDT14 LINC02298 PLD4 CRIP1
GH14J105031 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 26.1 +32.1 32144 3.1 NCOA3 POLR2A PRDM1 CREB1 RFX1 ZBTB33 ZEB2 CTBP1 NR2C1 GTF2F1 GPR132 CLBA1 CRIP1 GC14P105029 GC14P105040
GH14J105013 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.2 +44.2 44191 14.8 SP1 ZFX MNT ZNF148 NKRF ZNF121 RERE POLR2A ZNF687 ZSCAN21 CDCA4 CLBA1 GPR132 AHNAK2 PIR49972 GC14P105029
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR132 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR132 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • ER-alpha
  • p53
  • STAT5A
  • Zic1
  • Zic3

Genomic Locations for GPR132 Gene

Genomic Locations for GPR132 Gene
chr14:105,049,389-105,065,550
(GRCh38/hg38)
Size:
16,162 bases
Orientation:
Minus strand
chr14:105,515,728-105,531,782
(GRCh37/hg19)
Size:
16,055 bases
Orientation:
Minus strand

Genomic View for GPR132 Gene

Genes around GPR132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR132 Gene

Proteins for GPR132 Gene

  • Protein details for GPR132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNW8-GP132_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 132
    Protein Accession:
    Q9UNW8
    Secondary Accessions:
    • A8K7X7
    • B4E144
    • Q9BSU2

    Protein attributes for GPR132 Gene

    Size:
    380 amino acids
    Molecular mass:
    42499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR132 Gene

Post-translational modifications for GPR132 Gene

  • Glycosylation at posLast=3535
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR132 Gene

No data available for DME Specific Peptides for GPR132 Gene

Domains & Families for GPR132 Gene

Gene Families for GPR132 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR132 Gene

Suggested Antigen Peptide Sequences for GPR132 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75897, highly similar to Homo sapiens G protein-coupled receptor 132 (GPR132), mRNA (A8K7X7_HUMAN)
  • Truncated G protein-coupled receptor 132 (B2LM89_HUMAN)
  • cDNA FLJ56605, highly similar to Probable G-protein coupled receptor 132 (B4E144_HUMAN)
  • G2 accumulation protein (GP132_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UNW8

UniProtKB/Swiss-Prot:

GP132_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR132: view

Function for GPR132 Gene

Molecular function for GPR132 Gene

UniProtKB/Swiss-Prot Function:
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
UniProtKB/Swiss-Prot Induction:
By stress and DNA-damaging agents.

Phenotypes From GWAS Catalog for GPR132 Gene

Gene Ontology (GO) - Molecular Function for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR132: view
genes like me logo Genes that share phenotypes with GPR132: view

Animal Models for GPR132 Gene

MGI Knock Outs for GPR132:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GPR132 - Now 50% OFF >
  • * GPR132 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GPR132 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR132 Gene

Localization for GPR132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR132 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR132 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR132: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR132 Gene

Pathways & Interactions for GPR132 Gene

genes like me logo Genes that share pathways with GPR132: view

Pathways by source for GPR132 Gene

Interacting Proteins for GPR132 Gene

Gene Ontology (GO) - Biological Process for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IBA 21873635
genes like me logo Genes that share ontologies with GPR132: view

No data available for SIGNOR curated interactions for GPR132 Gene

Drugs & Compounds for GPR132 Gene

(2) Drugs for GPR132 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
9-hydroxyoctadecadienoic acid Pharma Full agonist, Agonist 0
Boc-Lys(Ac)-AMC Pharma GPCR G2A/GPR132 agonist 0

(1) ApexBio Compounds for GPR132 Gene

Compound Action Cas Number
Boc-Lys(Ac)-AMC GPCR G2A/GPR132 agonist
genes like me logo Genes that share compounds with GPR132: view

Transcripts for GPR132 Gene

mRNA/cDNA for GPR132 Gene

(4) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GPR132 Gene

G protein-coupled receptor 132:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GPR132 - Now 50% OFF >
  • * GPR132 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GPR132 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GPR132 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - - - - - -

Relevant External Links for GPR132 Gene

GeneLoc Exon Structure for
GPR132
ECgene alternative splicing isoforms for
GPR132

Expression for GPR132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR132 Gene

mRNA differential expression in normal tissues according to GTEx for GPR132 Gene

This gene is overexpressed in Whole Blood (x15.7).

Protein differential expression in normal tissues from HIPED for GPR132 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR132 Gene



Protein tissue co-expression partners for GPR132 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR132 Gene:

GPR132

SOURCE GeneReport for Unigene cluster for GPR132 Gene:

Hs.532504

mRNA Expression by UniProt/SwissProt for GPR132 Gene:

Q9UNW8-GP132_HUMAN
Tissue specificity: Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.

Evidence on tissue expression from TISSUES for GPR132 Gene

  • Lung(4.5)
  • Spleen(4.5)
  • Nervous system(4.3)
  • Kidney(2.5)
  • Blood(2.2)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with GPR132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR132 Gene

Orthologs for GPR132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR132 35 34
  • 98.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR132 35 34
  • 79.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR132 35 34
  • 78.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr132 17 35 34
  • 76.07 (n)
rat
(Rattus norvegicus)
Mammalia Gpr132 34
  • 75.85 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR132 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR132 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR132 35 34
  • 55.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR132 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr132 34
  • 55.13 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797380 34
  • 52.38 (n)
GPR132 (1 of 3) 35
  • 44 (a)
OneToMany
GPR132 (2 of 3) 35
  • 38 (a)
OneToMany
GPR132 (3 of 3) 35
  • 30 (a)
OneToMany
Species where no ortholog for GPR132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR132 Gene

ENSEMBL:
Gene Tree for GPR132 (if available)
TreeFam:
Gene Tree for GPR132 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR132: view image

Paralogs for GPR132 Gene

Paralogs for GPR132 Gene

(5) SIMAP similar genes for GPR132 Gene using alignment to 5 proteins:

  • GP132_HUMAN
  • A8K7X7_HUMAN
  • B2LM89_HUMAN
  • B4E144_HUMAN
  • F8VRH8_HUMAN
genes like me logo Genes that share paralogs with GPR132: view

Variants for GPR132 Gene

Sequence variations from dbSNP and Humsavar for GPR132 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000080371 -- 105,052,134(-) G/C intron_variant
rs1000124188 -- 105,049,186(-) G/T downstream_transcript_variant
rs1000167216 -- 105,063,671(-) C/T intron_variant
rs1000264162 -- 105,057,252(-) A/G 5_prime_UTR_variant, intron_variant
rs1000404832 -- 105,062,415(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR132 Gene

Variant ID Type Subtype PubMed ID
esv2665589 CNV deletion 23128226
esv2760014 CNV loss 17122850
esv3635634 CNV gain 21293372
nsv1042303 CNV gain 25217958
nsv1052190 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv1132386 CNV duplication 24896259
nsv456458 CNV loss 19166990
nsv566141 CNV gain 21841781
nsv566150 CNV loss 21841781
nsv566151 CNV loss 21841781
nsv566152 CNV loss 21841781
nsv9175 CNV gain 18304495

Variation tolerance for GPR132 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR132
Human Gene Mutation Database (HGMD)
GPR132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR132 Gene

Disorders for GPR132 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR132 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
lassa fever
  • lf
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR132

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR132 Gene

Publications for GPR132 Gene

  1. Identification and analysis of two splice variants of human G2A generated by alternative splicing. (PMID: 19855098) Ogawa A … Izumi T (The Journal of pharmacology and experimental therapeutics 2010) 3 4 58
  2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 45 58
  3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 45 58
  4. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. (PMID: 17475884) Frasch SC … Bratton DL (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 23 58
  5. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. (PMID: 16236715) Obinata H … Izumi T (The Journal of biological chemistry 2005) 3 23 58

Products for GPR132 Gene

Sources for GPR132 Gene

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